Clinical trials: Substance-Related Disorders
Alcohol-Related Disorders, Drinking and Driving
Interaction of Alcohol With Energy Drinks
The main objective of the project is to assess whether there is an interaction between the effects of ethanol and energy drinks on driving performance.
- Trial name
- AEDED (NCT02771587)
- Testing
- Alcohol and energy drink, Alcohol, Energy drink
- Where
- 2 sites in Spain
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Parc de Salut Mar
Alcohol Abuse
Brief Intervention for Families of Teens Treated in the Emergency Department for an Alcohol-Related Event
The purpose of this study is to compare the effectiveness of a brief family intervention in reducing alcohol use and alcohol-related problems among families of underage drinkers (13-17 years old) who are treated in a hospital…
- Trial name
- NCT00247221
- Testing
- MI/Family Check-up, MI only
- Where
- United States
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Brown University
Analgesic Rebound Headache
Detoxification and Treatment of Subjects With Medication Overuse Headache
The purpose of this study is to assess the benefits of almotriptan used as a transitional therapy and topiramate in subjects with medication overuse headaches (MOH.
- Trial name
- NCT00432549
- Testing
- Almotriptan, Topiramate
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The New England Center for Headache, P.C.
Acute Post-operative Pain, Chronic Post Operative Pain
Duloxetine Impact on Postoperative Pain Control and Outcomes
1. Evaluate differences between patients taking Duloxetine or placebo following lateral lumbar interbody fusion for postoperative narcotic consumption. 2.
- Conditions
- Acute Post-operative Pain, Chronic Post Operative Pain, Narcotic Use, Opioid Use
- Trial name
- NCT05611749
- Testing
- Duloxetine 60 MG
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Scripps Health
Opioid-use Disorder, Opioid Dependence
SMART Effectiveness Trial
The current study piloted two psychosocial interventions developed to increase buprenorphine-naloxone adherence in individuals with opioid use disorder (OUD).
- Conditions
- Opioid-use Disorder, Opioid Dependence, Treatment Adherence
- Trial name
- NCT04464421
- Testing
- Contingency Management (CM), Brief Motivational Intervention + Substance Free Activities Session + Mindfulness-Based Adherence Promotion (BSM)
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Karen Derefinko, PhD
Healthy Subject, Tobacco Use Disorder
Effect of Black Raspberry Phytochemicals on Oral Microbiome in Current Smokers and Non-smokers
This randomized clinical trial studies the effects of black raspberry compounds (phytochemicals) on the bacteria in the mouth (oral microbiome) of current smokers and non-smokers.
- Trial name
- NCT02439255
- Testing
- Laboratory Biomarker Analysis, Phytochemical, Screening Questionnaire Administration
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Substance-Related Disorders
DOX as a Potential Treatment for Methamphetamine Dependence
The purpose of the study is to asses the potential interactions between methamphetamine and doxazosin in methamphetamine-dependent volunteers who are not seeking treatment.
- Trial name
- DOX-Meth (NCT02785393)
- Testing
- Sugar Pill, Doxazosin
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Depression, Substance-Related Disorders
Treatment of Comorbid Depression and Substance Abuse in Young People
This study aims to treat young people with an adjunctive integrated cognitive behavioral therapy (CBT) intervention and to examine the acceptability of this treatment approach within this population.
- Trial name
- NCT00232284
- Testing
- sertraline, Cognitive Behavioural Therapy
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- Dan Lubman
Alcoholism
Acamprosate Treatment: Mechanisms of Action
This study will examine whether pretreatment with two doses of acamprosate for seven days prior to abstinence lessens the intensity of acute withdrawal from alcohol compared with a placebo.
- Trial name
- NCT00004552
- Testing
- acamprosate (Campral)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Yale University
Hazardous Drinking, Binge Drinking
A Stage 2 Cognitive-behavioral Trial: Reduce Alcohol First in Kenya Intervention
This study will determine whether a group cognitive-behavioral therapy intervention that demonstrates preliminary evidence of reducing alcohol use among HIV-infected outpatients in western Kenya is effective when compared against…
- Conditions
- Hazardous Drinking, Binge Drinking, HIV-infected
- Trial name
- RAFIKI (NCT01503255)
- Testing
- cognitive behavioral group therapy, health education group
- Where
- Kenya
- Volunteers
- 614 people
- Sponsor
- Brown University
Substance Use Disorders, Eating Disorders
Substance Use and Eating Disorders : Food Craving and Addiction Transfer
Substance Use Disorder (SUD) and Eating Disorders (ED) are severe and persistent disturbances that are associated with significant harm.
