Clinical trials: Substance Dependence
Cocaine-Related Disorders, Opioid-Related Disorders
Fluoxetine to Reduce Cocaine Use in Cocaine and Opioid Addicts
Cocaine addiction is a serious health problem with no available medical treatment for preventing relapse. Fluoxetine, a medication that is currently used to treat depression and anxiety disorders, may also be effective at…
- Trial name
- NCT00142779
- Testing
- Fluoxetine
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Modafinil, Sleep Architecture and Cocaine Relapse
The medication modafinil has been shown to reduce cocaine use in some cocaine users. The investigators have shown that modafinil taken in the morning improves sleep in chronic cocaine users.
- Trial name
- NCT01137396
- Testing
- Modafinil, Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Yale University
Tobacco Use Disorder
Smartphone-based Financial Incentives
Cigarette smoking during pregnancy increases risk for catastrophic pregnancy complications, growth retardation, other adverse fetal and infant health problems, and later-in-life chronic conditions among exposed offspring.
- Trial name
- NCT03922360
- Testing
- Smartphone-based Financial Incentives, Best Practices
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Nicotine Dependence, Tobacco Use Disorder
Effectiveness of Using Reduced Nicotine Cigarettes in Men and Women Smokers to Combat Nicotine Addiction
This is a 2-year study involving the progressive reduction in the nicotine content of cigarettes. The investigators believe that at the end of the study smokers of cigarettes with progressively reduced nicotine content will be…
- Trial name
- NCT00264342
- Where
- United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Opioid Dependence
Facilitating Rapid Naltrexone Initiation
The incidence of opioid use disorders (OUDs) has increased to near-epidemic proportions. While maintenance with long-acting opioids such as methadone or buprenorphine represents an effective treatment strategy, it may be…
- Trial name
- NCT03345173
- Testing
- CI-581-a, CI-581-b
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Cocaine Dependence, Alcohol Dependence
VIVITROL as a Treatment for Cocaine and Alcohol Dependence
To evaluate the efficacy of VIVITROL (naltrexone for extended-release injectable suspension) for the treatment of co-occurring cocaine and alcohol dependence
- Trial name
- NCT00777062
- Testing
- VIVITROL (Naltrexone extended-release injectable suspension)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Pennsylvania
Social Anxiety Disorder, Social Phobia
Paroxetine for Comorbid Social Anxiety Disorder and Alcoholism
The purpose of the study is to determine whether an SSRI, paroxetine, improves social anxiety symptoms and alcohol use in individuals who drink to cope with social anxiety disorder.
- Conditions
- Social Anxiety Disorder, Social Phobia, Alcohol Use Disorder, Alcohol Abuse
- Trial name
- NCT00246441
- Testing
- Paroxetine
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Medical University of South Carolina
Cocaine Dependence
Effectiveness of Enhanced Treatments for Drug Dependence
The purpose of this challenge grant is to conduct an initial test of a new, enhanced version of this protocol (telephone monitoring and counseling - enhanced, or TMAC-E), which has been modified to include the elements of our…
- Trial name
- EETDD (NCT01153477)
- Testing
- Telephone Monitoring and Counseling - Enhanced
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Pennsylvania
Smoking Cessation, Tobacco Dependence
De-nicotinised Cigarettes Study
The aim of this study is to determine if using a behavioural replacement for smoking (de-nicotinised cigarettes; DNCs), in addition to standard treatment during the first two weeks after the target quit date, can reduce urges to…
- Trial name
- Denic (NCT01250301)
- Testing
- De-nicotinised cigarettes + standard treatment, Standard Treatment
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Cocaine-Related Disorders
Effectiveness of Modafinil and D-amphetamine in Treating Cocaine Dependent Individuals
Cocaine dependence is a major public health problem; an effective primary treatment for cocaine dependent individuals has yet to be found.
- Trial name
- NCT00218062
- Testing
- D-Amphetamine 30mg, D-Amphetamine 60mg, Modafinil 200mg
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Cocaine-Related Disorders
Venlafaxine to Reduce Cocaine Dependence in Depressed Individuals
Preliminary research has shown that venlafaxine, a medication currently used for treating depression, may also discourage cocaine use in depressed individuals.
