Clinical trials: Synucleinopathies
Parkinson Disease, Idiopathic Parkinson Disease
Study to Determine Mutations in the Gaucher Gene in Patients With Idiopathic Parkinson's Disease for Phenotype-genotype Correlation
The genotype-phenotype correlation in patients with Parkinson's disease with specific mutations in the glucocerebrosidase gene (Gaucher gene) is known from own clinical experiences as well as from case reports in the literature.
- Trial name
- PadGau (NCT01272687)
- Where
- 15 sites in Germany, Thailand
- Volunteers
- 1,500 people
- Sponsor
- CENTOGENE GmbH Rostock
Parkinson Disease, Tremor
The Quality of Life in Individuals With Parkinson's Disease
This study aimed to examine the relationship of quality of life with tremor severity and upper limb functionality in individuals with Parkinson's Disease.
- Conditions
- Parkinson Disease, Tremor, Functionality
- Trial name
- NCT05906693
- Testing
- Quality of life, Upper limb functionality, Grip and pinch strength
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Pamukkale University
Parkinson Disease
Observational Small Intestine and Blood Fingerprint (SmIle) Study in Parkinson's Disease
Observational cross-sectional study in PD patients and healthy controls (HC) using an investigational medical device consisting of a passive small intestine microbiome aspiration (SIMBA) system (capsule) that is ingested orally…
- Trial name
- SmIle (NCT06003608)
- Testing
- Fluid biopsy capsule, Levodopa-Carbidopa Immediate Release
- Where
- Canada
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Nimble Science Ltd.
Parkinson Disease
O-ARM Stereotactic Imaging in Deep Brain Stimulation for Parkinson's Disease
During deep brain stimulation procedures in Parkinson's disease (PD), the most important prognostic element is the positioning of the surgical electrode in the subthalamic nucleus which is the anatomical target.
- Trial name
- STEREOBLOC (NCT05910008)
- Testing
- O-Arm Stereotactic imaging, Standard Stereotactic imaging
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Toulouse
Idiopathic Parkinson Disease
A Study to Evaluate in Patients With Parkinsonian Type Disorders
A Phase 2 study to evaluate the safety, tolerability and initial efficacy of pramipexole ER, given with aprepitant in patients with parkinsonian type disorders
- Trial name
- NCT03683225
- Testing
- CTC-413
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Chase Therapeutics Corporation
Parkinson Disease
A Two-Part Single and Multiple Ascending Dose Trial of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of LBT-3627 in Healthy Participants and in Participants With Parkinson's Disease.
Phase I a/b SAD/MAD study to evaluate safety and tolerability of LBT-3627 in both healthy volunteers and Parkinson's patients.
- Trial name
- NCT06466525
- Testing
- LBT-3627
- Where
- 3 sites in Australia
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Longevity Biotech Australia Pty Ltd (subsidiary)
Dementia Alzheimers, Dementia With Lewy Bodies
Dementias and Microbiota Composition: Is Possible to Revert the Dementia Symptoms Reverting the Microbiota Composition?
Dementia is the major cause of disability and dependency among older adults worldwide affecting memory, cognitive abilities and behavior, interfering with one's ability to perform daily lives activities.
- Conditions
- Dementia Alzheimers, Dementia With Lewy Bodies, Parkinson Disease Dementia, Dementia Frontotemporal
- Trial name
- DEM-BIOTA (NCT05943925)
- Testing
- No intervention, Probiotic supplement
- Where
- Spain
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University Rovira i Virgili
Parkinson's Disease and Parkinsonism
Diaphragmatic Thickness and Pulmonary Function in Parkinson's Disease
Ultrasound can give important information about the morphology of the diaphragm and the amount of contraction. Our aim, with the prediction that a restrictive pathology will occur in the pulmonary function with the addition of…
- Trial name
- NCT05194748
- Testing
- No intervention, observational only
- Where
- Turkey (Türkiye)
- Volunteers
- 37 people
- Sponsor
- Abant Izzet Baysal University
Parkinson's Disease, Quality of Life
Study of the Application of Magnetic Fields for the Treatment of Parkinson's Disease
The purpose of this study is to see if a device called the Resonator can help to improve aspects of health and quality of life that are relevant to patients with Parkinson's disease.
