Clinical trials: Stress
Moral Injury
A Novel Posttraumatic Stress Disorder Treatment for Veterans With Moral Injury
The objective of this project is to test the efficacy of an individual treatment for post-traumatic stress disorder (PTSD) stemming from moral injury called Impact of Killing (IOK), compared to a present-centered therapy (PCT)…
- Trial name
- IOK (NCT03764033)
- Testing
- Impact of Killing (IOK), Present Centered Therapy
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- VA Office of Research and Development
Obesity
Exercise as a Buffer Against Stress-induced Overeating
The purpose of this study is to examine the psychological benefits of chronic exercise as well as the effects of exercise training on eating behaviors and stress-induced overeating in overweight and obese women.
- Trial name
- NCT02936076
- Testing
- Exercise intervention, Delayed exercise intervention
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
Alcohol Use Disorder
Oxytocin and Stress Response in Alcohol Use Disorder
Individuals with alcohol use disorder (AUD) will complete one functional Magnetic Resonance Imaging (fMRI) scanning visit. Prior to the scan, individuals will receive a nasal spray of either 24 international units (IU) of…
- Trial name
- NCT03610633
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Medical University of South Carolina
Heart Transplant, Acute Graft Rejection
Stress Cardiac MRI for Evaluation of Nonspecific Allograft Dysfunction
The investigators will use cardiac MRI to measure the myocardial perfusion reserve and amount of myocardial edema and fibrosis in heart-transplant patients with nonspecific allograft dysfunction in contrast to those with normal…
- Conditions
- Heart Transplant, Acute Graft Rejection, Chronic Graft Rejection
- Trial name
- NCT02597543
- Testing
- Regadenoson, Gadolinium, Cardiac MRI
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Paul Kim
Posttraumatic Stress Disorder, Depression
Loving-Kindness Meditation for PTSD
This randomized controlled trial will assess whether a novel complementary and alternative medicines (CAM) intervention, Loving-kindness Meditation (LKM), is not meaningfully inferior to another group-based PTSD treatment …
- Trial name
- NCT01962714
- Testing
- Loving-Kindness Meditation, Cognitive Processing Therapy
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- VA Office of Research and Development
Stress, Pain
Evaluation of the Surgical Pleth Index During Spinal and General Anesthesia
The Surgical Pleth index (SPI) has been introduced as a non invasive tool to "measure" stress and pain during surgery. Preliminary studies were performed in patients under general anaesthesia with propofol and remifentanil.
- Trial name
- NCT00789438
- Where
- Germany
- Volunteers
- 69 people
- Sponsor
- University Hospital Schleswig-Holstein
Post-traumatic Stress Disorder (PTSD)
rTMS in the Treatment of PTSD
The purpose of this study is to assess the effects of repetitive transcranial magnetic stimulation (rTMS) in civilian patients with a confirmed diagnosis of post-traumatic stress disorder (PTSD).
- Trial name
- NCT01806168
- Testing
- rTMS
- Where
- Canada
- Volunteers
- 31 people
- Sponsor
- University of British Columbia
Oral Mucositis
Low-level Laser Therapy on Inflammatory Mediators During Chemotherapy-induced Oral Mucositis
The aim of the study is to evaluate the effect of low-level laser therapy (LLLT) on the severity of oral mucositis (OM) and inflammatory mediators (pro- and anti-inflammatory cytokines, metalloproteinases and growth factors)…
- Trial name
- LLLTHSCT (NCT02050373)
- Testing
- Low-Level laser
- Volunteers
- 51 people
- Sponsor
- Universidade Federal de Goias
Post-traumatic Stress Disorder, Generalized Anxiety Disorder
Primary Care Intervention Strategy for Anxiety Disorders
This study will compare the effectiveness of an intervention strategy for the treatment of people with post traumatic stress disorder, generalized anxiety disorder, panic disorder, and social anxiety disorder in the primary care…
- Conditions
- Post-traumatic Stress Disorder, Generalized Anxiety Disorder, Panic Disorder, Social Anxiety Disorder
- Trial name
- NCT00347269
- Testing
- Cognitive-behavioral therapy, Psychotropic medication optimization, Treatment as Usual
- Where
- 4 sites in United States
- Volunteers
- 1,004 people
- Sponsor
- University of Washington
Cigarette Smoking
Smoking, Stress, HIV and Mobile Technology
The present investigation aims to address disparities in cigarette use outcomes among Black/African American adults with HIV. The specific aims of this study are: (1) To modify a recently developed, culturally adapted, mobile…
- Trial name
- NCT05709002
- Testing
- MASP+, Control
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Houston
Compassion Fatigue, Burnout
Resilience Training for First Responders in the Opioid Epidemic
First responders (law enforcement, firefighters, and emergency medical system personnel) are subjected to daily pressures from their duties with resultant compassion fatigue, burnout, anger, poor mental and physical health…
- Conditions
- Compassion Fatigue, Burnout, Stress, Mindfulness
- Trial name
- NCT04929613
- Testing
- Mindfulness-Based Resilience Training
- Where
- 4 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- West Virginia University
Stress Disorders, Post-Traumatic, Alcohol Abuse
Combined Treatment for Alcohol-Dependent Individuals With PTSD
This treatment intervention trial is designed for men and women with either alcohol misuse (e.g. hazardous or binge drinking) or alcohol use disorders (alcohol abuse or dependence) and comorbid PTSD.
- Conditions
- Stress Disorders, Post-Traumatic, Alcohol Abuse, Substance-Related Disorders
- Trial name
- NCT00262223
- Testing
- Seeking Safety, Sertraline
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- New York State Psychiatric Institute
Urinary Incontinence
Comparison of Surgical Procedures to Reduce Urinary Stress Incontinence
The primary aim of this clinical trial is to compare the treatment success for two surgical procedures that are frequently used and have similar cure rates, yet have not been compared directly to each other in a large, rigorously…
- Trial name
- SISTEr (NCT00064662)
- Testing
- Burch Modified Tanagho, Autologous Fascia Sling
- Where
- 9 sites in United States
- Volunteers
- 655 people, healthy volunteers welcome
- Sponsor
- Carelon Research
Alcohol-related Disorders, Post-traumatic Stress Disorder
Couple-Based Treatment for Alcohol Use Disorders and Post-Traumatic Stress Disorder
The purpose of this study is to develop and test a couple-based treatment for Veterans with an alcohol use disorder and post-traumatic stress disorder.
- Trial name
- CTAP (NCT00946322)
- Testing
- Couple-Based Treatment for Alcohol Use Disorders and PTSD
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- VA Office of Research and Development
Severe Sepsis
Acetaminophen for the Reduction of Oxidative Injury in Severe Sepsis
Cell-free hemoglobin can be measured in the plasma of patients with sickle cell anemia, hemodialysis, after red blood cell transfusion, and in patients with sepsis.
- Trial name
- ACROSS (NCT01739361)
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Vanderbilt University
PTSD
Prolonged Exposure and Oxytocin
Posttraumatic stress disorder (PTSD) is a chronic, debilitating anxiety disorder that may develop after direct or indirect exposure to traumatic events.
- Trial name
- NCT03238924
- Testing
- Oxytocin
- Volunteers
- 17 people
- Sponsor
- Medical University of South Carolina
Family Relationship, Stress
Impact of Increased Parent Presence in the Neonatal Intensive Care Unit on Parent & Infant Outcomes
The purpose of this pilot study is to compare parent and infant outcomes and unit outcomes pre and post a planned unit-wide intervention aimed at increasing parent presence in the Neonatal Intensive Care Unit (NICU).
- Conditions
- Family Relationship, Stress, Breastfeeding, Bottle Feeding
- Trial name
- NCT02901665
- Testing
- FCC intervention
- Where
- 2 sites in United States
- Volunteers
- 191 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Cystic Fibrosis
Effect of Sulforaphane in Broccoli Sprouts on Nrf2 Activation
The purpose of this study to investigate the effect of sulforaphane from macerated broccoli sprouts in humans and to evaluate less invasive methods of assessing potential anti-inflammatory drugs in CF.
- Trial name
- NCT01315665
- Testing
- Broccoli sprouts
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Posttraumatic Stress Disorder
A Multi-Site Phase 3 Study of MDMA-Assisted Psychotherapy for PTSD (MAPP2)
The goal of this clinical trial is to learn if MDMA-assisted therapy is safe and effective in people with at least moderate PTSD.
- Trial name
- NCT04077437
- Testing
- Therapy, Midomafetamine
- Where
- 14 sites in United States, Israel
- Volunteers
- 121 people
- Sponsor
- Resilient Pharmaceuticals
Caregiver Burnout
Volunteering Program for Chinese Dementia Caregivers
Although many older Chinese Americans are expected to need intensive care because of cognitive impairment, a large gap exists in development of culturally sensitive interventions to reduce stress among caregivers in Chinese…
- Trial name
- NCT04346745
- Testing
- Peer Mentoring Program
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Columbia University
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