Clinical trials: Suicidal Thoughts and Behaviors
Nightmare
Cognitive-Behavioral Therapy for Children With Nightmares as a Mediator of Suicide Risk (COMAA)
Youth suicide risk has increased 56% in the last decade, and suicide is the leading cause of preventable death in children and adolescents.
- Trial name
- COMAA (NCT05588739)
- Testing
- Cognitive Behavioral Therapy
- Where
- 2 sites in United States
- Volunteers
- 58 people
- Sponsor
- University of Oklahoma
Domestic Violence, Post-Traumatic Stress Disorder
Mental Health Symptoms and Intimate Partner Violence
Using a touch screen computer, the researchers are screening emergency department patients for intimate partner violence and mental health issues.
- Conditions
- Domestic Violence, Post-Traumatic Stress Disorder, Depression
- Trial name
- NCT00166075
- Testing
- Computer screen with community resource printout
- Where
- United States
- Volunteers
- 569 people, healthy volunteers welcome
- Sponsor
- Emory University
Suicide, Suicidal
Safe Treatment for Emergency Presentation for Suicidal Ideation and Behavior in Youth
This randomized comparative effectiveness trial will compare two evidence-based approaches to emergency care for youth ages 13-24 who present to the Emergency Department (ED) with suicidal ideation or behavior.
- Conditions
- Suicide, Suicidal, Self-Harm
- Trial name
- SAFE STEPS (NCT05304065)
- Testing
- SAFETY-A within usual ED Care, Combined SAFETY-A within usual ED Care + CLASP Therapeutic Follow-Up Contacts
- Where
- 5 sites in United States
- Volunteers
- 1,600 people
- Sponsor
- University of California, Los Angeles
Suicidal Ideation and Behavior, Psychiatric Hospitalization
Trauma Exposure and Suicidal Behaviors in Adolescents Aged 11-17 Hospitalized in Child and Adolescent Psychiatry
It is a comparative monocentric study with longitudinal follow-up at 6 months in adolescents aged between 11 years and 17 years inclusive admitted to complete hospitalization either for suicidal behaviors or for other psychiatric…
- Trial name
- ATTAQ (NCT07430566)
- Testing
- Blood samples, genetic analysis, Questionnaires and scales
- Volunteers
- 120 people
- Sponsor
- University Hospital, Montpellier
Major Depressive Disorder
miRNAs, Suicide, and Ketamine - Plasma Exosomal microRNAs as Novel Biomarkers for Suicidality and Treatment Outcome
The purpose of this study is to examine whether neural-derived exosomal miRNAs are differentially expressed that are specific to suicidal ideation or behavior, and which by affecting specific miRNA targets and pathways, are…
- Trial name
- NCT02418195
- Testing
- ketamine
- Where
- United States
- Volunteers
- 247 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Suicidal Ideation
Evaluation of Creative Materials Supporting Healthcare Professionals in Discussing Suicidality in Children and Adolescents
Preliminary research clearly indicates a significant shortage of evidence-based tools and interventions specifically targeting suicidality among children and adolescents.
- Trial name
- NCT07043231
- Testing
- Creative materials
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Ghent
Suicide
Culturally Centered CBT for Latinx Youth
The primary aim of the proposed research is to test the effect of a culturally centered treatment protocol, the Socio-cognitive behavioral therapy (SCBT), versus Treatment as Usual on suicidal thoughts and attempts, and…
- Trial name
- NCT04278157
- Testing
- Socio-Cognitive Behavioral Therapy for Suicidal Behavior (SCBT-SB), Treatment as Usual
- Where
- 2 sites in United States
- Volunteers
- 114 people
- Sponsor
- Bradley Hospital
Suicide Prevention, Help-Seeking Behavior
Healthcare for Men with Suicidal Thoughts: Needs Assessment
The aim of the current project is twofold, namely 1. To gain insight into needs related to help-seeking among men with (previous) suicidal thoughts (STUDY 1).
- Conditions
- Suicide Prevention, Help-Seeking Behavior, Men
- Trial name
- KUJK2NEEDS (NCT06375200)
- Testing
- No intervention
- Where
- Belgium
- Volunteers
- 500 people
- Sponsor
- University Ghent
Suicide, Suicide, Attempted
Drivers of Suicide Mobile App Study
The central purpose of this project is to evaluate and facilitate access to evidence-based best practices for individuals struggling with suicidal ideation and co-occurring behavioral problems, including alcohol misuse, and…
- Conditions
- Suicide, Suicide, Attempted, Suicidal Ideation, Alcohol Use Disorder
- Trial name
- NCT05427734
- Testing
- WisePath for Adults, Active-Control app + electronic wellness resources brochure
- Where
- United States
- Volunteers
- 127 people
- Sponsor
- Evidence-Based Practice Institute, Seattle, WA
Psychosis
The Effectiveness of Individualized Imagery Scripts on Sleep, Psychosis, and Suicidality Among Inpatients With Psychosis
The purpose of this study is to see how feasible is the use of compact EEG and paired audio technology to administer sleep interventions for inpatients with psychosis, to see if individuals that receive individualized…
- Trial name
- NCT06194344
- Testing
- Individualized imagery, Control
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The University of Texas Health Science Center, Houston
Suicidal Ideation, Depression
Social Connections and Healthy Aging (The Senior Connection)
This randomized trial compares peer companionship to care-as-usual in primary care on the outcome of risk for suicidal behavior in late life.