- Trial name
- SUED (NCT05315635)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 294 people
- Sponsor
- Centre Hospitalier Charles Perrens, Bordeaux
Alcoholic Liver Disease, Alcoholic Fibrosis of Liver
Early Detection of Alcoholic Liver Disease
This is an observational study to identify the prevalence of advanced liver fibrosis among patients with excessive alcohol intake using a non-invasive method (FibroScan®) and to characterize the main environmental, genetic and…
- Conditions
- Alcoholic Liver Disease, Alcoholic Fibrosis of Liver, Alcoholic Cirrhosis, Excessive Drinking
- Trial name
- NCT04070508
- Sponsor
- University of Pittsburgh
Alcohol Related Disorders, Alcohol Drug Interactions
Healthy Living as You Age
Older persons who drink can be vulnerable to negative consequences of drinking. This trial aims to prevent harm from alcohol use in older adults through a program of screening and brief advice followed up with several health…
- Trial name
- HLAYA (NCT00379093)
- Testing
- Brief advice
- Where
- United States
- Volunteers
- 631 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Dependence
Research on Individualized Treatment for Alcoholism
The purpose of this study was to compare the effects of two psychosocial treatments that differed in scope and intensity (Broad Spectrum Treatment and Motivational Enhancement Treatment) combined with 3 or 6 months of treatment…
- Trial name
- RITA (NCT00523133)
- Testing
- naltrexone, Broad Spectrum Treatment, Motivational Enhancement Treatment
- Where
- United States
- Volunteers
- 185 people
- Sponsor
- Indiana University
Alcoholism, Depression
Sertraline and Cognitive Therapy in Depressed Alcoholics
This study will assess whether individuals treated with sertraline (Zoloft) and cognitive behavior therapy will experience improvement with their depression and consume less alcohol than individuals treated with a placebo and…
- Trial name
- NCT00000458
- Testing
- sertraline (Zoloft), cognitive behavior therapy
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Psychosis, Cannabis Use
Cannabis Potency Effects on Brain White Matter in Early Phase Psychosis
Canada reports some of the highest rates of cannabis use in our youth and young adult populations, among all the developed countries.
- Trial name
- NCT07001878
- Testing
- Metformin
- Where
- 2 sites in Canada
- Volunteers
- 24 people
- Sponsor
- Nova Scotia Health Authority
Alcohol Use Disorder, Alcohol Dependency
Project Relay Model for Recruiting Alcohol Dependent Patients in General Hospitals
The purpose of this study is to evaluate the Relay Model helping alcohol dependent patients at a general hospital to start specialized alcohol treatment in order to assess i) efficacy, ii) cost-effectiveness and iii) overall…
- Trial name
- Relay (NCT02188043)
- Testing
- Relay Model
- Where
- Denmark
- Volunteers
- 1,000 people
- Sponsor
- University of Southern Denmark
Alcohol-Related Disorders
Melatonin Use for Sleep Problems in Alcohol Dependent Patients
A double blind Randomized Controlled Trial with two arms will be used. Subjects with Alcohol use disorder and sleep problems will be recruited and assigned randomly to the active treatment Melatonin or Placebo arms.
- Trial name
- NCT03043443
- Testing
- Melatonin
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- Centre for Addiction and Mental Health
Diabetes, Chronic Kidney Diseases
Benchtop NMR Spectroscopy for Assessment of Clinical Human Pathologies (BRANCH-P STUDY)
This research programme seeks to combine the resources of NHS primary care, with the leading spectroscopic work in low-magnetic fields of the Wilson Group (Nottingham Trent University) to demonstrate the potential for benchtop…
- Conditions
- Diabetes, Chronic Kidney Diseases, Cancer, Bowel Disease
- Trial name
- BRANCH-P (NCT05473325)
- Where
- United Kingdom
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Willows Health
Opioid Use Disorder, Chronic Pain
Healing Opioid Misuse and Pain Through Engagement (HOPE) Trial
This study is a multisite randomized clinical trial of a treatment designed to reduce pain interference while simultaneously addressing relapse prevention among individuals who have co-occurring chronic pain and Opioid Use…
- Trial name
- HOPE (NCT05571917)
- Testing
- Acceptance and Commitment Therapy + Mindfulness Based Relapse Prevention (ACT + MBRP), Enhance Usual Care (EUC)
- Where
- 2 sites in United States
- Volunteers
- 160 people
- Sponsor
- University of New Mexico