Clinical trials: Substance Use Recovery
Substance Use Disorders
Drum-Assisted Therapy for Native Americans
Drum-Assisted Recovery Therapy for Native Americans (DARTNA) is an R-21 NIH/NCCAM-funded study aimed to complete the development and pilot a new substance abuse treatment protocol utilizing drumming for American Indians/Alaska…
- Trial name
- NCT01356667
- Testing
- DARTNA, Treatment-As-Usual
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Tobacco Use Disorder
Tobacco Cessation Field Study for Adults in Recovery - 1
The project's aim is to provide a targeted, computer-administered intervention to facilitate tobacco cessation for clients in alcohol treatment.
- Trial name
- NCT00109460
- Testing
- Tobacco Use Disorder
- Where
- 7 sites in United States
- Volunteers
- 203 people
- Sponsor
- Inflexxion, Inc.
Alcohol Use Disorder, Mild Cognitive Impairment
The Combination of Donepezil and Cognitive Training for Treating Alcohol Use Disorder
This is an open label feasibility trial to learn whether the combination of donepezil and cognitive remediation therapy (Donepezil + CRT) may improve neurocognitive functioning and decreasing alcohol use in Veterans with alcohol…
- Trial name
- NCT04318639
- Testing
- Donepazil
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- VA Connecticut Healthcare System
Opioid Use Disorder
A Study of Brenipatide in Participants With Opioid Use Disorder
The purpose of this study is to see if brenipatide, when compared to placebo, is safe and effective for participants with opioid use disorder, when used with buprenorphine with or without naloxone.
- Trial name
- RENEW-Op-1 (NCT07420283)
- Testing
- Brenipatide, Buprenorphine
- Where
- 61 sites in United States, Canada and 2 more
- Volunteers
- 465 people
- Sponsor
- Eli Lilly and Company
Liver Transplant Recipient, Alcohol Use Disorders (AUD)
Intervention for Alcohol Use Disorder Recovery After Liver Transplantation
The goal of this clinical trial is to learn if it is feasible and acceptable to use a recovery coach and an online sober active community to help with alcohol use disorder after liver transplant.
- Trial name
- ILTARP (NCT07214259)
- Testing
- Online Sober Active Community, Recovery coach
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Leigh Anne Dageforde
Opioid-use Disorder
Recovery Management Checkups for Opioid Use Disorder Experiment
The experiment will be conducted in collaboration with 6 jails representing discrete geographic counties in Illinois and the opioid treatment providers (OTP) that serve them.
- Trial name
- JCOIN-HUB (NCT04365920)
- Testing
- Recovery Management Checkups (RMC), RMC-Adaptive
- Where
- United States
- Volunteers
- 455 people
- Sponsor
- Chestnut Health Systems
Opioid Use Disorder
An Observational Study of Environmental and Socioeconomic Factors in Opioid Recovery - Long Term
The purpose of this study (RECOVER-LT) is to better understand the long-term paths of recovery from opioid use disorder (OUD) for an additional 5 year period after the original RECOVER (NCT03604861) study.
- Trial name
- RECOVER-LT (NCT04577144)
- Testing
- Online survey only
- Where
- United States
- Volunteers
- 216 people
- Sponsor
- Indivior Inc.
Alcohol Use Disorder
Long-term Recovery: Longitudinal Study of Neuro-behavioral Markers of Recovery and Precipitants of Relapse
The goals of this study are to provide a scientific understanding of recovery and relapse, as well as to identify novel targets for future relapse prevention interventions.
- Trial name
- NCT04788004
- Testing
- Online survey
- Where
- United States
- Volunteers
- 733 people
- Sponsor
- Virginia Polytechnic Institute and State University
Alcohol Use Disorder
Initiating Substance Use Disorder Treatment for Hospitalized Alcohol Use Disorder Patients
The purpose of this study is to evaluate the impact of a manualized in-hospital recovery coach intervention on rates of post-discharge treatment retention and alcohol use among hospitalized patients with alcohol use disorder.
- Trial name
- ISTAP (NCT04223011)
- Testing
- In-Hospital Recovery Coach Intervention
- Where
- United States
- Sponsor
- Brigham and Women's Hospital
Substance Use Disorders (SUD), Pregnancy
Culturally Engaged REcovery: MOms Connected Through Native communitY
Pregnant and postpartum American Indian and Alaska Native people (Native mothers) face a more than two-fold higher risk of maternal mortality compared to non-Hispanic White mothers.
