Clinical trials: Substance Dependence
Nicotine Dependence
Cessation Screening Project
This project will use the Multiphase Optimization Strategy (MOST) to guide the development of optimized treatment strategies for the two most effective smoking cessation medications (Combination Nicotine Replacement [C-NRT] and…
- Trial name
- NCT04188873
- Testing
- Preparation Varenicline and Standard Duration Varenicline, Preparation Varenicline and Extended Duration Varenicline, Standard Duration Varenicline
- Where
- 2 sites in United States
- Volunteers
- 538 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Heroin Dependence, Nicotine Dependence
Pioglitazone for Heroin and for Nicotine Dependence
The goal of the proposed research is to improve the effectiveness of treatments for opioid and for nicotine dependence by testing a novel pharmacological strategy.
- Trial name
- NCT01395797
- Testing
- PIO
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Mental Illness
Efficacy of Group Tobacco Cessation Interventions Among Tobacco Users With Mental Illness: Controlled Clinical Trial
The study seeks to provide group tobacco cessation interventions among patients who use tobacco, and who attend Mathari National referral hospital on outpatient follow up.
- Trial name
- NCT04013724
- Testing
- Group tobacco cessation interventions
- Where
- Kenya
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Nairobi
Alcoholism, Alcohol Dependence
Usability Study for SOBERLINK System
The Soberlink Cellular device, in its original packaging, along with the QuickStart guide will be provided to the end user in a simulated home use environment or by Rx in clinic.
- Trial name
- NCT02650180
- Testing
- Soberlink Cellular Device
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Soberlink Healthcare LLC
Tobacco Use Disorder
Effect of Galantamine on Short-term Abstinence
This is a randomized, double-blind, placebo-controlled study to test whether a medication called galantamine (Brand Name: Razadyne) will help smokers quit and whether it reduces cognitive problems that smokers experience during a…
- Trial name
- GAL-K (NCT01669538)
- Testing
- Galantamine
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- University of Pennsylvania
Cocaine-Related Disorders, Substance-Related Disorders
Prepulse Inhibition of Startle in Cocaine Dependence - 7
The purpose of this study is to assess the effects of chronic cocaine use on the acoustic startle response and on gating of this response in humans.
- Trial name
- NCT00015249
- Testing
- Amantadine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Tobacco Use Disorder, Smoking Cessation
Tobacco Treatment Medical Education in 10 Medical Schools
This study compares two methods of teaching the 5As (Ask, Advise, Assess, Assist, Arrange) for tobacco dependence treatment to medical students: 1) traditional medical education (TE), and 2) multi-modal education (MME).
- Trial name
- MSQuit (NCT01905618)
- Testing
- Web-based curriculum on tobacco dependence treatment, Tobacco Counseling Role Play, Preceptor Training and Teaching Medical Students
- Where
- 13 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of Massachusetts, Worcester
Pain, Chronic, Opioid Dependence
The Effects of Daily Anti-inflammatory Supplementation on Foundation Pain Index Scores in Chronic Opiate Patients
This is a research study to evaluate the effectiveness of daily supplementation with Root.Health, a plant-based dietary supplement, on reducing levels of 11 abnormal urine biomarkers associated with chronic pain.
- Conditions
- Pain, Chronic, Opioid Dependence, Opioid Use, Inflammation Chronic
- Trial name
- NCT05896878
- Testing
- Root.Health Dietary Supplement
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Hudson Medical
Opiate Dependence
Oxytocin in Opiate Dependence: A Pilot Study of the Effects of Intranasal Oxytocin on Emotional Processes and Stress Responses in Patients With Opiate Dependence
Opiate dependence is a serious problem, and oxytocin has many properties which make it attractive as a treatment for this type of substance dependence.
- Trial name
- NCT02052258
- Testing
- Oxytocin
- Where
- United States
- Sponsor
- MacDonald, Kai, M.D.
