Clinical trials: Sympathetic Activity
Untreated Essential Hypertension
Effects of Bisoprolol and Atenolol on Sympathetic Nervous Activity and Central Aortic Pressure in Patients With Essential Hypertension
β-blockers (BBs) with different pharmacological properties may have heterogeneous effects on sympathetic nervous activity (SNA) and central aortic pressure (CAP), which are independent cardiovascular factors for hypertension.
- Trial name
- NCT01762436
- Testing
- bisoprolol, atenolol
- Where
- China
- Volunteers
- 109 people
- Sponsor
- Ruijin Hospital
Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation
Treatment of Atrial Fibrillation in Patients by Pulmonary Vein Isolation in Combination With Renal Denervation or Pulmonary Vein Isolation Only
Prospective, randomized, controlled, multicenter, international clinical trial. The study population consist of patients with paroxysmal or persistent atrial fibrillation with out range hypertension or signs of sympathetic…
- Conditions
- Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation, Out of Range Hypertension, Signs of Sympathetic Overdrive
- Trial name
- ASAF (NCT02115100)
- Testing
- procedure
- Where
- 8 sites in Netherlands, Spain
- Volunteers
- 145 people
- Sponsor
- Diagram B.V.
Caffeine, Control
Caffeinated Chewing Gum & Wrestling Performance
The purpose of this study was to investigate the effect of caffeinated chewing gum on sympathetic nerve activity on wrestling simulation match.
- Trial name
- NCT06758336
- Testing
- caffeine
- Where
- Taiwan
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- National Taiwan Sport University
Neck Pain
The Effects of Spinal Mobilizations on Symptoms, Neck 3D Movement, Neck Muscle Electromyography and Sympathetic Nervous System Activity in People With Neck Pain
This study investigates the effects of spinal mobilizations on symptoms, 3D movement of the neck, neck muscle electromyography and sympathetic nervous system activity in people with neck pain.
- Trial name
- NCT02826590
- Testing
- Neck passive mobilizations, Manual contact
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- King's College London
Hypertension
Sympathetic Activity and Renal Denervation
Primary hypothesis: Catheter-based renal denervation reduces central sympathetic activation in patients with refractory hypertension. Secondary hypotheses: 1.
- Trial name
- ReD (NCT01355055)
- Where
- Germany
- Volunteers
- 26 people
- Sponsor
- Hannover Medical School
Primary Dysmenorrhea
Heart Rate Variability as an Indicator Associated With the Improvement of Dysmenorrhea After the Warm-water Footbath
The effect of warm-water footbath in improving primary dysmenorrhea (PD) was rarely investigated previously. We aimed to exam the hypothesis that warm-water footbath is effective to reduce the pain of PD, and the effect is…
- Trial name
- NCT04071028
- Testing
- warm-water footbath
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Camillians Saint Mary's Hospital Luodong
Heart Failure
Effects of Low-frequency Electrical Stimulation in Patients With Advanced HF
The purpose of this study is to verify the effects of low frequency functional electrical stimulation in heart failure patients hospitalized for treatment of the syndrome.
- Trial name
- NCT01886430
- Testing
- Functional electrical stimulation
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo General Hospital
Hypertension, Chronic Kidney Disease
Impact of Sympathetic Renal Denervation- a Study in Patients After Renal Transplantation
The study is aiming to document the safety and effectiveness of renal denervation in patients after renal transplantation with hypertension.
- Conditions
- Hypertension, Chronic Kidney Disease, Renal Transplantation, Sympathetic Activity
- Trial name
- ISAR-denerve (NCT01899456)
- Testing
- Catheter-based renal denervation
- Where
- Germany
- Volunteers
- 18 people
- Sponsor
- Technical University of Munich
Nicotine Dependence
E-Cigarettes and SNA
Randomized controlled trial of electronic cigarettes with nicotine, without nicotine, and sham control, on sympathetic nerve activity and markers of oxidative stress.
- Trial name
- NCT02724241
- Testing
- one time exposure to e-cig with nicotine, One time exposure to e-cigarette without nicotine, one time exposure to empty e-cigarette
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Traumatic Brain Injury, Dysautonomia
Controlling Hyperadrenergic Activity in Neurologic Injury
Traumatic brain injury (TBI) is frequently associated with a hyperadrenergic state accompanied by elevated levels of plasma catecholamines.
