Clinical trials: Substance Addiction
Addiction, Alcohol Use Disorder
Semaglutide Therapy for Alcohol Reduction (STAR)
Background: Alcohol use disorder (AUD) is a problematic pattern of alcohol use accompanied by clinically significant medical consequences.
- Trial name
- NCT06015893
- Testing
- Take Control, Semaglutide
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Addiction Nicotine
The CONQUER Trial - Cessation Of Nicotine, QUitting With E-cigarette Reduction
This clinical trial evaluates the VapeAway system, a novel, multi-modal intervention designed to address the multifaceted nature of vaping addiction.
- Trial name
- CONQUER (NCT07322432)
- Testing
- VapeAway filter system
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- VapeAway
Tobacco Use Disorder
Smoking Cessation Behavioral Treatment Study
The purpose of this study is to evaluate the effectiveness of two behavioral interventions on smoking behavior - Mindfulness-Oriented Recovery Enhancement (MORE) and Cognitive Behavioral Therapy (CBT).
- Trial name
- NCT03948893
- Testing
- Mindfulness-Oriented Recovery Enhancement (MORE), Cognitive Behavioral Therapy (CBT)
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Substance Use Disorders
Enhancing Addiction Treatment Through Psychoeducation
Addiction is a brain disorder characterized by a broad range of both apparent and subtle cognitive impairments in attention, memory, executive functions, and decision-making.
- Trial name
- NCT07178158
- Testing
- Installing the Metacognium software app, Continue treatment as usual
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Virginia Commonwealth University
Smoking Cessation, Tobacco Use Disorder
Effectiveness of Reducing Smoking in Facilitating Smoking Cessation in Adolescents - 2
Currently one in five high school students smoke. Smoking can harm adolescents well before they reach adulthood by causing a number of immediate, sometimes irreversible, health risks and problems.
- Trial name
- NCT00158158
- Testing
- Usual Care, Smoking Reduction
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Endocarditis, Bacterial, Opioid-use Disorder
Combining Opioid Addiction Treatment Services With CARe for Infectious Endocarditis
Hospitalizations for severe infections associated with opioid use disorder (OUD), such as infective endocarditis (IE), have doubled in the US over the past decade and are frequently prolonged and resource-intensive.
- Conditions
- Endocarditis, Bacterial, Opioid-use Disorder, Buprenorphine, Outpatient Parenteral Antibiotic Therapy
- Trial name
- CATS-CARE (NCT03048643)
- Testing
- Outpatient parenteral antibiotic therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Laura Fanucchi
Opioid Use Disorder, Chronic Pain
Pain Self-Management and Patient-Oriented Dosing for Pain and in Retention Opioid Treatment
This study seeks to improve the treatment of chronic pain in people who are taking buprenorphine (also known as Suboxone, Subutex, Zubsolv).
- Trial name
- TREETOP (NCT06367387)
- Testing
- Patient-Oriented Dosing (POD), Pain Self-Management (PSM), Usual Care
- Where
- 13 sites in United States
- Volunteers
- 273 people
- Sponsor
- Erin Winstanley
Smoking, Nicotine Addiction
The END Perioperative Smoking Pilot Study
The purpose of this pilot randomized trial is to determine the feasibility of e-cigarettes and telephone counselling (compared to transdermal nicotine replacement and telephone counselling) as a harm-reduction tool that may lead…
- Conditions
- Smoking, Nicotine Addiction, Surgery
- Trial name
- NCT02482233
- Testing
- ENDD (NJOY), NRT (NicoDerm CQ), telephone counseling
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Francisco
Community Reinforcement And Family Training, Family Health
Scalable Digital Delivery of Evidence-based Training for Professionals to Maximize Treatment Rates of OUD in Families
The goal of this project is to develop and evaluate the technical feasibility and commercial viability of a scalable digital counselor training program for CRAFT.
- Conditions
- Community Reinforcement And Family Training, Family Health, Substance-Related Disorders
- Trial name
- NCT05875142
- Testing
- Behavioral: Digital Tutorial Overview, Behavioral: Training Materials, Behavioral: Feedback and Coaching
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- We The Village, Inc.
Pain, Pain, Acute
Assessing Opioid Care Practices Using CPV Patient Simulation Modules
This study will test the quality of opioid-related physician care decisions using a patient-simulation based measurement and feedback approach that combines multiple-choice care decisions with real-time, personalized scoring and…
- Conditions
- Pain, Pain, Acute, Pain, Chronic, Pain, Neuropathic
- Trial name
- NCT04080037
- Testing
- Quality IQ Patient Simulations
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Qure Healthcare, LLC
Tobacco Use Disorder
Increasing Smoking Cessation Success Through Sleep-amplified Memory Consolidation
The goal of this subproject is to examine the hypothesized improvement of treatment with chess-based training and sleep enhancement, both together and on their own, in smokers.
