Clinical trials: Supplementation
Irritable Bowel Syndrome
Multi-strain Probiotic in the Management of IBS-D
1. To assess the effect of multistrain probiotics on abdominal pain using a validated symptom severity score in IBS patients. 2.
- Trial name
- NCT03251625
- Testing
- Probiotic Formula Capsule
- Volunteers
- 400 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Major Depression, Vitamin D Deficiency
Effects of Vitamin D Supplementation on Depression and Inflammatory Markers
The current study is designed as a prospective partially randomized patient preference (PRPP) trial and recruit psychiatric outpatients or inpatients.
- Trial name
- NCT04898725
- Testing
- Vitamin D3
- Where
- Taiwan
- Volunteers
- 142 people
- Sponsor
- Mackay Memorial Hospital
Dystonia, Focal
Oral Zinc Supplementation to Enhance Botulinum Neurotoxin Response
Botulinum neurotoxin (BoNT) is injected into muscles for treatment of dystonia. BoNTs are zinc proteases, and their enzymatic effect is reduced in the setting of low zinc.
- Trial name
- NCT05095493
- Testing
- Zinc Acetate
- Volunteers
- 54 people
- Sponsor
- University of Texas Southwestern Medical Center
Multiple System Atrophy
Progression Rate of MSA Under EGCG Supplementation as Anti-Aggregation-Approach
MSA is a rapidly progressive disorder with an average survival time of about 7 years after the first clinical manifestation. No potent symptomatic treatment is currently available.
- Trial name
- PROMESA (NCT02008721)
- Testing
- EGCG as putative neuroprotective agent
- Where
- 12 sites in Germany
- Volunteers
- 92 people
- Sponsor
- Dr. Johannes Levin
Breastfeeding Support
LATCH: Lactation Advice Thru Texting Can Help
The purpose of this study is to find out if a two-way texting platform to be used as an adjunct tool for breastfeeding peer counselors can improve breastfeeding behaviors among women enrolled in the WIC program in Connecticut.
- Trial name
- NCT02214849
- Testing
- LATCH Intervention
- Where
- United States
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Yale University
Paediatrics
Acceptability, Gastrointestinal Tolerance, Compliance and Palatability Study.
Acceptability, compliance and palatability study.
- Trial name
- NCT07210658
- Testing
- Oral nutritional supplementation
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Société des Produits Nestlé (SPN)
Hansen's Disease
Virgin Coconut Oil Oral Supplementation for Leprosy Patients
To date, there has been no clinical investigation on the effects of virgin coconut oil (VCO) oral supplementation on patients with Hansen's disease (HD) undergoing medical treatment.
- Trial name
- NCT01885611
- Testing
- Multi-Drug Therapy (Novartis Ⓡ), Virgin Coconut Oil
- Where
- Philippines
- Sponsor
- Philippine Dermatological Society
Autosomal Dominant Polycystic Kidney, Hypertension
Effect of Beetroot Juice on Reducing Hypertension in Autosomal Dominant Polycystic Kidney Disease
People with autosomal dominant polycystic kidney disease (ADPKD) develop high blood pressure and kidney disease. Previous studies have shown that a commonly occurring chemical, nitric oxide (NO), is reduced in ADPKD, and may…
- Conditions
- Autosomal Dominant Polycystic Kidney, Hypertension, Endothelial Dysfunction
- Trial name
- BEET-PKD (NCT05401409)
- Testing
- Beetroot juice, Nitrate-depleted beetroot juice
- Where
- 2 sites in Australia
- Volunteers
- 60 people
- Sponsor
- Western Sydney Local Health District
Nitrate, Caffeine
The Effects of Nitrate, Caffeine, and Cold Exposure on Cardiovascular Function.
Dietary inorganic nitrate supplementation may have positive implications on cardiovascular function. The aim of this project is to determine if nitrate supplementation can attenuate the effects that caffeine and cold exposure…
- Conditions
- Nitrate, Caffeine, Cold Exposure
- Trial name
- NCT06602921
- Testing
- TruBeet inorganic beetroot juice, Caffeine, Cold pressor test
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Upper Respiratory Tract Infections, Lower Respiratory Tract Infections
Maternal Vitamin D for Acute Respiratory Infections in Infancy
There is a growing body of data suggesting that vitamin D modulates the host's immune response to acute respiratory infection (ARI).
- Trial name
- MDARI (NCT02388516)
- Testing
- Vitamin D3
- Where
- Bangladesh
- Volunteers
- 1,214 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Village Children
Deworming and Enhanced Vitamin A Every 6 Month in Rural Indian Children Aged 1-6
Randomisation of 72 large rural areas ("blocks") into a 2 x 2 trial of six- monthly treatment of all village children aged 1-5 with albendazole(400mg), vitamin A (200000 iu), both or neither.
- Trial name
- NCT00222547
- Testing
- Vitamin A, Albendazole
- Where
- India
- Volunteers
- 720,000 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Exercise Capacity
The Effect of Sweet Orange and Pomegranate Extract Supplementation on Exercise Capacity in Middle-aged Adults
The aim of the present study is to investigate the effect of 12-week long daily administration of a sweet orange and pomegranate extract on exercise capacity in healthy adults.
- Trial name
- Actiful2 (NCT05133778)
- Testing
- Sweet orange and pomegranate extract, Maltodextrin control
- Where
- Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Food Allergy, Cow's Milk Allergy
Early Supplementation for Cow's Milk Allergy Prevention
Cow's milk allergy (CMA) is a common food allergy in infants and young children that can have a significant impact on the individual and their family due to dietary restrictions, risk of nutritional deficiencies, social…
- Trial name
- ESCAPE-PL (NCT06652698)
- Testing
- Cow's milk formula [CMF], Amino-acid formula [AAF], Donor human milk [DHM]
- Where
- Poland
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Cystic Fibrosis, Anemia, Iron-Deficiency
Does a Daily Iron Tablet Improve Anemia in Cystic Fibrosis
This study questions whether low-dose ferrous sulfate taken by mouth daily for 6 weeks increases hemoglobin concentration in adult subjects with cystic fibrosis and hypoferremic anemia.
- Trial name
- NCT01755455
- Testing
- Ferrous sulfate 325mg
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Pre Diabetes
Effect of Eriocitrin Supplementation in Subjects With Intermediate Hyperglycemia
First, it will be evaluated whether supplementation of eriocitrin reduces hyperglycemia and insulin resistance, significantly reducing the risk of diabetes.
- Trial name
- NCT03215043
- Testing
- Eriocitrin
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Thais Cesar
Air Pollution
The Effect of Juice Types on the Responses to Air Pollution
The study hypothesis is that drinking different juices will affect the body's responses to air pollution. Subjects will be exposed to air pollution during a 2-hour car ride on the NJ (New Jersey) Turnpike.
- Trial name
- NCT02027415
- Testing
- Beet juice, Orange juice
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Breastfeeding
Effects of 5-Methyltetrahydrofolic Acid Supplementation on Maternal Health and One-Carbon Metabolism During Lactation
This double-blind, randomized, placebo-controlled parallel trial evaluates the effects of maternal 5-methyltetrahydrofolate (5-MTHF) supplementation during breastfeeding.
- Trial name
- OCMS (NCT07508917)
- Testing
- 5-MTHF Supplementation
- Where
- 2 sites in Spain
- Volunteers
- 36 people
- Sponsor
- Fundació Sant Joan de Déu
Prematurity, Low Birth Weight Neonates
Metagenomic & Metabolomic Study: Bifidobacterium Probiotic Effects on Gut Microbiota & SCFA in Preterm NICU Infants
One million premature babies die due to prematurity complications, contributing the most to the causes of death in children under 5 years old.
- Trial name
- NCT07213414
- Testing
- Probiotics
- Where
- 3 sites in Indonesia
- Volunteers
- 72 people
- Sponsor
- Hasanuddin University
Attention Deficit Disorder With Hyperactivity
Tocotrienols for School-going Children With ADHD
The purpose of this study is to determine if tocotrienol supplementation given to school going children with ADHD will result in reduction of their ADHD symptoms.
- Trial name
- TOCAT (NCT01855984)
- Testing
- Oral mixed tocotrienols
- Where
- Malaysia
- Volunteers
- 160 people
- Sponsor
- RCSI & UCD Malaysia Campus
Muscle Fatigue, Muscle Strength
Short Term Omega-3 Supplementation on Performance
Nerves are the rate limiting factor that control muscle function. However, it is unknown if a nutritional supplement can change the nerve-muscle interaction, and therefore alter human performance.
- Trial name
- NCT02014233
- Testing
- Omega-3, Olive oil
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Toronto