Clinical trials: Syncope
Syncope, Pre-Syncope
Evaluation of a Mobile Cardiac Outpatient Telemetry System Versus Standard Loop Event Monitor
Comparing the arrhythmia diagnostic yield of MCOT as compared to standard loop event monitors in patients presenting with palpitations, syncope or near syncope occurring less frequently than every 24 hours.
- Conditions
- Syncope, Pre-Syncope, Palpitations
- Trial name
- NCT00295204
- Where
- 13 sites in United States
- Volunteers
- 300 people
- Sponsor
- Cardionet
Syncope
In Hospital 24 Hour Observation of Syncope Patients
Syncope is very common and has a broad differential diagnosis. Guidelines on syncope recommend to apply guideline based syncope algorithm (SA) to identify low- / intermediate risk syncope patients and recommend to discharge these…
- Trial name
- RISC (NCT06472375)
- Testing
- holter
- Where
- Netherlands
- Volunteers
- 640 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Neurally Mediated Syncope
Italian Cardioneuroablation Study for Neurocardiogenic Syncope Patients
Multicenter Italian interventional "proof of efficacy" clinical trial that aims to evaluate the incidence of asystolic pauses and heart rate in patients with CNS who performed severe CNA identified through asystolic pauses…
- Trial name
- ItalianCNA (NCT05751330)
- Testing
- Transcatheter ablation of cardiac ganglionated plexi
- Where
- 2 sites in Italy
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Policlinico Casilino ASL RMB
Syncope, Pulmonary Embolism
Prevalence of Pulmonary Embolism in Patients With Syncope
All patients consecutively referred with the first episode of transient and short-lasting loss of consciousness will have a diagnostic workup for the assessment of the most common causes of syncope, and will be evaluated for the…
- Trial name
- PESY (NCT01797289)
- Testing
- Lung CT or V/Q scanning in patients with a high pre-test clinical probability of PE and/or a positive D-dimer
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- University of Padova
Syncope, Vasovagal, Neurally-Mediated
Clinical Trial for the Prevention of Vasovagal Syncope
The main question in the study is whether people taking fludrocortisone are less likely to faint than people taking an inactive pill called a placebo. Fludrocortisone is a drug that stimulates the body to retain salt and water.
- Trial name
- NCT00118482
- Testing
- fludrocortisone acetate
- Where
- 14 sites in United States, Canada
- Volunteers
- 213 people
- Sponsor
- University of Calgary
POTS - Postural Orthostatic Tachycardia Syndrome
Postural Tachycardia Syndrome and Vasovagal Syncope in Relation to Serum Electrolytes and Adrenal Insufficiency
The present study aims to: 1. Estimate the prevalence of Postural Tachycardia Syndrome and vasovagal syncope among adults patients attend the Internal Medicine Clinic and ICU in period from 11/2022 to 10/2023 2.
- Trial name
- NCT05695755
- Testing
- ECHO, Serum electrolytes
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Syncope, Presyncope
Comparison of Continuous Sternal ECG Patch Monitors (Carnation and Zio) Trial
This study is intended to compare the new Carnation patch monitoring system with the Zio patch, which represents the current standard for continuous recording of the ECG over extended periods.
- Conditions
- Syncope, Presyncope, Palpitations, Atrial Fibrillation
- Trial name
- NCT02031484
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- Bardy Diagnostics, Inc.
Syncope, Seizures
Observational and Diagnostical Study on Transient Allostatic Responses of Thyroid Function After Syncopation and Seizure
Changes of thyroid function may occur after short loss of consciousness, but they haven't been systematically evaluated up to now, although occasional observations suggest temporal increases in TSH concentration.
- Trial name
- Thyro-Syncope (NCT04879147)
- Testing
- Evalution of thyroid function
- Where
- 4 sites in Germany
- Volunteers
- 350 people
- Sponsor
- Ruhr University of Bochum
Ventricular Tachycardia, Sudden Death
Feasibility of Contact Force Catheter Mapping and Ablation in Epicardial and Endocardial Ventricular Tachycardias
Ventricular tachycardia is one of the commonest cause of sudden death in chronic chagas disease. As most ventricular tachycardias originate from scar in patients with heart disease, catheter ablation is an important step in…
- Conditions
- Ventricular Tachycardia, Sudden Death, Syncope, Chest Pain
- Trial name
- EPICONTAC-VT (NCT01847378)
- Testing
- Catheter ablation
- Where
- 3 sites in Brazil
- Volunteers
- 10 people
- Sponsor
- Federal University of São Paulo
Brief Loss of Consciousness
Applicability of Syncope Guidelines in Cataluña
The aim of SYNCAT study is to study the level of adherence of the centers in Cataluña tu the Syncope Guidelines ESC2009 for the diagnosis and treatment of syncope and the impact that following them can have in the prognosis of…
- Trial name
- SYNCAT (NCT01721369)
- Testing
- Transient Loss of Consciousness (T-LOC)
- Volunteers
- 581 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Symptomatic Neurogenic Orthostatic Hypotension
Clinical Effect of Ampreloxetine (TD-9855) for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure
A Phase 3 study to evaluate efficacy, safety, and tolerability of ampreloxetine (TD-9855) in subjects with primary autonomic failures (MSA, PD, or PAF) and symptomatic nOH with up to 4 weeks of treatment.