- Trial name
- NCT05726045
- Testing
- Standard smoking cessation program (SCP), Cognitive remediation treatment (CRT), High-intensity interval training (HIIT evening)
- Where
- Germany
- Volunteers
- 140 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Pregnancy, Mental Disorder
Woman Mental Health and Addictions on Pregnancy
The study intend to achieve the following objectives Objective 1: Develop a collaborative infrastructure among different hospital services to support research that improves the accessibility, quality, and outcomes of integrated…
- Conditions
- Pregnancy, Mental Disorder, Substance Abuse
- Trial name
- WOMAP (NCT06965270)
- Testing
- Standardized clinical intervention, Internet/App intervention, Treatment as usual
- Volunteers
- 2,014 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
HIV Infections, Cocaine Dependence
Pharmacotherapy for HIV+ Stimulant Dependent Individuals
The hypotheses of this study are: 1. Ondansetron will show a decrease in cocaine use from baseline in individuals with HIV who are cocaine using. 2.
- Trial name
- NCT00599573
- Testing
- ondansetron
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Virginia
Cancer of Head and Neck, Breast Cancer
Brain Stimulation For Cancer Smokers
Smoking cessation and relapse prevention represent and important opportunity to improve cancer survival rates, reduce the risk of cancer treatment complication, and improve the quality of life of patients with and survivors of…
- Conditions
- Cancer of Head and Neck, Breast Cancer, Prostate Cancer, Nicotine Dependence
- Trial name
- NCT03419741
- Testing
- Transcranial Magnetic Stimulation Clinical Research System
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Medical University of South Carolina
Opioid Dependence
A Bioavailability and Safety Study of Probuphine Versus Sublingual Buprenorphine in Patients With Opioid Dependence
This study will measure the amount of buprenorphine found in the blood after taking sublingual buprenorphine tablets versus after implantation with 4 Probuphine (buprenorphine implants).
- Trial name
- PRO-810 (NCT00768482)
- Testing
- Probuphine (buprenorphine implant), Sublingual Buprenorphine
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Titan Pharmaceuticals
Addictive Behavior, Substance-Related Disorders
Evaluation of the Efficacy of the Individually Adjusted Therapy Scale (ATI) on the Addiction Severity
The management of the craving is a key element in addiction treatment as the craving is linked to the probability of relapse. Several cues could induce the craving, some generic substance-induced cues or addictive…
- Trial name
- AjusT (NCT03606759)
- Testing
- Weekly assessment, Weekly assessment ajusted
- Where
- 4 sites in France
- Volunteers
- 151 people
- Sponsor
- University Hospital, Bordeaux
Substance Dependence, Executive Function Disorder
Brain Mechanism and Intervention of Executive-control Dysfunction Among Substance Dependents
The investigators assume that tACS could improve amphetamine and alcohol dependent patients' executive-control function by adjusting the synchronization patterns and enhancing the functional connectivity of the prefrontal-ventral…
- Conditions
- Substance Dependence, Executive Function Disorder, Transcranial Alternating Current Stimulation
- Trial name
- NCT05312359
- Testing
- Transcranial alternating current stimulation-true stimulus
- Where
- China
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Nicotine Use Disorder, Smoking Cessation
Implementation of Tobacco Cessation Programming at Community Behavioral Health Sites
The goal of this study is to: partner with Respiratory Health Association and determine barriers and unmet smoking cessation treatment needs from leaders in behavioral health organizations, treatment programs and adults who smoke…
- Conditions
- Nicotine Use Disorder, Smoking Cessation, Smoking Cessation Intervention
- Trial name
- NCT06837220
- Testing
- Enhanced Courage to Quit
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Chicago
Amphetamine Addiction
The Novel Addiction Assessment Study in Synthetic Drugs Addiction
The purpose of this research is to develop an objective assessment based on the virtual reality techniques which is used for evaluate addiction severity.
- Trial name
- NCT02950376
- Testing
- DSM-5 +Virtual reality-based addiction assessment system, Virtual reality-based addiction assessment system
- Where
- China
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Mental Health Issue, Substance Use Disorders
Comparing the Effect of Adding a Remote Self-reporting Tool for Distress and Fit-for-purpose Mental Health & Addictions Service to Usual Case Management on Dropout Rates in a Vocational Training Program
Youth unemployment is a chronic problem in most societies. Some young adults are neither in employment, education or training (NEET), and are at high risk of chronic unemployment, social disengagement and poor quality of life.
- Conditions
- Mental Health Issue, Substance Use Disorders, Distress, Emotional
- Trial name
- TeachMeToBuild (NCT05626374)
- Testing
- Basic Case Management, Basic Case Management plus Distress Tool, Basic Case Management plus rapid mental health & addictions healthcare access
- Where
- Canada
- Volunteers
- 400 people
- Sponsor
- Royal Victoria Hospital, Canada