Clinical trials: Synaptic Plasticity
Stroke
Effectiveness of Interactive Augmented Reality and Electrical Neuromodulation System in Persons With Stroke
This study is to investigate the effects of Augmented Reality (AR) combined with Functional Electrical Stimulation (FES) intervention on cortical excitability, brain structure, lower limbs function, balance, and spasticity in…
- Trial name
- NCT04003571
- Testing
- Augmented Reality with Functional Electrical Stimulation group, Traditional physiotherapy
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Taipei Medical University Hospital
Stroke
HEROES: Human Extremity Robotic Rehabilitation and Outcome Enhancement for Stroke
HEROES is a multidisciplinary neurophysiological \& neural rehabilitation engineering project, developed by the Lab of Medical Physics \& Digital Innovation, School of Medicine, Faculty of Health Science Aristotle University of…
- Trial name
- HEROES (NCT06160453)
- Testing
- Brain-Computer Interface control of robotic arms with augmented reality, Serious game with augmented reality
- Where
- Greece
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Anxiety, Depressive Symptoms
A Single-Session Intervention for Adolescents and Young Adults With Internalizing Problems
With the increasing number of adolescents and young adults (AYA) experiencing depression and anxiety, paired with the lack of time, access, and funding towards social services, AYA need a mental health intervention that is…
- Trial name
- NCT05826392
- Testing
- Adolescent/Young Adult Self-Administered Web-Based Single-Session Intervention
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Healthy
The Modulatory Effect of Female Sex Hormones on Spinal Neuroplasticity
The goal of this project is to test our central hypothesis that the spinal cord neuroplasticity in females will be modulated by the level of estradiol concentration.
- Trial name
- TMSpine (NCT06656819)
- Testing
- Magstim Rapid2
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Depression, Major Depressive Disorder
RECOVERS - Realigning Emotion and COgnition Via prEcision Regulation networkS
In this research study, investigators examine how brain activity changes during tests of emotional processing, attention, and memory using multimodal neuroimaging methods including electroencephalography (EEG), functional…
- Conditions
- Depression, Major Depressive Disorder, Suicidal Ideation
- Trial name
- NCT05977439
- Testing
- Single-Pulse Transcranial Magnetic Stimulation, EEG-Synchronized Repetitive Transcranial Magnetic Stimulation (rTMS), Cognitive Behavioral Therapy (CBT)
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Stroke, Cerebrovascular Accident
Sensory-driven Motor Recovery in Poorly Recovered Subacute Stroke Patients
This research project addresses a scientifically important question that cannot be answered by other means. The use of peripheral nerve stimulation has the potential to enhance recovery in subacute stroke patients with poor…
- Trial name
- NCT03124186
- Testing
- S88 Dual Output Stimulator by Grass Technologies
- Volunteers
- 73 people
- Sponsor
- Lumy Sawaki
Healthy Ageing
Neuroplasticity: The Effects of Exercise Training on Cognitive and Affective Functioning of Older People
This study investigates the effects of exercise on older people's cognitive and affective functions, and the possible underlying neurobiological pathways.
- Trial name
- NCT04641429
- Testing
- Qigong exercise, Stretching exercise
- Where
- Hong Kong
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Joint Loose Bodies
Different Methods of Physical Therapy for Stroke
It is estimated that worldwide, about 15 million people are affected by vascular accident (CVA) per year, and in Brazil, the stroke is a major cause of death and disability, generating too much economic and social impact by…
- Trial name
- NCT02932631
- Testing
- THERAPY CONTROL AND MOVEMENT OF INDUCTION
- Where
- Brazil
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Universidade Metodista de Piracicaba
Ischemic Stroke, Acute, Acute Hemiparesis
Effect of Exercise Gene Expression and Histone Modifications in Patients With Hemiplegia
The aim of this study is to demonstrate the effect of routine exercise program on neuroplasticity through histone acetylation and gene expression changes in acute stroke survivors from an epigenetic perspective and to investigate…
- Trial name
- NCT06726941
- Testing
- Physiotherapy and Rehabilitation Practices
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Afyonkarahisar Health Sciences University
Stroke
Tele-CE in Severe Stroke
The goal of this clinical trial is to determine the effects of home-based cross-education on lower limb neuroplasticity in severe stroke.
- Trial name
- NCT07652970
- Testing
- Tele-CE, Tele-Control
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Illinois at Chicago
Stroke, Hemiparesis
Electrical Stimulation for Recovery of Ankle Dorsiflexion in Chronic Stroke Survivors
Ankle dorsiflexor weakness (paresis) is one of the most frequently persisting consequences of stroke. The purpose of this exploratory study is to compare two different treatments -- Contralaterally Controlled Neuromuscular…
- Conditions
- Stroke, Hemiparesis, Lower Extremity Paresis
- Trial name
- NCT01029912
- Testing
- Electrical stimulator
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- MetroHealth Medical Center
Hemispatial Neglect
Sleep as a Model to Understand and Manipulate Cortical Activity in Order to Promote Functional Recovery After Stroke
Brain functions are supported by multiple cell types, including neuronal and non-neuronal cells that are connected into complex networks.
- Trial name
- SSS (NCT03090711)
- Testing
- Transcranial Magnetic Stimulation (TMS), Transcranial Alternating Current Stimulation (tACS)
- Where
- Switzerland
- Volunteers
- 21 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Neck Pain, Whiplash
PROCO Neck: The Course and Neuroplasticity in Neck Pain-Associated Disorders and Whiplash-Associated Disorders
Neck pain-associated disorders (NAD) and whiplash-associated disorders (WAD) are major health problems. NAD has a lifetime prevalence of 54%.
- Conditions
- Neck Pain, Whiplash, Pain, Acute, Psychosocial Functioning
- Trial name
- NCT05468684
- Testing
- no intervention
- Where
- Switzerland
- Volunteers
- 168 people
- Sponsor
- University of applied sciences
Parkinson, Parkinson Disease
Neuroplasticity in Parkinson's Disease
The purpose of this project is to increase our understanding of the early state and temporal evolution of neuroplastic changes in the cortex and subthalamic nucleus (STN) of people with PD, and the relationship of these changes…
- Trial name
- NCT05286736
- Testing
- Neuroimaging, Quantitative assessments
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Brain Health, Longevity
L-serine and Strength Training in the Elderly
This study investigates whether taking the amino acid L-serine, either alone or in combination with targeted strength training, can have a positive effect on mental performance, brain function, and physical fitness in older…
- Conditions
- Brain Health, Longevity, Cognitive Performance, Strength Training Effects
- Trial name
- AAAging (NCT07466290)
- Testing
- Strength training, L-serine supplementation, Control (cornstarch)
- Where
- Austria
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Attention Deficit Hyperactivity Disorder
Neuroplasticity Technology for Attention-deficit/Hyperactivity Disorder (ADHD)
This study evaluates the impact of computerized inhibitory control training on attention-deficit hyperactivity disorder (ADHD) symptoms and ADHD-linked neural signatures in children with ADHD.
- Trial name
- NCT03363568
- Testing
- Adaptive Inhibitory Control Training, Non-adaptive Inhibitory Control Training
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Boston Children's Hospital
Parkinson's Disease
Biomarkers of Neurodegeneration and Neuroplasticity in Parkinson's Disease Patients Treated by Bilateral M1-iTBS
Intermittent theta-burst stimulation (iTBS) is a promising therapeutic option for Parkinson's disease patients. A study involving 24 patients will assess its effectiveness in alleviating clinical deficits.
- Trial name
- NCT06840145
- Testing
- repetitive transcranial magnetic stimulation
- Where
- Spain
- Volunteers
- 24 people
- Sponsor
- Instituto de investigación e innovación biomédica de Cádiz
Aging, Music
Brain Imaging and Behavioural Changes Following Cued-movement Training of Finger Sequences in Healthy Older Adults
The goal of this study is to examine changes in the brain, behavior, and personal experience when music is used to guide learning of finger movement sequences (compared to visual stimuli alone) in healthy older adults.
- Conditions
- Aging, Music, Motor Activity, Magnetic Resonance Imaging
- Trial name
- NMSOA (NCT06174740)
- Testing
- Music-cued audiovisual motor training, Visually-cued motor training
- Where
- Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universiteit Leiden
Depression, Mild Cognitive Impairment
Single-dose Ketamine Treatment to Improve Depression in Mild Cognitive Impairment
Ketamine is a NMDA-receptor antagonist that promotes synapse formation and has been shown to rapidly improve symptoms in depression.
- Trial name
- NCT06069843
- Testing
- IV Ketamine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Schizophrenia
Glutamate, Learning, and Working Memory
Impairments in plasticity and working memory in schizophrenia have been hypothesized to reflect dysfunction at the N-methyl-D-aspartate glutamate receptor (NMDAR).
- Trial name
- NCT02769936
- Testing
- D-cycloserine
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles