Clinical trials: Substance Related Disorder
Opiate Dependence
Study of Buprenorphine-Naloxone Sublingual Spray and Suboxone® Sublingual Film in Healthy Volunteers
The primary objective of this study is to compare the bioavailability of a test formulation of Buprenorphine Naloxone Sublingual (SL) spray to that of a single dose of Suboxone® (buprenorphine and naloxone) sublingual film, under…
- Trial name
- NCT02477267
- Testing
- SL spray, SL film
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- INSYS Therapeutics Inc
Drug Addiction
Recovery Housing For Drug Dependent Pregnant Women
For the past several years our research program has developed and tested an intensive outpatient intervention that is based in social learning theory and employs abstinence contingent access to recovery housing as a routine…
- Trial name
- HOME (NCT00497302)
- Testing
- RBT, usual care
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Johns Hopkins University
Tobacco Use Disorder
Effectiveness of a Web-Assisted Quitline for Smokeless Tobacco Users
The purpose of this record is to test whether (a) participants who receive a Web-based smokeless tobacco cessation intervention will be more likely to be abstinent than participants who do not receive this intervention, and (b)…
- Trial name
- NCT00820495
- Testing
- Web + Phone, Web Only, Phone Only
- Where
- 2 sites in United States
- Volunteers
- 1,683 people, healthy volunteers welcome
- Sponsor
- Oregon Research Institute
HIV Infections, HCV
The Ganchero Intervention for Migrant People Who Inject Drugs From Puerto Rico in New York City
The goal of this pilot clinical trial is to learn if an intervention that trains Gancheros (people who provide injection services in exchange for drugs or money) to conduct risk-reduction outreach could help lower risk for human…
- Conditions
- HIV Infections, HCV, Overdose
- Trial name
- NCT06316739
- Testing
- Ganchero intervention
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- North Jersey AIDS Alliance dba North Jersey Community Research Initiative (NJCRI)
Mindfulness, Guanfacine
Combined Guanfacine and Mindfulness Meditation as an Adjunct to Buprenorphine Maintenance in Opioid Use Disorder
The US is currently going through an opioid crisis, and while Medication Assisted Treatments such as buprenorphine (BUP) have proved highly effective at stabilizing the neurobiology underlying acute withdrawal, they have been…
- Conditions
- Mindfulness, Guanfacine, Opioid Use Disorder
- Trial name
- NCT06642181
- Testing
- Guanfacine pharmacotherapy, Mindfulness Oriented Recovery Enhancement (MORE)
- Where
- United States
- Volunteers
- 224 people
- Sponsor
- Rutgers, The State University of New Jersey
Schizophrenia, Nicotine Addiction
Effects of rTMS on Cigarette Smoking and Cognition in Schizophrenia
Cigarette smoking rates are extremely high in persons with schizophrenia and this increases the risk of disease and death due to tobacco-related disorders.
- Trial name
- rTMSsmokelab (NCT01523730)
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- Canada
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Opioid-use Disorder
Treatment Navigation for Opioid Use Disorder
The investigators will conduct a pilot randomized controlled trial (RCT) study of 100 people with a history of opioid use disorder releasing to WA Department of Corrections (DOC) community corrections supervision in King County.
- Trial name
- NCT03398265
- Testing
- Treatment Navigation (Intervention), Control
- Where
- 5 sites in United States
- Volunteers
- 17 people
- Sponsor
- University of Washington
Opioid Overdose
Preventing Opioid Overdose Deaths by Empowering Pharmacists to Dispense Naloxone
Objectives: The purpose of this study was to assess the impact of the Empowering Community Pharmacists program on pharmacists' knowledge, perceived barriers, attitudes, confidence, and intentions regarding naloxone services…
- Trial name
- NCT05093309
- Testing
- Educational Webinar, Resources, Reminders
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Auburn University
Substance-related Disorders, Alcohol-Related Disorders
LaunchPad: Supporting Healthy Decisions and Preventing Drug Use After High School
LaunchPad is an online substance use prevention program for high school seniors. The program is designed to help seniors develop skills and make informed decisions as they transition from high school to young adulthood.
- Conditions
- Substance-related Disorders, Alcohol-Related Disorders, Tobacco Use Disorder, Marijuana Use
- Trial name
- NCT07655609
- Testing
- Introduction, Norms re: Protective Behavior Strategies (PBS), Life Skills
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Prevention Strategies, LLC
Amphetamine-Related Disorders, Alcohol-Related Disorders
Mephedrone and Alcohol Interactions in Humans
The purposes of this study are 1) to evaluate the pharmacological effects after oral coadministration of mephedrone and alcohol and 2) determine the pharmacokinetics changes of mephedrone and alcohol concentrations after oral…
- Trial name
- NCT02294266
- Testing
- Mephedrone and alcohol, Mephedrone, Alcohol
- Where
- Spain
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Parc de Salut Mar
Sinusitis, Opioid Use
Pain Control Following Sinus Surgery
Given the ongoing national opioid epidemic, an increased interest has developed in optimizing opioid prescribing practices of physicians, including otolaryngologists.
- Conditions
- Sinusitis, Opioid Use, Opioid Abuse, Narcotic Use
- Trial name
- NCT03783702
- Testing
- OxyCODONE 5 Mg (milligram) Oral Tablet, Ibuprofen 600 Mg (milligram) Oral Tablet, Acetaminophen 650 MG (milligram) Oral Tablet
- Where
- 6 sites in United States, Canada
- Volunteers
- 118 people
- Sponsor
- Stanford University
Substance Use Disorders, Treatment Adherence and Compliance
Kentucky Access to Recovery Evaluation
Evaluate the long-term effectiveness of implementing vouchers as a linkage strategy in a population requiring recovery support services (RSS) when no other funding sources are available.
- Trial name
- NCT05889702
- Testing
- KATR Linkage Strategy
- Where
- 2 sites in United States
- Volunteers
- 458 people
- Sponsor
- Terry Bunn
Schizophrenia, Schizoaffective Disorder
Adapted Cognitive/Affective Remediation for Cannabis Misuse in Schizophrenia
This study will integrate and adapt a cognitive remediation (Cognitive Enhancement Therapy [CET]) and an affect regulation (Personal Therapy [PT]) intervention for 50 individuals with schizophrenia that misuse cannabis.
- Trial name
- NCT01292577
- Testing
- CET/PT, Treatment as Usual
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Pittsburgh
Marijuana Abuse
Marijuana Drug Discrimination and Self-Administration
This study is designed to investigate the associations among marijuana's discriminative stimulus, reinforcing, subjective (e.g. craving) and physiological effects, and to assess the relative ability of oral THC to block these…
- Trial name
- DDC (NCT00943930)
- Testing
- THC (delta-9 tetrahydrocannabinol), d-amphetamine, oral THC
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Wayne State University
Substance Use Disorders, Depression
A Novel Person-Centered Treatment Component for Substance Use Treatment
A person-centered substance use treatment component, the Natural Recovery Program, was developed in a residential substance use treatment setting.
- Conditions
- Substance Use Disorders, Depression, Bipolar Disorder, Psychosis
- Trial name
- NCT02005367
- Testing
- Natural Recovery-Horticulture, Natural Recovery-Art/Music
- Where
- United States
- Volunteers
- 643 people
- Sponsor
- Hampton VA Medical Center
Opioid Use, Opioid-use Disorder
Evaluating the Impact of the Bridge Clinic in Patients With Opioid Use Disorder
This study aims to determine whether referral to the Bridge Clinic reduces overall index hospital length of stay when compared to direct referral to a long-term outpatient addiction provider for patients with active opioid use…
- Trial name
- NCT04084392
- Testing
- Bridge Clinic, Usual Care
- Where
- United States
- Volunteers
- 335 people
- Sponsor
- Vanderbilt University Medical Center
Alcohol Use Disorder
A Study to Evaluate Mazdutide Compared With Placebo in Participants With Alcohol Use Disorder
The objective of this proof-of-concept study to evaluate mazdutide in participants with alcohol use disorder (AUD). For any individual participant, the maximum duration of study participation is approximately 36 weeks, including…
- Trial name
- NCT06817356
- Testing
- Mazdutide
- Where
- 25 sites in United States
- Volunteers
- 308 people
- Sponsor
- Eli Lilly and Company
Substance-Related Disorders, Alcohol-Related Disorders
Computer-delivered Psychosocial Intervention for Adolescent Substance Use Disorders
The purpose of this study is to develop and evaluate the acceptability and preliminary efficacy of a web-based, skills training program for adolescents with substance use disorders.
- Conditions
- Substance-Related Disorders, Alcohol-Related Disorders, Marijuana Abuse
- Trial name
- NCT00957775
- Testing
- Usual care, Computer-delivered ACRA
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- National Development and Research Institutes, Inc.
Nicotine Dependence
Effectiveness of GW468816, an NMDA Glycine Site Antagonist, for Prevention of Relapse to Smoking
The purpose of this study is to evaluate the efficacy of the glycine antagonist, GW468816, compared with placebo on duration of abstinence and rates of relapse in recently quit female smokers in a randomized, double-blind…
- Trial name
- NCT00218465
- Testing
- GW468816
- Where
- 2 sites in United States
- Volunteers
- 264 people
- Sponsor
- Massachusetts General Hospital
Marijuana Abuse
Efficacy and Safety of the Hcoil Deep TMS for the Treatment of Cannabis Addiction
Evaluation of efficacy and safety of H-coil deep transcranial magnetic stimulation 9 week treatment trial for cannabis addiction as assessed by measures of drug intake and craving.
- Trial name
- NCT00543036
- Testing
- H-Coil deep TMS
- Where
- Israel
- Sponsor
- Shalvata Mental Health Center