Clinical trials: Stiffness
Healthy Adolescents
Activity Breaks for Brain Health in Adolescents
The main aim for this study is to investigate to what extent physical activity of moderate or low intensity, relative to prolonged inactivity, may acutely alter neural activity-related prefrontal cortex oxygenated hemoglobin…
- Trial name
- ABBaH teens (NCT04552626)
- Testing
- Prolonged sitting (social breaks), Prolonged sitting with step-up exercise break, Prolonged sitting with simple resistance activity breaks
- Where
- Sweden
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- The Swedish School of Sport and Health Sciences
Vascular Stiffness
Effects of Fruit Consumption on Risk Factors of Chronic Disease
Acute, randomized, placebo controlled, double blind, postprandial crossover study in male subjects. 4 intervention arms consisting of control, orange juice, whole orange, and processed whole orange to determine the effect of the…
- Trial name
- NCT01963416
- Testing
- macro- and micro-nutrient matched control (240 ml), Orange juice, whole orange fruit
- Where
- United Kingdom
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Reading
Cystic Fibrosis
Blood Flow and Vascular Function in Cystic Fibrosis
Cystic fibrosis (CF) has many health consequences. A reduction in the ability to perform exercise in patients with CF is related to greater death rates, steeper decline in lung function, and more frequent lung infections.
- Trial name
- CF-FLOW (NCT02057458)
- Testing
- Sildenafil (Acute-1 hour), Sildenafil (Subchronic-4 weeks)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Augusta University
Facial Yoga, Facial Exercises
Effect of Face Yoga on Mimic Muscles
This study aimed to investigate the effect of facial yoga on tonus, stiffness and elasticity of facial muscles.
- Trial name
- NCT06765408
- Testing
- facial yoga exercise program
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bandırma Onyedi Eylül University
Knee Osteoarthritis
The Effect of "Laying on of Hands" in Older Women With Knee Osteoarthritis
Osteoarthritis (OA) is the most common form of chronic degenerative joint disease, as well as the main cause of pain and disability in older persons worldwide.
- Trial name
- NCT02917356
- Testing
- Spiritual laying on of hands (SP), Non-spiritual Laying on of Hands, Control group
- Where
- Brazil
- Volunteers
- 105 people
- Sponsor
- Federal University of Juiz de Fora
Kidney Transplantation for More Than One Year, Patients with a Kidney Transplantation on Cyclosporine
The Effect of Eplerenone on the Evolution of Vasculopathy in Renal Transplant Patients.
Cardiovascular (CV) pathologies are the leading cause of death in kidney transplant patients.Arterial stiffness is a prognostic factor for CV mortality in kidney transplantation.
- Trial name
- EVATRAN (NCT04450953)
- Testing
- Eplerenone 50mg/day (cross over design), Period without eplerenone (cross over design)
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Central Hospital, Nancy, France
Fibromyalgia
Safety and Efficacy Study of Xyrem® (Sodium Oxybate) in Subjects With Fibromyalgia.
The objective of this trial is to evaluate the safety and efficacy of Xyrem® in long term use.
- Trial name
- NCT00423605
- Testing
- Xyrem®
- Where
- 91 sites in United States, France and 5 more
- Volunteers
- 560 people
- Sponsor
- Jazz Pharmaceuticals
Asymmetric Limb Muscle Stiffness, Recovery, Psychological
Virtual Reality Asymmetric Training of Technology And Tactics for Professional Basketball Players
This study exploring the effects of virtual reality basketball asymmetric training on the technical and tactical ability of professional basketball players (male and female) through the use of virtual reality devices.
- Conditions
- Asymmetric Limb Muscle Stiffness, Recovery, Psychological, Body Schema
- Trial name
- NCT06544239
- Testing
- Virtual reality basketball asymmetric training, Traditional basketball asymmetric training
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
Healthy
Daily Intake of Cocoa Flavanols and Arterial Stiffness in Humans
A randomized, double-masked and cross-over dietary intervention study to investigate the effects of diet supplementation with cocoa flavanols on arterial stiffness in healthy adult human subjects.
- Trial name
- NCT03587883
- Testing
- Cocoa flavanols I, Control I, Cocoa flavanols II
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Breast Cancer Female
Impact of Pilates Method on Myofascial Stiffness, Cardiorespiratory Fitness and Quality of Life in Breast Cancer Women
The effectiveness of breast cancer treatment is quite well documented. Still, side effects can underpin other treatment-induced diseases such as osteopenia, diabetes, and especially cardiovascular dysfunction.
- Trial name
- NCT06419023
- Testing
- supervised physical activity intervention using the Pilates Method (exercises on the mat)
- Where
- Poland
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Chronic Hepatitis B Virus (HBV) Infection, Liver Fibrosis
Non-Invasive Model for Fibrosis Regression in HBV Patients
A total of 1000 chronic hepatitis B (CHB) patients with liver biopsy performed at least 1 year after antiviral therapy are retrospectively enrolled. All the patients received NAs treatment.
- Trial name
- NCT06874127
- Testing
- Nucleos(t)ide Analogs (NA)
- Where
- China
- Volunteers
- 1,100 people
- Sponsor
- Beijing Friendship Hospital
Preeclampsia, Hypertensive Disorder of Pregnancy
Multiparametric Assessment of Maternal Vascular Function in the Prediction of Hypertensive Disorders of Pregnancy
The present study is a single-centre prospective study that will enrol pregnant women during their first trimester of pregnancy (11+0 - 13+6 weeks of gestation).
- Trial name
- EDIPE (NCT05999851)
- Testing
- Arterial applanation tonometry, In vivo endothelial glycocalyx measurement, Serum markers of angiogenesis and endothelial dysfunction
- Where
- Italy
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Portal Hypertension, Liver Fibroses
Impact of Transjugular Intrahepatic Portosystemic Shunts on Liver Stiffness
Pilot study examining changes in liver stiffness measured by ultrasound before and after TIPS creation
- Trial name
- NCT03352882
- Testing
- Ultrasound
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Pennsylvania
Single Ventricle Heart Disease
Evaluation of Fontan-associated Hepatic Stiffness and the Efficacy of Udenafil in Reducing Liver Stiffness
A study to evaluate the efficacy of MZ101 therapy in reducing liver stiffness.
- Trial name
- FALD (NCT03430583)
- Testing
- Udenafil
- Where
- 17 sites in United States, Canada
- Volunteers
- 88 people
- Sponsor
- Mezzion Pharma Co. Ltd
Rare Diseases, Aortic Stiffness
Aortic Stiffness in Patients With Genetic Aortopathies
The goal of this observational study is to study arterial stiffness in patients with thoracic ascending aortic aneurysms (TAA), either syndromic or non-syndromic.
- Conditions
- Rare Diseases, Aortic Stiffness, Connective Tissue Defect
- Trial name
- PULSEWAVE (NCT05715203)
- Testing
- Pulsotonometry
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- IRCCS Policlinico S. Donato
Aortic Coarctation
Aortic Stiffness by CMR in Aortic Coarctation
This study investigates the correlation between medium-term systemic blood pressure control and aortic stiffness index in adults following coarctation stenting, using cardiac magnetic resonance (CMR) imaging.
- Trial name
- NCT06740461
- Volunteers
- 30 people
- Sponsor
- Assiut University
Achilles Tendon Rupture, Strength Training Adaptations
Effects of Strength Training on the Plantar Flexors' Properties After Achilles Tendon Rupture
Among the injuries that affect the Achilles tendon, rupture is one of the most frequent. This injury can generate functional, neuromuscular, and tendon deficits that can last for long periods or even be permanent.
- Conditions
- Achilles Tendon Rupture, Strength Training Adaptations, Neuromuscular Adaptations
- Trial name
- NCT06912269
- Testing
- Exercise
- Where
- Brazil
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Occupational Exposure
Effects of a 60-min Repeated Trunk Flexion Protocol on Trunk Neuromuscular Properties.
An interventional study on the effects of repeated trunk flexion exposure on trunk neuromuscular properties.
- Trial name
- NCT05511896
- Testing
- Repeated trunk flexion
- Where
- Slovenia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Primorska
Kidney Transplantation
Impact of Arterial Stiffness and Central Aortic Blood Pressure on Kidney Transplant Outcomes
People with CKD have higher prevalence of cardiovascular disease. The mechanism behind this increased risk is complex but there is strong evidence that changes in arterial stiffness play a central role.
- Trial name
- NCT02000869
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Louisiana State University Health Sciences Center Shreveport
Chronic Obstructive Pulmonary Disease, Endothelial Dysfunction
Micro-doses of Physical Activity for COPD
Chronic obstructive pulmonary disease (COPD) is a disease of the lungs that makes it hard for people to breath. Those with COPD spend considerably more time sitting and lying and less time performing physical activity than…
- Conditions
- Chronic Obstructive Pulmonary Disease, Endothelial Dysfunction, Vascular Stiffness, Hypertension
- Trial name
- COPD (NCT05553223)
- Testing
- Microdoses of activity
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia