Clinical trials: Symptom Cluster, open to volunteers
Low Anterior Resection Syndrome (LARS)
Early Implementation of Sacral Neuromodulation in Patients With Low Anterior Resection Syndrome.
A randomized, prospective, multicenter, open-label, pragmatic pilot study of patients with Low Anterior Resection Syndrome treated early (<120 days after discharge following intestinal bypass reconstruction) with sacral nerve…
- Trial name
- NCT07761884
- Testing
- Sacral neuromodulation
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Acute Coronary Syndrome
Prevalence of CYP2C19 Genetic Polymorphisms Among Egyptian Patients Receiving Clopidogrel Following PCI
Coronary artery disease occurs when the blood vessels supplying the heart become narrowed or blocked. Percutaneous coronary intervention (PCI) is a procedure used to restore blood flow to the heart, often by inserting a stent.
- Trial name
- NCT07876336
- Testing
- Clopidogrel
- Where
- Egypt
- Volunteers
- 1,000 people
- Sponsor
- October 6 University
AIDS
Mesenchymal Stem Cells Treatment for AIDS Patients at Late Stage
The goal of this study is to conduct a prospective, double-blind, randomized placebo-controlled clinical trial to investigate the safety and efficacy of mesenchymal stem cells treatment for AIDS patients at late stage.
- Trial name
- NCT05939167
- Testing
- mesenchymal stem cell, saline
- Where
- 4 sites in China
- Volunteers
- 150 people
- Sponsor
- Cell Energy Life Sciences Group Co. LTD
Post Intensive Care Syndrome
Post-Resuscitation Interdisciplinary Consultation System: a Randomized, Multicenter, Interventional Study to Assess Quality of Life After a Stay in the COPRéa Intensive Care Unit
A patient's stay in the ICU is not without consequences and can cause various physical and/or psychological sequelae such as anxiety, depression, post-traumatic stress disorder (PTSD), physical weakness and memory problems.
- Trial name
- COPRéa (NCT05625867)
- Testing
- Psychological and quality of life questionnaires, Interdisciplinary consultation at 4/5 months
- Where
- France
- Volunteers
- 404 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Lipedema, Hypermobility Syndrome (Disorder)
Investigation of Medial Longitudinal Arch and Foot Function in Patients With Lipedema
Lipedema is a chronic adipose tissue disorder that commonly leads to joint laxity, hypermobility, and functional limitations, yet its impact on foot morphology has not been systematically examined.
- Conditions
- Lipedema, Hypermobility Syndrome (Disorder), Pes Planus, Joint Hypermobility
- Trial name
- NCT07294014
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Marmara University
Myofascial Pain Syndrome (Upper Trapezius)
Emmett Technique Versus Bowen Technique for Upper Trapezius Myofascial Pain Syndrome
This randomized clinical trial compares the Emmett Technique and Bowen Therapy for patients with upper trapezius myofascial pain syndrome, focusing on their effects on pain, cervical range of motion, and functional disability.
- Trial name
- Emmett (NCT07767747)
- Testing
- Group A = Emmett Technique with conventional physiotherapy, Group B = Bowen Technique with conventional physiotherapy
- Where
- Pakistan
- Volunteers
- 46 people
- Sponsor
- University of Management and Technology Sialkot Pakistan
Polycystic Ovary Syndrome
Effect of Orlistat on Metabolic and Hormonal Features in Women With Polycystic Ovary Syndrome (PCOS): a Randomized Controlled Clinical Trial
This randomized controlled clinical trial aims to evaluate the effect of orlistat on the metabolic and hormonal features of women with polycystic ovary syndrome (PCOS).
- Trial name
- NCT07747909
- Testing
- Orlistat, Standard Lifestyle Advice
- Where
- Pakistan
- Volunteers
- 120 people
- Sponsor
- Khyber Medical University Peshawar
Long COVID, Post-Acute Sequelae of COVID-19
Mind Body Intervention for Long COVID-19
The goal of this study is to determine if a mind-body intervention can help people suffering from symptoms associated with Long COVID.
- Conditions
- Long COVID, Post-Acute Sequelae of COVID-19, COVID Long-Haul
- Trial name
- NCT06045338
- Testing
- Mind Body Intervention #1
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Beth Israel Deaconess Medical Center
ARDS: Acute Respiratory Distress Syndrome
Physiological Effects of Lung Impedance Tomography-Guided and Plat Pressure-Guided Phigh During APRV in Patients With ARDS
This study aims to investigate the effects of EIT-guided and Pplat-guided Phigh settings on regional ventilation and perfusion in ARDS patients during APRV, while also examining the impact of different Phigh settings on gas…
- Trial name
- NCT06696638
- Testing
- EIT-guided Phigh settings during APRV
- Where
- China
- Volunteers
- 26 people
- Sponsor
- XiaoJing Zou,MD
Bloodstream Infections, Central Nervous System Infections
INfectious DIsease REgistry BIObank
Prospective observational study designed to describe the clinical, laboratory, imaging, microbiological characteristics and treatment of specific infectious diseases, with the addition of a dedicated biobank.
