Clinical trials: Spine Disorder
Axial Spondyloarthritis, Ankylosing Spondylitis
Vilamakitug in Spondyloarthritis Placebo-controlled Investigation for Efficacy
The goal of this clinical trial is to find out if the study drug will work as a new therapy for axSpA patients. This study is placebo-controlled, and evaluates if study drug can treat symptoms of axSpA, including global disease…
- Conditions
- Axial Spondyloarthritis, Ankylosing Spondylitis, r-axSpA, Nr-axSpA
- Trial name
- V-SPINE (NCT06526377)
- Testing
- vilamakitug
- Volunteers
- 150 people
- Sponsor
- XBiotech, Inc.
Spine Disease
GDFT Based on PPV Compared With Standard Fluid Therapy in Patients Undergoing Complex Spine Surgery: RCT
The investigators will do the Goal directed fluid therapy by protocolized fluid management in the experimental group, using PPV to guide the fluid administration, compare with standard fluid management in patients undergoing…
- Trial name
- NCT03164811
- Testing
- goal directed fluid therapy, Controlled
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Mahidol University
Adult Spinal Deformity, Scoliosis
Prospective Evaluation of Complex Adult Spinal Deformity (CAD) Treated With Minimally Invasive Surgery
Evaluate surgical treatment outcomes and identify best practice guidelines for complex adult spinal deformity (ASD) patients treated with minimally invasive approach, including radiographic and clinical outcomes, surgical and…
- Conditions
- Adult Spinal Deformity, Scoliosis, Kyphosis, Sagittal Imbalance
- Trial name
- MIS (NCT04885244)
- Testing
- Index or spine revision surgery for complex adult spinal deformity
- Where
- 12 sites in United States
- Volunteers
- 500 people
- Sponsor
- International Spine Study Group Foundation
Pain, Postoperative, Postoperative Nausea and Vomiting
Comparison of Two Naloxone Infusion Rates on the Postoperative Recovery of Patients Undergoing Spine Fusion Surgery
There will be two groups in this study: one group will be given the standard infusion of naloxone, a drug which helps reduce side effects from opioids needed after surgery, and the other group will receive a higher dose.
- Conditions
- Pain, Postoperative, Postoperative Nausea and Vomiting, Scoliosis
- Trial name
- NCT01531439
- Testing
- Naloxone
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Children's Mercy Hospital Kansas City
Autoimmune Disease, Crohn Disease
Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO
This phase Ib trial studies the side effects of nivolumab and to see how well it works alone and in combination with other treatments, such as ipilimumab, cabozantinib, platinum containing therapy, and fluoropyrimidine, in…
- Conditions
- Autoimmune Disease, Crohn Disease, Dermatomyositis, Hematopoietic and Lymphoid Cell Neoplasm
- Trial name
- NCT03816345
- Testing
- Biospecimen Collection, Cabozantinib, Fluoropyrimidine
- Where
- 52 sites in United States, Canada
- Volunteers
- 300 people
- Sponsor
- National Cancer Institute (NCI)
Arthritis, Psoriatic, Arthritis, Rheumatoid
Study Evaluating Etanercept in Patients With Rheumatoid Arthritis(RA), Juvenile Idiopathic Arthritis (JIA), or Psoriatic Arthritis (PsA) in Spain
The purpose of this study is to assess the safety of etanercept in patients with rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA) or psoriatic arthritis (PsA) in Spain
- Trial name
- NCT00195377
- Testing
- Etanercept
- Where
- Spain
- Volunteers
- 1,000 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Scoliosis Idiopathic
Impact of Virtual Reality on the Postoperative Balance of Adolescents With Idiopathic Scoliosis
The aim of this randomized clinical trial is to evaluate the impact of immersive virtual reality on the static and dynamic balance and functionality of adolescents with idiopathic scoliosis after spinal correction surgery.
- Trial name
- NCT05950100
- Testing
- Virtual reality group
- Where
- Brazil
- Volunteers
- 56 people
- Sponsor
- Federal University of Health Science of Porto Alegre
Spondylitis, Ankylosing
A Study of RoActemra/Actemra (Tocilizumab) in Patients With Ankylosing Spondylitis Who Have Failed Treatment With NSAIDs
This randomized, double-blind, placebo-controlled study will evaluate the safety and efficacy of RoActemra/Actemra (tocilizumab) in patients with ankylosing spondylitis (AS) who have failed treatment with non-steroidal…
- Trial name
- NCT01209702
- Testing
- tocilizumab
- Where
- 139 sites in United States, Australia and 16 more
- Volunteers
- 306 people
- Sponsor
- Hoffmann-La Roche
Scoliosis, Scoliosis Idiopathic
Yoga in the Treatment of Adolescent Idiopathic and Degenerative Scoliosis
The effect of two isometric exercises is measured on Cobb angles from films taken 4-10 months apart.
- Trial name
- NCT03110965
- Testing
- Yoga poses
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Manhattan Physical Medicine and Rehabilitation, LLP
Ankylosing Spondylitis, Axial Spondyloarthritis
A Clinimetric Test of Spinal Sensors in Measuring Spinal Mobility in Axial Spondyloarthritis
This is a clinimetric study to validate the use of IMU spinal sensors to measure the range of spinal movement in a group of patients with axial spondyloarthritis.