- Conditions
- Substance Use Disorders (SUD), Pregnancy, Maternal Morbidity and Mortality, Cultural Adaptation
- Trial name
- CEREMONY (NCT06747442)
- Testing
- Cradleboard Journey
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- University of Utah
Substance Use Disorders
Heart Rate Variability Biofeedback for Substance Use Disorder: A Randomized Clinical Trial
Heart rate variability biofeedback (HRVB) is an biobehavioral intervention involving rhythmic breathing at resonance frequency that stimulates cardiovascular regulatory systems to help individuals better regulate affect and…
- Trial name
- NCT05454657
- Testing
- Heart rate variability biofeedback + treatment as usual, Treatment as usual only
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Massachusetts General Hospital
Opioid Use Disorder, Opioid Use
Overdose Recovery and Care Access (ORCA) Qualitative Stakeholder Interviews and County-level Data
The study is a quasi-experimental investigation of a sub-acute stabilization center (SASC) for people who have had or are at risk for having an opioid overdose and have an encounter with Seattle Fire Department emergency medical…
- Trial name
- NCT06768814
- Testing
- Sub-acute stabilization
- Where
- United States
- Volunteers
- 40,000 people
- Sponsor
- University of Washington
Alcohol Use Disorder (AUD)
Renewed Recovery: a Pilot Test of a Web-Based Mindfulness-Based Relapse Prevention Continuing Care Intervention for Alcohol Use Disorder
This study aims to design, implement, and evaluate a pilot test of a web-based Mindfulness-Based Relapse Prevention (MBRP) continuing care intervention to support individuals with alcohol use disorder (AUD) exiting standard…
- Trial name
- NCT06987526
- Testing
- Mindfulness-Based Relapse Prevention
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Georgia
Alcohol Withdrawal, Substance Use Disorders
NCARE, Transition to Recovery
This study tests the effectiveness of patient navigation for increasing enrollment in substance abuse treatment programs and preventing readmission to detoxification.
- Trial name
- NCT03737864
- Testing
- Patient navigation, Motivational interviewing (MI)
- Where
- United States
- Volunteers
- 206 people
- Sponsor
- University of Colorado, Denver
Opioid Use Disorder, Mental Health Disorder
Supporting Treatment Access and Recovery in COD
This 4-year study will randomize 1,000 people with co-occurring opioid use and mental health disorders (COD) at medication for opioid use disorder (MOUD) clinics to evaluate the effectiveness of MISSION, a multi-component team…
- Trial name
- STAR-COD (NCT05138614)
- Testing
- Medication for Opioid Use Disorder, MISSION Critical Time Intervention, MISSION Peer Support
- Where
- 5 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- University of Massachusetts, Worcester
Alcohol Use Disorder (AUD), Alcohol Abstinence
SER-ABS-AUD: Neuropsychosocial-Spiritual Correlates of Serene Abstinence in Adults With AUD
SER-ABS-AUD is a single-centre, non-interventional, mixed retrospective-prospective longitudinal cohort study of 70 adults aged 18-70 years with documented alcohol use disorder, at least 12 consecutive months of continuous…
- Trial name
- SER-ABS-AUD (NCT07561749)
- Where
- Romania
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Grigore T. Popa University of Medicine and Pharmacy
Mental Disorders, Substance Use Disorders
Promoting Recovery by Overcoming Self-stigma in Mental Health Disorders With a Narrative Enhancement and Cognitive Therapy (NECT) Group Intervention
This study will evaluate whether Narrative Enhancement and Cognitive Therapy (NECT) can promote recovery among adults living with severe mental health disorders, including substance use disorders.
- Trial name
- NCT07735481
- Testing
- Narrative Enhancement Cognitive Therapy, Control Group Sessions
- Where
- Switzerland
- Volunteers
- 106 people
- Sponsor
- Louise Penzenstadler
Alcohol Use Disorder (AUD)
A Critical Illness Recovery Navigator for Alcohol
Excessive alcohol consumption is common in patients admitted to the intensive care unit (ICU). Among patients who survive an ICU admission, excessive alcohol consumption is associated with a higher risk of being admitted the…
- Trial name
- CIRNA (NCT03059082)
- Testing
- Recovery Navigator on an as needed basis up to 6 months, Recovery Navigator prior to hospital discharge, No interaction with Recovery Navigator
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- University of Colorado, Denver
Opioid Use, Prescription Drug Abuse and Dependency
No Opioids PrescrIptions On Discharge After Surgery
Opioid analgesics are routinely prescribed for these patients for post-operative pain control. Even a short exposure to opioids in opioid-naïve patients following minor or major surgery has been associated with de novo habitual…
- Conditions
- Opioid Use, Prescription Drug Abuse and Dependency, Surgery, Postoperative Pain
- Trial name
- NOPIOiDS (NCT04469868)
- Testing
- No opioids at discharge
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Albany Medical College
Opioid Use Disorder
Sustaining Recovery for People on Opioid Agonist Treatment With Conversational Agents
This study aims to improve retention in buprenorphine treatment, a medication used for opioid use disorder, through the use of a smartphone-delivered recovery support intervention.
- Trial name
- SARA RCT (NCT06732596)
- Testing
- Embodied conversational agent (ECA), Technical support, Additional ECA messages
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Boston Medical Center