- Conditions
- Bloodstream Infections, Central Nervous System Infections, Bone and Joint Infections, Endovascular Infections
- Trial name
- INDI-REBIO (NCT06418048)
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- IRCCS San Raffaele
Subacromial Impingement Syndrome, Shoulder Pain
Effects of Kinesio Taping on Thoracolumbar Fascia Flexibility in Patients With Shoulder Injury
The aim of this randomized controlled trial is to investigate the acute effects of fascia correction Kinesio Taping applied to the thoracolumbar fascia (TLF) in individuals with Subacromial Impingement Syndrome (SIS).
- Trial name
- NCT07624136
- Testing
- kinesio taping
- Where
- Turkey (Türkiye)
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Kübra Sarıoğlu
Paroxysmal Nocturnal Hemoglobinuria (PNH), Paroxysmal Hemoglobinuria
A Study of Pegcetacoplan in Pediatric Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)
The purpose of this study is to evaluate the safety, effectiveness, and biological activity (how the investigational medication is processed by the body) of pegcetacoplan in 12-17 year-olds (adolescents) who have paroxysmal…
- Trial name
- NCT04901936
- Testing
- Pegcetacoplan
- Where
- 12 sites in United States, Czechia and 7 more
- Volunteers
- 12 people
- Sponsor
- Apellis Pharmaceuticals, Inc.
Atheroscleroses, Coronary, Microbiota
Gut Microbiota Modulation With Synbiotics After Acute Coronary Syndrome
Acute coronary syndrome (ACS) remains one of the leading causes of morbidity and mortality worldwide despite major advances in acute management and secondary prevention.
- Trial name
- SYMBIO-ACS (NCT07411287)
- Testing
- Pro-B (Bionaturis),, Guideline-Directed Medical Therapy (GDMT)
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier de Bienne
Paroxysmal Nocturnal Hemoglobinuria (PNH)
Long-term Safety and Tolerability of MY008211A Tablets in Patients With Paroxysmal Nocturnal Hemoglobinuria
This is a multicenter, single-arm, open-label study to characterize long-term safety and tolerability of MY008211A tablets and to provide access to MY008211A tablets to patients with PNH who have completed Phase 2 or 3 studies…
- Trial name
- NCT06933914
- Testing
- MY008211A tablets
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Wuhan Createrna Science and Technology Co., Ltd
Myofascial Trigger Point Pain
The Effectiveness of Dry Needling Treatment in Patients Diagnosed With Dorsal Myofascial Pain Syndrome.
Back pain is commonly seen in the working-age population, with the peak occurrence around the age of 40. Its frequency does not increase with age and is not associated with age-related degenerative changes in the spine.
- Trial name
- NCT06338514
- Testing
- Real dry needling
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Kutahya Health Sciences University
Ataxia Telangiectasia
Safety and Efficacy of Mutation-targeted Precision Genetic Therapy for Ataxia-Telangiectasia (A-T)
This project aims to evaluate the safety and efficacy of precision genetic therapy for patients with Ataxia-telangiectasia (A-T), a rare neurodegenerative disease caused by mutations in the ATM gene.
- Trial name
- NCT07215416
- Testing
- Antisense oligonucleotide targeting the ATM gene
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Timothy Yu
Long COVID
Home Monitoring and Molecular Phenotyping of Patients With Post-COVID With Focus on Lung Involvement
Post-acute COVID syndrome (PACS) /post-acute sequale of COVID-19 (PASC) / post-COVID is a novel clinical syndrome with unknown biological mechanisms, and to date no standard-of-care, routines for follow-up, or evidence-based…
- Trial name
- HemCOV (NCT05894616)
- Where
- Sweden
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Acute Leukemia, Immune Deficiency Disorder
Umbilical Cord Blood Transplantation From Unrelated Donors
This study is being done to determine how long it takes for the engraftment (recovery of blood cell counts) of umbilical cord stem cells and also how often engraftment of umbilical cord stem cells transplanted from an unrelated…
- Conditions
- Acute Leukemia, Immune Deficiency Disorder, Congenital Hematological Disorder, Metabolism Disorder
- Trial name
- NCT03016806
- Testing
- Total Body Irradiation 1200 cGy, Total Body Irradiation 200 cGy, Cyclophosphamide
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Rochester
Acute Leukemia, Acute Lymphoblastic Leukemia
Donor Stem Cell Transplant With Treosulfan, Fludarabine, and Total-Body Irradiation for the Treatment of Hematological Malignancies
This phase II trial studies how well a donor stem cell transplant, treosulfan, fludarabine, and total-body irradiation work in treating patients with blood cancers (hematological malignancies).
- Conditions
- Acute Leukemia, Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Adult Diffuse Large Cell Lymphoma
- Trial name
- NCT04195633
- Testing
- Allogeneic Hematopoietic Stem Cell Transplantation, Cyclophosphamide, Cyclosporine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Obstructive Sleep Apnea (OSA)
CPAP vs High-Flow Nasal Cannula for Treating Sleep Apnea in Children
This study is looking at two different treatments for obstructive sleep apnea (OSA) in children. OSA is a sleep condition where breathing repeatedly stops and starts during sleep, which can affect a child's health, behavior…
- Trial name
- CHOSA (NCT07600333)
- Testing
- High Flow Nasal Cannula, Continuous Positive Airway Pressure
- Where
- Canada
- Volunteers
- 258 people
- Sponsor
- The Hospital for Sick Children
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