- Trial name
- NCT03159767
- Testing
- ViMove Spinal Sensor
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Dr Philip Gardiner
Axial Spondyloarthritis
Explore the Associations of Behavioral Factors With Treatment Adherence in Axial Spondyloarthritis Patients Treated With Biotherapy.
The management of chronic inflammatory rheumatism, including spondyloarthritis (SpA), has been revolutionized in recent decades with the arrival of biological therapy.
- Trial name
- MAINTAIN II (NCT04925037)
- Testing
- self-questionnaire to patients undergoing SpAax follow-up
- Where
- 5 sites in France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Clermont-Ferrand
Lumbar Disc Herniation
Quadratus Lumborum Block for Lumbar Spinal Surgery
Spine surgery in thoracolumbar region is one of the most common surgeries performed for the treatment of leg and back pain. Pain management is especially important for these patients since chronic pain often occurs after surgery.
- Trial name
- NCT04981301
- Testing
- Quadratus Lumborum Block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Medipol University
Syringomyelia
Study and Surgical Treatment of Syringomyelia
The goal of this study is to establish the mechanism(s) of progression of primarily spinal syringomyelia (PSS). Our preliminary study of syringomyelia emphasized syringomyelia associated with craniocervical junction abnormalities…
- Trial name
- NCT00011245
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cervical Spine Degenerative Disease Nos, Cervical Spondylosis With Myelopathy
Baxter: Actifuse SHAPE vs DBX in ACC
The purpose of this single-center, prospective, randomized study is to determine the fusion rates along with the clinical outcomes of commercially available bone graft substitutes Actifuse mixed with bone marrow aspirate (BMA)…
- Trial name
- NCT02005081
- Testing
- Actifuse SHAPE, Autograft with Demineralized Bone Matrix
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Wayne State University
Lumbar Spinal Stenosis, Neuropathic Pain
Neuropathic Pain in Patients With Degenerative Lumbar Stenosis
Pre- and postoperative pain in patients with degenerative stenosis requires great attention, as it can mislead the doctor about treatment tactics.
- Conditions
- Lumbar Spinal Stenosis, Neuropathic Pain, Spinal Disease
- Trial name
- NCT06407167
- Testing
- DN4 (Douleur Neuropathique 4 Questions) questionnaire
- Where
- Russia
- Volunteers
- 147 people
- Sponsor
- N.N. Priorov National Medical Research Center of Traumatology and Orthopedics
Spine Surgery, Excessive Repair
Use of Spinal Sealant System During Spinal Surgery
1. To evaluate the safety and efficacy of the Spinal Sealant as an adjunct to sutured dural repair compared with standard of care methods (control) to obtain watertight dural closure intraoperatively in patients undergoing spinal…
- Conditions
- Spine Surgery, Excessive Repair, Spinal Cord Injuries, Complication of Surgical Procedure
- Trial name
- NCT00458354
- Testing
- Spinal Sealant, Standard Methods of Closing of the Dura
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- M.D. Anderson Cancer Center
Pseudoarthrosis, Spinal Stenosis
A Study Comparing Fusion Rates of Two Lumbar Fusion Procedures
The purpose of this study is to demonstrate the relative efficacy of two lumbar fusion procedures: transacral lumbar interbody fusion when used in conjunction with unilateral or bilateral posterior pedicle screw fixation as an…
- Conditions
- Pseudoarthrosis, Spinal Stenosis, Spondylolisthesis, Degenerative Disc Disease (DDD)
- Trial name
- NCT01972256
- Where
- 5 sites in United States
- Volunteers
- 60 people
- Sponsor
- Baxano Surgical, Inc.
Pneumonia, COPD
Feasibility of a Physical Therapy Intervention on Older Adults With Hyperkyphosis or Forward Head Posture
The original intent was to use a manual therapy and therapeutic exercise intervention with older patients with pneumonia post-hospitalization.
- Conditions
- Pneumonia, COPD, Hyperkyphosis, Postural, Thoracic Kyphosis
- Trial name
- NCT04114331
- Testing
- Manual therapy and exercise
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Spinal Stenosis, Spinal Cord Compression
Comparative Effectiveness of Microdecompression and Laminectomy for Central Lumbar Spinal Stenosis
Introduction: This observational study is designed to test the equivalence between the clinical effectiveness of microdecompression and laminectomy in the surgical treatment of central lumbar spinal stenosis.
- Trial name
- NCT02006901
- Testing
- microdecompression, laminectomy
- Where
- Norway
- Volunteers
- 721 people
- Sponsor
- St. Olavs Hospital
Low Back Pain, Brace
Lumbar Brace Deployment in the Emergency Department for Benign Low Back Pain
Low back pain accounts for billions of dollars in health care expenditures. Most cases of back pain do not have a clear cause. Thus, low back pain management methods usually rely on targeting people' pain and discomfort.
- Conditions
- Low Back Pain, Brace, Emergencies, Pain
- Trial name
- NCT03829631
- Testing
- Horizon 627 Lumbar Brace, Aspen Medical Company, Oak Canyon, Irvine, CA 92618
- Where
- Australia
- Volunteers
- 152 people
- Sponsor
- University of Alberta