Clinical trials: Spine Surgery
Anaesthesia
Bilateral Erector Spinae Plane Block Versus Bilateral Quadratus Lumborum Plane Block for Postoperative Anaelgesia After Lumbar Spine Surgery
The aim of this study is to compare postoperative analgesia and duration for each block performance plus complications after surgery in lumbar spine fixation.
- Trial name
- NCT07517822
- Testing
- Ultrasound-guided quadratus lumborum block (QLB)
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Medium-/Long-segment Spinal Fusion Patients, Spine Surgeons
Evaluation of an Online Peri-operative Health Education Platform for Patients Undergoing Spine Surgery: Ready Set Recover
Chronic back pain is the world's leading cause of disability, with spine surgery being a common yet costly intervention. However, many patients experience suboptimal recovery, with persistent pain and functional limitations…
- Conditions
- Medium-/Long-segment Spinal Fusion Patients, Spine Surgeons, Chronic Low Back Pain, Scoliosis Patients
- Trial name
- NCT07766824
- Testing
- Ready Set Recover
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National University of Natural Medicine
Radiculopathy Lumbar, Radiculopathy Sacral
Precision Treatment of Lumbar Spine Surgery Through Advanced Nerve Root Blockade
The overall purpose of the study is to investigate whether selective spinal nerve root blocks can improve diagnostics of radiculopathy due to lumbar disc herniation (LDH), foraminal stenosis (FS), and recess stenosis (RS), and…
- Conditions
- Radiculopathy Lumbar, Radiculopathy Sacral, Herniated Disc, Foraminal Stenosis
- Trial name
- PLAN (NCT06143813)
- Testing
- Selective nerve root block (SNRB)
- Where
- Denmark
- Volunteers
- 180 people
- Sponsor
- University of Aarhus
Skull Base Chordoma, Vertebral Chordoma
Improvement of Local Control in Skull Base, Spine and Sacral Chordomas Treated by Surgery and Protontherapy Targeting Hypoxic Cells Revealed by [18F]FAZA) PET/CT Tracers
Improved local control of chordoma initially treated with surgery or not, thanks to adjuvant radiotherapy oriented by conventional imaging Computed Tomography /Magnetic Resonance Imaging (CT / MRI) and guided by the [18Fluor]…
- Trial name
- PROTONCHORDE01 (NCT02802969)
- Testing
- Surgery, Protontherapy, 18F FAZA
- Where
- France
- Volunteers
- 64 people
- Sponsor
- Institut Curie
ATTR Amyloidosis, Cardiopathy
Orthopaedic Specimen Pathology and Early Diagnosis of ATTR Cardiopathy (ATTR-ORTHO)
The goal of this observational study is to learn about the frequency of ATTR amyloid, cardiac involvement and associated features, in 150 patients aged 50 or more years, and operated for an idiopathic carpal tunnel syndrome…
- Conditions
- ATTR Amyloidosis, Cardiopathy, Carpal Tunnel Syndrome, Lumbar Spine Stenosis
- Trial name
- ATTR-ORTHO (NCT06367842)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Institut Mutualiste Montsouris
Revision Spine Surgery, Fusion of Spine
Pre-Operative Ketamine Infusion for Post Operative Pain Control After Revision Spinal Surgery
To determine if a pre-operative ketamine infusion would provide a similar decrease in post-operative analgesic and opioid consumption as intra-operative ketamine, but expand the monitoring period through the post-operative phase…
- Conditions
- Revision Spine Surgery, Fusion of Spine, Cervical Fusion, Lumbar Fusion
- Trial name
- KIPSs (NCT06066879)
- Testing
- Ketamine Hydrochloride
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- AXIS Spine Center- a division of Northwest Specialty Hospital
Staphylococcus Aureus, Colonization, Asymptomatic
Decolonization Efficacy of Polyhexanide vs. Mupirocin
This pilot randomized controlled trial evaluates the feasibility, tolerability, and preliminary efficacy of a decolonization regimen using polyhexanide in reducing Staphylococcus aureus colonization in the preoperative phase of…
- Trial name
- SPADE (NCT06633588)
- Testing
- Polyhexanide, Mupirocin and Chlorhexidine
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- Swiss Paraplegic Research, Nottwil
Spine Surgery
Radiological and Clinical Efficacy of a Hybrid Spinal Implant ("Topping Off"): a Mono-center, Prospective Clinical Trial
The study aim is to show the effectiveness of a hybrid system (DTO) regarding clinical outcome and radiological alteration in a single-center prospective setting.
- Trial name
- NCT03404232
- Testing
- Dynesys DTO device (Zimmer Spine, Inc.)
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital, Aachen
Pain, Postoperative, Opioid Use
Transcutaneous Auricular Neurostimulation After Lumbar Surgery
The purpose of this study, entitled "Delivering Transcutaneous Auricular Neurostimulation as an Adjunct Non-Opioid Pain Management Therapy for Patients Undergoing Lumbar Surgery", is to demonstrate whether transcutaneous…
- Conditions
- Pain, Postoperative, Opioid Use, Lumbar Spine Injury
- Trial name
- NCT06100172
- Testing
- Sparrow Ascent Transcutaneous Auricular Neurostimulation (tAN)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Texas Southwestern Medical Center
Postoperative Infection
The Effect of Prolonged Postoperative Antibiotics Administration on Rate of Infection in Patients Undergoing Posterior Spine Surgery Requiring a Hemovac Drain
Post-operative antibiotics for infection prophylaxis are routinely given to most surgical patients, and for orthopaedic surgery patients, the standard of care is treatment for 24 hours following any elective procedure (1).
- Trial name
- PARISS (NCT01458223)
- Testing
- Antibiotic
- Where
- Canada
- Volunteers
- 645 people
- Sponsor
- The London Spine Centre
Adolescent Idiopathic Scoliosis, Cerebral Palsy
Pain Assessment in Children Undergoing Spine Surgery
Musculoskeletal (MSK) pain is one of the most common types of pain among children and adolescents. Recurring episodes of MSK pain conditions have a major impact on the daily lives.
- Trial name
- NCT04244760
- Testing
- Pain assessment for verbal patients, Pain assessment for non-verbal patients
- Where
- Canada
- Volunteers
- 240 people
- Sponsor
- Catherine Ferland
Early Onset Scoliosis, Congenital Spinal Deformities
The Treatment of Progressive Early Onset Spinal Deformities: A Multi-Center Outcome Study
The purpose of this study is to examine the treatment, both surgical and non-surgical, of patients with any form of early onset scoliosis.
- Conditions
- Early Onset Scoliosis, Congenital Spinal Deformities, Infantile Idiopathic Scoliosis, Neuromuscular Spinal Deformity
- Trial name
- GSSG (NCT02299362)
- Where
- 27 sites in United States, Canada and 5 more
- Volunteers
- 2,602 people
- Sponsor
- Growing Spine Study Group
Surgery
A Pilot Trial to Determine the Effective N-acetylcysteine Dose for Opioid Reduction for Spine Surgery.
Determine the optimal dose of IV N-acetylcysteine (NAC) to produce opioid reduction following spine surgery and estimate the difference in opioid consumption between placebo and the selected optimal dose.
- Trial name
- NCT04562597
- Testing
- Dose Response Curve N-acetylcysteine 50 mg/kg, Dose Response Curve N-acetylcysteine 100 mg/kg, Dose Response Curve N-acetylcysteine 150 mg/kg
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Scoliosis, Kyphosis
The Spinal Navigation Trial - Surgical Navigation or Free Hand Technique in Spine Surgery
The spinal navigation trial (SPINAV) is a randomized controlled trial (RCT) evaluating the use of computer-assisted navigation in surgery for spinal deformity
- Trial name
- SPINAV (NCT05107310)
- Testing
- Pedicle screws insertion by free hand technique, Pedicle screws insertion using ARSN, Pedicle screws insertion using IRSN
- Where
- Sweden
- Volunteers
- 62 people
- Sponsor
- Karolinska Institutet
Smoking Cessation
Stop Smoking in Spine Surgery
Patients that are subjected to a medium complex surgical intervention in neck (posterior) or lumbar spine (posterior) with instrumentation are motivated to stop smoking.
- Trial name
- NCT06361459
- Testing
- Stop smoking
- Where
- Netherlands
- Volunteers
- 210 people
- Sponsor
- Leiden University Medical Center