Clinical trials: Sternotomy
Cardiac Surgery
Ropivacaine Though Laterosternal Catheters After Cardiac Surgery
This is a prospective double-blinded and randomised study involving patients undergoing cardiac surgery with median sternotomy, the effects on postoperative analgesia of a 48-hr continuous infusion of ropivacaine 2 mg.mL-1, at…
- Trial name
- NCT01196767
- Testing
- Ropivacaine (in one arm); catheterization (in both).
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Clermont-Ferrand
Cardiac Disease, Surgery
Parasternal Block Combined With Rectus Sheath Block for Cardiac Surgery Under Sternotomy
The aim of this randomized controlled trial is to examine the effect of ultrasound guided bilateral Parasternal Nerve Block combined with rectus sheath block on preoperative analgesia, opioid consumption and respiratory function…
- Conditions
- Cardiac Disease, Surgery, Analgesia, Acute Pain
- Trial name
- PARARECTUS (NCT05764616)
- Testing
- PARASTERNAL BLOCK, LOCAL INFILTRATION OF DRAINAGE EXIT SITES, RECTUS SHEATH BLOCK
- Where
- Italy
- Volunteers
- 58 people
- Sponsor
- Campus Bio-Medico University
Postoperative Pain Management
Additive Regional Fascial Plain Blocks to Pectointercostal Fascial Block for Postoperative Pain Management After Cardiac Surgery: a Randomized Controlled Trial
Acute postoperative pain is severe in cardiac patients undergoing sternotomy, and pain intensity is more severe than expected. Many patients referred to tube insertion as the most painful site after coronary artery bypass…
- Trial name
- NCT06865404
- Testing
- PIFPB block, PIRSB Block, PIEOB block
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Alexandria University
Right Ventricular Dysfunction
TEE 3D RV Assessment for SAVR, Mini AVR, and TAVR
Three-dimensional echocardiography has become a gold standard to assess right ventricular (RV) function, and investigators plan to use 3D transesophageal echocardiography to assess RV function in 3 types of aortic valve…
- Trial name
- NCT05804240
- Testing
- 3D TEE RVEF
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Thomas Jefferson University
Cardiac Surgery, Post-operative Pain
Reduce Nonsteroidal Antiinflammatory Drugs Doses for Analgesia After Sternotomy
Currently, the management of pain after cardiac surgery is based on the concept of multimodal analgesia: Combined use of non-opioid analgesics associated with morphine intravenous analgesia by a system controlled by the patient…
- Trial name
- LoDoNSAID (NCT02180087)
- Testing
- Ketoprofen
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Clermont-Ferrand
Cardiac Surgery Requiring Cardiopulmonary Bypass and Median Sternotomy, Cardiopulmonary Bypass
Safety and Hemostatic Efficacy of Fibrin Sealant Vapor Heated, Solvent/Detergent Treated (FS VH S/D) Compared With Currently Licensed TISSEEL VH Fibrin Sealant in Subjects Undergoing Cardiac Surgery
The objective of this study is to demonstrate equivalent hemostatic efficacy and safety between FS VH S/D and TISSEEL VH fibrin sealant in subjects undergoing cardiac surgery requiring cardiopulmonary bypass.
- Conditions
- Cardiac Surgery Requiring Cardiopulmonary Bypass and Median Sternotomy, Cardiopulmonary Bypass, Sternotomy
- Trial name
- NCT00161733
- Testing
- Fibrin Sealant Vapor Heated Solvent/Detergent Treated (FS VH S/D), TISSEEL VH fibrin sealant
- Where
- 22 sites in United States
- Sponsor
- Baxter Healthcare Corporation
Sternotomy
SuperCable vs. Conventional Steel Wire for Closure After a Median Sternotomy
During certain heart surgeries, the sternum is opened and must then be closed securely. The study compares two closure methods - steel wires and SuperCable - in terms of stability, healing, and patient satisfaction.
- Trial name
- SURE (NCT07251881)
- Testing
- SuperCable®, Steel Wires
- Where
- Switzerland
- Volunteers
- 86 people
- Sponsor
- University of Zurich
Cardiac Surgical Procedures, Thoracic Surgical Procedures
Pulse Pressure Variation Measured During Valsalva Maneuver to Predict Fluid Responsiveness Under Open-chest Condition
Pulse pressure variation (PPV) is a well-known dynamic preload indicator to predict fluid responsiveness. However, its usefulness in open-chest conditions has been equivocal.
- Conditions
- Cardiac Surgical Procedures, Thoracic Surgical Procedures, Sternotomy
- Trial name
- NCT02457572
- Testing
- Valsalva maneuver, Fluid loading
- Where
- South Korea
- Volunteers
- 55 people
- Sponsor
- Samsung Medical Center
Complete Vertical Midline Sternotomy / Cardiac Surgery
Prevention of the Risk of Complete Sternotomy Scar Dehiscence in Cardiac Surgery: A Clinical Investigation Comparing Negative Pressure Wound Therapy (NPWT) vs. Standard Dressing
Mediastinitis is the most feared infectious complication after cardiac surgery. Several risk factors are known such as: obesity, diabetes, chronic obstructive pulmonary disease, double breast sampling, immunodeficiency…
- Trial name
- PRISTER (NCT06207630)
- Testing
- Dressing Device
- Where
- 5 sites in France
- Volunteers
- 660 people
- Sponsor
- Poitiers University Hospital
Heart Valve Surgery
Effect Of Bioelectric Therapy On Sternal Instability In Patients With Median Sternotomy After Heart Valve Surgery
The aim of this study is to investigate the effect of bioelectric therapy on sternal instability in patients with median sternotomy after heart valve surgery.