- Trial name
- NCT00249483
- Testing
- Venlafaxine
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- New York State Psychiatric Institute
Marijuana Dependence
Vilazodone Treatment for Marijuana Dependence
Marijuana is the most commonly used illicit drug, yet few clinical trials have evaluated pharmacotherapy treatments for marijuana dependence.
- Trial name
- NCT01574183
- Testing
- Vilazodone
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Medical University of South Carolina
Nicotine Dependence, E-Cig Use
Research and Innovation to Stop E-cigarette/Vaping in Young Adults
The aim of this study is to test intervention components to help young adults quit vaping. A 2x2 factorial design will be used where all participants receive quitline-delivered behavioral phone counseling, and components to be…
- Trial name
- (RISE) (NCT04974580)
- Testing
- Nicotine patch, Phone Counseling, Digital Coaching
- Where
- United States
- Volunteers
- 508 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Smoking, Nicotine Dependence
Alcohol Counseling for Telephone Quitline Callers
The goal of this study is to train phone counselors working for the New York (NY) State Smokers' Quitline to advise callers who drink at hazardous levels to limit or abstain from alcohol use to determine whether this improves…
- Conditions
- Smoking, Nicotine Dependence, Alcohol Dependence
- Trial name
- NCT01120080
- Testing
- Practical Counseling, Alcohol Intervention Counseling
- Where
- United States
- Volunteers
- 1,948 people
- Sponsor
- Yale University
Cocaine-Related Disorders
Effectiveness of Memantine in Treating Cocaine-Dependent Individuals - 2
Cocaine is one of the most widely abused drugs in the United States. Memantine is a type of drug called an NMDA receptor antagonist. It works by decreasing normal excitement in the brain.
- Trial name
- NCT00134901
- Testing
- Memantine
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- New York State Psychiatric Institute
Alcoholism
Relationship Between D2 Receptors SPECT and the Apomorphine Test in Patients With OH Dependence (ALC-DRD2-APO)
OH dependence is associated with DA receptor changes. Both, the apomorphine test and the D2Rec SPECt are usefull for monitoring DA receptor status.
- Trial name
- ALC-DRD2-APO (NCT00437177)
- Testing
- apomorphine, [(123)I] iodobenzamide
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Nicotine Dependence, Alcohol Dependence
Topiramate to Aid Smoking Cessation in Alcohol Dependent Men
The purpose of this study is to determine whether topiramate is effective as an aid to smoking cessation for recovering alcohol dependent men.
- Trial name
- NCT00802412
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- VA Office of Research and Development
Nicotine Dependence
Smoked Nicotine Induced Changes in Hormone Function, Mood States and Behaviors
The proposed clinical studies will evaluate the acute effects of nicotine on the hypothalamic-pituitary-gonadal axis in women to test the hypothesis that nicotine alters gonadal steroid hormones, and/or disrupts feedback…
- Trial name
- NCT01636323
- Testing
- Nicotine
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Heroin Dependence, Opioid-Related Disorders
Buprenorphine/Naloxone Treatment for Opioid Dependence-Experiment I(2) - 2
The purpose of this study is to compare the clinical efficacy of daily vs. 3-day (MWF) buprenorphine/naloxone combination tablet administration and determine whether outcomes are improved when using a 3-day schedule in which all…
- Trial name
- NCT00000327
- Testing
- Heroin Dependence
- Where
- United States
- Sponsor
- University of Colorado, Denver
Low Back Pain
Buprenorphine and Methadone for Opioid-dependent Chronic Back Pain Patients
Chronic pain patients are treated with prescription opioids and many exhibit opioid addiction. Currently, there are no evidence-based guidelines to better manage patients with chronic pain and coexistent opioid addiction.
- Trial name
- NCT01559454
- Testing
- Methadone, Buprenorphine/naloxone
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- State University of New York at Buffalo