Clinical trials: Substance Dependence
Alcoholism, Gambling
Effectiveness of Sertraline in Treating Pathological Gamblers With a Diagnosis of Alcohol Dependence - 1
Pathological gamblers often are also dependent on alcohol and clinically depressed. Sertraline (Zoloft) is currently used to treat depression, panic disorder, and obsessive-compulsive disorder.
- Trial name
- NCT00249431
- Testing
- Sertraline, Relapse Prevention Therapy
- Volunteers
- 9 people
- Sponsor
- New York State Psychiatric Institute
Bipolar Disorder, Anxious Disorder
Effectiveness of TCC Followed by MBCT and Predictive Factors (Genetic, Clinical and Cognitive) Response
The purpose of this study is to determine whether a Cognitive and Behavioral group Therapy (CBT) + Mindfulness Based Cognitive Therapy (MBCT) decreased relapses and hospitalizations and improved outcomes (depressive and manic…
- Conditions
- Bipolar Disorder, Anxious Disorder, Alcohol Dependence
- Trial name
- TCC-MBCT (NCT02472483)
- Testing
- Cognitive and Behavior Therapy (CBT), Mindfulness Based Cognitive Therapy (MBCT)
- Where
- France
- Volunteers
- 158 people
- Sponsor
- Centre Hospitalier St Anne
Opioid-Related Disorders, Substance-Related Disorders
Evaluation of Lofexidine for Treatment of Opioid Withdrawal - 3
The purpose of this study is to determine the safety of lofexidine in the treatment of opiate withdrawal. Preliminary data will also be obtained to assess the ability of lofexidine to alleviate opiate withdrawal signs and…
- Trial name
- NCT00000354
- Testing
- Lofexidine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders, Substance-Related Disorders
Pergolide Treatment for Substance Abusers - 4
The purpose of this study is to evaluate the safety and efficacy of pergolide for cocaine dependence.
- Trial name
- NCT00000269
- Testing
- Pergolide
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Smoking Cessation, Nicotine Dependence
Engaging Sexual and Gender Minority Cigarette Smokers Into Social Media-based Treatment
This research study will evaluate the preliminary efficacy of Pride Posts Plus, a social media-based smoking cessation treatment.
- Conditions
- Smoking Cessation, Nicotine Dependence, Tobacco Use, Cigarette Smoking
- Trial name
- NCT04461288
- Testing
- Social media-based education, counseling, and support, Nicotine replacement therapies (NRT), Gamification
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cancer of Head and Neck, Breast Cancer
Brain Stimulation For Cancer Smokers
Smoking cessation and relapse prevention represent and important opportunity to improve cancer survival rates, reduce the risk of cancer treatment complication, and improve the quality of life of patients with and survivors of…
- Conditions
- Cancer of Head and Neck, Breast Cancer, Prostate Cancer, Nicotine Dependence
- Trial name
- NCT03419741
- Testing
- Transcranial Magnetic Stimulation Clinical Research System
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Medical University of South Carolina
Depression, Alcohol Dependence
Ketamine for Depression and Alcohol Dependence
The purpose of this study is to evaluate the efficacy of ketamine in reducing depressive symptoms in subjects with a comorbid major depressive episode and alcohol dependence.
- Trial name
- KetamineDep (NCT01551329)
- Testing
- Ketalar (ketamine)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Yale University
Opioid Dependence, Injection Drug Use
Pilot Test of a Community-based Buprenorphine Treatment Intervention
The main goal of this study is to pilot test the community-based buprenorphine treatment (CBBT) intervention, examining buprenorphine treatment initiation, opioid use, and HIV risk behaviors.
- Trial name
- NCT01761110
- Testing
- Community-based buprenorphine treatment (CBBT) intervention
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Albert Einstein College of Medicine
Vaping, Vaping Cessation
Social Media Support Groups for Adolescent Vaping Cessation
The purpose of this study is to pilot test feasibility and acceptability of the Quit the Hit Toolkit, a social media-based nicotine vaping cessation program for adolescents and young adults, adapted for use in community settings.
- Conditions
- Vaping, Vaping Cessation, Nicotine Dependence
- Trial name
- NCT07540780
- Testing
- Social Media Intervention
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
HIV, Opioid Dependence
Study of Integrating Antiretroviral Therapy With Methadone Treatment for People Who Inject Drugs
To improve ART initiation among people who inject drugs, the investigators propose to develop and pilot a multi-component Integrated Methadone and Antiretroviral Therapy strategy (IMAT) in Dar es Salaam, Tanzania.
