Clinical trials: Surgical Resection
Prevention, LARS - Low Anterior Resection Syndrome
Effectiveness of Pelvic Floor Exercise to Prevent LARS (Low Anterior Resection Syndrome)
The main aim of this randomized study will be to determine the effectiveness of pelvic floor exercises on the incidence or severity of LAR syndrome in patients after mini-invasive rectal resection.
- Conditions
- Prevention, LARS - Low Anterior Resection Syndrome, Pelvic Floor Disorders, Rectal Cancer
- Trial name
- CH1 (NCT06519006)
- Testing
- Pelvic floor exercise
- Where
- Slovakia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- F. D. Roosevelt University Hospital
Non-Small Cell Lung Cancer, Lung Neoplasms
McMaster Catheterization for Thoracoscopic Surgery Study
It is common practice to insert a Foley catheter into the bladder to drain urine during and after a lung resection. Recently, there has been increasing interest in the potential risks associated with this catheterization…
- Conditions
- Non-Small Cell Lung Cancer, Lung Neoplasms, Metastatic Lung Cancer, Urinary Retention
- Trial name
- UCATh (NCT02640326)
- Testing
- No Foley Urinary Catheter, Standard of care Foley urinary catheter insertion
- Where
- Canada
- Sponsor
- McMaster University
Low Anterior Resection Syndrome, Cancer
Contributing Factors to Anterior Resection Syndrome and Its Impact on Quality of Life: A Retrospective Cohort Study
This study adds to the understanding of the contributing factors leading to LARS, the long term effects of this syndrome post-operatively and its impact on quality of life.
- Conditions
- Low Anterior Resection Syndrome, Cancer, Quality of Life
- Trial name
- NCT04114591
- Testing
- anterior resection
- Where
- Malta
- Volunteers
- 179 people
- Sponsor
- University of Malta
Preoperative, Sleep Disturbance
Preoperative Oral Midazolam to Postoperative Pain Relief in Sleep Disturbance or Anxiety Patients With Colorectal Cancer
Previous studies have indicated a high incidence of sleep disturbances and anxiety symptoms in individuals with colorectal cancers prior to undergoing surgery, leading to worsened postoperative pain, slower recovery, and higher…
- Conditions
- Preoperative, Sleep Disturbance, Anxiety, Midazolam
- Trial name
- POMPPR (NCT06407518)
- Testing
- Midazolam oral solution
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Sigmoid Diseases
Robotic-assisted Versus Laparoscopic Sigmoid Resection
Retrospective multi-center comparative chart review of robotic-assisted versus laparoscopic sigmoid resection for both benign and malignant disease
- Trial name
- NCT02636673
- Testing
- Sigmoid Resection
- Where
- 6 sites in United States
- Volunteers
- 518 people
- Sponsor
- Intuitive Surgical
Adult Anaplastic Astrocytoma, Adult Anaplastic Oligodendroglioma
Aminolevulinic Acid During Surgery in Treating Patients With Malignant Brain Tumors
This phase I trial is studying the side effects and best dose of aminolevulinic acid during surgery in treating patients with malignant brain tumors.
- Conditions
- Adult Anaplastic Astrocytoma, Adult Anaplastic Oligodendroglioma, Adult Giant Cell Glioblastoma, Adult Glioblastoma
- Trial name
- NCT01148966
- Testing
- aminolevulinic acid, laboratory biomarker analysis, therapeutic conventional surgery
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Washington
Postoperative Retention of Urine, Postoperative Urinary Tract Infection
Day Zero Urinary Catheter Removal in Gen Thoracic Surgery Patients
Current standard of practice in study institution dictates day of surgery urinary catheter removal in general thoracic surgery patients receiving thoracic epidural analgesia.
- Trial name
- NCT01309529
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Memorial Health System
Kidney Cancer, Sarcoma
Combination Chemotherapy and Radiation Therapy in Treating Patients With Peripheral Neuroectodermal Tumors, Ewing's Sarcoma, Wilms' Tumor, or Bone Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug or combining chemotherapy with radiation therapy may kill more tumor cells.
- Trial name
- NCT00002466
- Testing
- cyclophosphamide, doxorubicin hydrochloride, etoposide
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Barrett Esophagus, Barrett Esophagus Adenocarcinoma
A Study of Barrett's Esophagus Patients: Optimization of a Risk Model to Better Predict the Development of Cancer Recurrence and the Effect of Risk Profile Disclosure on Patient Quality of Life and Fear of Cancer
The goal of the study is: The collection of various tissue samples (blood, biopsies and "esophageal brushes") and their analysis.
- Conditions
- Barrett Esophagus, Barrett Esophagus Adenocarcinoma, Adenocarcinoma - GEJ, Gastroenterology
- Trial name
- Endeavor-2 (NCT07455422)
- Testing
- Risk profile disclosure
- Where
- 10 sites in Belgium, Denmark and 5 more
- Volunteers
- 266 people
- Sponsor
- University Hospital, Antwerp
Liver Resection, Colorectal Carcinoma Liver Metastases
Safety of HRX215 in Patients After Minor and Major Liver Resection
The goal of this clinical trial is to learn if HRX215 is safe, tolerable and active in adults who have undergone liver resection due to colorectal carcinoma metastases. The objectives are: 1.
- Trial name
- NCT06638502
- Testing
- HRX215 capsules
- Where
- 14 sites in United States, France and 3 more
- Volunteers
- 80 people
- Sponsor
- HepaRegeniX GmbH
Postoperative Analgesia, Quality of Recovery
Effect of SNB on the QoR in Patients Undergoing Supratentorial Tumor Resection
Patients with Supratentorial tumor undergoing craniotomy have a higher risk of postoperative pain, which will affect their postoperative quality of recovery (QoR).
- Conditions
- Postoperative Analgesia, Quality of Recovery, Supratentorial Tumor, Craniotomy
- Trial name
- NCT06157359
- Testing
- scalp nerve block
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Brain Tumor, Stroke
Effect of Perioperative Ulinastatin on Postoperative Stroke in Patients With Brain Tumor
Previous studies have shown that the incidence of postoperative stroke, particularly covert stroke, is high following brain tumor resection and is closely associated with inflammatory responses and disruption of the blood-brain…
- Conditions
- Brain Tumor, Stroke, Ulinastatin, Perioperative Anti-inflammatory Therapy
- Trial name
- NCT07520370
- Testing
- Ulinastatin, 0.9% Saline
- Volunteers
- 1,370 people
- Sponsor
- Beijing Tiantan Hospital
Eye Diseases
Next Generation Ophthalmic Irrigating Solution Posterior Segment Study
The purpose of this study is to evaluate the safety of Next Generation Ophthalmic Irrigating Solution (NGOIS) compared to BSS PLUS for use during surgery for removal of epimacular membrane and vitrectomy.
- Trial name
- NCT00333203
- Testing
- Next Generation Ophthalmic Irrigating Solution (NGOIS), BSS Plus
- Where
- United States
- Volunteers
- 369 people
- Sponsor
- Alcon Research
Non Metastatic Breast Cancer
The Impact of Oncoplastic Breast Surgery on the Oncological Safety and Patient Satisfaction
The aim of this study is to asses the oncological safety of oncoplastic breast surgery, its impact on patient satisfaction and is it worthy for general breast surgeon to learn different oncoplastic techniques.
- Trial name
- NCT02901223
- Testing
- Standard quadrantectomy, oncoplastic breast surgery
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Surgical Site Infection
Efficacy of NPWT in Reducing the Incidence of Wound Infection After Pancreatic Surgery
A disposable negative wound pressure device will be compared to standard sterile wound dressing in reducing the rate of wound infection after clean-contaminated surgical procedures on biliary tract and pancreas in patients at…
- Trial name
- NCT03700086
- Testing
- Disposable negative wound pressure device (PICO), OPsite post-op visible standard sterile dressing
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Liver Neoplasms, Liver Regeneration
Registry of Major Liver Resections Including ALPPS and Other Liver Resections in Two Stages
Recently a new method of induce similar hypertrophy in the liver as is observed after hepatectomy has been described and was given the eponym "ALLPS".
- Trial name
- ALPPSREG (NCT01924741)
- Testing
- ALPPS
- Where
- Switzerland
- Volunteers
- 500 people
- Sponsor
- University of Zurich
Adenocarcinoma of the Rectum
Can we Save the Rectum by Watchful Waiting or TransAnal Surgery Following (Chemo)Radiotherapy Versus Total Mesorectal Excision for Early REctal Cancer?
Bowel cancer is the second most common tumour with 41 000 new cases diagnosed annually in the UK, 447 000 across Europe and 1.36 million worldwide; of which one third are located in the rectum.
- Trial name
- STAR-TREC (NCT02945566)
- Testing
- Standard TME surgery, Long course concurrent chemoradiation with capecitabine and radiotherapy, Short course radiotherapy
- Where
- 5 sites in Belgium, Denmark and 3 more
- Volunteers
- 380 people
- Sponsor
- University of Birmingham
Neuroblastoma
Combination Chemotherapy Followed by Stem Cell Transplant in High-risk Neuroblastoma Patients
Improvement of event free survival of high-risk neuroblastoma patients by introduction of two additional topotecan containing chemotherapy cycles into the multimodal standard treatment (induction chemotherapy, myeloablative…
- Trial name
- NB2004-HR (NCT03042429)
- Testing
- Cycles N8, N5 and N6, Cycles N5 and N6
- Where
- Germany
- Volunteers
- 360 people
- Sponsor
- University of Cologne
Colon Cancer, Lymph Node Dissection
A Comparative Study of Tumor Specific Mesocolic Excision and Complete Mesocolic Excision for Right Sided Colon Cancer : Asian Multicenter Retrospective Study
The goal of this observational study is to determine the optimal surgical strategy based on oncologic outcomes in patients with stage I-III right-sided colon cancer who underwent curative right hemicolectomy.
- Conditions
- Colon Cancer, Lymph Node Dissection, Laparoscopic Colon Surgery, Robotic Surgical Procedure
- Trial name
- NCT06865586
- Where
- South Korea
- Volunteers
- 3,326 people
- Sponsor
- Asan Medical Center
Laparoscopic General, Gynecological and Urologic Surgeries
Evaluation of the Sevoflurane Consumption During General Anesthesia When Using the MemsorbTM Membrane
The study aims at determining whether replacing the classical chemical absorber Dräegersorb 800+ on Dräeger Perseus A500 machines (Dräeger, Lübeck, Germany) by the new membrane technology-based product (Memsorb™, DMF Medical…
- Trial name
- MEMSEV (NCT04539405)
- Testing
- To evaluate sevoflurane consumption when using Memsorb, To evaluate sevoflurane consumption when using classical Dräegersorb
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal