Clinical trials: Spine Osteoarthritis
Lumbar Osteoarthritis, Spondylosis
Post-op Acetaminophen vs NSAID Use on Lumbar Spinal Fusion Outcomes
Patients undergoing spine surgery often have considerable pain post-operatively and frequently require opioid medication (Percocet, Norco, oxycodone, morphine, etc.) to control their pain postoperatively.
- Conditions
- Lumbar Osteoarthritis, Spondylosis, Lumbar Disc Disease, Spinal Stenosis
- Trial name
- NCT02700451
- Testing
- Ketorolac, Acetaminophen
- Where
- United States
- Volunteers
- 178 people
- Sponsor
- Hospital for Special Surgery, New York
Psoriasis (PsO), Psoriatic Arthritis (PsA)
Psoriatic Disease and Related Manifestations; Real World Evidence in Brazilian Secukinumab Environment
This was a retrospective observational study that relied on data extracted from patient chart review at the participating sites.
- Trial name
- NCT06666114
- Where
- Brazil
- Volunteers
- 232 people
- Sponsor
- Novartis Pharmaceuticals
Psoriatic Arthritis, Withdrawal
Impact of Tapering Immunosuppressants on Maintaining Minimal Disease Activity in Adult Subjects With Psoriatic Arthritis
The rationale for this study is to investigate whether in psoriatic arthritis (PsA) patients in stable remission a reduction or complete discontinuation of immunosuppressive therapy can be achieved in a treat-to-target approach…
- Conditions
- Psoriatic Arthritis, Withdrawal, Reduction
- Trial name
- NCT04610476
- Testing
- Prednisolone, Sulfasalazine, Leflunomide
- Where
- Germany
- Volunteers
- 270 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Axial Spondylarthritis (axSpA), Secukinumab
Efficacy and Influencing Factors of Secukinumab in Patients With Axial Spondyloarthritis
This study aimed to explore the efficacy and influencing factors of secukinumab in axSpA patients by conducting a real-world retrospective analysis.
- Trial name
- NCT07130331
- Testing
- Secikinumab
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Ankylosing Spondylitis, Coxitis
Clinical and Radiological Manifestations of Coxitis in Patients With Ankylosing Spondylitis Treated With Golimumab
Rationale. Coxitis in AS is inflammation of hip(s) affecting significant number of patients. It is associated with worse function and more expressed axial disease requiring hip replacement at end-stage.
- Trial name
- GO-COX (NCT03557853)
- Testing
- Golimumab Injection
- Where
- 6 sites in Russia
- Volunteers
- 39 people
- Sponsor
- MSD Pharmaceuticals LLC
Arthritis, Psoriatic, Arthritis, Rheumatoid
Fertility Study of Women With Chronic Inflammatory Rheumatism
Etiopathogenesis of Chronic inflammatory rheumatisms (CIR) includes genetic, autoimmune and environmental factors. Their impact on the quality of life is important, leading to a sometimes severe disability.
- Conditions
- Arthritis, Psoriatic, Arthritis, Rheumatoid, Ankylosing Spondylitis, Chronic Juvenile Arthritis
- Trial name
- FERTIRHUM (NCT03452735)
- Testing
- Questionnaire about fertility
- Where
- France
- Volunteers
- 2,900 people
- Sponsor
- University Hospital, Toulouse
Psoriatic Arthritis
A Clinical Trial of TQH3906 Capsules in the Treatment of Active Psoriatic Arthritis
This study is a marketing-oriented clinical trial of TQH3906 Capsules. A total of 156 participants are planned to be enrolled, aiming to evaluate the dose-effect relationship of TQH3906 versus placebo in the treatment of active…
- Trial name
- NCT07406035
- Testing
- TQH3906 Capsule, Tofacitinib Citrate Tablet 5 mg
- Where
- 44 sites in China
- Volunteers
- 156 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd.
Rheumatoid Arthritis, Psoriatic Arthritis
Yoga-mindfulness for Pain Management in Inflammatory Arthritis
This study evaluates the potential effects on pain, pain-related symptoms and quality of life of a yoga-mindfulness program, compared to patient education and physiotherapy, for patients with inflammatory arthritis and persistent…
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Pain
- Trial name
- NCT04065958
- Testing
- Yoga-mindfulness, Patient education and physiotherapy
- Where
- 2 sites in Sweden
- Volunteers
- 60 people
- Sponsor
- Karolinska Institutet
Spondylodiscitis
CORset Versus OstéoSynthese in Adult Pyogenic Spondylodiscitis
Pyogenic spondylitis in adults is usually treated by antibiotics according to bacteria evidenced in a diagnostic intervertebral disc puncture.
- Trial name
- COROSIVE (NCT03524209)
- Testing
- Percutaneous instrumentation of the thoracolumbar spine, Brace
- Where
- 15 sites in France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Strasbourg, France
Arthritis, Rheumatoid, Arthritis, Psoriatic
A Study to Investigate the Use of Golimumab (Simponi®) in Participants With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis (P06554)
This is a study to assess the use of golimumab (Simponi®) in participants with rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis.
- Conditions
- Arthritis, Rheumatoid, Arthritis, Psoriatic, Spondylitis, Ankylosing
- Trial name
- GO-NICE (NCT01313858)
- Testing
- Simponi®, Methotrexate
- Volunteers
- 1,613 people
- Sponsor
- Merck Sharp & Dohme LLC
Rheumatoid Arthritis, Systemic Lupus Erythematosus
Prevention of Arthritis-Related Work Disability
People with rheumatic disorders (arthritis) often have trouble keeping their jobs. This study will look at whether vocational rehabilitation (VR) will improve the ability of employed people with arthritis to keep their jobs.
- Conditions
- Rheumatoid Arthritis, Systemic Lupus Erythematosus, Osteoarthritis, Knee, Ankylosing Spondylitis
- Trial name
- NCT00000416
- Testing
- Rehabilitation counseling
- Where
- United States
- Volunteers
- 242 people
- Sponsor
- Boston University Charles River Campus
Spondylitis, Ankylosing
Growth Factor Concentration to Predict an Ankylosing Spondylitis Patient's Response to Infliximab (Study P04041)(COMPLETED)
This is a Phase 4, multi-center, open-label, one-arm, pilot study in patients with active ankylosing spondylitis refractory to conventional treatment.
- Trial name
- NCT00779935
- Testing
- Remicade
- Volunteers
- 44 people
- Sponsor
- Merck Sharp & Dohme LLC
Axial Spondyloarthritis
High-intensity Training in Patients With Spondyloarthritis: a Randomized Controlled Trial
Project summary Background: For people diagnosed with a spondyloarthritis (SpA) e.g. ankylosing spondylitis or undifferentiated spondyloarthritis, physical activity and exercise are important components in the self-management.
- Trial name
- NCT05781763
- Testing
- High intensity interval training (HIIT), Control group
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Halmstad University
Psoriatic Arthritis
A Placebo-controlled Study With an Extension Examining the Safety and Efficacy of Alefacept in Psoriatic Arthritis
Randomized, double-blind, 24-week study of patients with psoriatic arthritis comparing alefacept + methotrexate (MTX) vs. placebo + MTX followed by a 24-week open-label extension with only alefacept + MTX treatment.
- Trial name
- NCT00659412
- Testing
- Alefacept, Methotrexate
- Where
- 27 sites in United States, Canada and 3 more
- Volunteers
- 185 people
- Sponsor
- Astellas Pharma Inc
Rheumatoid Arthritis, Spondyloarthritis
Evaluation of the Switch From the Original Infliximab to Its Biosimilar in Daily Practice at Cochin Hospital
The purpose of this study is to evaluate the effectiveness of the switch from the original infliximab ( REMICADE®) to its biosimilar (INFLECTRA®) in all the patients at Cochin hospital receiving REMICADE® for either a rheumatic…
- Conditions
- Rheumatoid Arthritis, Spondyloarthritis, Crohn's Disease, Uveitis
- Trial name
- SIC (NCT02998398)
- Testing
- Switch from REMICADE® to INFLECTRA®
- Where
- France
- Volunteers
- 262 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Spondylitis, Ankylosing
Prediction of the Answer to the Treatment by Biotherapies for Naive Spondyloarthritis by Combinatorial Analysis of Serum Biomarkers
The aim of this trial is the caracterisation of a predicting algorithm of the answering response for patients with etanercept treatment in spondyloarthritis disease.
- Trial name
- PRESA (NCT03033095)
- Testing
- Etanercept ® 50 mg
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Grenoble
Spondyloarthropathy
Identification of Serum Level of Glutathione Peroxidase 4
Analysis of the level of glutathione peroxidase 4 (GPX4) in ankylosing spondylitis and axial psoriatic arthritis patients. The association of glutathione peroxidase 4 (GPX4) with disease activity and severity in ankylosing…
- Trial name
- NCT06554392
- Testing
- Blood sample
- Where
- Egypt
- Volunteers
- 85 people
- Sponsor
- Assiut University
Psoriasis, Ankylosing Spondylitis
A Study of HB0017 Injection in Healthy Volunteers to Evaluate Safety and Tolerability of a Single Subcutaneous Injection in Low-Body-Weight Subjects; and Pharmacokinetics at Different Subcutaneous Injection Sites at the Same Dose
The goal of this clinical trial is to (PART 1) to evaluate the safety and tolerability of a single subcutaneous injection of HB0017 Injection in healthy subjects with low body weight; ( PART 2) to compare the pharmacokinetics…
- Trial name
- NCT07920861
- Testing
- HB0017 Injection
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Huabo Biopharm Co., Ltd.
Spinal Tuberculosis
Cobalt Alloy Pedicle Screw Implantation for Severe Kyphosis Deformity in Spinal Tuberculosis
To investigate whether implantation of cobalt alloy pedicle screws is effective in treating severe kyphosis deformity in spinal tuberculosis, and to determine the factors that are likely to have influenced the curative effects.
- Trial name
- NCT02971644
- Testing
- cobalt alloy pedicle screw implantation
- Volunteers
- 84 people
- Sponsor
- Affiliated Hospital of Hebei University
Ankylosing Spondylarthritis
Ankylosing Spondylitis and Antiphospholipid Antibodies
The main objective is to evaluate the prevalence of anti-phospholipid antibodies (APLA) in patients with ankylosing spondylitis (AS).
- Trial name
- ASAA (NCT02809300)
- Testing
- blood collection
- Where
- France
- Volunteers
- 80 people
- Sponsor
- CHU de Reims
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