Clinical trials: Subcutaneous Fat
Obesity
A Study of Safety and Efficacy of Topiramate in Male Patients With Abdominal Obesity
The purposes of this study are to compare the effects of Topiramate and placebo on abdominal visceral fat accumulation at 6 months and to evaluate the safety of Topiramate for up to 12 months of continued treatment in male…
- Trial name
- NCT00231608
- Testing
- topiramate
- Volunteers
- 68 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Obesity
Description of the Endothelial Phenotypes From the Subcutaneous Abdominal and Gluteo-femoral Adipose Tissues in Women
The endothelium is a key barrier between blood and tissue compartments. It is a major target of factors involved in metabolic and cardiovascular pathologies.
- Trial name
- ADIPENDO (NCT02672826)
- Testing
- Adipose tissue surgery
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Toulouse
Lipedema
Quadrivas Therapy® to Reduce Lipedema Subcutaneous Adipose Tissue (QUADRIVAS)
Quad Rivas Therapy has been developed by Alyna Eekma from the Netherlands for over thirteen years; anecdotally she has been able to significantly reduce lipedema SAT in women with Stage 1 and 2 lipedema, and can reduce lipedema…
- Trial name
- QUADRIVAS (NCT02907411)
- Testing
- Quadrivas Therapy
- Where
- 2 sites in United States
- Volunteers
- 7 people
- Sponsor
- University of Arizona
Obesity
Technical Validation of Lunar iDXA (GE Healthcare) Visceral Fat Tool
The goal of this project is to compare visceral fat measurements derived from Lunar iDXA total body scans and from Computed Tomography (CT) scans of the abdominal region.
- Trial name
- NCT00987298
- Testing
- Visceral fat mass measurement
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- GE Healthcare
Digestive Organs--Cancer, Bariatric Surgery Candidate
Mitochondrial Oxygraphy on Subcutaneous and Peri-visceral Adipose Tissue: Influence of Body Composition
The objective of this study is to adapt the oxygraphy technique on human adipocytes and to characterize respiration measurements according to patients' body mass index and white adipose tissue localization (subcutaneous vs…
- Conditions
- Digestive Organs--Cancer, Bariatric Surgery Candidate, Parietal Region Trauma
- Trial name
- OxMiTiAd (NCT05417581)
- Testing
- adipose surgery
- Where
- France
- Volunteers
- 67 people
- Sponsor
- University Hospital, Clermont-Ferrand
Skin and Subcutaneous Tissue Bacterial Infections, Wound Infection
A Study of Safety, Tolerability, and Efficacy of AFN-12520000 in the Treatment of Acute Bacterial Skin and Skin Structure Infections Due to Staphylococci
The purpose of the study is to determine the safety, tolerability and effectiveness of AFN-12520000 for in the treatment of Staphylococcal infections of the skin.
- Conditions
- Skin and Subcutaneous Tissue Bacterial Infections, Wound Infection, Cutaneous Abscess, Burn Infection
- Trial name
- NCT01519492
- Testing
- AFN-12520000
- Where
- 14 sites in United States, Canada
- Volunteers
- 103 people
- Sponsor
- Affinium Pharmaceuticals, Ltd
Subcutaneous Fat
A Study to Evaluate the Safety, Tolerability, and Preliminary Efficacy of CBL-514 Injection for Reducing Convexity or Fullness of Abdominal Subcutaneous Fat
The Phase 2a component of the study will be a randomized, open-label, parallel, and multiple dose study to further examine the safety and efficacy profile of 3 CBL-514 dose levels based on the results from Phase 1 of the study.
- Trial name
- NCT04698642
- Testing
- CBL-514
- Where
- Australia
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Caliway Biopharmaceuticals Co., Ltd.
Obesity
Microvascular Flow Assessment Repeatability Study: The MARS Study
The purpose of this study is to test a method of imaging (taking a picture) of the abdomen (belly), neck, thigh and calf (lower leg) areas of the body, using ultrasound along with a drug which makes the pictures look clearer.
- Trial name
- MARS (NCT01242020)
- Testing
- Perflutren Lipid Microsphere Injectable Suspension
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Subcutaneous Fat
A Phase 1 Study to Evaluate the Safety and Tolerability of CBL-514 Injection on Convexity or Fullness of Abdominal Subcutaneous Fat in Healthy Volunteers
The Phase 1 component of the study is a double-blind, placebo-controlled, single ascending dose (SAD) design intended to assess the safety, tolerability, and PK of CBL-514. The SAD part will involve 9 proposed dosing cohorts.
