Clinical trials: Substance-Induced Psychoses
Affective Disorders, Rumination
Study on the Effectiveness of Journaling as an add-on to Cognitive Behavioral Therapy
The aim of the present study is to examine the effects of keeping a therapy journal (journaling) on the effectiveness of cognitive behavioral therapy (CBT).
- Conditions
- Affective Disorders, Rumination, Childhood Trauma, Eating Disorder
- Trial name
- NCT06863909
- Testing
- Journaling, Treatment as Usual (TAU)
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- University Hospital Tuebingen
Bipolar Disorders, Schizophrenia
Injectable Versus Oral Naltrexone Treatment of Alcohol Dependence In Serious Mental Illness (SMI)
The primary aim of this study is to determine the feasibility of long-acting injectable naltrexone administration in a clinical trial in patients with SMI who also have a diagnosis of alcohol dependence.
- Conditions
- Bipolar Disorders, Schizophrenia, Schizoaffective Disorders, Alcohol Dependence
- Trial name
- vivitrol (NCT00453804)
- Testing
- injectable naltrexone, oral naltrexone
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- State University of New York - Upstate Medical University
Schizophrenia, Schizoaffective
Safety and Tolerability of Varenicline in Schizophrenia (SATOVA)
This is a 15 week trial to determine (1) the safety and tolerability of varenicline when used for smoking cessation/reduction in individuals with schizophrenia; (2) if treatment with varenicline affects the symptoms of…
- Conditions
- Schizophrenia, Schizoaffective, Psychosis
- Trial name
- NCT00702793
- Testing
- Varenicline
- Sponsor
- University of British Columbia
Schizophrenia, Schizoaffective Disorder
Injectable Naltrexone Treatment of Alcohol Dependence in Serious Mental Illness (SMI)
The overall goal of this project is to improve the treatment of alcohol dependence in patients with serious mental illness (SMI).
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Alcohol Dependence
- Trial name
- vivitrol (NCT00453609)
- Testing
- long-lasting injectable naltrexone
- Where
- 3 sites in United States
- Volunteers
- 15 people
- Sponsor
- State University of New York - Upstate Medical University
Smoking Cessation, Nicotine Addiction
Circuitry-Guided Smoking Cessation in Schizophrenia (UH3)
Patients with schizophrenia spectrum disorder (SSD) will be exposed to active repetitive transcranial magnetic stimulation (rTMS) from F8 coil or active rTMS from H coil for smoking cessation.
- Conditions
- Smoking Cessation, Nicotine Addiction, Schizophrenia
- Trial name
- NCT05276050
- Testing
- active F8-coil delivered rTMS, active H-coil delivered rTMS
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The University of Texas Health Science Center, Houston
Schizophrenia, Drug Abuse/Dependency
Influence of Nicotine on Cognitive Function in Schizophrenic Patients With and Without Comorbid Drug Dependence
Background: Individuals with schizophrenia have a significantly higher tendency to develop substance abuse or dependence than the general population.
- Trial name
- NCT01037075
- Where
- 2 sites in United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Schizophrenia
Cannabis and Thought Disorder in Schizophrenia
Recent studies have suggested a strong relationship between cannabis use and the level of thought disorder in subjects with schizophrenia.
- Trial name
- CANDI (NCT03608137)
- Testing
- Cannabis and thought disorder in schizophrenia:clinical and neuroimaging relationships
- Where
- France
- Volunteers
- 63 people
- Sponsor
- Hôpital le Vinatier
Alcohol Use Disorder (AUD), Alcohol Abuse
Neurobiological Effects of Transcranial Direct Current Stimulation Treatment in Alcohol Use Disorder
Background: Alcohol Use Disorder (AUD) is a complex psychiatric disorder, involving several brain areas and neurocircuits. Transcranial Direct Current Stimulation (tDCS) allows to stimulate superficial areas of brain using a weak…
- Conditions
- Alcohol Use Disorder (AUD), Alcohol Abuse, Alcohol Dependence, Alcohol-Related Disorders
- Trial name
- NCT04897295
- Testing
- Active transcranial Direct Current Stimulation
- Volunteers
- 30 people
- Sponsor
- ITAB - Institute for Advanced Biomedical Technologies
Alcohol Abuse, Alcohol Use Disorder
The Effect of Comorbid Alcohol/Substance Use
Study Design This study was designed as a comparative, cross-sectional case-control study examining the effect of comorbid alcohol and substance use disorder (ASUD) on clinical course and social inclusion among individuals with…
- Conditions
- Alcohol Abuse, Alcohol Use Disorder, Substance Use Disorders, Severe Mental Disorder
- Trial name
- NCT07692984
- Testing
- case (comorbid diagnosis), control
- Where
- Turkey (Türkiye)
- Volunteers
- 297 people
- Sponsor
- Abant Izzet Baysal University
Cannabis-Related Disorder, Substance-Related Disorders
First Episode Schizophrenia and Cannabis-Related Disorder Study
Many individuals with schizophrenia abuse cannabis at the onset of their illness, portending a poorer course of illness and poorer treatment response.
- Conditions
- Cannabis-Related Disorder, Substance-Related Disorders, Schizophrenia, Psychotic Disorders
- Trial name
- NCT00573287
- Testing
- clozapine, risperidone
- Where
- 5 sites in United States
- Volunteers
- 14 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Psychosis, Substance Use
Brief Motivational Enhancement Therapy for Concurrent Disorders
The investigators are proposing a project that will examine the effectiveness of brief motivational enhancement therapy in a population with concurrent psychotic disorders and substance use disorders.
- Trial name
- NCT01924039
- Testing
- Brief Motivational Enhancement Therapy, treatment as usual
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- Centre for Addiction and Mental Health
Schizophrenia, Bipolar Disorder
Family Intervention for Mental Illness and Substance Abuse
This study will evaluate a family intervention program for individuals with bipolar disorder, schizophrenia, or schizoaffective disorder and co-occurring substance use disorders.
- Conditions
- Schizophrenia, Bipolar Disorder, Substance-related Disorders
- Trial name
- NCT00043693
- Testing
- Family Intervention for Dual Diagnosis, Family psychoeducation program
- Where
- 2 sites in United States
- Volunteers
- 108 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Psychosis, Substance Use Disorders
Clozapine Versus Olanzapine as Treatment for Comorbid Psychotic Disorder and Substance Use Disorder
The purpose of this trial is to determine if patients with comorbid psychotic disorder and substance use disorder will continue in treatment longer if treated with clozapine than with olanzapine, and will have greater reductions…
- Trial name
- NCT03857581
- Testing
- Clozapine, Olanzapine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Augusta University
Smoking, Nicotine Dependence
Neural Inhibition as a Mechanism of Nicotine Dependence Among Persons With Schizophrenia
Cigarette smoking decreases life expectancy, causes devastating health complications, and costs society billions of dollars each year.
- Conditions
- Smoking, Nicotine Dependence, Schizophrenia, Schizophreniform Disorders
- Trial name
- NCT00407277
- Testing
- Nicotine patch, smoking cessation group therapy
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
None Volunteer
An Investigation of Mechanisms That Underly Paranoia in Behaviour and Brain That Can Inform Clinical Diagnoses That Include Paranoid Symptoms.
The study team is studying how delta-9-tetrahydrocannabinol (THC) - the component of cannabis that is responsible for "getting people feeling high" - influences how people think about the behaviour of others and a variety of…
- Trial name
- NCT07878130
- Testing
- Low-dose THC administration via IV, High-Dose THC administration via IV, Saline administration via IV
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- King's College London
Schizophrenia, Alcohol Use Disorder
A Study of ALKS 3831 in Subjects With Schizophrenia and Alcohol Use Disorder
This double-blind, randomized study will evaluate the efficacy, safety and tolerability of ALKS 3831 in subjects with schizophrenia and alcohol use disorder (AUD).
- Trial name
- NCT02161718
- Testing
- Samidorphan + olanzapine (ALKS 3831)
- Where
- 71 sites in United States, Bulgaria and 1 more
- Volunteers
- 300 people
- Sponsor
- Alkermes, Inc.
Tobacco Use Disorder, Smoking Cessation
Effectiveness of a Smoking Cessation Intervention in a Mental Health Day Hospital
Background: Nicotine contained in tobacco is highly addictive and tobacco use is a major risk factor for cardiovascular and respiratory diseases. Every year, more than 8 million people die from tobacco use.
- Conditions
- Tobacco Use Disorder, Smoking Cessation, Mental Disorder
- Trial name
- ESCIM (NCT05045326)
- Testing
- Smoking cessation program
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Hospital Clinic of Barcelona
Hepatitis C, Substance Use Disorders
Overcoming Psychiatric Barriers to the Treatment of Hepatitis C
The purpose of this study is to develop and evaluate a 9-month psychosocial intervention that will assist patients with hepatitis C in overcoming barriers that prevent them from becoming appropriate candidates for interferon…
- Conditions
- Hepatitis C, Substance Use Disorders, Mental Disorder
- Trial name
- NCT00407732
- Testing
- psychosocial intervention
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- University of North Carolina, Chapel Hill
Cannabis
The Study of Pharmacological Treatment Pattern for Cannabis-induced Psychosis
A cross-sectional and retrospective chart review study was conducted at the Princess Mother National Institute on Drug Abuse Treatment (PMNIDAT), Thailand.
- Trial name
- NCT04945031
- Testing
- cannabis
- Where
- Thailand
- Volunteers
- 317 people
- Sponsor
- Mahidol University
Psychotic Disorder, Marijuana Use
A Cannabis Harm Reduction e-Intervention for Young Cannabis Users With Early Psychosis
Cannabis users who experienced a psychosis are particularly vulnerable to cannabis-related harms, which can include worse psychotic symptoms and more hospitalizations.
- Conditions
- Psychotic Disorder, Marijuana Use, Young Adult
- Trial name
- CHAMPS (NCT04968275)
- Testing
- CHAMPS
- Where
- 5 sites in Canada
- Volunteers
- 101 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)