Clinical trials: Stone, Kidney
Kidney Stone, Renal Stone
Antibiotic Selection Using Next Generation Sequencing vs Urine Culture
This is a randomized controlled clinical study evaluating the use of next-generation sequencing (NGS) to improve antibiotic prescribing before ureteroscopy or percutaneous nephrolithotomy.
- Conditions
- Kidney Stone, Renal Stone, Infection, Bacterial
- Trial name
- ACCESS (NCT04404855)
- Testing
- NGS + Antibiotic Recommendation, Standard of Care treatment
- Where
- 3 sites in United States
- Volunteers
- 240 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Urinary Stone
A Study to Assess the Effect of Cannabidiol Oil on Pain After Ureteroscopy for Kidney Stones
The purpose of this study is to determine if CBD oil has any effect on decreasing postoperative pain control following ureteroscopy for urinary stone disease, and to determine if CBD oil has any effect in decreasing the amount of…
- Trial name
- NCT04387617
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Mayo Clinic
Nephrolithiasis
Thulium vs. Hol:YAG Laser
This is a randomized prospective study to compare stone free rates and operative efficiency of two laser systems used during retrograde intrarenal surgery for kidney stone disease: 1.
- Trial name
- NCT05808257
- Testing
- Thulium Fibre Laser, Holmium:Yttrium-Aluminum-Garnet
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Healthy, Kidney Stone
Assessment of Endogenous Oxalate Synthesis
This study aims to determine the daily rate of endogenous synthesis of oxalate using carbon 13 oxalate isotope tracer technique and a low-oxalate controlled diet.
- Conditions
- Healthy, Kidney Stone, Obesity
- Trial name
- NCT05229952
- Testing
- Low-oxalate controlled diet, Primed, continuous intravenous infusion of 13C2-oxalate
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Hyperoxaluria
A Novel Approach for Reducing Hyperoxaluria and Kidney Stone Risk.
This pilot study is proposing a novel approach to directly target intestinal oxalate absorption with the drug Tenapanor, which was recently FDA-approved for treating hyperphosphatemia in patients with chronic kidney disease.
- Trial name
- NCT06481150
- Testing
- Tenapanor
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Kidney Calculi, Urologic Diseases
Tranexamic Acid to Improve Same-day Discharge Rates After Holmium Laser Enucleation of the Prostate (HoLEP)
This study is designed to assess if there is a significant difference in same day discharge rates after Holmium Laser Enucleation of the Prostate (HoLEP).
- Conditions
- Kidney Calculi, Urologic Diseases, Benign Prostatic Hypertrophy
- Trial name
- NCT05082142
- Testing
- Tranexamic acid
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Northwestern University
Kidney Stones
Feasibility and Impact of a Decision Rule for Imaging of Emergency Department Patients With Suspected Kidney Stone
This is the third phase (feasibility and impact) of a three-phase project designed to derive, validate and test the feasibility and impact of implementing clinical decision support to safely limit the use of Computerized…
- Trial name
- NCT01869647
- Testing
- Ultra low dose CT scan, Regular CT or Low Dose CT scan, No imaging
- Where
- United States
- Volunteers
- 264 people
- Sponsor
- Yale University
Renal Stone
High Versus Low Power Settings During Ureteroscopic Laser Lithotripsy
The primary aim of the study is to compare the operative times following ureteroscopic lithotripsy for renal stones with Thulium Fiber Laser using low and high power settings.
- Trial name
- NCT05697250
- Testing
- Laser power settings (Thulium Fiber Laser)
- Where
- Norway
- Volunteers
- 150 people
- Sponsor
- Haukeland University Hospital
Renal Stone, Ureteral Stone
Better Lithotripsy and Ureteroscopy Evaluation of Stenting (BLUES)
This multi-center trial is being completed to compare patient outcomes related to the Imajin silicone stent in comparison to non-silicone polyurethane stents after ureteroscopy.
- Trial name
- BLUES (NCT05026710)
- Testing
- Silicone (Coloplast Imajin Hydro) ureteral stent, Non-silicone (Polyurethane/Percuflex) ureteral stent (any manufacturer)
- Where
- 10 sites in United States
- Volunteers
- 224 people
- Sponsor
- University of Michigan
Urinary Tract Stone
Moses vs. Thulium Laser Study
The incidence of urinary tract stone disease is increasing. According to the National Health and Nutrition Examination Survey, as of 2012, 10.6% of men and 7.1% of women in the United States are affected by renal stone disease.