- Trial name
- SEQUOIA (NCT03750552)
- Testing
- ampreloxetine
- Where
- 125 sites in United States, Australia and 17 more
- Volunteers
- 195 people
- Sponsor
- Theravance Biopharma
Syncope, Vasovagal
Compression Stockings for Treating Vasovagal Syncope Trial
Syncope, a sudden, transient loss of consciousness (TLOC), is a common inconvenience of daily function and quality of life (QoL).
- Trial name
- COMFORTS II (NCT05086679)
- Testing
- Compression Stockings with 25-30 mm Hg pressure, Compression stockings with up to <=10 mm Hg pressure, Lifestyle modification
- Where
- Iran
- Volunteers
- 268 people
- Sponsor
- Tehran Heart Center
Atrial Fibrillation, Syncope
BIO|CONCEPT.BIOMONITOR III
The objective of the study is to confirm the safety and efficacy of the BIOMONITOR III system. Furthermore, the insertion procedure, the use and handling of the incision and insertion tools and the sensing quality of the…
- Conditions
- Atrial Fibrillation, Syncope, Tachyarrhythmia
- Trial name
- NCT03850327
- Testing
- BIOMONITOR III
- Where
- 7 sites in Australia
- Volunteers
- 48 people
- Sponsor
- Biotronik SE & Co. KG
Orthostatic Hypotension, Syncope
The Effect of Water Carbonation on Orthostatic Tolerance
The primary purpose of this investigation is to determine whether water carbonation can improve orthostatic tolerance in healthy control volunteers.
- Conditions
- Orthostatic Hypotension, Syncope, Vasovagal Syncope
- Trial name
- NCT05621460
- Testing
- 500mL carbonated water, 500mL still water, 50mL still water
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Simon Fraser University
Syncope, Syncope, Vasovagal
Assessment of the Mechanism of Non-cardiac Syncope
Identifying the mechanism of non-cardiac syncope is the essential prerequisite for an effective personalized therapy. Aim of this multicentre, prospective, cross-sectional, observational study is to assess effectiveness and…
- Conditions
- Syncope, Syncope, Vasovagal, Orthostatic Hypotension, Syncope, Carotid Sinus
- Trial name
- 2STEPS (NCT05728255)
- Testing
- ABPM plys SCAFB
- Where
- 8 sites in France, Italy and 3 more
- Volunteers
- 330 people
- Sponsor
- Istituto Auxologico Italiano
(Near) Syncope
Syncope Patient Evaluation in the Emergency Department
Patients with the symptom complex syncope or near-syncope are quite often in the emergency department. Most patients with syncope have a positive prognosis.
- Trial name
- NCT01916070
- Where
- Germany
- Volunteers
- 397 people
- Sponsor
- Klinikum Nürnberg
Syncope
BAsel Syncope EvaLuation (BASEL IX) Study
Syncope is a major health problem. In the emergency department (ED), the management of patients with syncope still remains a clinical challenge because underlying diseases and prognosis can be extremely various.
- Trial name
- NCT01548352
- Where
- 15 sites in United States, Argentina and 7 more
- Volunteers
- 3,500 people
- Sponsor
- University Hospital, Basel, Switzerland
Syncope, Vasovagal, Neurally-Mediated
Mechanism-based Therapy of Hypotensive Syncope
The aim of this study is to assess the efficacy of a therapeutic strategy aimed to increase 24-hour systolic blood pressure (SBP) values, assessed by 24-hour ambulatory blood pressure monitoring (ABPM), in reducing syncope…
- Trial name
- 2STEPtherapy (NCT06513650)
- Where
- 9 sites in France, Italy and 3 more
- Volunteers
- 140 people
- Sponsor
- Istituto Auxologico Italiano
Lennox-Gastaut Syndrome
Safety and Effectiveness of Open-Label Clobazam in Subjects With Lennox-Gastaut Syndrome
The objective of this study is to evaluate the long-term safety and effectiveness of open-label clobazam in the treatment of drop seizures in subjects with LGS.
- Trial name
- LGS (NCT01160770)
- Testing
- Clobazam
- Volunteers
- 267 people
- Sponsor
- Lundbeck LLC
Vasovagal Syncope
Assessment of Stroke Volume and Cardiac Output in Response to Varying Heart Rates
The investigators will seek to determine the effects of different heart rates on both stroke volume and cardiac output using non-invasive hemodynamic assessments.
- Trial name
- Pacing_SV (NCT03446326)
- Testing
- Pacing
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- University of Calgary