Clinical trials: Split-mouth Design
Tooth, Impacted
Comparison Between the Lingually Based and the Buccally Based Triangular Flap Design in the Surgical Removal of Impacted Mandibular Third Molars
The primary objective of this study was to compare between the lingually based triangular flap with the buccally based triangular flap in the surgical removal of impacted mandibular third molars.
- Trial name
- NCT04192864
- Testing
- Lingually based triangular flap, Buccally based triangular flap
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Nourhan M.Aly
Periodontal Bone Loss
Evaluation of Peri Implant Bone Loss of Immediately Versus Conventionally Loaded Implants With a Single Prosthesis
The main objective of this prospective, controlled, and randomized clinical study is to evaluate the peri-implant bone loss of immediately loaded versus conventionally loaded implants with a single prosthesis.
- Trial name
- Mpigozzo (NCT02416700)
- Testing
- immediate implant surgery, implant surgery (Straumann®)
- Where
- Brazil
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Mônica Nogueira Pigozzo
Patient Comfort, Malocclusion
Comparison of Patient-Reported Comfort Between Two Clear Aligner Trimming-Line Designs: A Split-Mouth Study
The trimming-line design of clear aligners (supragingival versus juxtagingival) is a routine clinical decision whose influence on patient-reported comfort has not been established; available evidence on aligner comfort derives…
- Conditions
- Patient Comfort, Malocclusion, Oral Health
- Trial name
- COMFORT-ALIGN (NCT07660809)
- Testing
- Supragingival trimming-line design, Juxtagingival festooned trimming-line design
- Where
- Romania
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures
Implant Osteotomy
Implant Site Preparation With Piezosurgery vs Conventional Drills in Terms of Operation Time, Implant Stability and Bone Density
The preparation of the implant site has a major influence on the success rate and long-term survival of dental implants. Piezoelectric devices and special implant drilling inserts are now emerging to replace conventional drills.
- Trial name
- NCT05512273
- Testing
- Piezosurgery assisted osteotomy, Conventional drilling osteotomy
- Where
- Lebanon
- Volunteers
- 24 people
- Sponsor
- Hams Hamed Abdelrahman
Crestal Bone Loss
Clinical and Radiographic Evaluation of Crestal Bone Loss Around Implant With or Without Platform Switching Design
Implants have become the preferred method of single tooth replacement these days, patients receiving implant treatments not only expect restoration of masticatory function, they also expect that the prostheses will be…
- Trial name
- PS (NCT02761226)
- Testing
- Platform Matched Design (Group A), Platform Switching Design (Group B)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cairo University
Morbidity, Third Molars Extraction
Betamethasone and Complications of Lower Third Molar Surgery
Pain, swelling, and trismus are common sequalae of surgical removal of impacted third molars. The aim of this study is to evaluate effect of local administration of betamethasone, into the pterygomandibular space, on these…
- Conditions
- Morbidity, Third Molars Extraction, Steroid Injection
- Trial name
- NCT07297264
- Testing
- Betamethasone, normal saline
- Where
- Iraq
- Volunteers
- 40 people
- Sponsor
- Shehab Ahmed Hamad
Edentulous Jaw, Bone Loss, Alveolar
Effects of Different Centrifuged Platelet Concentrates on Bone Remodelling Around Dental Implants
Platelet concentrates obtained from blood have been used as regenerative biomaterials in periodontal surgery. Along with the migration and proliferation of osteogenic cells, platelets accelerate bone regeneration by increasing…
- Conditions
- Edentulous Jaw, Bone Loss, Alveolar, Resorption, Bone
- Trial name
- NCT04851002
- Testing
- Application of concentrated growth factor with dental implants, Application of advanced platelet rich fibrin with dental implants, Control side of concentrated growth factor study group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Muhammet Atilgan
Dental Plaque Accumulation, Oral Hygiene Education Methods
Evaluation of a Novel Dual-Headed Toothbrush Design for Periodontal Health: Split-Mouth Randomized Blind Clinical Trial
The goal of this clinical trial is to evaluate the effectiveness and patient satisfaction of a novel dual-headed toothbrush design compared to a conventional single-headed toothbrush in adult dental professionals aged 22-45 years…
- Conditions
- Dental Plaque Accumulation, Oral Hygiene Education Methods, Toothbrushing
- Trial name
- NCT07030088
- Testing
- Dual-Headed Manual Toothbrush, Conventional Single-Headed Manual Toothbrush
- Where
- Saudi Arabia
- Volunteers
- 40 people
- Sponsor
- Dar Al Uloom University
Sphingosine 1-phosphate, Interleukin 1-beta
IL-1β and S1P Levels After Periodontal Therapy: A Split-Mouth Study
This randomized split-mouth clinical trial aimed to evaluate the changes in interleukin-1 beta (IL-1β) and sphingosine-1-phosphate (S1P) levels in gingival crevicular fluid (GCF) following non-surgical periodontal therapy (NSPT)…
- Conditions
- Sphingosine 1-phosphate, Interleukin 1-beta, Gingival Crevicular Fluid, Non-surgical Periodontal Therapy
- Trial name
- NCT06930430
- Testing
- Non-Surgical Periodontal Therapy (NSPT)
- Where
- Turkey (Türkiye)
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Malocclusion, Malocclusion; Displaced or Missing Teeth
Effectiveness of Auxiliary Segmental Lingual Appliances in Leveling the Curve of Wilson at Second Molars
This study aims to evaluate the effectiveness of auxiliary segmental lingual appliances in leveling the Curve of Wilson at the second molars in patients undergoing labial fixed orthodontic treatment.
- Conditions
- Malocclusion, Malocclusion; Displaced or Missing Teeth, Malocclusions, Orthodontic Treatment
- Trial name
- EASLALCW (NCT06858670)
- Testing
- Auxiliary Segmental Lingual Appliances
- Where
- Vietnam
- Sponsor
- Hanoi Medical University
White Spot Lesion, Enamel Hypomineralization
Evaluation of CPP-ACP Prophylactic Effect on Enamel Surface During Orthodontic Treatment
This study is aiming in preventing the formation of WSL associated with orthodontic treatment which occurs to more than 50% of orthodontically treated patients through applying CPP-ACP on the enamel surface once every 2 weeks for…
- Trial name
- NCT03187548
- Testing
- Casein Phosphopeptide-Amorphous Calcium Phosphate Dental Paste
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Cairo University
Orthodontic Appliance Complication, Orthodontic Appliance Design
Periodontal and Orthodontic Outcomes of Straight vs. Looped Fixed Retainers
The goal of this split-mouth, head-to-head, randomized controlled trial is to compare the effects of a fixed straight retainer with the V- loop bonded retainer on periodontal health in patients with the requirement of continuous…
- Conditions
- Orthodontic Appliance Complication, Orthodontic Appliance Design, Orthodontic Treatment
- Trial name
- NCT05644119
- Testing
- V- loop Bonded Orthodontic Retainer, Straight Wire Retainer
- Where
- Saudi Arabia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Bone Loss, Flap Design
The Effect Of Vertical Releasing Incision On Implant Procedures
This study evaluated the clinical and biochemical aspects of flap design in dental implant applications regarding implantation success and patient comfort.
- Trial name
- Vertikal (NCT06322901)
- Testing
- Flap
- Where
- Turkey (Türkiye)
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Dental Caries
Clinical Performance of Injectable and Conventional Resin Composites in Posterior Class I Restorations
This study compared the one-year clinical performance of two tooth-colored filling materials used for restoring cavities in posterior teeth: a highly filled injectable resin composite and a conventional resin composite.
- Trial name
- NCT07806578
- Testing
- G-ænial Universal Injectable, G-ænial Posterior
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- Yuzuncu Yil University
Impacted Mandibular Third Molar, Wound Healing
Adjacent Molar Outcomes After Third Molar Surgery With PRF or Collagen Sponge
This study aims to compare platelet-rich fibrin (PRF) and an absorbable collagen sponge in extraction sockets following impacted mandibular third molar removal in terms of postoperative clinical healing and periodontal and…
- Conditions
- Impacted Mandibular Third Molar, Wound Healing, Postoperative Pain
- Trial name
- PRFvsCOLL-3M (NCT07530068)
- Testing
- Platelet-rich fibrin (PRF), Absorbable Collagen Sponge
- Where
- Turkey (Türkiye)
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Gazi University
Jaw, Edentulous
A Study to Treat Patients With Edentulous Mandibles With Two Straumann 3.3mm Diameter Bone Level Implants
The purpose of this study is to assess the change of crestal bone level at the Titanium Zirconium (TiZr) compared to Titanium (grade IV) implant between surgery and 6, 12, 24, and 36 month post surgery.
- Trial name
- NCT00905840
- Testing
- Titanium Zircon implant, Titanium Grade IV implant
- Where
- 8 sites in Belgium, Germany and 3 more
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Institut Straumann AG
Impacted Mandibular Third Molar Extraction, Post Operative Complications
A Comparison of Recovery After Impacted Wisdom Tooth Removal
Justification of the Study There is a high prevalence of impacted third molars, often accompanied by a range of postoperative complications.
- Trial name
- CESE-3M (NCT07304882)
- Testing
- serratiopeptidase, Escin, Conventional drugs
- Where
- Yemen
- Volunteers
- 24 people
- Sponsor
- University of Science and Technology, Yemen
Periodontal Diseases, Malocclusion
Influence of Finishing Clear Aligner Marginal Termination Design on Subgingival Periodontal Microbiota During Orthodontic Treatment: A Split-Mouth Study.
The goal of this clinical trial is to learn whether the edge design of a finishing orthodontic clear aligner at the gumline affects the bacteria living in the groove between the tooth and the gum (the gingival sulcus) in patients…
- Conditions
- Periodontal Diseases, Malocclusion, Oral Health
- Trial name
- PATHO-ALIGN (NCT07533058)
- Testing
- CA Pro tri-layer finishing clear aligner (SCHEU-DENTAL GmbH)
- Where
- Romania
- Volunteers
- 36 people
- Sponsor
- George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures
Peri-implantitis, Dental Implants
Natural Bioactive Gel for Peri-Implantitis
This study is a randomized controlled clinical trial using a split-mouth design to evaluate the effectiveness of a natural bioactive gel (Sterify Gel®) as an adjunct to standard non-surgical therapy for peri-implantitis.
- Conditions
- Peri-implantitis, Dental Implants, Non-surgical Periodontal Therapy
- Trial name
- PERISTER (NCT07088679)
- Testing
- Sterify Gel (mucoadhesive bioactive gel), Standard Non-Surgical Peri-Implantitis Therapy
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Pavia
Dental Disorders Hard Tissues of Teeth, Tooth Discoloration
Effect of Preparation Design on the Functional and Esthetic Outcome of CAD/CAM Lithium Disilicate Laminate Veneers
Conservatism is considered the main concern in any treatment plan, the feather edge preparation design of laminate veneers have been introduced yet clinical studies are lacking to evaluate their clinical performance.The aim of…
- Trial name
- NCT04840524
- Testing
- Laminate veneers preparation
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cairo University