- Trial name
- CHAIN (NCT01343329)
- Testing
- Esmolol, Propranolol
- Where
- United States
- Sponsor
- Johns Hopkins University
Obesity, Ageing
Brown Adipose Tissue Activity and Age
In this study the investigators aim to investigate whether the sympathetic stimulation of BAT, as assessed with a 123I-metaiodobenzylguanidine single-photon emission computed tomography computed tomography scan, differs between…
- Trial name
- NCT02130154
- Testing
- 18-FDG PET CT scan and 123I-MIBG SPECT scan
- Where
- Netherlands
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Hypertension
Role of Sympathetic Activity and Splanchnic Capacitance in Hypertension
The purpose of this study is to better understand the role of the abdominal veins (splanchnic capacitance) and the sympathetic nervous system in human hypertension.
- Trial name
- NCT02425566
- Testing
- Trimethaphan, Nitroglycerin
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Chronic Kidney Diseases, Heart Failure
REducing Sympathetic Activity Through Ultrasound-based Renal deneRvation in Excessive Cardiovascular Risk populaTions.
The is a non-randomized pilot trial, open-label evaluation of the physiologic response of native kidney denervation using the Paradise denervation system in CKD, End Stage Renal Disease (ESRD), and Heart failure (HF)
- Conditions
- Chronic Kidney Diseases, Heart Failure, End Stage Renal Disease
- Trial name
- RESURRECT (NCT05703620)
- Testing
- Renal Denervation
- Where
- Australia
- Volunteers
- 75 people
- Sponsor
- Royal Perth Hospital
Obesity, Polycystic Ovary Syndrome
Heat Therapy and Cardiometabolic Health in Obese Women
Traditional medical treatments are often based on research done exclusively in males, and recent research efforts in the physiology community have highlighted critical sex differences in disease presentation and progression.
- Conditions
- Obesity, Polycystic Ovary Syndrome, Prehypertension, PreDiabetes
- Trial name
- CMH (NCT03644524)
- Testing
- Heat therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Oregon
Metabolic Syndrome X
Sympathetic Activity in Individuals With the Metabolic Syndrome: Benefits of Lifestyle Interventions
An abdominal distribution of fat is associated with the greatest heart disease risk, because commonly, several risk factors of metabolic origin (high blood pressure, unfavourable cholesterol profile, elevated blood sugar…
- Trial name
- NCT00163943
- Testing
- Dietary weight loss +/- aerobic exercise
- Where
- Australia
- Volunteers
- 66 people
- Sponsor
- Bayside Health
Cocaine Induced Sympathoexciation and Vasoconstriction
Study to Improve Scientific Understanding of the Cardiovascular Actions of Cocaine
The purpose of this study is to improve the scientific understanding of the cardiovascular actions of cocaine, in particular the ability of cocaine to increase blood pressure.
- Trial name
- NCT00338546
- Testing
- Cocaine hydrochloride, Dexmedetomidine, Microneurography
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Polycystic Ovary Syndrome
Polycystic Ovary Syndrome (PCOS) - Effect Of Physical Exercise And Electroacupuncture
Hypothesis: The overall hypothesis is that women with PCOS, both obese and non-obese, have larger adipocytes, altered metabolism and signs of inflammation in adipose tissue and that these changes are associated with high…
- Trial name
- PCOSNTS (NCT00484705)
- Testing
- Electroacupuncture, Physical exercise, Untreated control
- Where
- Sweden
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Elevated Blood Pressure
Mindfulness and Neural Cardiovascular Control in Humans
This study evaluates the impact of mindfulness-based stress reduction (MBSR) on sympathetic nerve activity and arterial stiffness.
- Trial name
- NCT03626363
- Testing
- Stress Management
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Michigan Technological University
Restless Legs Syndrome, Neuropathic Pain
Spinal Cord Stimulation for Restless Legs Syndrome
The overall goal of this proposed study is to evaluate the underlying mechanisms of neural control of blood flow in the lower extremities in humans with restless leg syndrome (RLS).
- Trial name
- NCT03539081
- Testing
- Dual-energy X-ray absorptiometry Scan, Laboratory Measurements, Blood Flow Measurement
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Marshall Holland
Hypertension
Renal Nerve Stimulation in Uncontrolled Hypertensive Patients Undergoing Renal Denervation
Study design: Investigator initiated, single center The study is aimed 1) To investigate the blood pressure (BP) change to renal nerve stimulation(RNS), and subsequently perform a renal denervation(RDN) procedure 1) to verify the…
- Trial name
- RND (NCT05421767)
- Testing
- nerve stimulation guided renal denervation procedure
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital