Clinical trials: Symptomatic Irreversible Pulpitis
Symptomatic Irreversible Pulpitis
Postendodontic Pain on Using Max-i-Probe vs NaviTip as Irrigation Needles
The aim of this prospective, randomized, clinical trial was to evaluate the effect of the side-vented Max-i-Probe versus the end-vented NaviTip as endodontic needles during syringe irrigation on post-operative pain in adult…
- Trial name
- NCT04119661
- Testing
- Max-i-Probe, NaviTip
- Volunteers
- 180 people
- Sponsor
- Cairo University
Symptomatic Irreversible Pulpitis (SIP), Dental Pain
Local Dexamethasone Administration in Symptomatic Irreversible Pulpitis
Symptomatic irreversible pulpitis is associated with a high incidence of inadequate pulpal anesthesia during endodontic treatment, particularly in mandibular molar teeth.
- Trial name
- SIPDEX (NCT07672873)
- Testing
- Saline (0.9%, sterile, for infusion), Dexamethasone
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Marmara University
Local Anesthesia
Effect of Sodium Bicarbonate Buccal Infiltration on the Success of Inferior Alveolar Nerve Block
The purpose of this prospective, randomized, double blind study was to evaluate the effect of a buccal infiltration of sodium bicarbonate on the anesthetic success of the inferior alveolar nerve block (IANB) in patients with…
- Trial name
- NCT02726737
- Testing
- sodium bicarbonate, Lidocaine, sterile distilled water
- Where
- Iran
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Masoud Saatchi
Symptomatic Irreversible Pulpitis
Effect of Diclofenac Potassium Versus Prednisolone on Post-endodontic Pain and Pulpal IL-8 Expression
To assess the effect of using diclofenac potassium versus prednisolone as a pre-medication compared to placebo on: Intensity of post-endodontic pain in patients with symptomatic irreversible pulpitis. Pulpal IL-8 expression.
- Trial name
- NCT04608981
- Testing
- Prednisolone 30 mg, Diclofenac Potassium 50mg Tab
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Cairo University
Symptomatic Irreversible Pulpitis
Effectiveness of Premedication on the Success Rate of Inferior Alveolar Nerve Block
Purpose: The aim of this prospective, double-blind, randomized controlled trial is to compare the effect of oral premedication of dexamethasone, ketorolac, meloxicam, ibuprofen or placebo on the success of inferior alveolar nerve…
- Trial name
- NCT05097768
- Testing
- Dexamethasone 0.5mg, Ketorolac 10 Mg Oral Tablet, Meloxicam 7.5 mg
- Where
- Saudi Arabia
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Alfarabi Colleges
Symptomatic Irreversible Pulpitis and Post Operative Pain
Ultrasonic Activated Irrigation and Intracanal Cryotherapy for Reducing Pain After Root Canal Treatment
This randomized controlled trial aims to evaluate the effect of ultrasonic activated irrigation with and without intracanal cryotherapy on postoperative pain following single-visit root canal treatment in teeth with symptomatic…
- Trial name
- NCT07663227
- Testing
- Ultrasonic Activated Irrigation, Intracanal cryotherapy
- Volunteers
- 60 people
- Sponsor
- Dr Arsalan Ali Khan
Pulpectomy, Primary Teeth Indicated for Pulp Therapy
Comparative Evaluation of Pediatric Rotary Files and Hand Files in Primary Molars
The goal of this clinical trial is to evaluate and compare the efficacy of Kedo-Nano Plus rotary files, Kedo-S Square rotary files, and manual K-files for biomechanical preparation during pulpectomy of primary mandibular molars…
- Conditions
- Pulpectomy, Primary Teeth Indicated for Pulp Therapy, Mandibular Molar Teeth With Symptomatic Irreversible Pulpitis
- Trial name
- NCT07702877
- Testing
- Pulpectomy, Kedo-S Square rotary file, Manual K files
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Goa Dental College
Symptomatic Irreversible Pulpitis With Apical Peridontitis
Neurokinin A and Matrix Metalloproteinase 9 Levels in Gingival Crevicular Fluid Samples of Teeth With Symptomatic Irreversible Pulpitis With Symptomatic Apical Periodontitis
The aim of this study is to investigate the levels Neurokinin A and of Matrix Mtalloproteinase (MMP-9) in gingival crevicular fluid samples (GCF) as potential biomarkers for the diagnosis of symptomatic irreversible pulpitis with…
- Trial name
- NCT07289074
- Testing
- Gingival crevicular fluid samples from the symptomatic teeth and the healthy contrlateral teeth
- Where
- Egypt
- Volunteers
- 23 people
- Sponsor
- Hadeer Mostafa El Mohamady El Feky
Endodontics, Pain
A Comparison of Two Different Single Doses of Prednisolone on Endodontic Inter-appointment Pain
The purpose of this prospective randomized, double-blind, placebo-controlled study is to compare the efficiency of 2 different single doses of pre-operative oral prednisolone (20 \& 40 mg) for the control of inter-appointment…
- Trial name
- NCT04481971
- Testing
- Prednisolone, lactose in capsules gelatin
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- King Saud University
Pulpitis - Irreversible
Pulpotomy vs Root Canal Treatment for Teeth With Symptomatic Irreversible Pulpitis
This study is a randomised controlled trial for complete pulpotomy as an alternative to root canal treatment for teeth with clinical diagnosis of symptomatic irreversible pulpitis (i.e.
- Trial name
- NCT05964933
- Testing
- Complete Pulpotomy, Pulpectomy and Root Canal Treatment
- Where
- Singapore
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Irreversible Pulpitis
The Effect of Totalfil and Neosealer Sealers on the Post-endodontic Pain
The goal of this clinical trial is to evaluate the effect of Totalfil and Neosealer sealers on post-endodontic pain compared to AH plus sealer in mandibular molars with symptomatic irreversible pulpitis.
- Trial name
- NCT06194773
- Testing
- Totalfil, NeoSealer, AH-Plus sealer
- Where
- United Arab Emirates
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Gulf Medical University
Symptomatic Irreversible Pulpitis
The Effect of Three Different Medications on Anesthetic Success and Postoperative Pain
Pain is a very important factor in Endodontic treatment, Both intra- and Post-operatively. In case of symptomatic Irreversible pulpitis, a build up of inflammatory mediators makes it very difficult for the operator to reach the…
- Trial name
- NCT06298383
- Testing
- Trypsin, Bromelain and Rutoside, Diclofenac Potassium 50mg Tab, Prednisolone Oral Tablet
- Where
- 2 sites in Egypt
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Cairo University
Post Operative Pain, Post-Op Complication
Effect of Occlusal Reduction on Relief of Pain and Sensitivity to Percussion in Patients With Irreversible Pulpitis
One of the most important aspects of endodontic practice is to abate pain during and post root canal treatment. An endodontist by all means should provide a painless endodontic treatment to their patients.
- Trial name
- NCT05306535
- Testing
- Occlusal reduction
- Where
- Pakistan
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Altamash Institute of Dental Medicine
Symptomatic Irreversible Pulpitis
Volume Increase Versus Supplemental 4% Articaine Buccal Infiltration on Mepivacaine Inferior Alveolar Nerve Block Success
To assess the anesthetic success of inferior alveolar nerve block (IANB), intraoperative pain intensity and need for supplemental anesthesia on administration of 1.8ml or 3.6ml 2% mepivacaine IANB, or 1.8ml 2% mepivacaine IANB…
- Trial name
- NCT05238727
- Testing
- 1.8 ml mepivacaine hydrochloride, 3.6 ml mepivacaine hydrochloride, 1.8 ml mepivacaine hydrochloride IANB plus 1.8 ml articaine hydrochloride BI
- Volunteers
- 75 people
- Sponsor
- Cairo University
Pulpitis
Intraligamentary Injections and Post-endodontic Pain
This study will aim to evaluate postoperative pain after intraligamentary injections of dexamethasone (4mg/ml), diclofenac sodium (25mg/ml), 0.5% bupivacaine and 2% lidocaine given to the patients with symptomatic irreversible…
- Trial name
- NCT06186921
- Testing
- Dexamethasone
- Where
- India
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Jamia Millia Islamia
Endodontic Disease
the Efficacy of Ginger Powder as an Analgesic for Intraoperative and Post- Endodontic Pain Management
The aim of the study is to evaluate the analgesic effect of ginger powder capsules compared to placebo on intra-operative and post-operative pain of single-visit endodontic treatment of mandibular molars with symptomatic…
- Trial name
- NCT06439212
- Testing
- Ginger powder capsule
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Symptomatic Irreversible Pulpitis (SIP)
The Effect of Commercial and Medical Grade Sodium Hypochlorite on Post Endodontic Pain
the aim of the current study is to evaluate the effects of commercial and medical formulations of NaOCl on postoperative pain after endodontic treatment of mandibular posterior teeth with acute irreversible pulpitis.
- Trial name
- NCT07248189
- Testing
- commercially available Sodium Hypochlorite, Medical grade Sodium Hypochlorite
- Where
- 2 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Symptomatic Irreversible Pulpitis (SIP)
The Effect of Electroacupuncture (EA) on the Success of Inferior Alveolar Nerve Block (IANB) and Post-operative Pain Relief in Mandibular Molar With Symptomatic Irreversible Pulpitis (SIP) Among Malaysians: A Study Protocol for Randomized Double-Blinded Clinical Pilot Study
Acupuncture is recognized for its pain relief effect. Electroacupuncture(EA) is a form of acupuncture where electric current is passed between pairs of acupuncture needles in order to achieve therapeutic effect.
- Trial name
- NCT04804761
- Testing
- Electroacupuncture
- Where
- Malaysia
- Volunteers
- 20 people
- Sponsor
- IMU University, Malaysia
Postoperative Pain
Effect of Passive Ultrasonic Irrigation Activation Cycle on Postoperative Pain
One of the most important goals of root canal treatment is to eliminate bacteria from infected canals. However, conventional irrigation methods combined with mechanical preparation applied during root canal treatment may not be…
- Trial name
- NCT06711029
- Testing
- Conventional needle irrigation, Passive Ultrasonic Irrigation with 3*20 sn, Passive Ultrasonic Irrigation with 6*10 sn
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Esin Özlek
Irreversible Pulpitis
Pulpotomy in Vital Primary Molars Diagnosed With Symptomatic Irreversible Pulpitis
This is a clinical trial to assess the treatment outcomes of pulpotomy in vital primary molars diagnosed with symptomatic irreversible pulpitis.
- Trial name
- NCT06149845
- Testing
- Full Pulpotomy
- Where
- 2 sites in Qatar
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Qatar University