Clinical trials: Stroke, open to volunteers
Ischemic Stroke
Connectomic Alterations Following Acute Ischemic Stroke in the MCA Territory
This study seeks to use safe, powerful, non-invasive computing tools, including machine learning and advanced neuroimaging analysis, to better understand how stroke affects the brain's network of connections.
- Trial name
- NCT07584681
- Testing
- MRI with connectomic sequencing
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Northwell Health
Acute Stroke
mSOAR and Early Mortality in Acute Stroke
This observational study aims to evaluate the predictive accuracy of the Modified SOAR score for early mortality in patients with acute stroke.
- Trial name
- NCT07355881
- Testing
- No Intervention (Observational Study)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sohag University
Stroke, Acute
Acute Stroke: Prehospital Versus In-HospitAL Initiation of Recanalization Therapy- ASPHALT
ASPHALT is an academic-driven open-label randomized controlled trial of Mobile Stroke Unit (MSU) deployment versus standard care in France, with blinded assessment of efficacy endpoints.
- Trial name
- ASPHALT (NCT05649670)
- Testing
- Mobile Stroke Unit deployment
- Where
- 11 sites in France
- Volunteers
- 450 people
- Sponsor
- Centre Hospitalier St Anne
Spinal Cord Injuries (SCI)
AI-Guided Multi-Electrode Transcutaneous Spinal Cord Stimulation for Gait Rehabilitation in People With Spinal Cord Injury or Stroke
The goal of this clinical trial is to investigate whether personalized multi-electrode transcutaneous spinal cord stimulation (tSCS), guided by machine learning (ML) and combined with gait training, can improve walking function…
- Trial name
- NCT07895888
- Testing
- Single-Electrode Tonic tSCS, Multi-Electrode Spatiotemporal tSCS
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- University of Sao Paulo General Hospital
Stroke
Cognition and Imaging With Tigertriever
The objective of the COGNITIVE Study is to evaluate whether successful reperfusion with Tigertriever is associated with cognitive benefit.
- Trial name
- COGNITIVE (NCT05531461)
- Where
- 6 sites in United States
- Volunteers
- 424 people
- Sponsor
- Rapid Medical
Ischemic Stroke, Acute, Blood Pressure Variability
Continuous Blood Pressure Variability and Small Vessel Disease in Acute Ischemic Stroke
This prospective observational cohort study examines whether blood pressure variability and nighttime blood pressure patterns, measured non-invasively over 72 hours with a cuffless ring-type wearable device, help predict recovery…
- Conditions
- Ischemic Stroke, Acute, Blood Pressure Variability, Cerebral Small Vessel Disease, White Matter Hyperintensity
- Trial name
- COMPASS (NCT07903922)
- Testing
- Cuffless ring-type continuous blood pressure monitor
- Where
- South Korea
- Volunteers
- 450 people
- Sponsor
- Minyoul Baik
Stroke, Acute, Ischemic Stroke, Acute
MyStroke for Stroke Survivors and Caregivers
The goal of this multicenter randomized trial is to evaluate the impact of a personalized video-based stroke education platform on patient-centered and health system-centered outcomes.
- Trial name
- NCT06442631
- Testing
- MyStroke
- Where
- 5 sites in United States
- Volunteers
- 690 people
- Sponsor
- University of Pennsylvania
Stroke, Healthy
Cerebello-motor Neuromodulation After Stroke. CERSTIM.
The CERSTIM study is a physiopatholgical study investigating transcranial alternating current stimulation in stroke patients in the cerebello-motor loop.
- Trial name
- CERSTIM (NCT06599931)
- Testing
- tACS Transcranial alternating stimulation
- Where
- 2 sites in France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Cerebral Ischemia
Autologous Mitochondrial Transplant for Cerebral Ischemia
The investigators propose to infuse healthy autologous mitochondria into cerebral vessels supplying brain tissue experiencing ischemia in patients who undergo standard-of- care endovascular reperfusion therapy.
- Trial name
- NCT04998357
- Testing
- Endovascular autologous mitochondrial transplantation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Washington
Ischemic Stroke, Acute
Shuxuening Injection in the Treatment With Intravenous Thrombolysis in Patients With Ischemic Stroke (SHINY)
Shuxuening injection is a multi-target neuroprotective agent, it is expected to play a neuroprotective role on the basis of intravenous thrombolysis therapy.
- Trial name
- NCT06157502
- Testing
- Shuxuening Injection
- Where
- 82 sites in China
- Volunteers
- 1,380 people
- Sponsor
- Beijing Tiantan Hospital
Stroke, Aphasia
Combined Exercise and Targeted Therapy for Post-Stroke Reading Deficits
The goal of the proposed project is to test the effectiveness of a novel hybrid approach to treatment of reading disorders after stroke, in which exercise training will be used in combination with a targeted reading treatment.
- Conditions
- Stroke, Aphasia, Reading Disorder
- Trial name
- NCT06213272
- Testing
- Phono-Motor Therapy, Aerobic Exercise Training (AET), Stretching
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Kessler Foundation
Carotid Stenosis
Risk Prediction Model for Cerebrovascular Events in Carotid Artery Stenosis
Atherosclerotic carotid artery stenosis is a major cause of stroke, and early identification of high-risk patients combined with surgical intervention can significantly reduce stroke risk.
- Trial name
- NCT06452173
- Testing
- Plasma, carotid high-resolution magnetic resonance imaging
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Beijing Tiantan Hospital
Ischemic Strokes, Traditional Chinese Medicine (TCM)
Spatiotemporal Evolution of Traditional Chinese Medicine Mechanisms in Acute Ischemic Stroke Treated With Dengzhan Xixin and Dengzhan Shengmai
To integrate large-scale RCT data on clinical symptoms, TCM syndromes, prognosis, and multi-omics profiles, construct a spatiotemporal dynamic network for disease-syndrome evolution of acute ischemic stroke (AIS) in the acute and…
- Conditions
- Ischemic Strokes, Traditional Chinese Medicine (TCM), Prognosis
- Trial name
- STEM-DZ (NCT07591883)
- Testing
- Dengzhan Shengmai - Erigeron breviscapus sequential intervention, corresponding control group sequential intervention
- Volunteers
- 358 people
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
Stroke, Ischemic Stroke
Detecting and Predicting Post-stroke Cognitive Impairment Using the Oxford Cognitive Screen
Cognitive problems are common after a stroke and must be identified early so that rehabilitation can be initiated to improve outcome.
- Conditions
- Stroke, Ischemic Stroke, Hemorrhagic Stroke, Intracerebral, Cognitive Dysfunction
- Trial name
- OCS-PRECISE (NCT07897916)
- Where
- 2 sites in Denmark
- Volunteers
- 180 people
- Sponsor
- University of Copenhagen
Cardiovascular Diseases, Surgery
Pressure Recording Analytical Method Parameters and Their Relationship With Hypotension in Hypertensive Patients
Perioperative anesthesiologists can benefit from easily obtainable hemodynamic variables detecting or quantifying the lack of an adequate compensatory capacity of the cardiovascular system in order to optimize patient management…
- Conditions
- Cardiovascular Diseases, Surgery, Hypotension, Hypotension on Induction
- Trial name
- PRAM-in-HYPO (NCT05960604)
- Testing
- Passive leg raising
- Where
- 5 sites in Turkey (Türkiye)
- Volunteers
- 660 people
- Sponsor
- Recep Tayyip Erdogan University
Stroke Rehabilitation, Gait Disorders, Neurologic
Efficacy of Cerebello-spinal Direct Current Stimulation (csDCS) on Functional Mobility in Chronic Stroke Patients
The aim of this clinical trial is to determine if cerebello-spinal direct current stimulation (csDCS) is effective in treating gait disorders in individuals with chronic stroke.
- Conditions
- Stroke Rehabilitation, Gait Disorders, Neurologic, tDCS
- Trial name
- NCT07073287
- Testing
- Cerebello-spinal direct current stimulation
- Where
- 3 sites in Brazil
- Volunteers
- 30 people
- Sponsor
- Universidade Federal de Pernambuco
Stroke, Traumatic Brain Injury
Comparison of Gait Metrics in Patients With Stroke, Traumatic Brain Injury, and Multiple Sclerosis
People with neurological conditions often have difficulty walking, including problems such as foot drop. Functional electrical stimulation (FES) is a treatment that uses electrical signals to activate muscles and support walking.
- Conditions
- Stroke, Traumatic Brain Injury, Multiple Sclerosis
- Trial name
- NCT07492602
- Testing
- Functional Electrical Stimulation, Normal care
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Stroke, Stroke Sequelae
Novel Wrist Sensor System to Promote Hemiparetic Arm Use in Home Daily Life of Chronic Stroke Survivors
The proposed study is a two-arm randomized clinical trial designed to assess the effects of the StrokeWear system on clinical outcomes over a period of 6-months in chronic stroke survivors.
- Conditions
- Stroke, Stroke Sequelae, Hemiparesis;Poststroke/CVA
- Trial name
- NCT05626894
- Testing
- StrokeWear Motor and Behavioral Intervention, Usual Care
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Spaulding Rehabilitation Hospital
Acute Ischemic Stroke
Sublingual Edaravone Dexborneol for Inter-hospital Transfer Acute Ischemic Stroke (SLEDAIS)
This is a multicenter, randomized, double-blind, placebo-controlled clinical trial (SLEDAIS) involving 1,040 patients with acute ischemic stroke (AIS) who require inter-hospital transfer for potential endovascular therapy.
- Trial name
- SLEDAIS (NCT07682922)
- Testing
- Edaravone dexborneol sublingual tablet
- Where
- China
- Volunteers
- 1,040 people
- Sponsor
- Xinqiao Hospital of Chongqing
Ischemic Stroke
Individual Alpha Frequency-Based rTMS for Post-Stroke Motor Recovery: Efficacy and Neurophysiological Mechanisms
The goal of this clinical trial is to evaluate the efficacy of a personalized brain stimulation technique, Individual Alpha Frequency (IAF)-based rTMS, for motor function recovery in adult patients with a first-ever ischemic…
- Trial name
- NCT07498777
- Testing
- Active Individual Alpha Frequency-based Repetitive Transcranial Magnetic Stimulation (IAF-rTMS)
- Where
- Taiwan
- Volunteers
- 34 people
- Sponsor
- National Taiwan University Hospital
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