Clinical trials: Substance Dependence
Nicotine Dependence
Initial Screening of Gemfibrozil as a Novel Treatment for Tobacco Addiction
The purpose of this study is to investigate the effect of gemfibrozil on nicotine reinforcement and cue-elicited craving. Other objectives of this study include screening for the ability of gemfibrozil to aid smoking abstinence…
- Trial name
- NCT01876810
- Testing
- Gemfibrozil
- Where
- 2 sites in Canada
- Volunteers
- 28 people
- Sponsor
- Centre for Addiction and Mental Health
Depression, Smoking
Fluoxetine as a Quit Smoking Aid for Depression-Prone Smokers
This project is a treatment-matching study to test whether adding antidepressant pharmacotherapy to behavioral cessation treatment improves the depression-prone smoker's ability to quit, while not undermining cessation goals for…
- Trial name
- NCT00018174
- Testing
- Fluoxetine, Behavioral group smoking cessation treatment
- Where
- United States
- Volunteers
- 247 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Cocaine-Related Disorder, Opiate Dependence
Clinical Efficacy of Disulfiram in LAAM-Maintained Cocaine Abusers
This 18-week, randomized, double blind clinical trial provided treatment for 160 cocaine-dependent opioid addicts, aged 18-65 years.
- Trial name
- NCT00580827
- Testing
- Disulfiram
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Yale University
Alcohol Dependence, Post-Traumatic Stress Disorder (PTSD)
Progesterone Effect on Individuals Diagnoses With AD and PTSD.
This is a randomized control trial with an anticipated 36 participants diagnosed with post-traumatic stress disorder (PTSD) and comorbid alcohol dependence. Participants will be randomized to receive either progesterone (200 mg.
- Trial name
- NCT02187224
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Yale University
Cocaine Addiction
Cognitive Enhancement and Relapse Prevention in Cocaine Addiction
For this project, the investigators are interested in exploring a new way to extend and maintain drug abstinence in people who are addicted to crack cocaine.
- Trial name
- NCT01067846
- Testing
- Seromycin (D-cycloserine, DCS), Computerized Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- University of Arkansas
Opiate Dependence
ALK21-013: Efficacy and Safety of Medisorb® Naltrexone (VIVITROL®) in Adults With Opioid Dependence
This is a Phase 3 multi-center trial designed to evaluate the clinical efficacy and safety of VIVITROL® (Medisorb® naltrexone 380 mg) versus placebo when administered to adults upon discharge from inpatient treatment for opioid…
- Trial name
- NCT00678418
- Testing
- VIVITROL® 380 mg
- Where
- Russia
- Volunteers
- 250 people
- Sponsor
- Alkermes, Inc.
Opioid Dependence
Starting Treatment With Agonist Replacement Therapies Follow-up Study
The purpose of the study is to conduct a follow-up of substance abuse patients (n=1,269) about 2 to 5 years since they were originally recruited from 8 substance abuse treatment clinics (located in 5 states) to participate in a…
- Trial name
- NCT01592461
- Where
- 8 sites in United States
- Volunteers
- 877 people
- Sponsor
- University of California, Los Angeles
Cocaine-Related Disorders
Infusion Laboratory: Protocol 4 (Dihydrexidine) - 13
The purpose of this study is to evaluate safety issues pertaining to dihydrexidine (DHX), to cocaine, and to its interaction, and to determine how pretreatment with DHX modifies the subjective as well as physiological effects of…
- Trial name
- NCT00000348
- Testing
- Dihydrexidine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Methamphetamine, Amphetamine Dependence
Study of Medical Treatment for Methamphetamine Addiction
Currently there are no medications approved for the treatment of methamphetamine addiction. Bupropion is an antidepressant that is approved by the Food and Drug Administration (FDA) for the treatment of depression and for…
- Conditions
- Methamphetamine, Amphetamine Dependence, Pharmacogenetics, Methamphetamine Dependence
- Trial name
- BUP PGx (NCT00833443)
- Testing
- Bupropion
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- University of California, Los Angeles
Cocaine Dependence
Neuropsychological Rehabilitation on Cocaine/Crack Dependents
Cocaine/Crack Dependence has been associated with neuropsychological impairments mainly in executive functions and decision-making, which are predominantly managed by the prefrontal cortex (PFC) in the brain.
- Trial name
- NCT01914835
- Testing
- Motivational Chess
- Where
- Brazil
- Volunteers
- 56 people
- Sponsor
- University of Sao Paulo General Hospital
Alcoholism
Naltrexone Treatment of Alcohol Dependence
The long-range goal of this ongoing research program is to find more effective treatments for alcohol dependence by combining medication with the appropriate psychosocial support.
- Trial name
- NCT00000452
- Testing
- naltrexone (Revia), Compliance Enhancement Tech., Cognitive Behavior Therapy
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Social Isolation or Loneliness, Anxiety
Health Surveillance at Constructor University Bremen (CUB)
The aim of Health Surveillance is to analyze and describe the state of health of students at Constructor University, key influencing factors and individual resources by using mixed-method design.
- Conditions
- Social Isolation or Loneliness, Anxiety, Anxiety Depression (Mild or Not Persistent), Health Behavior
- Trial name
- CUB-HS2025 (NCT06899308)
- Testing
- questionnaire
- Where
- 2 sites in Germany
- Volunteers
- 373 people, healthy volunteers welcome
- Sponsor
- Jacobs University Bremen gGmbH
Alcohol Dependence
Trans-cranial Direct Current Stimulation on Alcohol Craving
The goal of thisclinical trial is to investigate the efficacy of trans cranial direct current stimulation (tDCS) for alcohol craving in individuals with alcohol dependence.
- Trial name
- NCT05854693
- Testing
- transCranial direct current stimulation
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taipei City Hospital
Nicotine Dependence, Tobacco Smoking
Effects of Intranasal Oxytocin on Cigarette Smoking
Socioemotional processing dysfunctions (i.e., disruptions in affective, cognitive, and neural processes that encode, interpret, and respond to socially and emotionally relevant stimuli) have been implicated in tobacco smoking and…
- Trial name
- NCT02595749
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Opioid Dependence
The German Project of Heroin Assisted Treatment of Opiate Dependent Patients
The study will test the hypotheses that heroin assisted treatment, compared to methadone maintenance treatment, is more effective with regard to the improvement of health, reduction of illicit drug consumption, decrease of…
- Trial name
- NCT00268814
- Testing
- Diacetylmorphine, Psycho-education and Counselling, Methadone
- Where
- 7 sites in Germany
- Volunteers
- 1,015 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Cocaine-Related Disorders
Infusion Laboratory: Protocol 5 (Flupenthixol) - 14
The purpose of this study is to evaluate clinical safety issues pertaining to flupenthixol, to cocaine, and to their interaction, and to determine how pretreatment with flupenthixol modifies the subjective as well as…
- Trial name
- NCT00000349
- Testing
- Flupenthixol
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Hepatitis C, Opiate Dependence
A Video-Based HCV Curriculum for Drug Users
The investigators hypothesize that a well-designed hepatitis C (HCV)video education curriculum for high-risk drug users will show measurable benefits in improving HCV testing, hepatitis A and B vaccinations, and HCV knowledge…
- Trial name
- NCT00241917
- Testing
- Hepatitis C educational video, Video
- Where
- 3 sites in United States
- Volunteers
- 450 people
- Sponsor
- Organization to Achieve Solutions in Substance Abuse (OASIS)
Opioid Dependence, Alcohol Dependence
A Clinical Trial to Assess Pharmacokinetic Profiles, Safety and Tolerability of IVL3004 and IVL4002 in Healthy Male Subjects.
A Clinical Trial to Assess Pharmacokinetic Profiles, Safety and Tolerability of IVL3004 and IVL4002 in Healthy Male Subjects.
- Conditions
- Opioid Dependence, Alcohol Dependence, Multiple Sclerosis
- Trial name
- NCT05620940
- Testing
- Vivitrol Injectable Product, IVL3004, IVL4002
- Where
- Australia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Inventage Lab., Inc.
Tobacco Use Disorder
Smoking Cessation Treatment With Transdermal Nicotine Replacement Therapy - 1
The purpose of this study is to look at how feasible it is to incorporate a state-of-the-art smoking cessation treatment program into community substance abuse treatment programs and its impact on substance abuse and cigarette…
- Trial name
- NCT00067158
- Testing
- nicotine transdermal system
- Where
- 13 sites in United States
- Volunteers
- 585 people
- Sponsor
- New York University
Alcohol Dependence
Gabapentin for Abstinence Initiation in Alcohol Dependence
Primary Hypotheses: 1. Gabapentin will significantly reduce alcohol consumption and promote abstinence as compared to placebo. The primary outcome measure will be the number of the heavy drinking days (defined as any day where…
- Trial name
- GAINS (NCT01141049)
- Testing
- Gabapentin
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- New York State Psychiatric Institute