Clinical trials: Stiffness
Arterial Stiffness, Autonomic Nervous System
Effects of Active Stretching on Cardiovascular Response and Arterial Stiffness in Older Adults With Low Flexibility
A study of the effects of active static stretching exercise in elderly people with poor lower extremity muscle flexibility on autonomic and cardiovascular responses and balance ability.
- Conditions
- Arterial Stiffness, Autonomic Nervous System, Musculoskeletal Diseases, Range of Motion
- Trial name
- stretching (NCT06944886)
- Testing
- Active Static Stretching Exercise Combined with Breathing Exercise (Experimental Group)
- Where
- Thailand
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Phayao
Vascular Stiffness, Endothelial Dysfunction
Targeting Inflammation to Treat Cardiovascular Aging
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the United States with older age being a primary risk factor.
- Conditions
- Vascular Stiffness, Endothelial Dysfunction, Diastolic Dysfunction
- Trial name
- TIVA (NCT01775865)
- Testing
- Salsalate
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Gary L. Pierce
Arterial Stiffness
Response To Cardiac Resynchronization Therapy In Heart Failure: Role Of Arterial Stiffness
To determine if arterial stiffness as measured by non-invasive pulse wave velocity can predict the response to resynchronization therapy in heart failure.
- Trial name
- NCT00970476
- Volunteers
- healthy volunteers welcome
- Sponsor
- Creighton University
Cervix; Pregnancy, Cervical Stiffness
Pregnolia System Intra-observer Variability
The Pregnolia System is a CE-marked medical device assessing the mechanical stiffness of cervical tissue in women. The Pregnolia Probe has been engineered to minimize the influence of differences in handling and technique by the…
- Trial name
- NCT05200117
- Testing
- Pregnolia System
- Where
- Switzerland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Pregnolia AG
Exercise-induced Muscle Soreness, Exercise-induced Joint Pain
Effects of Eggshell Membrane and Curcumin Extract Supplementation, Separately or Combined, on Recovery From Intense Exercise
Eggshell membrane and Curcumin supplementation prior to intense exercise may reduce inflammation, muscle and joint pain, and promote recovery.
- Conditions
- Exercise-induced Muscle Soreness, Exercise-induced Joint Pain, Exercise-induced Joint Stiffness, Exercise-induced Cartilage Turnover
- Trial name
- NCT07766720
- Testing
- NEM® brand eggshell membrane powder, curQ+® brand highly absorbable curcumin, NEM® plus curQ+® combination
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- ESM Technologies, LLC
Chronic Kidney Disease, Pediatric
The Cardiovascular Comorbidity in Children With Chronic Kidney Disease Study
Children and adolescents with chronic kidney disease (CKD) are at high risk for cardiovascular (CV) morbidity and mortality. Recent studies suggest that pediatric patients with even moderately impaired kidney function may be…
- Conditions
- Chronic Kidney Disease, Pediatric, Cardiovascular Disease
- Trial name
- 4C (NCT01046448)
- Where
- 50 sites in Austria, Belgium and 13 more
- Volunteers
- 650 people
- Sponsor
- Heidelberg University
Vascular Stiffness, Obesity
Early Vascular Ageing Among Cypriots
The LifeEVA project aims to tackle the significant public health challenge of cardiovascular disease (CVD) by addressing early vascular ageing (EVA), characterized by increased arterial stiffness and reduced vascular compliance…
- Trial name
- LifeEVA (NCT06601491)
- Testing
- Lifestyle Intervention
- Where
- Cyprus
- Volunteers
- 352 people, healthy volunteers welcome
- Sponsor
- University of Cyprus
Achilles Tendinopathy
"NSAIDs in Acute Achilles Tendinopathy: Effect on Pain Control, Leg Stiffness and Functional Recovery in Athletes"
The purpose of this study is to evaluate etoricoxib efficacy in pain control, leg stiffness and functional recovery of patients suffering acute Achilles tendinopathy.
- Trial name
- NCT00792376
- Testing
- etoricoxib, diclofenac
- Where
- Argentina
- Volunteers
- 56 people
- Sponsor
- Argentine Tennis Association
Joint Pain, Stiffness, Function
Instaflex and Joint Pain in Community Adults
The primary purpose of this study is to assess the effect of 8-weeks ingestion of the Instaflex Joint Support supplement (Direct Digital, Charlotte, NC) compared to placebo on joint pain, stiffness, and function (questionnaires…
- Trial name
- NCT01956500
- Testing
- Instaflex
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Adaptation, Lumbar Stiffness
'Lumbar Stiffness Disability Index' Turkish Adaptation
Despite advancements in assessment and treatment methods, diagnosing and treating lower back pain remains challenging for researchers and clinicians.
- Trial name
- NCT06184776
- Testing
- Lumbar Stiffness Disability Index
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Istanbul Bilgi University
Diabetes Mellitus, Type 2, Metabolic Syndrome X
Effects of Cilostazol on Plasma Adipocytokine and Arterial Stiffness
Cilostazol is an antiplatelet agent used to reduce the symptoms of intermittent claudication. Cilostazol inhibits phosphodiesterase III (PDE III), which causes it to be a vasodilator and inhibitor of platelet aggregation.
- Trial name
- NCT00573950
- Testing
- cilostazol
- Where
- South Korea
- Volunteers
- 48 people
- Sponsor
- Korea University Anam Hospital
Cystic Fibrosis
Blood Flow and Vascular Function in Cystic Fibrosis
Cystic fibrosis (CF) has many health consequences. A reduction in the ability to perform exercise in patients with CF is related to greater death rates, steeper decline in lung function, and more frequent lung infections.
- Trial name
- CF-FLOW (NCT02057458)
- Testing
- Sildenafil (Acute-1 hour), Sildenafil (Subchronic-4 weeks)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Augusta University
Obesity, Adolescent
The Effects of a Combined Exercise Training Program on Vascular Health and Metabolic Profile in Obese Adolescent Girls.
The purpose of this study was to examine the impact of 12 weeks of combined exercise training (CET) on arterial stiffness, endothelial function, inflammatory markers, insulin resistance, and body composition in obese adolescent…
- Trial name
- NCT03146026
- Testing
- Combined Exercise Training
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pusan National University
Hypertension and Cardiovascular Risk Factors
Knowledge of Vascular Age Contributes to Improve the Collaboration Between Community Pharmacies and Primary Health Care Physicians in Reducing Blood Pressure in Hypertensive Patients.
Cardiovascular diseases are the main cause of death worldwide and elevated blood pressure (BP), called hypertension (HTN), is the principal and most frequent factor for suffering cardiovascular diseases.
- Trial name
- TOGETHER (NCT06761235)
- Testing
- Standard BP intervention, EVA intervention
- Where
- 6 sites in Austria, Portugal and 1 more
- Volunteers
- 1,246 people
- Sponsor
- Enrique Rodilla
Overactive Bladder Syndrome
Comparisons of the Effects of Solifenacin Versus Mirabegron on Autonomic System, Arterial Stiffness and Psychosomatic Distress and Clinical Outcomes
Background/Purpose: The overactive bladder syndrome (OAB) affects around 17 % of female population. Antimuscarinics can affect autonomic system, arterial stiffness and psychosomatic distress.
- Trial name
- NCT02540707
- Testing
- solifenacin, mirabegron
- Where
- Taiwan
- Volunteers
- 113 people
- Sponsor
- National Taiwan University Hospital
Portal Hypertension
Ultrasound Elastography Assessment of Spleen and Liver Stiffness Before and After Transjugular Intrahepatic Portosystemic Shunt (TIPS) Procedure
The primary purpose of this project is to determine if acute monitoring of shunt patency via ultrasound elastography measurements of splenic stiffness before and after TIPS placement results in reduced morbidity and mortality…
- Trial name
- NCT03427164
- Testing
- Transjugular Intrahepatic Portosystemic Shunt
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Kansas Medical Center
Mitral Stenosis
Assessment of Exercise Capacity, Muscle Oxygenation and Aortic Stiffness in Patients With Mitral Stenosis
Heart valve diseases are the most common cause of mortality and morbidity after coronary artery disease, hypertension, and heart failure.
- Trial name
- NCT07394998
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Gazi University
Spleen; Fibrosis
Optimization of Spleen VCTE Examinations with FibroScan
This is an European, prospective, interventional, and multicenter clinical investigation which main objective is to develop a spleen examination dedicated to overweight or obese patients and assess its applicability.
- Trial name
- NCT05122416
- Testing
- FibroScan examination (S), FibroScan examination (M), FibroScan examination (XL)
- Where
- 4 sites in Netherlands, Romania and 1 more
- Volunteers
- 433 people
- Sponsor
- Echosens
Office Workers
Flexibility Exercises, Created by AI and Humans, on Office Workers' Flexibility, Back-health and Muscle-stiffness.
While the benefits of flexibility exercises for office workers are well known, there is no randomized controlled comparison to determine whether these exercises can be delivered more effectively and safely by a specialist or by…
- Trial name
- NCT07242287
- Testing
- AI-created exercise, Human-created exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Erzurum Technical University
Lv Hypertrophy, Heart Failure, Diastolic
Prevention of Cardiovascular Stiffening With Aging and Hypertensive Heart Disease
The purpose of this study is to determine whether vigorous exercise training 4-5 days/week for one year in sedentary middle aged (ages 40-64) individuals at high risk for future development of heart failure will improve cardiac…
- Conditions
- Lv Hypertrophy, Heart Failure, Diastolic, Stiffness, Vascular
- Trial name
- LVH (NCT03476785)
- Testing
- High intensity exercise, Yoga
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center