- Trial name
- NCT04963062
- Testing
- Holmium laser with Moses lasers, Holmium laser with thulium lasers
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- University of Wisconsin, Madison
Urinary Lithiasis, Kidney Diseases
Toradol to Reduce Ureteroscopic Symptoms Trial
Double blinded randomized controlled clinical trial to assess the impact of intraoperative Toradol on post-operative pain scores for patients undergoing ureteroscopy for urinary stone management.
- Conditions
- Urinary Lithiasis, Kidney Diseases, Kidney Stone, Pain, Postoperative
- Trial name
- TRUST (NCT03111381)
- Testing
- Toradol
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Yale University
Flank Pain, Urinary Bladder, Overactive
Therapeutic Merit of Solifenacin in the Mitigation of Ureteral Stent-induced Pain and Lower Urinary Tract Symptoms
Most ureteral stent insertions follow ureteroscopy procedures for stone management. Stents are essentially designed to prevent the blockage of the ureter.
- Trial name
- NCT01381120
- Testing
- Solifenacin succinate treatment, Oxycodone and acetaminophen combination treatment
- Where
- Canada
- Volunteers
- 84 people
- Sponsor
- Barrie Urology Associates
Urinary Stones
Prevention of Urinary Stones With Hydration
A randomized clinical trial to investigate the impact of increased fluid intake and increased urine output on the recurrence rate of urinary stone disease (USD) in adults and children.
- Trial name
- PUSH (NCT03244189)
- Testing
- Fluid prescription, Financial incentive, Structured Problem Solving
- Where
- 8 sites in United States
- Volunteers
- 1,658 people
- Sponsor
- Duke University
Postoperative Pain Management, Urolithiasis
The Use of Intranasal Ketoralac for Pain Management (Sprix)
Despite an overall reduction in the perioperative complication rate, post operative pain management after ureteroscopic removal of stones (URS) remains a major factor delaying discharge of patients.
- Trial name
- NCT01736358
- Testing
- Intranasal Ketoralac
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Montefiore Medical Center
Urolithiasis
Study of Tomography of Nephrolithiasis Evaluation
This is a multi-center, randomized controlled trial of ultrasonography (ultrasound) compared to computed tomography (CT) for the initial emergency room evaluation of patients with suspected renal colic.
- Trial name
- STONE (NCT01451931)
- Testing
- Point-of-care Ultrasound, Radiology Ultrasound, Radiology CT
- Where
- 15 sites in United States
- Volunteers
- 2,776 people
- Sponsor
- University of California, San Francisco
Kidney Calculi
Initial Clinical Experience With the MONARCH Platform, Urology for the Treatment of Kidney Stones
The purpose of this study is to collect descriptive performance data using the MONARCH Platform, Urology (a novel robotic device) to perform mini-percutaneous nephrolithotomy (kidney stone removal) procedures.
- Trial name
- NCT05835323
- Testing
- Robotic-assisted mini-PCNL
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Auris Health, Inc.
Kidney Calculi
Stone Access and Removal (STAR) Study
The purpose of the study is to assess procedural completion, the post-operative stone clearance and the safety profile following robotic mini-Percutaneous Nephrolithotomy (PCNL) performed with the MONARCH Platform, Urology.
- Trial name
- STAR (NCT06330701)
- Testing
- Robotic-assisted mini-PCNL
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Auris Health, Inc.
Kidney Stones
Clinical Evaluation of BackStop in Patients Undergoing Ureteroscopic Lithotripsy
The purpose of this clinical study is to evaluate BackStop, a polymer-based device that is intended to be used during ureteroscopic lithotripsy to prevent retrograde stone migration.
- Trial name
- NCT02122341
- Testing
- BackStop
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- University of Southern California
Hyperuricosuria, Kidney Stones
Febuxostat Versus Allopurinol or Placebo in Patients With Hyperuricosuria and Calcium Oxalate Stones
The purpose of this study is to determine the efficacy of febuxostat, once daily (QD), compared to allopurinol or placebo in patients with excessive amounts of uric acid in their urine and who have recently had kidney stones.
- Trial name
- NCT01077284
- Testing
- Febuxostat, Allopurinol
- Where
- 28 sites in United States
- Volunteers
- 99 people
- Sponsor
- Takeda
Stone Ureter, Stone;Renal
Clinical Trial Evaluating the Efficiency of Holmium Laser Settings on Urinary Stones
The primary objective of this study is to compare the time to acceptable stone fragmentation during clinical use of the holmium laser when using energy settings 0.2J vs 0.8J.
- Conditions
- Stone Ureter, Stone;Renal, Surgery
- Trial name
- NCT03526458
- Testing
- Holmium:YAG laser
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Wisconsin, Madison