Clinical trials: Sternotomy Pain
Pain, Postoperative, Opioid Use
Exparel vs. Marcaine ESP Block for Post-cardiac Surgical Pain
The goal of this pilot study is to describe and compare Ultrasound-Guided Erector Spinae Plane (ESP) Blocks using Exparel® (bupivacaine liposome injectable suspension) to Marcaine® (bupivacaine hydrochloride) for pain management…
- Conditions
- Pain, Postoperative, Opioid Use, Perioperative Complication, Heart Diseases
- Trial name
- NCT06077422
- Testing
- bupivacaine liposome injectable suspension, Bupivacaine Hydrochloride
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Rutgers, The State University of New Jersey
Cardiac Surgery, Postoperative Pain
Erector Spinae Plane (ESP) Block With 20 ml Versus 30 ml in Cardiac Surgery
Even though erector spinae plane (ESP) block is shown to be efficient in cardiac surgery, it is still controversial how much volume is necessary for efficient analgesic effect for sternotomy and drain tube pain relief.
- Trial name
- NCT04928521
- Testing
- bilateral erector spinae plane block with 30 mL 0.25 % bupivacaine, bilateral erector spinae plane block with 20 mL 0.25 % bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Ankara City Hospital Bilkent
Pain
A Study Comparing the Efficacy and Safety of Valdecoxib Plus Parecoxib Versus Valdecoxib Plus Placebo for the Treatment of Pain After Coronary Artery Bypass Surgery
The purpose of this study is to evaluate the efficacy and safety of parecoxib/valdecoxib therapy and placebo/valdecoxib therapy for the treatment of pain after coronary artery bypass surgery
- Trial name
- NCT00636064
- Testing
- Parecoxib Sodium/Valdecoxib
- Where
- 206 sites in United States, Argentina and 25 more
- Volunteers
- 1,671 people
- Sponsor
- Pfizer
Post Operative Pain
Intermittent Bolus vs Continuous Infusion Via ESP Catheters RCT
The purpose of this prospective randomized controlled trial is to compare the effectiveness of two different delivery methods for postoperative pain management following cardiac surgery requiring median sternotomy: intermittent…
- Trial name
- NCT05642416
- Testing
- Continuous Infusion of ropivacaine, Intermittent bolus of ropivacaine
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Henry Ford Health System
Postoperative Pain, Sternotomy
Preoperative Deep Parasternal Intercostal Plane Block and Intraoperative Opioid Use in Cardiac Surgery
Median sternotomy is commonly used in cardiac surgery and is associated with significant intraoperative and postoperative pain, often requiring substantial opioid administration.
- Conditions
- Postoperative Pain, Sternotomy, Opioid Consumption, Intraoperative Pain Control
- Trial name
- NCT07315308
- Testing
- Deep Parasternal Intercostal Plane Block, Standard Multimodal Analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Gaziantep City Hospital
Cardiac Surgery
Bilateral Erector Spinae Plane Block for Management of Acute Postoperative Pain After Pediatric Cardiac Surgeries Through a Midline Sternotomy
Many analgesic modalities have been investigated in pediatrics. The analgesic efficacy of bilateral ultrasound-guided erector spinae plane block in pediatric patients undergoing open midline sternotomy will be examined.
- Trial name
- NCT05142176
- Testing
- Erector spinae catheters insertion, Postoperative pain management
- Volunteers
- 75 people
- Sponsor
- Tanta University
Sternotomy Closure,Open Heart Surgery, Cardiac Surgery
Prediction of Chronic Pain in Cardiac Surgery: Evaluation by Algocartography Predict-ALGOCARTE
Sternotomy results in chronic postoperative pain in 30-55% of subjects. Few studies have been published on chronic pain in cardiac surgery, but there appears to be a relationship between the area of peri-scar hyperalgesia, which…
- Conditions
- Sternotomy Closure,Open Heart Surgery, Cardiac Surgery, Chronic Pain Post-Procedural
- Trial name
- Predict-ALGOCA (NCT06681272)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 84 people
- Sponsor
- Hospices Civils de Lyon
Chronic Pain, Sternotomy
Remifentanil vs Fentanyl During Cardiac Surgery and Chronic Thoracic Pain
This study will investigate the influence of intra-operative use of remifentanil versus fentanyl on the percentage of patients with chronic thoracic after cardiac surgery via sternotomy.
- Conditions
- Chronic Pain, Sternotomy, Remifentanil, Fentanyl
- Trial name
- REFLECT (NCT02031016)
- Testing
- Fentanyl, Remifentanil
- Where
- Netherlands
- Volunteers
- 126 people
- Sponsor
- St. Antonius Hospital
Cardiac Surgery Subjects
Objective Measurement of the Mechanical Pain Threshold With an Algometer for Predicting Intraoperative Opioid Consumption in Patients Who Will be Operate by Thoracotomy and Sternotomy in Cardiac Surgery
The study aims to test the relationship between the preoperative pain threshold and the intraoperative need for opioids. The objective of the study is to try to predict a patient's analgesic needs based on their objectively…
- Trial name
- NCT07513974
- Testing
- Measure of the minimal pain threshold with an algometer
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Université Libre de Bruxelles
Cardiac Surgery
A Phase II/III Study of Continuous Local Anesthetic Infusion in Median Sternotomy Following Cardiac Surgery
Cardiac surgery is associated with pain in the post-operative period. We plan to conduct a study of local anesthetic, ropivacaine, infusion into the sternal wound in adult patients undergoing cardiac surgery to see if it will be…
- Trial name
- NCT00586976
- Testing
- Ropivacaine, Normal saline
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Mayo Clinic
Bariatric Surgery, Cardiac Surgery With Sternotomy
Suzetrigine-enhanced MultimOdal Opioid-sparing THerapy in Cardiac and Bariatric SURGery
This is prospective, randomized study. The purpose of this study is to evaluate whether the addition of Suzetrigine to well established multimodal pain regimen for participants undergoing bariatric patients undergoing weight-loss…
- Conditions
- Bariatric Surgery, Cardiac Surgery With Sternotomy, Post-operative Pain
- Trial name
- SMOOTH-SURG (NCT07539623)
- Testing
- Suzetrigine
- Where
- United States
- Volunteers
- 235 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Postoperative Pain, Sternotomy
Comparison of the Efficacy of Combined Transversus Thoracic Plane Block and Serratus Anterior Plane Block Versus Erector Spinae Plane Block in the Management of Sternotomy Pain
Background and Purpose: Median sternotomy is the standard surgical approach for cardiac procedures, yet it is associated with significant postoperative pain.
- Conditions
- Postoperative Pain, Sternotomy, Nerve Block, Patient Outcome Assessment
- Trial name
- NCT07452627
- Testing
- TTP Block, ESP Block, SAP Block
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Uludag University
Pain, Postoperative
Gabapentin to Reduce Opioid Use Postoperatively (GROUP) in Children
The primary objective of this study is to determine if the peri and post operative use of gabapentin in children reduces the need for narcotics after thoracic surgery.
- Trial name
- NCT04724252
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, Davis
Postoperative Pain
Parasternal Block and TENS for Cardiac Surgery
the objective of the present study was to compare the efficacy of TENS and parasternal block with local anesthetic infiltration in relieving pain during the first 24 h period following median sternotomy.
- Trial name
- NCT02725229
- Testing
- parasternal block, TENS group, control group
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Antalya Training and Research Hospital
Postoperative;Pain Management
Effects of Serratus Posterior Superior Intercostal Plane Block and Pectoralis Nerve Block in Coronary Artery Surgery
Postoperative analgesia is a critical risk factor for the development of pulmonary and cardiovascular complications in all types of chest surgery, particularly coronary artery bypass graft (CABG) surgery.
- Trial name
- NCT06242431
- Testing
- Group serratus posterior superior intercostal plane block (SPSIPB), Group pectoralis nerve block (PECS-II)
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Hitit University
Anesthesia
PABLOS 2.0 - Chronic Pain After Sternotomy
The PABLOS study (NCT05345639) recently realised at the University Hospital of Angers looked at the place of loco-regional anesthesia (LRA) in the optimization of analgesia and the early post-operative recovery of patients…
- Trial name
- PABLOS2 (NCT06534775)
- Testing
- Questionnary
- Where
- France
- Volunteers
- 253 people
- Sponsor
- University Hospital, Angers
Pain, Postoperative
Gabapentin for Postoperative Pain Management After Cardiac Surgery With Median Sternotomy
In this study we will focus on the postoperative recovery. A successful postoperative recovery should bring the patient to at least to the pre-surgical level.
- Trial name
- NCT00572208
- Testing
- Gabapentin group
- Where
- 2 sites in Denmark
- Volunteers
- 64 people
- Sponsor
- Aarhus University Hospital
Postoperative Pain
PAIN - Postoperative Analgesia INvestigation
The purpose of this study is to assess the efficacy of the intraoperative injection of prolonged acting (liposomal) bupivacaine in postoperative pain control after truncal surgical incisions.
- Trial name
- PAIN (NCT02111746)
- Testing
- Exparel, Bupivacaine hydrochloride, Patient Controlled Analgesia (PCA)
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cardiac Surgery
Ropivacaine Though Laterosternal Catheters After Cardiac Surgery
This is a prospective double-blinded and randomised study involving patients undergoing cardiac surgery with median sternotomy, the effects on postoperative analgesia of a 48-hr continuous infusion of ropivacaine 2 mg.mL-1, at…
- Trial name
- NCT01196767
- Testing
- Ropivacaine (in one arm); catheterization (in both).
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Clermont-Ferrand
Postoperative Pain
Deep Parasternal Intercostal Plane (DPIP) Block
In this study, we aimed to compare the effects of this block, which is routinely applied in our hospital but has not been studied in our hospital or in the literature before, on the pain in the first 24 hours after the operation…
- Trial name
- NCT06558123
- Testing
- block
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istinye University