Clinical trials: Syncope
Atrial Fibrillation Paroxysmal, Atrial Fibrillation, Persistent
Assert-IQ Implantable Cardiac Monitor (ICM) Post Market Study
This is a prospective, non-randomized, multi-center, real-world post-market study to collect and evaluate data regarding the performance of the enhanced atrial fibrillation detection algorithm of the Assert-IQTM Implantable…
- Conditions
- Atrial Fibrillation Paroxysmal, Atrial Fibrillation, Persistent, Cardiac Arrhythmia, Ablation
- Trial name
- Assert-IQ (NCT06172699)
- Testing
- Holter monitoring in patients who have been successfully implanted with an Abbott Assert-IQ ICM device
- Where
- 11 sites in United States
- Volunteers
- 151 people
- Sponsor
- Abbott Medical Devices
Syncope
Canadian Prehospital Syncope Risk Score (Prehospital CSRS)
Background: Syncope is defined as a sudden, brief loss of consciousness (LOC) followed by a rapid complete recovery. It accounts for 160,000 emergency department (ED) visits each year in Canada.
- Trial name
- NCT05560126
- Where
- Canada
- Volunteers
- 4,875 people
- Sponsor
- Venkatesh Thiruganasambandamoorthy
Syncope, Vasovagal
The Effect of CPC on Aborting Tilt Induced Syncope in Patients With a History of Vasovagal Syncope or Near Syncope
Syncope is defined as transient loss of consciousness associated with inability to maintain postural tone with rapid and spontaneous recovery.
- Trial name
- NCT04972123
- Testing
- CPC - Capsaicin, Phenylephrine, Caffeine, Tilt Table Test
- Where
- United States
- Volunteers
- 143 people
- Sponsor
- University of Wisconsin, Madison
Arrhythmias, Cardiac
Biospecimen Repository for Cardiac Arrhythmias at the Cleveland Clinic
Biorepository of blood and or tissue samples from patients presenting with cardiac arrhythmia syndromes.
- Trial name
- NCT00921986
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Postural Orthostatic Tachycardia Syndrome (POTS), Syncope
Abdominal and Lower Extremity Compression During Tilt Table Testing in Adolescent POTS Patients
Postural orthostatic tachycardia syndrome (POTS) is a common cause of orthostatic intolerance in adolescents and adults. Compression stockings are commonly recommended as a treatment modality for POTS, but the effects of…
- Trial name
- NCT01795469
- Testing
- Zoex compression garment
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Nationwide Children's Hospital
Hydration, Loss of Consciousness
Effect of Chronic Oral Hydration in Patients With Recurrent Unexplained Syncope
Beneficial effect of chronic hydration with salt supplementation in patients with recurrent unexplained syncope is not established.
- Conditions
- Hydration, Loss of Consciousness, Neurocardiogenic Syncope
- Trial name
- NCT00143754
- Testing
- Hydration
- Sponsor
- University Hospital, Angers
Syncope
Exercise and Prevention of Syncope: EXPOSE
The purpose of this study is to determine whether eight weeks of exercise performed at an intensity of approximately 65% VO2max will improve symptoms associated with fainting (vasovagal syncope).
- Trial name
- NCT00203593
- Testing
- Exercise, Blood volume, VO2max test
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Syncope, Heart Block
Syncope: Pacing or Recording in the Later Years
Syncope affects about 50% of Canadians, is the cause of 1 - 2% of all emergency room visits, and probably is responsible for CDN $250 million in health care spending each year.
- Conditions
- Syncope, Heart Block, Conduction Disorder of the Heart
- Trial name
- Spritely (NCT01423994)
- Testing
- pacemaker, implantable loop recorder
- Where
- 17 sites in United States, Canada and 3 more
- Volunteers
- 120 people
- Sponsor
- Canadian Institutes of Health Research (CIHR)
Syncope, Arrhythmia
Remote Cardiac Monitoring of Higher-Risk Emergency Department Syncope Patients After Discharge - A Pilot Study
2-3% of emergency department (ED) syncope patients suffer arrhythmia/death within 30 days of disposition (either as an inpatient or at home) and we have recently developed the Canadian Syncope Risk Score (CSRS) to predict these…
- Trial name
- REMOSYNC (NCT02786940)
- Testing
- Cardiophone
- Where
- Canada
- Volunteers
- 99 people
- Sponsor
- Ottawa Hospital Research Institute
Autonomic Nervous System Diseases
PET Scan in Patients With Neurocardiologic Disorders
This study is designed to use PET scans in order to measure activity of the sympathetic nervous system. The sympathetic nervous system is the portion of the nervous system that maintains a normal supply of blood and fuel to…
- Trial name
- NCT00001418
- Where
- United States
- Volunteers
- 335 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Syncope, Pediatric
Pediatric Adhesion and New Dermal Approach Study
The purpose of this study is to see if the Zio® monitor device can be worn by children for up to 14-days and to determine if the skin preparation process will provide good adherence to the skin and clear signal quality.