- Trial name
- NCT04699669
- Testing
- CBL-514
- Where
- Australia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Caliway Biopharmaceuticals Co., Ltd.
Subcutaneous Fat
A Study to Evaluate the Efficacy, Safety and Tolerability of CBL-514 Injection for Reducing Abdominal Subcutaneous Fat
This is a randomized, placebo-controlled, Phase 2b study to evaluate the efficacy, safety, and tolerability of CBL-514 injection for reducing subcutaneous fat.
- Trial name
- NCT05736107
- Testing
- CBL-514 Injection, 0.9% Sodium Chloride
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Caliway Biopharmaceuticals Co., Ltd.
Lipoma
Lipomas Treated With Subcutaneous Injections of Cooled or Warmed Sodium Chloride
Lipomas are benign tumors composed of mature adipose tissue. While harmless, these are the most common type of soft tissue growths with some patients developing numerous lipomas.
- Trial name
- NCT06820164
- Testing
- Cooled Sodium Chloride Injection, Warmed Sodium Chloride Injection
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- West Virginia University
Overweight and Obesity, Metabolic Syndrome
Testing the Adipose Expandability Hypothesis In Vivo During Overfeeding
Adipose, or fat, tissue is a plastic organ that retains the ability to expand and store excess calories during positive energy balance in humans.
- Trial name
- EAT 2 (NCT04583514)
- Testing
- Control, Overfeeding
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Breast Cancer, Obesity
A Pilot Study of Docosahexaenoic Acid (DHA) in Obese Menopausal Women
This study aims to determine if a supplement of an omega-3-fatty acid (docosahexaenoic - DHA) lowers inflammation in human fat tissue thereby lowering estrogen production and the potential risk for breast cancer.
- Trial name
- NCT01127867
- Testing
- dietary intervention
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Colorectal Cancer, Sarcopenia
Predictive Effect of Abdominal Fat and Muscle Area Calculated Based on Abdominal CT on Colorectal Cancer Patients
This study aims to create a clinical prediction model. Abdominal fat and muscle area also play an important role in the prediction of surgical outcomes in colorectal cancer.
- Conditions
- Colorectal Cancer, Sarcopenia, Obesity and Overweight
- Trial name
- NCT06614699
- Testing
- abdominal fat and muscle area
- Where
- 3 sites in China
- Volunteers
- 8,000 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Generalized Lipodystrophy
A Study of the Safety of Mibavademab in Pediatric and Adult Participants Switching From Metreleptin to Mibavademab for the Treatment of Generalized Lipodystrophy (GLD)
This study is researching an experimental drug called mibavademab. The study is focused on participants with GLD who have been on metreleptin treatment for at least 6 months with no change in dose for the last 3 months.
- Trial name
- NCT06548100
- Testing
- mibavademab
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- Regeneron Pharmaceuticals
Subcutaneous Adipose Tissue Reduction
Dose Ranging and Dose Frequency of LIPO-102
Dose Ranging and Dose Frequency of LIPO-102
- Trial name
- NCT00918814
- Testing
- LIPO-102
- Where
- 2 sites in United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Neothetics, Inc
Subcutaneous Adipose Tissue Reduction
An Evaluation of the Pharmacokinetics and Safety of LIPO-102 in Healthy Volunteers
An Evaluation of the PK and Safety of LIPO-102 in Healthy Volunteers.
- Trial name
- NCT00918606
- Testing
- LIPO-102
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Neothetics, Inc
Injury to Subcutaneous Tissue
Study Safety and Effectiveness of CURVE Laser Therapy for Circumference Reduction of the Waistline.
The purpose of this study is to assess the safety and effectiveness of the CURVE Low-Level Laser Therapy for circumference reduction of the waistline.
- Trial name
- NCT02909790
- Testing
- Curve Low Level Laser Therapy
- Volunteers
- 40 people
- Sponsor
- Yolo Medical Inc.
Surgical Site Infection
Betadine Versus Saline in Swapping of Subcutaneous Tissue
Caesarean section is an increasingly common major surgical procedure performed on women. Last decade an overall increase of the global rate of caesarean section, of up to 31.2%, was reported.
- Trial name
- NCT06595823
- Testing
- Betadine
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Egymedicalpedia
Ultrasound, Sarcopenia
Muscle Quality and Subcutaneous Adipose Tissue in the Rectus Femoris and Rectus Abdominis Muscles: Ultrasound Evaluation and Functional Correlation in Older Adults
The goal of this observational, cross-sectional study is to examine the relationship between body composition and muscle quality in women over the afe of 65.
- Conditions
- Ultrasound, Sarcopenia, Obesity
- Trial name
- NCT07069777
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- University of Salamanca