Substance-Related Disorders
Brain Changes in Stimulant Dependent Subjects - 8
The purpose of this study is to identify the neurophysiologic indicators of cocaine or methamphetamine use and withdrawal, to examine the relationship between subjects' reports of depression, craving, and stimulant use, and…
- Trial name
- NCT00000343
- Testing
- counseling
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cancer, Tobacco Use
Improving Tobacco Treatment Rates for Cancer Patients Who Smoke
The research objective is to identify a simple, pragmatic, innovative way of enhancing Tobacco Use Treatment (TUT) rates within oncology.
- Conditions
- Cancer, Tobacco Use, Smoking, Nicotine Dependence
- Trial name
- NCT04738643
- Testing
- Tobacco Use Treatment Service and Varenicline Management
- Where
- 2 sites in United States
- Volunteers
- 685 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Tobacco Dependence
Use of Nicotine Pouches Among Daily Smokers
The purpose of this clinical trial is to understand the health effects of a new oral nicotine pouch, and also to understand if this product can help reduce traditional cigarette smoking. The main aims are: 1.
- Trial name
- NCT06043362
- Testing
- 0 mg nicotine pouch, 3 mg nicotine pouch, 6 mg nicotine pouch
- Where
- 2 sites in United States
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Cocaine Dependence
A Placebo-Controlled Study of Mixed Amphetamine Salts and Topiramate for the Treatment of Cocaine Dependence
The proposed protocol is a double-blind, placebo-controlled outpatient study of the safety and efficacy of Adderall-XR (ER-MAS) and topiramate in the treatment of cocaine dependence.
- Trial name
- TACT (NCT00421603)
- Testing
- Adderall-XR and Topiramate
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- New York State Psychiatric Institute
Opioid Use Disorder
SUBLOCADE Long-term Outcomes
This study will provide the opportunity to generate data on the long-term use of SUBLOCADE under real-world conditions, and to observe enduring changes in lifestyle, health, and sociodemographic factors that are part of the…
- Trial name
- NCT05860959
- Where
- 49 sites in United States, Australia and 2 more
- Volunteers
- 480 people
- Sponsor
- Indivior Inc.
Alcohol Dependence, Schizophrenia
Treatment With Acamprosate in Patients With Schizophrenia and Comorbid Alcoholism
The aim of this study is to evaluate the safety and efficacy of acamprosate for patients with alcohol dependence and comorbid schizophrenia spectrum disorders.
- Trial name
- NCT00463346
- Testing
- Acamprosate
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Yale University
Cocaine Dependence, Cocaine Withdrawal
Carvedilol for Psychostimulant Dependence
This study examines whether carvedilol prolongs abstinence in recently abstinent cocaine dependent participants.
- Trial name
- NCT01171183
- Testing
- controlled release carvedilol
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Arkansas
Tobacco Use Disorder
Role of Metabolites in Nicotine Dependence (2) - 5
The purpose of this study is to determine the effects of varying doses of cotinine on cigarette self-administration.
- Trial name
- NCT00000288
- Testing
- Cotinine fumarate
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid-Related Disorders
Opioid Agonist and Antagonist Effects on Opioid Dependence
The purpose of this study is to examine the acute agonist and antagonist effects of a full opioid agonist medication, an opioid antagonist medication, and a partial opioid agonist medication in individuals who have different…
- Trial name
- NCT00142727
- Testing
- Methadone, Full opioid agonist, Partial opioid agonist
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Tobacco Smoking, Nicotine Dependence
Smoking Interventions in General Medical Practices
Primary care physicians can play an important role in reducing tobacco smoking in the population. The general practice is a suitable setting for implementing proactive smoking interventions, because a large proportion of the…
- Trial name
- PRO GP (NCT00679861)
- Testing
- Counselling Intervention, Expert-system intervention
- Volunteers
- 3,215 people
- Sponsor
- University Medicine Greifswald
Opiate Dependence
Linking Hospitalized Injection Drug Users to Buprenorphine
This study tests whether starting Suboxone (buprenorphine) during a medical hospitalization, and then providing an appointment (a "link") for after discharge to maintenance buprenorphine in an outpatient setting will reduce HIV…
- Trial name
- NCT00987961
- Testing
- Linkage
- Where
- United States
- Volunteers
- 147 people
- Sponsor
- Butler Hospital