Clinical trials: Stroke Recurrence
Acute Ischemic Stroke, Stroke Recrudescence
Multilevel System Intervention Based on Information Platform to Reduce Ischemic Stroke Recurrence Rate
A prospective, multicenter and cluster randomised controlled trial will be conducted, using hospital as randomisation unit. Hospitals in Zhejiang Province, China, will be randomised into two arms (1:1): an intervention arm and a…
- Conditions
- Acute Ischemic Stroke, Stroke Recrudescence, Quality Improvement
- Trial name
- NCT05852080
- Testing
- multilevel system intervention based on information platform
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Stroke, TIA
Reducing Risk of Recurrence
Adults who have had a previous stroke or transient ischemic attack (TIA) remain at risk for having a second serious event, especially if they have uncontrolled blood pressure or cholesterol.
- Conditions
- Stroke, TIA, Hypertension, Hyperlipidemia
- Trial name
- RRR (NCT01122394)
- Testing
- TI, AP
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- VA Office of Research and Development
Hypertension, Stroke
Recurrent Stroke Prevention Clinical Outcome Study
1. Objectives and Hypothesis 1. Objectives: This study evaluates whether strict BP management is useful for the prevention of recurrent stroke.
- Conditions
- Hypertension, Stroke, Blood Pressure
- Trial name
- RESPECTS (NCT01198496)
- Testing
- Losartan, Losartan and HCTZ, Amlodipine , Spironolactone
- Where
- Japan
- Volunteers
- 5,000 people
- Sponsor
- Biomedis International Ltd.
Ischemic Stroke, Paroxysmal Atrial Fibrillation
Paroxysmal Atrial Fibrillation in Patients With Acute Ischemic Stroke
The purpose of this study is to estimate the clinical relevance of monitoring patients with acute ischemic stroke with 48 hours' inpatient cardiac telemetry in relation to evaluate the presence of brief runs of premature atrial…
- Conditions
- Ischemic Stroke, Paroxysmal Atrial Fibrillation, Premature Atrial Complexes
- Trial name
- NCT02610803
- Where
- Denmark
- Volunteers
- 863 people
- Sponsor
- Odense University Hospital
Cognitive Decline, Intracerebral Hemorrhage
Triple Therapy Prevention of Recurrent Intracerebral Disease EveNts Trial (TRIDENT) Cognitive Sub-Study
A Sub-Study of an investigator initiated and conducted, multicentre, international, double-blinded, placebo-controlled, parallel-group, randomised controlled trial (TRIDENT) to determine the effect of more intensive long-term…
- Conditions
- Cognitive Decline, Intracerebral Hemorrhage, Dementia, Vascular, Cerebral Small Vessel Diseases
- Trial name
- TRIDENT COG (NCT03785067)
- Testing
- telmisartan 20mg + amlodipine 2.5mg +indapamide 1.25mg
- Where
- 4 sites in Australia, Netherlands
- Volunteers
- 1 people
- Sponsor
- The George Institute
Cerebral Infarction
Post-marketing Study of Cilostazol (Cilostazol Stroke Prevention Study 2)
The purpose of this study is to investigate the efficacy of cilostazol in preventing recurrence of cerebral infarction and the safety of long-term administration of the drug (100 mg, twice daily) in patients with cerebral…
- Trial name
- NCT00234065
- Testing
- Cilostazol, Aspirin
- Where
- Japan
- Volunteers
- 2,800 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Stroke, Acute Ischemic, Intracerebral Hemorrhage
The Stroke Aetiology and VascuLar Disease in Stroke and TIA Study - A Clinical Study Analysing the Effects on Cardiovascular Health and Disease With an Extended Investigation Into Conditions Causative of Stroke and Concomitant Cardiovascular Disease in Patients Admitted for Acute Stroke or TIA
Annually, about 4000 Swedes suffer a recurrent stroke, and for many, their lives change dramatically. To prevent recurring strokes, knowledge about the individual's risk of recurrence is needed to tailor an effective preventive…
- Conditions
- Stroke, Acute Ischemic, Intracerebral Hemorrhage, TIA, Hypertension
- Trial name
- SALSA (NCT07491744)
- Testing
- Extended assessment
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Region Stockholm
Cryptogenic Stroke, Atrial Fibrillation
Incidence and Predictors of Recurrent Stroke in Cryptogenic Stroke Patients With Atrial Fibrillation
Brief Summary: This study aimed to investigate the risk and factors that predict recurrent stroke in patients who initially had a stroke with no clear cause (called cryptogenic stroke) and were later found to have atrial…
- Conditions
- Cryptogenic Stroke, Atrial Fibrillation, Recurrent Ischemic Stroke
- Trial name
- NCT07126184
- Testing
- Extended Cardiac Monitoring
- Where
- Pakistan
- Volunteers
- 109 people
- Sponsor
- Nangarhar University
Ischemic Stroke, Transient Ischemic Attack (TIA)
Ambulatory Stroke Unit Treatment for Elderly Patients
ARTIFICE is a prospective, multicenter, randomized, controlled, exploratory non-inferiority trial evaluating whether an ambulatory stroke unit model (aSU) is non-inferior to conventional inpatient stroke unit care (SU) in…
- Conditions
- Ischemic Stroke, Transient Ischemic Attack (TIA), Retinal Ischemia
- Trial name
- ARTIFICE (NCT07420374)
- Testing
- Ambulatory Stroke Unit Care, Conventional Stroke Unit Care
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- University Hospital Heidelberg
Ischemic Stroke
Research on AIS Recurrence Risk Prediction Model Using XGBoost Combined With Convolutional Neural Network Algorithm
The purpose of this observational study is to construct a recurrence risk prediction model for ischemic stroke within 1, 3, 6, and 12 months using XGBoost combined with Convolutional Neural Network (CNN) algorithm.
- Trial name
- NCT06796283
- Where
- China
- Volunteers
- 2,628 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Ischemic Stroke
Improved Prediction of Recurrent Stroke and Detection of Small Volume Stroke
Rationale: Over 20.000 people suffer an ischemic stroke in the Netherlands each year. Large artery occlusions are easy to identify and can be treated with endovascular clot removal.
- Trial name
- ENCLOSE (NCT04019483)
- Where
- 3 sites in Netherlands
- Volunteers
- 439 people
- Sponsor
- UMC Utrecht
Cardioembolic Stroke, Anticoagulant Therapy
Keeping Oral o Parental AnticoaguLation in the Acute Phase of Cardioembolic Ischemic Stroke
This is an observational, prospective, multicenter, cohort study in patients with cardioembolic stroke and previous oral or parenteral anticoagulant therapy.
- Conditions
- Cardioembolic Stroke, Anticoagulant Therapy, Stroke Recurrence, Haemorrhagic Transformation Stroke
- Trial name
- KOALA-IS (NCT05486351)
- Testing
- Observation
- Where
- 3 sites in France, Spain
- Volunteers
- 318 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Cardiovascular Diseases, Cerebrovascular Accident
Predictors of Recurrent Stroke in the PROGRESS Study
To investigate mechanisms of recurrent stroke.
- Conditions
- Cardiovascular Diseases, Cerebrovascular Accident, Cerebrovascular Disorders, Hypertension
- Trial name
- NCT00049894
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Ischemic Stroke
Stroke Registration of Young Adults in China
This is a multi-center, prospective,continuous registry study. The investigators will include 3000 young adult (18-45 years old) patients with confirmed first-ever acute ischemic stroke in China.
- Trial name
- REACH (NCT03024164)
- Testing
- Treatment following current guidelines
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Yi Yang
Intracranial Vascular Disorders
Mechanisms of Early Recurrence in Intracranial Atherosclerotic Disease
The objective of this study is to determine the mechanisms of stroke in patients with Intracranial Atherosclerotic Disease (IAD) by specifically evaluating limitations of antegrade flow through the stenotic artery, distal tissue…
- Trial name
- MyRIAD (NCT02121028)
- Where
- 10 sites in United States
- Volunteers
- 105 people
- Sponsor
- University of Miami
Stroke, Ischemic, Transient Ischemic Attack
TIA Scores' Mortality Predictions and Recurrent TIA and Stroke Prediction
Our study adopts a prospective design. Our research aims to determine the significance of ABCD2, ABCD3-I, Canadian TIA Score, and NIHSS Score in predicting the likelihood of ischemic stroke within 30 days in patients presenting…
- Trial name
- NCT06515392
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Saglik Bilimleri Universitesi
Ischemic Stroke, Atrial Fibrillation
Cardiac Assessment for Recurrent Stroke Risk Evaluation in Atrial Fibrillation
Background Atrial fibrillation (AF) is the most common cardiac arrhythmia, affecting up to 10% of the elderly. Ischemic stroke is the main complication of AF and cardioembolism is one of the leading causes of ischemic stroke…
- Conditions
- Ischemic Stroke, Atrial Fibrillation, Cerebrovascular Disorders, Brain Diseases
- Trial name
- CARE-AF (NCT06954610)
- Testing
- No intervention
- Where
- Switzerland
- Volunteers
- 500 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Stroke, Acute
Obesity Effect on Stroke and Cardiovascular Events
The relation between obesity and stroke recurrence is still under debate. In this study it has been sought whether baseline obesity is associated with recurrent stroke and major cardiovascular events in a long-time period.
- Trial name
- OSR (NCT04062643)
- Testing
- Obesity assessment
- Volunteers
- 9,285 people
- Sponsor
- Ege University
Stroke, PFO - Patent Foramen Ovale
The PROOF Trial - Prospective, Open-label, Multicenter, Non-randomized Investigation on Percutaneous Patent Foramen Ovale (PFO) Closure Using the Occlutech PFO Occluder to Prevent Recurrence of Stroke in Patients With Cryptogenic Stroke and High Risk PFO
Percutaneous transcatheter closure of a patent foramen ovale (PFO) to reduce the risk of recurrent ischemic stroke in patients who have had a cryptogenic stroke due to a presumed paradoxical embolism.
- Trial name
- PROOF (NCT04029233)
- Testing
- Occlutech PFO Occluder
- Where
- 17 sites in Canada, France and 2 more
- Volunteers
- 582 people
- Sponsor
- Occlutech International AB
Stroke
Left Atrial Function in Recurrent Stroke of Unknown Cause
Stroke is an important cause of disability and the third leading cause of death. Approximately 30 to 40 % of all strokes are estimated to be cryptogenic (i.e. no cause can be found).
- Trial name
- NCT02968329
- Where
- Belgium
- Volunteers
- 500 people
- Sponsor
- Hasselt University