Clinical trials: Substance Dependence
Substance Abuse, Substance Dependence
Group Therapy for Women Prisoners With Comorbid Substance Use and Depression
The purpose of the study is to determine whether interpersonal psychotherapy is effective for treating co-occurring depression and substance use among women prisoners.
- Conditions
- Substance Abuse, Substance Dependence, Depressive Disorder
- Trial name
- NCT00606996
- Testing
- Group interpersonal psychotherapy (IPT-G), Psychoeducation on co-occurring disorders (PSYCHOED)
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Brown University
Substance Abuse, Cocaine Dependence
Bupropion-Enhanced Contingency Management (CM) for Cocaine Dependence
This project will examine effects of bupropion extended release (XL) at a dose of 300mg/day for cocaine abstinence among persons receiving methadone for the treatment of opioid use disorder.
- Trial name
- NCT02111798
- Testing
- Bupropion XL, Abstinence Initiation, Relapse Prevention
- Where
- 2 sites in United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Addiction, Substance, Alcohol Use Disorder
Validation of the French Version of the Prediction of the Alcohol Withdrawal Severity Scale (PAWSS)
The goal of this observational study is to validate the French version of the PAWSS scale in a population of patients with Alcohol Use Disorders.
- Conditions
- Addiction, Substance, Alcohol Use Disorder, Alcohol Dependence, Alcohol Withdrawal
- Trial name
- PAWSS-VF (NCT06675539)
- Testing
- French version PAWSS
- Where
- France
- Volunteers
- 545 people
- Sponsor
- Etablissement Public de Santé Barthélemy Durand
Drug Dependence, Drug Use Disorders
Preliminary Efficacy and Safety of Ibogaine in the Treatment of Methadone Detoxification
Methadone is a very long-acting opiate very difficult to detox from. In Spain there are a lot of methadone dependent people in the aftermath of the heroin epidemic of the 1980s.
- Conditions
- Drug Dependence, Drug Use Disorders, Opioid Dependence
- Trial name
- NCT04003948
- Testing
- Ibogaine Hydrochloride
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- International Center for Ethnobotanical Education, Research, and Service
Alcohol Use Disorder (AUD), Alcoholism
Role of Pavlovian Mechanisms for Control Over Substance Use
During the first funding period (1st FP), the investigators developed a novel full Pavlovian-to-instrumental transfer (PIT) task that allows assessing both, general and specific PIT to investigate whether specific PIT differs…
- Conditions
- Alcohol Use Disorder (AUD), Alcoholism, Substance Use Disorders, Cannabis Use Disorder
- Trial name
- ReCoDe (NCT06701487)
- Testing
- fMRI imaging (BOLD), sMRI (structure), Pavlovian-to-instrumental transfer (PIT) paradigm
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Technische Universität Dresden
Tobacco Dependence, Withdrawal Symptoms
Varenicline OTC Trial on Efficacy and Safety
The primary goal of the proposed research is to test whether varenicline (Chantix) is safe and effective as an over-the-counter (OTC) medication.
- Conditions
- Tobacco Dependence, Withdrawal Symptoms, Smoking Cessation
- Trial name
- VOTC (NCT03557294)
- Testing
- 1.0mg Varenicline b.i.d., 0.5mg Varenicline b.i.d.
- Where
- 2 sites in United States
- Volunteers
- 313 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Addiction, Substance Abuse
Breathwork-assisted Treatment for Cannabis Use Disorder
The purpose of this proof-of-concept study is to evaluate the safety, feasibility and acceptability of a breathwork workshop intervention in individuals with cannabis use disorder.
- Conditions
- Addiction, Substance Abuse, Cannabis Use Disorder, Cannabis Use
- Trial name
- NCT05219825
- Testing
- Breathwork workshop
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Elias Dakwar
Substance Use Disorders, Opioid Use Disorder
Enhanced Digital-Chemosensory-Based Olfactory Training for Remote Management of Substance Use Disorders
The overarching goal of this study phase, Phase II component is to implement Enhanced Digital-Chemosensory-Based Olfactory Training for Remote Management of Substance Use Disorders (EDITOR) device in substance use disorder (SUD)…
- Conditions
- Substance Use Disorders, Opioid Use Disorder, Alcohol Use Disorder, Cocaine Use Disorder
- Trial name
- EDITOR (NCT06434818)
- Testing
- EDITOR (CBOT with olfactory stimulants, OFC tasks & remote monitoring of treatment compliance), CBOT with olfactory stimulants & OFC tasks
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- Evon Medics LLC
Chemically-Induced Disorders, Substance-Related Disorders
Study of Structural Imaging
Background: The way alcohol affects brain structure has been widely studied. But the way it affects all parts of the brain is still unknown.
- Conditions
- Chemically-Induced Disorders, Substance-Related Disorders, Mental Disorders, Alcohol Dependence
- Trial name
- NCT02564991
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Substance Abuse, Substance Dependence
Continuing Care Following Drug Abuse Treatment: Linkage With Primary Care
This component of a larger Center of Research Excellence Grant improves treatment for drug abuse by developing effective linkages between specialty drug treatment and primary health care.
- Conditions
- Substance Abuse, Substance Dependence, Substance, Addiction, Alcohol Abuse
- Trial name
- Linkage (NCT01621711)
- Testing
- Linkage patient activation intervention
- Where
- United States
- Volunteers
- 504 people
- Sponsor
- Kaiser Permanente
Methamphetamine, Methamphetamine Abuse
Delivering Contingency Management in Outpatient Addiction Treatment
Methamphetamine misuse has become a growing concern in Alberta, creating a burden on the health care system. Further, individuals who use methamphetamine in Alberta exhibit significant difficulty remaining in treatment.
