Clinical trials: Spontaneous Breathing Trial
Mechanical Ventilation, Mechanical Ventilator Weaning
Diaphragmatic Ultrasound Associated With RSBI Predict Weaning Issue: the Rapid Shallow Diaphragmatic Index (RSDI)
The Rapid Shallow Breathing Index (RSBI) is the ratio between respiratory rate (RR) and tidal volume (VT). It is routinely used to predict mechanical ventilation weaning outcome in ICU patients.
- Conditions
- Mechanical Ventilation, Mechanical Ventilator Weaning, Extubation, Diaphragm Ultrasound
- Trial name
- CODEX (NCT03479047)
- Testing
- assess diaphragmatic displacement (DD) using ultrasonography
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Critically Ill Adult Patients With Difficult Weaning
Pressure Support and Positive End Expiratory Pressure During Spontaneous Breathing Trial
The aim of this study is to assess if a bundle associating pressure support and positive end-expiratory pressure during spontaneous breathing trial and detection by T-piece of patients with high-risk of extubation failure can…
- Trial name
- SBT-ICU (NCT03861117)
- Testing
- Assisted strategy, Non assisted strategy
- Where
- France
- Volunteers
- 98 people
- Sponsor
- Hospices Civils de Lyon
Heart Transplant
Non-Intubated Anesthesia for Adult Heart Transplantation
This prospective, multicenter, randomized controlled trial aims to evaluate whether non-intubated spontaneous ventilation anesthesia (NISVA) supported by a supraglottic airway can reduce cardiopulmonary complications and promote…
- Trial name
- NISVA-HTx (NCT07758894)
- Testing
- Non-Intubated Spontaneous Ventilation Anesthesia, Conventional Anesthesia, Standardized Perioperative Anesthetic and Analgesic Medication Regimen
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Chronic Obstructive Pulmonary Disease
Efficacy of Helium/Oxygen Compared to Air/Oxygen in Severe Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)
The primary objective of the study is to evaluate the efficacy of Helium/Oxygen (He/O2) 78%/22% compared to a conventional Air/O2 mixture in reducing endotracheal intubation rate and mortality in patients with severe hypercapnic…
- Trial name
- ECHO/ICU (NCT01155310)
- Testing
- Helium/Oxygen 78%/22%, Air/Oxygen
- Where
- 16 sites in Belgium, France and 4 more
- Volunteers
- 446 people
- Sponsor
- Air Liquide Santé International
Critical Illness, Intensive Care Units (ICUs)
Surface Electrical Myography, Oxygen Consumption, Effort, and Weaning in the Mechanically Ventilated Patient in the Intensive Care Unit
The goal of this observational study is to measure effort using esophageal pressure measurements, oxygen consumption and diaphragm activity in mechanically ventilated Intensive Care Unit patients during a Spontaneous Breathing…
- Conditions
- Critical Illness, Intensive Care Units (ICUs), Weaning Failure, Mechanical Ventilation
- Trial name
- SERA-Effort (NCT07109570)
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Leiden University Medical Center
TAVI
PRELOAD-TAVI Trial
The aim is to assess the response of cardiac output and stroke volume to volume preload optimization in patients with severe aortic stenosis treated with aortic prosthesis implantation.
- Trial name
- PRELOAD-TAVI (NCT05914051)
- Testing
- Colloid preload
- Volunteers
- 50 people
- Sponsor
- Fundación de investigación HM
Spontaneous Breathing Trial in ICU, Spontaneous Breathing Trial
Effectiveness of Pet-Robotic Intervention in Intensive Care Unit Patients
This study aims to develop a novel nursing intervention involving robotic pet companionship to reduce anxiety in patients undergoing spontaneous breathing trials.
- Trial name
- NCT07163247
- Testing
- Robotic pet (PARO) companionship
- Where
- Taiwan
- Volunteers
- 24 people
- Sponsor
- National Taiwan University Hospital
Mechanical Ventilation, Weaning
Automated Ventilator Controlled Weaning vs Daily Spontaneous Breathing Trial in Difficult to Wean ICU Patients
This study will compare Drager Smart Care (SC), a commercially available automated ventilator controlled weaning mode to the current daily spontaneous breathing trial (SBT) weaning protocol.
- Trial name
- NCT00813839
- Testing
- daily weaning trails
- Where
- United States
- Sponsor
- University of California, San Francisco
Relationship Between Dyspnea and Ventilatory Variability
Respiratory Variability and Dyspnea During Spontaneous Breathing Trial
In intensive care unit, dyspnea, the distressing and fearful awareness of breathing, is frequent and harmful. To be treated, dyspnea must be detected and quantified, which is impossible in approximately 50% of patients receiving…
- Trial name
- DYSREVA (NCT05762614)
- Testing
- Dyspnea assessment
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Respiratory Failure
Intra-abdominal Pressures During the Spontaneous Breathing Trial
Increased intra-abdominal pressure (IAP) affects pulmonary dynamics. However, little is studied whether pulmonary dynamics affects IAP. We hypothesize that the change of IAP can also reflect the change of pulmonary dynamics.
- Trial name
- IAP_SBT (NCT01797614)
- Where
- 2 sites in Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Chronic Respiratory Failure
Impact of Respiratory Muscle Unloading on Respiratory Muscle Endurance
This study investigates how different degrees of muscular unloading during mechanical ventilation impact endurance of succeeding spontaneous breathing trials
- Trial name
- NCT00415896
- Testing
- positive pressure ventilation
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Krankenhaus Kloster Grafschaft
Respiratory Insufficiency
Prediction of Outcome of Weaning From Mechanical Ventilation Using the Electrical Activity of the Diaphragm
Several types of spontaneous breathing trials (SBTs) have been proposed to evaluate when a patient is ready to be weaned from the ventilator based on breathing pattern measurements.
- Trial name
- OWED (NCT02539732)
- Where
- 3 sites in Canada, France and 1 more
- Volunteers
- 110 people
- Sponsor
- Unity Health Toronto
Acute Respiratory Insufficiency
Ventilation Strategies During Spontaneous Breathing Trial
Patients who are intubated and mechanically ventilated for acute respiratory failure in the Intensive Care Unit (ICU) are at some point eligible for weaning.
- Trial name
- WEANING (NCT02939963)
- Testing
- ATC then pressure support 7 cm H2O PEP 4 cm H2O, Pressure support 7 cm H2O PEP 4 cm H2O then ATC
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
Coronavirus Infections, Pneumonia, Viral
Nitric Oxide Gas Inhalation Therapy for Mild/Moderate COVID19 Infection
The scientific community is in search for novel therapies that can help to face the ongoing epidemics of novel Coronavirus (COVID-19) originated in China in December 2019.
- Conditions
- Coronavirus Infections, Pneumonia, Viral, Dyspnea
- Trial name
- NoCovid (NCT04290858)
- Testing
- Nitric Oxide
- Sponsor
- Xijing Hospital
Coronavirus Infections, Pneumonia, Viral
Nitric Oxide Gas Inhalation Therapy for Mild/Moderate COVID-19
The scientific community is in search for novel therapies that can help to face the ongoing epidemics of novel Coronavirus (SARS-Cov-2) originated in China in December 2019.
- Conditions
- Coronavirus Infections, Pneumonia, Viral, Acute Respiratory Distress Syndrome
- Trial name
- NoCovid (NCT04305457)
- Testing
- Nitric Oxide
- Where
- 2 sites in United States
- Volunteers
- 62 people
- Sponsor
- Massachusetts General Hospital
Acute Respiratory Failure, Ventilator Weaning Assessment
Electrical Impedance Tomography-derived Flow Index During Spontaneous Breathing Trial Stratifies the Risk of Reintubation Within 48 h After Extubation
Accurate prediction of readiness to liberate patients from mechanical ventilation remains challenging. Conventional indices such as the rapid shallow breathing index (RSBI) and maximal inspiratory pressure (MIP) often miss early…
- Trial name
- EIT-FI Weaning (NCT06876792)
- Testing
- electrical impedance tomography
- Where
- 3 sites in China
- Volunteers
- 150 people
- Sponsor
- Ruijin Hospital