- Trial name
- TSC (NCT01408654)
- Testing
- Peer Companionship
- Where
- United States
- Volunteers
- 368 people
- Sponsor
- University of Rochester
Suicide Prevention, Suicide Safety Planning
Suicide Safety Planning
The goal of this clinical trial is to learn the best way to provide suicide prevention care to adults receiving outpatient mental health care.
- Conditions
- Suicide Prevention, Suicide Safety Planning, Suicidal Ideation, Suicide Attempt
- Trial name
- STAY (NCT07783490)
- Testing
- Local Care Continuity, Centralized Care Navigation
- Where
- United States
- Volunteers
- 176,000 people
- Sponsor
- Kaiser Permanente
Suicide, Attempted, Suicidal Ideation
Developing and Implementing an Adolescent Suicide Prevention Program in a Community Mental Health Setting
This is a three phase study to develop and implement an adolescent suicide prevention program in a community mental health setting.
- Trial name
- NCT03992391
- Testing
- Suicide Prevention Intensive Outpatient Program
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- University of Texas Southwestern Medical Center
Psychological Distress, Suicidal Ideation
Development and Testing of imHere4U: A Digital Suicide Prevention Intervention for Cyberbullied Adolescents
The objective of this study is to test the feasibility and preliminary efficacy of Flourish (formerly referred to as imHere4U), a digital suicide prevention intervention for cyberbullied adolescents.
- Trial name
- NCT06002191
- Testing
- Flourish, Questionnaires of Online Experiences
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Pittsburgh
Suicidal Ideation
Effectiveness of the MindBridge Mobile Health Module for Young Adults at Risk of Suicide
This study will evaluate the effectiveness of MindBridge, a dialectical behavior therapy (DBT)-informed mobile health module delivered through a WeChat mini-program, among Chinese young adults aged 18 to 24 years with…
- Trial name
- MindBridge (NCT07767604)
- Testing
- MindBridge Mobile Health Intervention, Attention-Matched General Well-Being Program
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Jiangsu Medical College
Insomnia, Depression
Adjunctive Brief Behavioral Treatment of Insomnia (BBTI) for Sleep Intervention (SI)
There is a strong association between sleep disturbance and suicidal thoughts and behaviors. Sleep disturbance is also highly comorbid with other common conditions associated with suicide such as depression and posttraumatic…
- Conditions
- Insomnia, Depression, Posttraumatic Stress Disorder, Suicidal Ideation
- Trial name
- NCT02248675
- Testing
- CBT-I, TAU
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- VA Office of Research and Development
Bipolar Depression, Suicidal Ideation
NRX101 Glx Biomarker Validation Study
Subnormal level of Glutamate+Glutamine (Glx) in the Anterior Cingulate Cortex (ACC) of the brain has been associated with depression and PTSD.
- Trial name
- NRX-GLX (NCT03402152)
- Testing
- NRX-101, Lurasidone HCl
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- NeuroRx, Inc.
Binge Alcohol Consumption, Suicidal Ideation
Preliminary Trial of an Avatar Guided Digital Intervention for Emerging Adults
The goal of this clinical trial is to learn whether a novel digital avatar (virtual coach) support program can help emerging adults ages 18-29 who present to the emergency department with suicidal thoughts and alcohol misuse…
- Trial name
- EA-Avatar (NCT07418047)
- Testing
- EA-Avatar, Suicide safety planning app
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of Massachusetts, Worcester
Depressive Disorder, Major Depressive Disorder
The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects
The purpose of this study is to test the hypothesis that the anti-depressant and anti-suicidal effects of the N-methyl-D-aspartate receptor (NMDAR) antagonist Ketamine is critically dependent on stimulation of…
- Conditions
- Depressive Disorder, Major Depressive Disorder, Bipolar Disorder, Post Traumatic Stress Disorder
- Trial name
- NCT05786066
- Testing
- Perampanel 6 MG, Ketamine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Yale University
Suicidal Thoughts and Behaviors, Major Depressive Episode (MDE)
Biomarker Discovery for Suicide Precision Circuit Therapeutics
This is a prospective observational biomarker study assessing changes in clinical, behavioral, neuroimaging, and neurophysiological measurer following ketamine/esketamine or electroconvulsive therapy (ECT) in adults with suicidal…
- Trial name
- NCT07723066
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital