Clinical trials: Symptom Management
Infertility, Obesity
Weight Management Intervention for Obese Women and the Live Birth Outcome of in Vitro Fertilization (IVF)
The primary aim of the study is to evaluate if weight management intervention for obese women (BMI≥30<35 kg/m2) prior to IVF improves the outcome assessed as live birth per participating woman, as compared to women where no…
- Trial name
- NCT01566929
- Testing
- Low calorie diet treatment
- Where
- 9 sites in Denmark, Iceland and 1 more
- Volunteers
- 317 people
- Sponsor
- Sahlgrenska University Hospital
Pain Management
Ketorolac at Lower Doses for Analgesic Pain Control in ICU: A Pilot Feasibility Study
Opiates are commonly used to control pain in critically ill patients in the ICU. However, increased rates of opiate use in hospital may lead to increased prescription-based opiate dependence after leaving the ICU.
- Trial name
- KETOROLAC-ICU (NCT06819956)
- Testing
- Ketorolac
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Alberta
Postoperative Pain, Hypospadias
Comparison of Sacral ESP Block and Dorsal Penile Nerve Block in Pediatric Hypospadias Surgery
This randomized controlled trial aims to compare the postoperative analgesic efficacy of ultrasound-guided Sacral Erector Spinae Plane (ESP) block versus Dorsal Penile Nerve Block (DPNB) in pediatric patients aged 1-7 years…
- Trial name
- NCT07426731
- Testing
- Sacral ESP Block Group, Dorsal Penile Nerve Block Group
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Medipol University
Procedural Pain, Nursing Caries
The Effect of Mechanical Vibration and Helfer Skin Tap Technique on Procedural Pain in Infants During Vaccination
This study will be conducted to determine the effect of mechanical vibration and Helfer Skin Tap technique applied during intramuscular vaccinations on procedural pain level, crying time and procedure time in healthy infants.
- Conditions
- Procedural Pain, Nursing Caries, Pain, Acute
- Trial name
- NCT06454812
- Testing
- Mechanical vibration, Helfer skin tap technique (HSTT)
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Transplant;Failure,Kidney, Transplant; Failure, Heart
EASE-SOT Pilot Study
Many transplant recipients may experience physical and emotional symptoms, such as anxiety, fatigue, sleep problems, pain, etc. Often, these symptoms are not reported or managed well, and can affect a patient's quality-of-life.
- Conditions
- Transplant;Failure,Kidney, Transplant; Failure, Heart, Transplant; Failure, Liver, Transplant; Failure, Pancreas
- Trial name
- NCT06396702
- Testing
- EASE-SOT
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University Health Network, Toronto
Septic Shock, Fluid Resuscitation
Bicarbonated Ringer's Solution Versus Lactated Ringer's Solution in Patients With Septic Shock
In this prospective randomized controlled trial, investigators aim to study the effects and safety of bicarbonated Ringer's solution in patients with septic shock compared with lactated ringer's solution, and provide evidence for…
- Conditions
- Septic Shock, Fluid Resuscitation, Crystalloid Solution, Intensive Care Unit
- Trial name
- NCT04449757
- Testing
- Bicarbonated Ringer's solution, Lactated Ringer's solution
- Where
- China
- Volunteers
- 260 people
- Sponsor
- Zhongnan Hospital
Childhood Obesity
Family Connections Weight Management
The prevalence of overweight children has increased significantly over the past 3 decades and 3 out of every 4 overweight children become obese adults.
- Trial name
- NCT00433901
- Testing
- Targeted parental instruction for positive lifestyle change with follow-up calls.
- Volunteers
- 220 people
- Sponsor
- Kaiser Permanente
Diabetes Mellitus, Type 2, Cardiovascular Diseases
Clinical Utility of a Genomic Predictor Test on the Management of Cardiorenal Complications of Type 2 Diabetes
The goal of this pragmatic trial is to provide Real World Evidence (RWE) on the impact of the result of a polygenic risk prediction test of cardiorenal complications of T2D, so that more patients at high risk of these…
- Conditions
- Diabetes Mellitus, Type 2, Cardiovascular Diseases, Diabetic Nephropathy Type 2
- Trial name
- GENOCORDIA (NCT06586203)
- Testing
- Polygenic Risk Score
- Where
- 2 sites in Canada
- Volunteers
- 2,714 people
- Sponsor
- Optithera
Cardiovascular Diseases, Frailty
Managing Frailty Through Mobilization in Males and Female Inpatients With Cardiovascular Disease
Frailty describes the overall health of a person. Inpatients with cardiovascular problems have a higher risk for frailty - or the sick are more likely to get sicker - causing longer hospital stays, hospital readmission, and…
- Trial name
- NCT06810661
- Testing
- Mobility promotion
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Université de Sherbrooke
Pain
Nasal Administration of Sufentanil+Ketamine for Procedure-related Pain in Children
The aim of the study is to investigate the absorption and clinical effect of nasal administration of an analgesic nasal spray containing sufentanil+ketamine for pain related to medical procedures in hospitalized children.
- Trial name
- NCT01047241
- Testing
- Intranasal sufentanil/ketamine
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Danish University of Pharmaceutical Sciences
Diarrhea, Rotavirus Infection
Probiotics in the Management of Acute Rotavirus Diarrhea in Bolivian Children
The purpose of this study is to determine the effect of probiotics in rotavirus acute diarrhea in children. The investigators will compare the effect of two different probiotics products.
- Trial name
- NCT00981877
- Testing
- GB (Florestor), GRALB
- Where
- Bolivia
- Volunteers
- 76 people
- Sponsor
- Centro Pediatrico Albina de Patino
Renal Insufficiency, End Stage Renal Disease
A Study of Tirzepatide (LY3298176) in Participants With Impaired Kidney Function
The purpose of this study is to assess how fast tirzepatide gets into the blood stream and how long it takes the body to remove it in participants with impaired kidney function compared to healthy participants.
- Trial name
- NCT03482024
- Testing
- Tirzepatide
- Where
- 4 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Chronic Obstructive Pulmonary Disease (COPD)
Exacerbation Self-management in COPD: The ACCESS Study
Aim is to test the effect of ACCESS ("Adaptive Computerized COPD Exacerbation Self-management Support"), a software application designed to support patients with COPD in self-management of exacerbations.
- Trial name
- ACCESS (NCT02553096)
- Testing
- ACCESS
- Where
- Netherlands
- Volunteers
- 87 people
- Sponsor
- Radboud University Medical Center
Cryptogenic Sensory Polyneuropathy
Patient Assisted Intervention for Neuropathy: Comparison of Treatment in Real Life Situations
The purpose of this large comparative effectiveness study led by Richard J. Barohn, MD, of the University of Kansas Medical Center, is to learn about the safety and effectiveness of nortriptyline, duloxetine, pregabalin and…
- Trial name
- PAIN-CONTRoLS (NCT02260388)
- Testing
- Nortriptyline, Duloxetine, Pregabalin
- Where
- 46 sites in United States, Canada
- Volunteers
- 402 people
- Sponsor
- University of Kansas Medical Center
Longevity, Quality of Life
Effectiveness of Microdosed GLP-1 in Improving Health, Quality of Life, and Longevity Measures
The goal of this clinical study has two objectives. The Primary Objective is to evaluate the effectiveness of microdosed GLP-1 receptor agonists in improving measures of health, quality of life, and longevity.
- Conditions
- Longevity, Quality of Life, Mood, Inflammation
- Trial name
- NCT07092605
- Testing
- GLP-1
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- AgelessRx
Osteoarthritis, Pain
A SAD Study to Evaluate the Safety, Tolerability and PK/PD of iN1011-N17 in Healthy Volunteers
A First-in-Human, Double-blind, Randomized, Placebo-controlled, Single Ascending Dose Study to Evaluate Safety, Tolerability, Pharmacokinetics/Pharmacodynamics of iN1011-N17 after Oral Administration in Healthy Volunteers.
- Conditions
- Osteoarthritis, Pain, Post Herpetic Neuralgia, Neuropathic Pain
- Trial name
- NCT05496205
- Testing
- iN1011-N17
- Where
- Australia
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- iN Therapeutics Co., Ltd.
Atrial Fibrillation
Dynamic Data-Driven Management of Atrial Fibrillation Using Implantable Cardiac Monitors: The MONITOR-AF Study
Observational, multi-center, retrospective study to evaluate the use of ICM (implantable cardiac monitor) versus traditional, non-ICM (non-implantable cardiac monitor) methods such as ECGs (electrocardiogram), Holter, and mobile…
- Trial name
- NCT06352060
- Testing
- No intervention or administration will be performed due to the observational nature of the study
- Where
- 7 sites in United States
- Volunteers
- 598 people
- Sponsor
- Kansas City Heart Rhythm Research Foundation
Inflammation, Fungal Infection
Effect of Inflammation on Voriconazole Concentration
Voriconazole is a broad-spectrum antifungal agent. There is evidence for a relation between the efficacy and safety of voriconazole and voriconazole trough concentrations.
- Trial name
- NCT02074462
- Where
- Netherlands
- Volunteers
- 36 people
- Sponsor
- University Medical Center Groningen
Immune Thrombocytopenia, Bruton's Tyrosine Kinase
A Clinical Trial of the Orelabrutinib in the Management of Refractory ITP
BTK participates in a variety of signal transduction of innate and adaptive immunity, and has an important role in cell proliferation, differentiation and apoptosis.
- Trial name
- NCT05020288
- Testing
- Orelabrutinib
- Volunteers
- 40 people
- Sponsor
- Shandong University
Pain After Total Knee Arthroplasty, Pain Management
Combined Distal Femoral Nerve Block for Pain Control After Knee Replacement
The goal of this clinical trial is to see whether a combined distal femoral nerve block improves pain relief after total knee replacement in adults having planned surgery.
- Trial name
- FEM-COMB (NCT07629388)
- Testing
- Combined distal femoral nerve block, Saphenous nerve block alone, Standard perioperative care in both groups
- Where
- France
- Volunteers
- 240 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche