Clinical trials: Splenomegaly
Hematopoietic Neoplasm
Phase 2 Study of SAR302503 in Patients With Myelofibrosis
Primary Objective: To evaluate the efficacy of daily oral doses of 300 mg, 400 mg, and 500 mg SAR302503 for the reduction of spleen volume as determined by magnetic resonance imaging (MRI).
- Trial name
- NCT01420770
- Testing
- SAR302503
- Where
- 4 sites in United States
- Volunteers
- 30 people
- Sponsor
- Bristol-Myers Squibb
Myeloid Malignancy
Therapeutic RSK1 Targeting in Myeloid Malignancies
This study hypothesizes that PMD-026, an oral inhibitor of ribosomal protein S6 kinase A1 (RSK1), is safe and well tolerated in participants with myelofibrosis (MF) and myelodysplastic syndromes/myeloproliferative neoplasms…
- Trial name
- NCT07379125
- Testing
- PMD-026
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Washington University School of Medicine
Anemia, Fatigue
Metformin Hydrochloride and Ritonavir in Treating Patients With Relapsed or Refractory Multiple Myeloma or Chronic Lymphocytic Leukemia
This pilot clinical trial studies the side effects and best dose of metformin hydrochloride and ritonavir in treating patients with multiple myeloma or chronic lymphocytic leukemia that has returned after a period of improvement…
- Conditions
- Anemia, Fatigue, Fever, Lymphadenopathy
- Trial name
- NCT02948283
- Testing
- Laboratory Biomarker Analysis, Metformin Hydrochloride, Pharmacological Study
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- City of Hope Medical Center
Splenomegaly, Myelofibrosis
High Dose Ruxolitinib and Allogeneic Stem Cell Transplantation in Myelofibrosis Patients With Splenomegaly
To learn if giving ruxolitinib and busulfan before a stem cell transplant can help to reduce spleen size and help the transplant to succeed.
- Trial name
- NCT06345495
- Testing
- Ruxolitinib, Allogeneic Stem Cell Transplantation, Levetiracetam
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- M.D. Anderson Cancer Center
Gastroesophageal Varices, Colorectal Cancer
Early Diagnosis of Oxaliplatin-induced Portal Hypertension
Oxaliplatin has been used as the first choice for the adjuvant chemotherapy of colorectal cancer and it has significantly improved the outcomes in patients with colorectal cancer.
- Conditions
- Gastroesophageal Varices, Colorectal Cancer, Received Oxaliplatin-based Chemotherapy
- Trial name
- NCT04524650
- Testing
- the level of vWF
- Where
- China
- Volunteers
- 370 people
- Sponsor
- Shanghai Zhongshan Hospital
Intermediate- and High-risk Myelofibrosis (MF) Patients With Splenomegaly
A Study to Evaluate Safety , Efficacy and Pharmacokinetics of WJ01024 Tablets Combined With Ruxolitinib in Patients With Myelofibrosis
This is a Phase Ib/II clinical study to evaluate the safety , efficacy and pharmacokinetics of WJ01024 tablets combined with Ruxolitinib tablets in patients with myelofibrosis.The study will be conducted in two phases: Phase 1b…
- Trial name
- NCT06909136
- Testing
- Ruxolitinib phosphate tablet（Jakavi,NOVARTIS,9104733)
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Suzhou Junjing BioSciences Co., Ltd.
Cirrhosis, Splenectomy; Status
Effect of Laparoscopic Splenectomy on Renal Function in Cirrhotic Patients With Hypersplenism (2-Year Follow-Up)
Patients with liver cirrhosis often have impaired or at-risk kidney function due to the close link between liver and kidney (hepatorenal syndrome).
- Conditions
- Cirrhosis, Splenectomy; Status, Hypersplenism, Kidney Function Issue
- Trial name
- LS-RF (NCT07585773)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Northern Jiangsu People's Hospital
Splenomegaly
Ultrasound Estimation of Spleen Size
In internal medicine, assessment of spleen size on physical examination is an extremely important part of the overall evaluation of patients with many illnesses.
- Trial name
- NCT01810419
- Testing
- Vscan Ultrasound (GE Healthcare, USA), Conventional Ultrasound
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- University of British Columbia
Postoperative Pain
Prospective Randomized Comparison of Clinical Results of Hand Assisted Laparoscopic Splenectomies and Open Splenectomies
ABSTRACT Background: Although there are some comparative studies between laparoscopy and hand-assisted laparoscopic splenectomy (HALS) in splenomegaly cases, there is no study of the differences between HALS and open splenectomy…
- Trial name
- NCT00754806
- Volunteers
- 27 people
- Sponsor
- Istanbul University
Myelofibrosis
Phase 2 Study in Japanese Patients With Intermediate-2 or High Risk Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, Post-Essential Thrombocythemia Myelofibrosis With Splenomegaly
Primary Objective: To evaluate the efficacy of daily oral doses of 300 mg, 400 mg, and 500 mg SAR302503 and combined for the response rate defined with the ≥35% reduction of spleen volume as determined by magnetic resonance…
- Trial name
- NCT01692366
- Testing
- SAR302503
- Where
- 7 sites in Japan
- Volunteers
- 8 people
- Sponsor
- Bristol-Myers Squibb
Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis
Pacritinib Versus Best Available Therapy to Treat Myelofibrosis
Phase 3, randomized, controlled study to evaluate the safety and efficacy of oral pacritinib compared to Best Available Therapy (BAT) in patients with primary or secondary myelofibrosis.
- Conditions
- Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis
- Trial name
- NCT01773187
- Testing
- Pacritinib, Best Available Therapy
- Where
- 81 sites in United States, Australia and 10 more
- Volunteers
- 327 people
- Sponsor
- CTI BioPharma
Hyper-reactive Malarial Splenomegaly, Malaria
Prednisone Plus Chloroquine for the Treatment of Hyper-reactive Malarial Splenomegaly
This randomized clinical trial will address a complication related to recurrent episodes of malaria in endemic areas - hyper-reactive malarial splenomegaly.
- Conditions
- Hyper-reactive Malarial Splenomegaly, Malaria, Anaemia
- Trial name
- LiHMS (NCT01785979)
- Testing
- prednisone induction - chloroquine, Chloroquine
- Where
- Papua New Guinea
- Sponsor
- Lihir Medical Centre
Gaucher Disease, Splenomegaly, Acid SphingoMyelinase Deficiency
A Non-Interventional National Study in Pediatric Patients With Unexplained Enlarged Spleen
Primary Objective: To assess prevalence of Gaucher disease (GD) diagnosed in pediatric patients presenting with unexplained splenomegaly (SMG) after exclusion of first intention-diagnoses (e.g.
- Trial name
- OPPUS (NCT04845958)
- Where
- 40 sites in France
- Volunteers
- 60 people
- Sponsor
- Sanofi
Splenomegaly
Spleen Size in Peripheral Blood Stem Cell Donors
This study will determine whether the spleen in people who donate stem cells (bone marrow cells collected from the blood) enlarges as a result of taking granulocyte colony-stimulating factor (G-CSF).
- Trial name
- NCT00006148
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Cholecystitis, Perforated Duodenal Ulcer
Incentive Spirometry and Upper Abdominal Laparoscopic Surgery
To compare the effects of volume-oriented versus flow-oriented incentive spirometry on pulmonary function tests and functional capacity in patients of upper abdominal laparoscopic surgery.
- Conditions
- Cholecystitis, Perforated Duodenal Ulcer, Diaphragmatic Hernia, Benign Pancreas Tumor
- Trial name
- NCT04716166
- Testing
- Volume-oriented incentive spirometry, Flow-oriented incentive spirometry
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Riphah International University
Hepatomegaly, Myelofibrosis Transformation in Essential Thrombocythemia
Nivolumab in Treating Patients With Primary Myelofibrosis, Post-Essential Thrombocythemia Myelofibrosis, or Post-Polycythemia Vera Myelofibrosis
This phase II trial studies how well nivolumab works in treating patients with primary myelofibrosis, post-essential thrombocythemia myelofibrosis, or post-polycythemia vera myelofibrosis.
- Conditions
- Hepatomegaly, Myelofibrosis Transformation in Essential Thrombocythemia, Polycythemia Vera, Post-Polycythemic Myelofibrosis Phase, Primary Myelofibrosis
- Trial name
- NCT02421354
- Testing
- Laboratory Biomarker Analysis, Nivolumab, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- M.D. Anderson Cancer Center
Splenomegaly; Congestive, Chronic, Panhematopenia; Splenic
Ultrasound Guided Microwave Ablation of Splenomegaly in Children
Children with liver cirrhosis frequently develops portal hypertension. One of the serious complications to portal hypertension is splenomegaly, which may result in pancytopenia, especially thrombocytopenia that may cause bleeding…
- Conditions
- Splenomegaly; Congestive, Chronic, Panhematopenia; Splenic, Portal Hypertension
- Trial name
- NCT05050994
- Testing
- Microwave ablation
- Where
- Sweden
- Volunteers
- 10 people
- Sponsor
- Karolinska Institutet
Hereditary, Hemolysis
Hemolysis in Patients With Hereditary Spherocytosis (HS)
In the present study the investigators are going to explore the oxidative status of HS-RBC and its contribution to hemolysis
- Trial name
- NCT01201174
- Testing
- fermented papaya preparation (FPP)
- Where
- Israel
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Wolfson Medical Center
BCR-JAK2 Fusion Protein Expression, Blasts 20 Percent or Less of Peripheral Blood White Cells
Ruxolitinib in Treating Patients With Hypereosinophilic Syndrome or Primary Eosinophilic Disorders
This phase II trial studies how well ruxolitinib works in treating patients with hypereosinophilic syndrome or primary eosinophilic disorders.
- Conditions
- BCR-JAK2 Fusion Protein Expression, Blasts 20 Percent or Less of Peripheral Blood White Cells, Blasts More Than 5 Percent of Bone Marrow Nucleated Cells, Blasts More Than 5 Percent of Peripheral Blood White Cells
- Trial name
- NCT03801434
- Testing
- Ruxolitinib
- Where
- 4 sites in United States
- Volunteers
- 8 people
- Sponsor
- Stanford University
Unrecognized Condition
Evaluate DF-003 in ex Vivo Assays Using Peripheral Blood Mononuclear Cell From Subjects With ROSAH Syndrome
Alpha-1 kinase (ALPK1) has been reported as a potential causative gene for ROSAH Syndrome. Genetic variants including T237M have been found in ROSAH Syndrome patients.
- Trial name
- ROSAH (NCT05319132)
- Testing
- Adult subjects with ROSAH syndrome
- Where
- 5 sites in France
- Volunteers
- 4 people
- Sponsor
- Hospices Civils de Lyon