Clinical trials: Stress Response
Obesity, Bariatric Surgery
Impact of Weight Loss After a Bypass Surgery on Renal Hemodynamic Under Stress Conditions
The sympathetic nervous (SNS) and the renin angiotensin aldosterone system (RAS) have a direct impact on renal hemodynamic, hormonal secretion and vasoactive peptide.
- Conditions
- Obesity, Bariatric Surgery, Blood Pressure
- Trial name
- OBBYSS (NCT02218112)
- Testing
- bariatric surgery (gastric bypass)
- Where
- Switzerland
- Volunteers
- 36 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Heat Stress, Aging
Aging, Beta Blockers, and Thermoregulatory Responses
This study will test the hypothesis that the drugs propranolol and metoprolol will result in greater increases in core body temperature during 3 hours of extreme heat exposure in older adults.
- Trial name
- NCT06582680
- Testing
- Ambient Heat
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Anesthesia, Infertility
Sevoflurane Versus Propofol; Neuro Endocrine Response in Patients of Oociyt Pick up
Patients in the study will be grouped as 1st group Propofol, 2nd Group Sevofluran.Preoperative blood will be taken from the patients and cortisol, acth, glucagon, aldosterone, PGE2, CRH will be studied.
- Conditions
- Anesthesia, Infertility, Pain, Postoperative, Stress, Psychological
- Trial name
- NCT03507621
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Yavuz Orak
Stress
Intermediate Cervical Plexus Block on Stress Response
The aim of the present study is to investigate the effect of Bilateral Ultrasound-Guided intermediate cervical plexus Block combined with general anesthesia on the stress and inflammatory response in patients undergoing anterior…
- Trial name
- NCT06064214
- Testing
- u/s guided intermediate cervical plexus block
- Where
- Egypt
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Cairo University
Sepsis, Severe, Sepsis
Multiple Biomarkers in ICU Sepsis Patients
Acute kidney injury (AKI) is a common condition among sepsis patients in the intensive care unit (ICU) and is associated with high morbidity and mortality.
- Conditions
- Sepsis, Severe, Sepsis, Septic Shock, AKI
- Trial name
- NCT03802136
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Zhongnan Hospital
Stress, Psychological Stress
Examine the Effects of Meditation on Daily Psychological Stress Responses in Woman With a History of Child Adversity
The aim of the Everyday Moments of Mindfulness (EMMI) study is to test whether brief mindfulness-based practices will improve daily psychological stress responses in women (age 30-60) who report a history of early life adversity.
- Conditions
- Stress, Psychological Stress, Child Maltreatment, Depressive Symptoms
- Trial name
- EMMI (NCT04606199)
- Testing
- Mindfulness-based intervention, up to 5 minutes 0-3 times/day
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Pregnancy
Mitigating Response to Stressors in Pregnant Women
Stress-induced pregnancy complications are significant contributors to preterm labor as well as maternal and perinatal morbidity and mortality.
- Trial name
- NCT06718907
- Testing
- Simulated stimuli, Stress Management
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Nova Southeastern University
Atrial Septal Defect (ASD), Dexmedetomidine
Effect of Dexmedetomidine Supplementation to General Anaesthesia in Paediatric Transcatheter Closure of Atrial Septal Defect
The aim of this randomized trial is to determine efficacy of dexmedetomidine in improving quality of recovery in pediatric patients undergoing interventional catheter closure of ASD while maintaining the hemodynamic parameters.
- Conditions
- Atrial Septal Defect (ASD), Dexmedetomidine, Delirium - Postoperative, Stress Response
- Trial name
- NCT06631534
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Alexandria University
Normal Subjects
Acute Effects of Artificial Sweeteners or Sugar on Hemodynamic and Metabolic Stress Responses
This exploratory study aims at investigating the acute effects of artificially sweetened and sugar beverage consumption (as compared to water consumption) on acute hemodynamic and metabolic stress response.
- Trial name
- EduStress (NCT02973334)
- Testing
- Ingestion of artificially-sweetened beverages, Ingestion of sugar-sweetened beverages, Ingestion of water
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Major Depressive Disorder
Impact of Transcutaneous Vagal Nerve Stimulation on Stress Response in Major Depression
This study will identify the sex-dependent impact of expiratory-gated transcutaneous vagus nerve stimulation (tVNS) on the modulation of the stress response circuitry and associated physiology in major depressive disorder (MDD).
- Trial name
- tVNS_MDD_Sex (NCT04448327)
- Testing
- active tVNS
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Massachusetts General Hospital
Pain, Postoperative, Analgesic Requirement
Effect of Intraperitoneal and Intravenous Lignocaine on Pain Relief Following Laparoscopic Cholecystectomy
Laparoscopic Cholecystectomy is the treatment of choice for patients with symptomatic gall stones. For pain relief following laparoscopic cholecystectomy both intraperitoneal and intravenous administration of lignocaine has been…
- Conditions
- Pain, Postoperative, Analgesic Requirement, Stress Response, Return of Bowel Activity
- Trial name
- NCT01717222
- Testing
- Intraperitoneal Lignocaine, Intravenous Lignocaine
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Jawaharlal Institute of Postgraduate Medical Education & Research
Stress Disorders, Post-Traumatic
Enhancing PTSD Treatment Outcomes by Improving Patient-Provider Communication
The purpose of this clinical trial is to learn whether existing treatments for posttraumatic stress disorder (PTSD) can be improved.
- Trial name
- AWARE (NCT06088303)
- Testing
- Adjunctive writing to amplify response and engagement (AWARE), Cognitive processing therapy (CPT), Prolonged exposure (PE)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Boston University
Postoperative Cognitive Dysfunction
Cognitive Dysfunction Following Cardiac Surgery
Postoperative cognitive dysfunction (POCD) is the most common complication after cardiac surgery. This prospective study was conducted to investigate the mechanisms of development of POCD following cardiac surgery taking into…
- Trial name
- CDCS (NCT02767713)
- Testing
- Dexamethasone
- Volunteers
- 171 people
- Sponsor
- Clinical Hospital Center, Split
Aging
Effects of Resistance Training Programes At Different Intensities on Musculoskeletal, Metabolic, Lipid, Immunological, Inflammatory, Well-being and Functional Parameters in Older Adults.
The aging of the global population is recognized by the World Health Organization (WHO) as a major issue due to the disabilities and comorbidities related to this process, with women being the gender most affected.
- Trial name
- NCT06618469
- Testing
- Elastic band-based resistance training program at high intensity (HI), Elastic band-based resistance training program at moderate-high intensity (MHI-bands), Elastic band-based resistance training program at moderate intensity (MI)
- Where
- Spain
- Volunteers
- 320 people
- Sponsor
- University of Valencia
Healthy
Validation of a Wearable Sensor for Stress Response in a Virtual Reality Environment
Monitor stress response in a virtual reality environment using a wearable sensor to analyze and track heart rate variability (HRV).
- Trial name
- NCT02321774
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Scripps Translational Science Institute
Acute Stress Response During Orthodontic Mini-screw Placement
Effects of Music Therapy on Stress During Orthodontic Mini-screw Placement
This randomized clinical trial evaluated acute stress responses during orthodontic mini-screw placement and whether listening to music during the procedure influenced these responses.
- Trial name
- NCT07793669
- Testing
- Music Listening Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Himmet YILDIRIM
Coronary Disease, Heart Valve Diseases
CTI-01 (Ethyl Pyruvate) Safety and Complication Prevention in Cardiac Surgery Patients on Cardiopulmonary Bypass (CPB)
Over 500,000 patients undergo cardiac surgery with CPB in the United States annually. Although mortality rates have decreased with advances in perioperative care, many patients are affected by postoperative organ dysfunction.
- Trial name
- NCT00107666
- Testing
- CTI-01 (ethyl pyruvate)
- Where
- 17 sites in United States
- Volunteers
- 150 people
- Sponsor
- Critical Therapeutics
Chronic Pelvic Pain Syndrome (CPPS), Radiation-Induced Disorder
Gene and Molecular Pathways of Ozone Treatment Response in Gynecological Tumor Patients With Chronic Pelvic Pain Secondary to Cancer Treatment
Gynecological cancers, including those affecting the ovaries, uterus, and cervix, represent a significant health burden for women.
- Conditions
- Chronic Pelvic Pain Syndrome (CPPS), Radiation-Induced Disorder, Radiotherapy Side Effects, Side Effect of Chemotherapy
- Trial name
- OzoGynEpigen (NCT06816095)
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Bernardino Clavo, MD, PhD
Stress
Using Affectionate Communication as a Response to Acute Stress
This study will examine the effects of tending to significant social relationships on managing and reducing stress.
- Trial name
- NCT00468572
- Testing
- Affectionate Writing, Meaningless Writing
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Depressive Disorder, Major, Treatment Outcome
Precision Medicine in the Depression Treatment
The BrainDrugs-D study uses multimodal neuroimaging combined with self-report measures, clinical and molecular markers to identify clinically relevant predictors that can identify subtypes of major depressive disorder (MDD) and…
- Conditions
- Depressive Disorder, Major, Treatment Outcome, Cognitive Dysfunction, Cognitive Behavioral Therapy
- Trial name
- BDD (NCT05616559)
- Testing
- Treatment Package for First-Episode Depression
- Where
- Denmark
- Volunteers
- 800 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet