Clinical trials: Substance Abuse Disorders
PTSD
Paroxetine Treatment in Outpatients With Comorbid PTSD and Substance Dependence
Pharmacotherapy has demonstrated efficacy in a number of controlled trials in the treatment of PTSD. The selective serotonin reuptake inhibitors have proven particularly useful in treating this disorder.
- Trial name
- NCT00330239
- Testing
- Paroxetine CR
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Medical University of South Carolina
Hypertension
Hemp Seed Protein and Bioactive Peptides Consumption for Hypertension
This clinical trial is being conducted to study the effect of whole hemp seed protein, hemp seed protein hydrolysate derived bioactive peptide and casein protein consumption on systolic and diastolic ambulatory blood pressure.
- Trial name
- NCT03508895
- Testing
- Whole hemp seed protein, Whole hemp seed protein plus bioactive peptides, Casein protein
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- University of Manitoba
Alcohol-Related Disorders, Alcohol Use Disorders
Component Analysis for Motivational Interviewing
The purpose of this study is to investigate the critical components of motivational interviewing (MI), a psychotherapeutic intervention, in reducing heavy or problematic drinking.
- Conditions
- Alcohol-Related Disorders, Alcohol Use Disorders, Alcohol Drinking, Alcoholism
- Trial name
- NCT01642381
- Testing
- Full Motivational Interviewing ("FMI"), Spirit Only Motivational Interviewing ("SOMI")
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- Northwell Health
Usual Aftercare, Oxford House
Evaluating Alternative Aftercare Models for Ex-Offenders
The primary aim of this project is to study more closely the role played by post-release aftercare in the outcomes of criminal offenders who received in-prison substance abuse treatment.
- Conditions
- Usual Aftercare, Oxford House, Therapeutic Community
- Trial name
- NCT00664092
- Testing
- Residential
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- DePaul University
Tobacco Use Disorder, Cannabis Use Disorder
Varenicline for the Treatment of Cannabis and Tobacco Use Disorders in Veterans
After initial eligibility screening, Veterans who use both cannabis and tobacco will be randomly assigned to receive either varenicline (Chantix) or placebo for 12 weeks.
- Trial name
- Vet Cat (NCT05294263)
- Testing
- Varenicline
- Where
- United States
- Sponsor
- VA Office of Research and Development
Cannabis Use
A Trial of Guanfacine-er for Cannabis Use Disorder
The primary purpose of this study is to investigate the effect of guanfacine-ER on reductions in cannabis use and explore its effects on impulsivity and withdrawal through a hybrid in-person and virtual trial of treatment-seeking…
- Trial name
- NCT05273567
- Testing
- guanfacine-ER
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- New York State Psychiatric Institute
Cannabis Dependence
Efficacy of Community Reinforcement Approach (CRA) in the Treatment of Cannabis Users
Substance abuse is not a new phenomenon in Pakistan. Its prevalence is increasing day by day due to multi-factorial reasons including psychological, cultural, biological, environmental, social and personal factors.
- Trial name
- Lifecare (NCT04513756)
- Testing
- Community Reinforcement Approach
- Where
- 2 sites in Pakistan
- Volunteers
- 120 people
- Sponsor
- International Islamic University, Islamabad
Prescription Drug Abuse (Not Dependent)
Influence of Medication on Functional Connectivity
This study will assess the effects of acute low-dose opioid administration on functional neuroimaging measures in healthy individuals
- Trial name
- NCT03612713
- Testing
- Oxycodone Medication First
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Yale University
Stress, Drug Abuse
Developing Field Tools for Real-Time Assessment of Exposure to Psychosocial Stress and Drug Use in an Outpatient Treatment Population
Background: Researchers are interested in developing more accurate methods to assess environmental influences on psychological stress and drug use.
- Trial name
- NCT00787423
- Where
- United States
- Volunteers
- 373 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Housing Problems, Household Substance Abuse
Innovating Technology Solutions for Residents in Support Housing Communities w SUD Through Community-Engaged Research
The goal of this clinical trial is to understand whether a technology-based solution, provided to residents in permanent supportive housing, is acceptable, feasible to implement, and has promise for improving resident stability.
- Conditions
- Housing Problems, Household Substance Abuse, Substance Use Disorders, Harm Reduction
- Trial name
- HousingSUD (NCT07001020)
- Testing
- Technology-based Intervention
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Oregon Research Behavioral Intervention Strategies, Inc.
Abuse Cannabis, Pain
High Potency Cannabis: Acute and Protracted Effects
The purpose of this research is to assess the effects of smoked cananbis when cannabis is smoked during periods of cannabis use as usual and after a brief period of abstinence.
- Conditions
- Abuse Cannabis, Pain, Pharmacokinetics
- Trial name
- HIGH-CAP (NCT06859723)
- Testing
- Low dose THC, High dose THC
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Cocaine Abuse
Prize Contingency Management for Cocaine-Dependent Methadone Patients
The investigators will randomize 300 cocaine-dependent methadone patients to 1 of 6 conditions: (a) a control group, (b) a contingency management condition that arranges a 100% probability of winning a prize with each draw and…
- Trial name
- NCT01401270
- Testing
- prize contingency management
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- UConn Health
Domestic Violence, Mental Health Impairment
Trial of a Multi-pronged Intervention to Address Prevention of Violence in Zambia
This study evaluates the effectiveness of a multi-pronged intervention in reducing and preventing violence against women and children compared to a treatment as usual control group among families living in Lusaka, Zambia.
- Conditions
- Domestic Violence, Mental Health Impairment, Child Abuse, Alcoholism
- Trial name
- NCT02790827
- Testing
- CETA, Treatment as usual
- Where
- Zambia
- Volunteers
- 626 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Drug Addiction, Drug Abuse
Impact of Online Patient Feedback (OQ) to Therapist
Dropout represents one of the largest problems in substance abuse treatment. International and Nordic research show that only 20 - 40 % of substance abusers complete treatment as intended.
- Trial name
- NCT01891045
- Testing
- OQ-45.2 no feedback, OQ-45.2
- Where
- 2 sites in Norway
- Volunteers
- 160 people
- Sponsor
- Oslo University Hospital
Marijuana Dependence
Ph1 Marinol Interaction Study - Part 1 - 1
The purpose of this study is to examine the effects of oral dronabinol tetrahydrocannabinol (THC) on withdrawal symptoms in marijuana dependent volunteers, and evaluate the safety, pharmacokinetics (PK), and cardiovascular…
- Trial name
- NCT00438139
- Testing
- Dronabinol
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Substance Abuse Disorder
Evaluating Three Methods for Helping Syringe Exchangers Begin Methadone Maintenance
This research is being done to evaluate the effectiveness of three different treatment strategies for helping subjects begin and adjust to methadone maintenance treatment at Addiction Treatment Services (ATS).
- Trial name
- NCT01142986
- Testing
- Low intensity care, Voucher reinforcement
- Where
- United States
- Volunteers
- 223 people
- Sponsor
- Johns Hopkins University
Substance Abuse, HIV Infections
Stonewall Treatment Evaluation Project
This treatment outcome evaluation of the Stonewall Project will recruit 150 participants to complete a face-to-face assessment visit at baseline, 3-month follow-up, and 6-month follow-up to examine treatment outcome with respect…
- Trial name
- STEP (NCT01129401)
- Testing
- Stonewall Project
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- University of California, San Francisco
Alcohol Dependence, Alcohol Abuse
Carisbamate as a Potential Treatment for Alcohol Dependence
The purpose of this study is to determine the effects of treatment with carisbamate compared to treatment with placebo, on alcohol-induced stimulant and subjective effects in non-treatment seeking alcohol-dependent human…
- Conditions
- Alcohol Dependence, Alcohol Abuse, Substance Abuse
- Trial name
- NCT02435381
- Testing
- Carisbamate
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Baylor College of Medicine
Cannabis Use, Major Depressive Disorder
Extended Effects of Cannabis Abstinence on Clinical Symptoms and Cognition in Depression
The prevalence of major depressive disorder (MDD) is ~5.0%, and rates of co-occurring SUDs in these patients approach 40-50%. Specifically, rates of co-morbid cannabis use disorder (CUD) in patients with MDD are elevated 2-3 fold…
- Conditions
- Cannabis Use, Major Depressive Disorder, Cognitive Impairment
- Trial name
- NCT04935619
- Testing
- Contingency Reinforcement, Non-Contingency Reinforcement
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- Centre for Addiction and Mental Health
Marijuana Dependence
Ph1 Marinol Interaction Study - Part 2 - 1
This study will examine the effects of oral dronabinol tetrahydrocannabinol (THC) on withdrawal symptoms in marijuana dependent volunteers, and evaluate the safety, pharmacokinetics (PK), and cardiovascular effects of the…
- Trial name
- NCT00490269
- Testing
- Dronabinol
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)