- Trial name
- NCT00863226
- Testing
- Resonator Device
- Where
- 6 sites in United States
- Volunteers
- 72 people
- Sponsor
- pico-tesla Magnetic Therapies, LLC
Parkinson Disease, Other Neurological Disorders
Prevalence of Visual Dysfunction in Neurological Disorders
The objective is to determine the prevalence of visual dysfunction in People with Parkinson's Disease (PwP). The investigators will administer the: Visual Impairment in Parkinson's Disease Screen and Revised-Self-Report…
- Conditions
- Parkinson Disease, Other Neurological Disorders, Healthy
- Trial name
- NCT04836715
- Where
- 2 sites in United States
- Volunteers
- 92 people
- Sponsor
- University of Florida
Parkinson's Disease
Satisfaction Survey on PINS Stimulator System for Patients With Parkinson's Disease
This study will be done because the investigators would like to evaluate product satisfaction of two PINS products (product A, product B) that are to evaluate the effectiveness of rechargeable and non-rechargeable Deep Brain…
- Trial name
- NCT02251808
- Where
- China
- Volunteers
- 612 people
- Sponsor
- Beijing Pins Medical Co., Ltd
Parkinson Disease
Pain in Parkinson's Disease With Motor Fluctuations.
Pain (spontaneous pain) is a fundamental non-motor symptom (NMS) of Parkinson's disease (PD) that is prevalent throughout the condition and often unrecognized and undertreated.
- Trial name
- PAINinPD (NCT03648671)
- Testing
- safinamide metansolfonato (12 weeks), rasagilina mesilato (12 weeks)
- Where
- Italy
- Volunteers
- 48 people
- Sponsor
- Universita di Verona
Parkinson Disease
A Novel Measurement Concept to Objectively Quantify Severity of Vocal and Speech Related Symptoms Associated With Parkinson's Disease
The aim of this research program is to develop and validate a smartphone app-based digital measurement concept that: Objectively quantifies the severity of Parkinson's Disease (PD) related vocal and speech symptoms; Accurately…
- Trial name
- Voice-PD (NCT05421832)
- Testing
- Digital Speech Application
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Levodopa Induced Dyskinesia
Levetiracetam Administration for the Management of Levodopa-Induced Dyskinesias in Parkinson's Disease
Levodopa-induced dyskinesias have been associated with irregular oscillatory discharge characteristics of basal ganglia. From the other hand, LEV which shares a different electrophysiologic profile than other antiepileptics…
- Trial name
- NCT00291733
- Testing
- Levetiracetam
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- 1st Hospital of Social Security Services
Parkinson Disease, Freezing of Gait
Neurorehabilitation of Sequence Effect in Parkinson's Disease
The sequence effect (SE), defined as a reduction in amplitude of repetitive movements, is a common clinical feature of Parkinson's disease (PD), being a major contributor to freezing of gait (FOG).
- Trial name
- NCT04921748
- Testing
- Neurorehabilitation
- Where
- Italy
- Volunteers
- 43 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Healthy, Neurodegenerative Disease
Brain Health Registry: An Online Registry to Identify and Assess Subjects for Brain Research
The overall goal of this project is to identify, assess and longitudinally monitor subjects who are interested in participating in brain research.
- Trial name
- BHR (NCT02402426)
- Where
- United States
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Parkinson Disease
Deep Brain Stimulation of the Cuneiform Nucleus for Levodopa-resistant Freezing of Gait in Parkinson's Disease
The purpose of this research study is to determine if DBS is a safe and effective therapy for severe freezing of gait in patients with Parkinson's Disease.
- Trial name
- DBS + FOG (NCT04218526)
- Testing
- Vercise DBS System
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Jonathan Jagid
Parkinson Disease
Development and Research of an Individualized Intelligent Platform for Rehabilitaion in Parkinson's Disease
The present study aims to compare the clinical efficacy of intelligent POWER therapy, intelligent LSVT-BIG therapy, and the three exercise models currently in clinical use.
- Trial name
- NCT03212014
- Testing
- LSVT-BIG, POWER, Traditional rehabilitation
- Where
- Taiwan
- Volunteers
- 75 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Parkinson's Disease
Ambulatory Assessment of Motor State in Patients With Parkinson's Disease in Real Daily Life
Patients with Parkinson's disease (PD) suffer from motor fluctuations and levodopa induced dyskinesia. The prupose of this study is to evaluate the effect of an automatic system to assess the motor state of PD patients in real…
- Trial name
- NCT00184808
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Radboud University Medical Center
Neurodegenerative Diseases, Parkinson Disease
Neurodegenerative Diseases Progression Markers (MARKERS-NDD)
MARKERS-NDD is a prospective, observational, longitudinal study, which aims to collect data from patients affected by neurodegenerative diseases (NDD) followed longitudinally for routine examinations performed as part of normal…
- Conditions
- Neurodegenerative Diseases, Parkinson Disease, Synucleinopathies, Lewy Body Disease
- Trial name
- MARKERS-NDD (NCT06596746)
- Testing
- Observation
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- Casa di Cura San Raffaele Cassino