- Conditions
- Syncope, Pediatric, Congenital Athymia, Congenital Heart Disease
- Trial name
- PANDA (NCT07118124)
- Testing
- Zio monitor
- Where
- 4 sites in United States
- Volunteers
- 36 people
- Sponsor
- iRhythm Technologies, Inc.
Neurocardiogenic Syncope, Vasovagal Syncope
Cardioneuroablation for Neurocardiogenic Syncope
The purpose of this study is to evaluate the effectiveness of cardioneuroablation for the treatment of neurocardiogenic syncope (NCS), also known as "vaso-vagal" syncope.
- Trial name
- Ablate-NCS (NCT02009982)
- Testing
- Cardioneuroablation, Biosense Webster Navistar ThermoCool Diagnostic/Ablation Deflectable Tip Catheter
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- David B. De Lurgio
Syncope
Propranolol to Treat Fainting in Children With Sympathoadrenal Imbalance
This study will examine the effectiveness of the drug propranolol in preventing fainting in patients with sympathoadrenal imbalance (SAI).
- Trial name
- NCT00093860
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Arrhythmias, Cardiac, Bradycardia
One Hospital ClinicalService Project
The One Hospital ClinicalService Project is an integrated system composed by a network of International Hospital Departments, a clinical data repository and a shared environment for the collection, management, analysis and…
- Conditions
- Arrhythmias, Cardiac, Bradycardia, Syncope
- Trial name
- OHCS (NCT01007474)
- Testing
- Implantable Cardioverter-Defibrillator (ICD), Implantable Pacemaker Generator (IPG), Implantable Loop Recorder (ILR)
- Where
- 41 sites in Germany, Iceland and 7 more
- Sponsor
- Medtronic Italia
Vasovagal Syncope
Study of Atomoxetine in the Prevention of Vasovagal Syncope
Project rationale: Vasovagal syncope (VVS) affects up to 50% of people, and recurrent syncope markedly reduces quality of life. We recently reported that it is frequently associated with injury and not surprisingly with clinical…
- Trial name
- POST7 (NCT05159687)
- Testing
- Atomoxetine Hydrochloride
- Where
- Canada
- Volunteers
- 180 people
- Sponsor
- University of Calgary
Syncope, Near Syncope
Validation of the San Francisco Syncope Rule
This study was designed to validate the "San Francisco Syncope Rule". This set of rules was derived by Quinn et. al. to help guide the treatment of patients evaluated in the Emergency Department who had an episode of syncope…
- Trial name
- NCT00300625
- Testing
- Application of the San Francisco Syncope Rule
- Where
- United States
- Sponsor
- Albert Einstein College of Medicine
Syncope, Postural Tachycardia Syndrome
EEG Characteristics in Youth POTS and/or Syncope
Orthostatic intolerance refers to symptoms that occur with standing and improve or resolve with recumbency. Few studies have evaluated orthostatic intolerance symptoms by electroencephalography (EEG), and none of those studies…
- Conditions
- Syncope, Postural Tachycardia Syndrome, Orthostatic Intolerance
- Trial name
- NCT02167412
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Nationwide Children's Hospital
Bradycardia; Syncope, Bradyarrhythmia
Temporary Transvenous Pacemaker Placement by Intracavitary Electrocardiogram Monitoring
Traditional temporary pacing catheter insertion by intracavitary electrocardiogram (IC-ECG) monitoring which only monitoring tip polar, the negative one.
- Conditions
- Bradycardia; Syncope, Bradyarrhythmia, Brady-tachy Syndrome, Tachycardia Bradycardia
- Trial name
- NCT04905199
- Testing
- Temporary transvenous cardiac pacing
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Hunan Provincial People's Hospital
Bradycardia, Syncope
Cardioneuroablation for Bradyarrhythmia
This is a multicenter prospective randomized blind controlled trial with a sham procedure group of the efficacy and safety of cardioneuroablation as a method of treating symptomatic bradycardia without a permanent pacemaker…
- Conditions
- Bradycardia, Syncope, Sick Sinus Syndrome
- Trial name
- CARDIOBOOST (NCT06288633)
- Testing
- Ganglionated plexi ablation, Electrophysiological study
- Where
- Russia
- Volunteers
- 106 people
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Chronic Fatigue Syndrome, Myalgic Encephalomyelitis
Reducing Orthostatic Intolerance With Oral Rehydration in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients
We and others have shown that many younger patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) have orthostatic intolerance (OI), i.e., they can't tolerate prolonged standing.
- Conditions
- Chronic Fatigue Syndrome, Myalgic Encephalomyelitis, Systemic Exertion Intolerance Disease (SEID), Postural Tachycardia Syndrome (POTS)
- Trial name
- NCT02854683
- Testing
- Normal Saline, Oral Rehydration Solution
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- New York Medical College