- Trial name
- IMAT (NCT02167425)
- Testing
- IMAT
- Volunteers
- 800 people
- Sponsor
- Pangaea Global AIDS Foundation
Obesity, Alcohol Dependence
Imaging of Cannabinoid 1 Receptors Using [11C]OMAR and PET
The aim of the present study is to conduct a human trial of [C-11]OMAR, a new PET imaging agent for the brain cannabinoid type 1 receptors (CB1), to determine its pharmacokinetics and binding characteristics.
- Conditions
- Obesity, Alcohol Dependence, High Stress
- Trial name
- NCT01719497
- Testing
- [C-11]OMAR
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Yale University
Nicotine Dependence
The Gender-Sex Hormone Interface With Craving & Stress-Related Changes in Smoking
The purpose of the overall parent study is to determine the impact of gender and hormones (estradiol, progesterone, testosterone and cortisol) on responses to stress and smoking cues presented in daily, "real-world" cue…
- Trial name
- SCOR-III (NCT01576874)
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Kevin Gray, MD
Amphetamine-Related Disorders
Cognitive Correlates of Substance Abuse - 11
The purpose of this study is to characterize the cognitive performance of methamphetamine abusers by comparing them with cocaine abusers and normal controls.
- Trial name
- NCT00000346
- Testing
- counseling
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opiate Dependence, Chronic Pain
Clinical Trial of Integrated Treatment for Pain and Opioid Dependence
This study is designed to develop an effective psychotherapy for chronic pain and opioid dependence.
- Trial name
- POD (NCT00634803)
- Testing
- CBT, Buprenorphine, Educational Counseling
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Yale University
Smoking Cessation, Tobacco Dependence
Smoking-cessation: A Spanish-Language Clinical Trial
The purpose of this study is to develop and test a series of culturally relevant and appropriate booklets in Spanish, designed to assist Hispanic smokers in quitting smoking and remaining smoke-free.
- Trial name
- NCT02611076
- Testing
- Stop Smoking for Good Intervention in Spanish (SS-SP), Usual care (UC)
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Nicotine Dependence
Multiple Cigarette Induced Changes in Hormone Function, Mood States and Behavior
The proposed clinical studies will analyze the interactions between nicotine, alterations in endocrine hormones, mood and cardiovascular measures. They also intend to examine the contribution of gender and menstrual cycle phase.
- Trial name
- NCT01636310
- Testing
- Nicotine
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Cocaine Abuse, Cocaine Dependence
Progesterone for Postpartum Cocaine Relapse
The investigators propose a placebo-controlled, randomized clinical trial that would enroll 50 postpartum women with a history of cocaine abuse or dependence to assess whether progesterone (100mgs twice daily) decreases…
- Trial name
- NCT01249274
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Yale University
Tobacco Dependence, Smoking Cessation
Tailoring Varenicline to Individual Needs (TVIN Study)
Varenicline is a partial nicotinic agonist which acts on alpha4 beta2 nicotinic receptors. It is presumed to alleviate withdrawal discomfort, but also to diminish rewarding effects of cigarettes.
- Trial name
- TVIN (NCT01206010)
- Testing
- Varenicline
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Opioid Dependence
A Bioavailability and Safety Study of Probuphine Versus Sublingual Buprenorphine in Patients With Opioid Dependence
This study will measure the amount of buprenorphine found in the blood after taking sublingual buprenorphine tablets versus after implantation with 4 Probuphine (buprenorphine implants).
- Trial name
- PRO-810 (NCT00768482)
- Testing
- Probuphine (buprenorphine implant), Sublingual Buprenorphine
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Titan Pharmaceuticals
Opiate Dependence
Clinical Efficacy and Serum Proteomic Profiling of Suan-Zao-Ren Tang for Sleep Disturbance During Methadone Maintenance
The purpose of this study is to evaluate the efficacy of Suan-Zao-Ren Tang in improving sleep quality, anxiety, depression, and heroin craving among methadone-maintained persons with sleep complaints.
- Trial name
- NCT01913418
- Testing
- Suan-Zao-Ren Tang
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- China Medical University, Taiwan