- Trial name
- SI (NCT04949581)
- Testing
- bioelectric therapy, cardiac rehabilitation program
- Volunteers
- 40 people
- Sponsor
- Cairo University
Coronary Artery Disease, Sternal Pain
Pecto-Intercostal Fascial Block for Postoperative Analgesia After Cardiac Surgery
The purpose of this study is to determine whether administration of a pecto-intercostal fascial plane block (PIFB) with bupivacaine is a more effective therapy for postoperative analgesia after cardiac surgery as compared to…
- Trial name
- NCT03482973
- Testing
- Bupivacaine Group
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Beth Israel Deaconess Medical Center
Sternotomy
Percutaneous Ketamine Versus Lidocaine for Mid-Sternotomy
Since midsternotomy is painful postoepratively, and since ketamine has been shown to be optimal postoeprative analgessic adjuvant, the investigators wish to assess its percutaneous preemptive effect, comparing it to lidocaine…
- Trial name
- NCT00822419
- Testing
- lidocaine, ketamine, non-drug cream
- Where
- Israel
- Volunteers
- 75 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Heart Surgery
Study of Diaphragm Mobility on Tissue Doppler
Diaphragm dysfunction is found in 10 to 90% of patients following heart surgery. In current practice diaphragm dysfunction is evaluated by 2D ultrasonography. Tissue Doppler is a validated technique to study heart contractility.
- Trial name
- DD (NCT03295344)
- Testing
- Diaphragm ultrasonography, Tissue Doppler
- Where
- France
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Complete Revascularization, Coronary Artery Bypass Grafting
Complete Revascularization Via Inferior Part-sternotomy
To verify the effectiveness and safety of minimally invasive coronary artery bypass grafting for complete revascularization of multivessel coronary artery disease via inferior part-sternotomy, We aim to randomize 260 patients…
- Conditions
- Complete Revascularization, Coronary Artery Bypass Grafting, Multivessel Coronary Artery Disease
- Trial name
- NCT05835167
- Testing
- Inferior part-sternotomy, Full median sternotomy
- Volunteers
- 260 people
- Sponsor
- China National Center for Cardiovascular Diseases
Sternotomy Closure,Open Heart Surgery
Comparison Between Interlocking Multi-twisted Wires and Eight Figure of Sternum Closure
Comparison between interlocking multi-twisted wires and Eight figure of sternum closure post open heart surgery in egptian patients
- Trial name
- NCT03343990
- Testing
- Interlocking multi-twisted wires in sternal closure, Eight Figure techniqe in sternal closure
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Keloids, Hypertrophic Scars
Effect of Pulse Width on Scar Treatment Using a 595-nm Pulsed Dye Laser
To investigate the effect of pulse width on the treatment response of keloidal and hypertrophic sternotomy scars to a 595-nm pulsed dye laser
- Trial name
- NCT00142441
- Testing
- Pulsed dye laser
- Where
- Thailand
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Cardiac Valve Disease, Aortic Valve Disease
The Effects of 360-degree Virtual Reality on Pre-procedural Anxiety in Patients Awaiting Elective Cardiac Surgery Involving a Sternotomy
Rationale: Patients awaiting cardiac surgery can experience pre-procedural anxiety. This anxiety is associated with increased analgesic needs, increased risk of mortality and prolonged recovery time.
- Conditions
- Cardiac Valve Disease, Aortic Valve Disease, Mitral Valve Disease, Tricuspid Valve Disease
- Trial name
- NCT06001489
- Testing
- 360-degree Virtual Reality Patient Tour, State Trait Anxiety Inventory, Amsterdam Preoperative Anxiety and Information Scale
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Coronary Artery Bypass Grafting or Heart Valve Surgery Via Median Sternotomy
Transversus Thoracis Muscle Plane Block Plus Rectus Sheath Block in the Perioperative Pain Management of Cardiac Surgery
An emerging regional block technique, transverse thoracic muscle block covers the T2-T6 intercostal nerves and can effectively relieve perioperative pain during median sternotomy.
- Trial name
- NCT04838132
- Testing
- Bilateral transversus thoracis muscle plane and rectus sheath block with ropivacaine, Bilateral transversus thoracis muscle plane and rectus sheath puncture with saline
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Guangzhou First People's Hospital
Bariatric Surgery, Cardiac Surgery With Sternotomy
Suzetrigine-enhanced MultimOdal Opioid-sparing THerapy in Cardiac and Bariatric SURGery
This is prospective, randomized study. The purpose of this study is to evaluate whether the addition of Suzetrigine to well established multimodal pain regimen for participants undergoing bariatric patients undergoing weight-loss…
- Conditions
- Bariatric Surgery, Cardiac Surgery With Sternotomy, Post-operative Pain
- Trial name
- SMOOTH-SURG (NCT07539623)
- Testing
- Suzetrigine
- Where
- United States
- Volunteers
- 235 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cardiac Surgery
Efficacy of Ultrasound Guided PIFB Versus Lidocaine Infusion on Postoperative Pain After Sternotomy
Chronic pain is a common complication after cardiothoracic surgery. The prevalence of post-sternoyomy pain syndrome (PSPS) ranges from 33% to 91%.
- Trial name
- NCT05885230
- Testing
- pecto intercostal fascial block using bupivacaine 0.25%, lidocaine infusion
- Where
- Egypt
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University