Clinical trials: Substance Dependency
Alcohol Dependence
The Approach and Avoidance Task (AAT) in Alcoholic Inpatients
The approach and avoidance task (AAT) has evolved as a promising treatment add-on in the realm of psychology. Certain psychiatric diseases, such as behavioural addictions, social anxiety disorder, and arachnophobia, are…
- Trial name
- NCT04054336
- Testing
- Inhibit AAT, classical AAT, Control Group
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Cocaine Dependence
Imaging the Neurobiology of Behavioral and Medication Treatment for Cocaine Dependence
The proposed study will look at cocaine dependent individuals and will consist of three consecutive phases: 1) the 2-week outpatient lead-in phase during which behavioral therapy will be administered; 2) the 15-21 day inpatient…
- Trial name
- COST (NCT01468012)
- Testing
- levodopa carbidopa and entacapone (LCE)
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Nicotine Dependence Tobacco Product
Comparing SMS and E-mail Reminders in an Online Smoking Cessation Intervention
The primary purpose of the current study is to compare the effect of SMS-textmessage vs e-mail reminders on user engagement and proportion of reported quit attempts in an online smoking cessation intervention.
- Trial name
- NCT03276767
- Testing
- Endre
- Where
- 2 sites in Czechia, Norway
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Severe Mental Illness, Nicotine Dependence
Electronic Decision Support Systems for Smokers With Severe Mental Illness
This randomized clinical trial among SMI smokers assessed whether the EDSS with carbon monoxide monitor and health-checklist feedback lead to higher rates of initiation of smoking cessation treatment, days of smoking abstinence…
- Conditions
- Severe Mental Illness, Nicotine Dependence, Schizophrenia, Tobacco Use Disorder
- Trial name
- NCT01412866
- Testing
- EDSS with CO feedback and health checklist, EDSS with health checklist feedback alon
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Nicotine Dependence, Nicotine Dependence, Cigarettes
Clinical Study Comparing 7 ENDS Products and 1 Combustible Cigarette Using 2 Delivery Methods.
A Randomized Study Comparing Nicotine Pharmacokinetics of Seven Electronic Cigarette Products and One Traditional Cigarette Across Two Delivery (10 puff and ad- libitum) Conditions, in Healthy Adult Smokers
- Conditions
- Nicotine Dependence, Nicotine Dependence, Cigarettes, Tobacco Use, Tobacco Smoking
- Trial name
- NCT03700112
- Testing
- JUUL Virginia Tobacco flavored 5.0% ENDS, PMI iQOS Heat sticks, Reynolds VUSE Solo ENDS - Original
- Where
- New Zealand
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Juul Labs, Inc.
Alcohol Dependence
Advanced Nurses vs. General Practitioners for the Management of Outpatient Alcohol Detox: a Safety and Cost Comparison
The SAMBA study aims to assess the safety and cost comparison of the management of outpatient alcohol detoxification, between an advanced nurse protocol on the one hand (experimental group), and a GP-based treatment on the other…
- Trial name
- SAMBA (NCT03056365)
- Testing
- Advanced Nurse (AN), General Practitioner (GP)
- Where
- 26 sites in France
- Volunteers
- 73 people
- Sponsor
- University Hospital, Lille
Addiction, Substance Abuse
Breathwork-assisted Treatment for Cannabis Use Disorder
The purpose of this proof-of-concept study is to evaluate the safety, feasibility and acceptability of a breathwork workshop intervention in individuals with cannabis use disorder.
- Conditions
- Addiction, Substance Abuse, Cannabis Use Disorder, Cannabis Use
- Trial name
- NCT05219825
- Testing
- Breathwork workshop
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Elias Dakwar
Methamphetamine Dependence
A Cognitive Behavioral Therapy-Based Text Messaging Intervention for Methamphetamine Dependence
This Phase I, randomized, 22-day crossover study seeks to improve treatment outcomes for methamphetamine-dependent subjects by developing a cognitive behavioral therapy (CBT)- based short message service (SMS) text messaging…
- Trial name
- NCT01577797
- Testing
- Text messages
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- New Leaf Treatment Center
Cocaine-Related Disorders
Cocaethylene as a Treatment for Cocaine Dependence - 1
Cocaine has been cited as the primary drug threat in the United States. The purpose of this study is to determine if cocaethylene, used as a prototype drug, is a safe and effective treatment for cocaine dependence.
- Trial name
- NCT00124696
- Testing
- Cocaethylene
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcoholism
ALK21-006: Long-Term Study of Medisorb® Naltrexone (VIVITROL®)
This was a Phase 3 multicenter randomized, open-label, safety study assessing the safety of repeat doses of Medisorb® naltrexone 380 mg (VIVITROL®) administered for up to 1 year to adults with alcohol and/or opioid dependence as…
- Trial name
- NCT01218997
- Testing
- Medisorb naltrexone 380 mg, Oral naltrexone 50 mg
- Volunteers
- 436 people
- Sponsor
- Alkermes, Inc.
Cannabis, Dependence
Effects of Sativex(Registered Trademark) and Oral THC on Attention, Affect, Working Memory, Reversal Learning, Physiology and Brain Activation
Background: The therapeutic modalities of cannabis have received more research attention recently with the discovery of its ability to stimulate appetite and to provide pain and nausea relief in patients with AIDS, cancer, and…
- Conditions
- Cannabis, Dependence, Cannabis Abuse, Pharmacokinetics
- Trial name
- NCT01037608
- Testing
- Sativex(Registered Trademark), THC
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Heroin Dependence, Opioid-Related Disorders
Studies of Opioid Seeking Behavior: Yohimbine and Hydrocortisone Effects
This research deals with behaviors that are part of opioid dependence. The purpose is to study the extent to which stress and other factors, including money and amount of work effort, affect opioid choice.
- Trial name
- YHO (NCT01536925)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Wayne State University
Tobacco Smoking, Nicotine Dependence
Neurophysiological and Immunological Effects of the Transition From Combustible to Electronic Cigarettes
The objective of this study is to examine the cognitive, immunological, and neurophysiological effects of transitioning from tobacco cigarettes to electronic cigarettes.
- Trial name
- ECIG (NCT02433015)
- Testing
- Electronic Cigarette, Tobacco Cigarette
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Laureate Institute for Brain Research, Inc.
Alcohol Dependence
Network Support for Treatment of Alcohol Dependence
Relapse is the most serious problem in alcoholism treatment. The overall aim of the present study was to determine if a treatment directed at changing the patient's social network, from one that reinforces drinking behavior to…
- Trial name
- NCT00845208
- Testing
- Network Support
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- UConn Health
Opioid-Related Disorders
Suboxone: (Buprenorphine/Naloxone) Comparison of Two Taper Schedules - 1
The purpose of this protocol is to to compare the clinical utility of two dosage tapering regimens in Buprenorphine/Naloxone stabilized subjects for opiate detoxification.
- Trial name
- NCT00078117
- Testing
- Buprenorphine
- Where
- 11 sites in United States
- Volunteers
- 516 people
- Sponsor
- University of California, Los Angeles
Bipolar Disorders, Schizophrenia
Injectable Versus Oral Naltrexone Treatment of Alcohol Dependence In Serious Mental Illness (SMI)
The primary aim of this study is to determine the feasibility of long-acting injectable naltrexone administration in a clinical trial in patients with SMI who also have a diagnosis of alcohol dependence.
- Conditions
- Bipolar Disorders, Schizophrenia, Schizoaffective Disorders, Alcohol Dependence
- Trial name
- vivitrol (NCT00453804)
- Testing
- injectable naltrexone, oral naltrexone
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- State University of New York - Upstate Medical University
Nicotine Dependence, Tobacco Dependence
ROSCAP: Reduction of Smoking in Cardiac Patients Study
Background. The ROSCAP Study was a randomized controlled trial in heart disease patients to test the effect of a smoking reduction intervention on cigarettes per day (cpd) and biochemical and clinical indicators of tobacco…
- Conditions
- Nicotine Dependence, Tobacco Dependence, Cardiac Disease
- Trial name
- NCT00301626
- Testing
- smoking reduction intervention (including NRT)
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- National Institutes of Health (NIH)
Alcohol Use Disorder, Alcohol Dependence
Altering Memories That Increase Risk of Relapse in Alcohol Use Disorders
The purpose of this study is to examine the effects of rapamycin (sirolimus) versus a placebo, an inactive substance, on responses to alcohol cues in individuals with alcohol use disorder.
- Trial name
- NCT03732248
- Testing
- Rapamycin
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Heroin Dependence
Pharmacogenomics Study of Sleep Disturbance and Neurocognitive Impairments in the Opioid Addicts
Opioid abuse is a complex problem, which not only impacts on addicts' physical and psychological health individually, but also threats the society.
- Trial name
- NCT01668706
- Where
- 5 sites in Taiwan
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- National Health Research Institutes, Taiwan
Opiate Dependence
Extended-Release Naltrexone for Opioid Relapse Prevention Following Release From Jail
This pilot study's primary aim is to compare rates of sustained opioid relapse, defined as self-reported opioid use >50% (>15 of 30) of days during the first 30 days following release from jail, among persons treated with XR-NTX…
- Trial name
- NCT01180647
- Testing
- Extended-Release Naltrexone, Motivational Enhancement Counseling
- Where
- 2 sites in United States
- Volunteers
- 48 people
- Sponsor
- NYU Langone Health