- Conditions
- Methamphetamine, Methamphetamine Abuse, Methamphetamine-dependence, Contingency Management
- Trial name
- PRISE (NCT04544124)
- Testing
- Contingency management
- Where
- 2 sites in Canada
- Volunteers
- 88 people
- Sponsor
- University of Calgary
Human Immunodeficiency Virus, Acquired Immunodeficiency Syndrome
Intervention of HIV, Drug Use and the Criminal Justice System in Malaysia
The purpose of this study is to evaluate the relative impact a medical drug (methadone) or behavioral counseling program (Holistic Health Recovery Program) or both (methadone and Holistic Health Recovery Program) has on reducing…
- Conditions
- Human Immunodeficiency Virus, Acquired Immunodeficiency Syndrome, Opiate Addiction, Drug Dependence
- Trial name
- Harapan (NCT02396979)
- Testing
- Methadone, Holistic Health Recovery Program
- Volunteers
- 300 people
- Sponsor
- Yale University
Alcoholism, Substance Abuse
Recognition and Early Intervention for Alcohol and Substance Abuse in Adolescence in Adolescent
ASSIST mini-intervention is applied in an electric form in adolescent outpatients to see if it
- Conditions
- Alcoholism, Substance Abuse, Alcohol Dependence, Alcohol-Related Disorders
- Trial name
- REAL-SMART (NCT06262958)
- Testing
- ASSIST, Treatment as usual
- Where
- Finland
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Kuopio University Hospital
Cocaine Abuse, Cocaine Dependence
Substance Abuse Pre-Treatment Screening Study
The overarching goal of this project is to have a consolidated consent and evaluation procedure that will lead potential subjects to the most appropriate clinical trial or human laboratory study (and its consent process) for…
- Conditions
- Cocaine Abuse, Cocaine Dependence, Opiate Dependence, Alcohol Dependence
- Trial name
- NCT00439049
- Testing
- modafinil, d-amphetamine, L-Dopa
- Where
- United States
- Volunteers
- 7,500 people
- Sponsor
- The University of Texas Health Science Center, Houston
Potential Treatment for Alcohol Dependence-Alcohol Interaction
Effects of Ethanol on the Pharmacokinetics of PT-150 (Formerly ORG34517) (PT150 PK Study)
The purpose of this clinical study is to assess pharmacokinetic interactions between ethanol (EtOH) and PT150 (900 mg qd) in non-treatment-seeking alcohol-experienced volunteers-(to include military service members, veterans…
- Trial name
- NCT04331288
- Testing
- PT150, Beverage
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Pop Test Oncology LLC
Alcohol Abuse, Alcohol Use Disorder
Skills-training for Reducing Risky Alcohol Use in App Form
This study evaluates the efficacy of a skills training web-based mobile phone application, Telecoach among individuals in the general population seeking help for their risky alcohol consumption on the Internet.
- Conditions
- Alcohol Abuse, Alcohol Use Disorder, Alcohol Drinking, Alcohol Dependence
- Trial name
- NCT03696888
- Testing
- Telecoach, TeleCoach control
- Where
- Sweden
- Volunteers
- 678 people
- Sponsor
- Karolinska Institutet
Depression, Substance Dependence
Motivational Therapy for Substance Users With Depression
The primary objective of the study is to test the incremental efficacy and outcomes of an aftercare program of Cognitive Behavioral Therapy combined with motivational therapy (CBT-MT) relative to treatment as usual (TAU) in…
- Trial name
- Aftercare (NCT01189799)
- Testing
- Motivational therapy, Dual Recovery Anonymous/Tx as usual
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of California, Los Angeles
Cannabis Dependence, Tobacco Use
Characterization of the Pattern of Consumption and Withdrawal Syndrome From Dual Cannabis and Tobacco Use
Aims: To characterize the pattern of cannabis and tobacco use and withdrawal symptoms in people who start treatment for cannabis use disorders (exclusive cannabis, concurrent and/or simultaneous with various tobacco products)…
- Conditions
- Cannabis Dependence, Tobacco Use, Withdrawal Syndrome, Substance Abuse
- Trial name
- DuCATA_GAMCaT (NCT05512091)
- Volunteers
- 282 people
- Sponsor
- Cristina Martínez Martínez
Alcohol Use Disorder, Substance Use
Emergency Department Initiated Extended-Release Naltrexone and Case Management for the Treatment of Alcohol Use Disorder
This is a phase 4, open-label, feasibility study of extended release naltrexone (Vivitrol, Alkermes Pharmaceutical) and case management for treatment of alcohol use disorders in the ED.
- Conditions
- Alcohol Use Disorder, Substance Use, Alcohol Abuse or Dependence
- Trial name
- NCT04094584
- Testing
- Vivitrol (Extended Release Naltrexone)
- Where
- United States
- Volunteers
- 179 people
- Sponsor
- University of California, San Francisco
Drug Abuse, Intravenous, Substance Dependence
A Cross-Sectional Observational Study on Retained Drug Needle Fragments in People Who Use Intravenous Drugs
In addition to the well-known toxicological harms of intravenous drug (IVD) use, there can also be local tissue complications, including infections, venous sclerosis, tissue necrosis, and drug needle fragment retentions.
- Conditions
- Drug Abuse, Intravenous, Substance Dependence, Needle Injury, Soft Tissue Injuries
- Trial name
- NCT05679284
- Testing
- Low-dose X-ray of subcutaneous tissues
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Tampere University Hospital