Clinical trials: Spinal Metastases
Post-Dural Puncture Headache
Comparing the Effects of Ondansetron Versus Dexamethasone on the Incidence of Post-dural Puncture Headache (PDPH) , Nausea and Vomiting After Spinal Anaesthesia of Parturients Undergoing Caesarean Section
Comparing dexamethasone and ondanestrone injection in ncidence of postdural puncture headache and post-partum nausea and vomiting
- Trial name
- NCT05202574
- Testing
- Intravenous drug
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Minia University
Vertebral Bony Metastases
Differentiated Resistance Training of the Paravertebral Muscles in Patients With Unstable Spinal Bone Metastasis Under Concomitant Radiotherapy
Standard indications for palliative radiation of bony metastases include pain, spinal cord compression, and impending pathologic fractures.
- Trial name
- DISPO-2 (NCT02847754)
- Testing
- Isometric resistance training
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Heidelberg University
Neurogenic Bladder, Tethered Spinal Cord Syndrome
Urological Deterioration in Secondary Tethered Cord Syndrome and Clue to Detect It
Secondary tethered cord syndrome (STCS) has been diagnosed with signs of progressive deterioration in urological or neuroorthopedic systems following primary tethering surgery.
- Trial name
- NCT04483570
- Testing
- Redo-tethering operation
- Volunteers
- 54 people
- Sponsor
- Seoul National University Hospital
Spine Metastasis
A Phase II Trial Evaluating Radiation Boost to Painful Spinal Metastases
Spine SBRT is considered a standard of care for the treatment of spinal metastases. Compared to conventional radiation therapy, spine SBRT delivers high doses of radiation to the affected areas to the spinal metastases.
- Trial name
- OPTIMAL (NCT07478289)
- Testing
- Radiation Boost
- Where
- Canada
- Volunteers
- 108 people
- Sponsor
- Sunnybrook Health Sciences Centre
Spine Metastases
Prophylactic Radiotherapy of MInimally Symptomatic Spinal Disease
Early palliative care has been shown to improve the quality of life and even survival for patients with metastatic cancer. More and more supportive oncology teams in cancer centers now advocate for early integration of radiation…
- Trial name
- PROMISSeD (NCT05534321)
- Testing
- Prophylactic Radiotherapy, Standard of care systemic therapy
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Baptist Health South Florida
Bone Lesion, Bone Metastases
Ablation and Cementoplasty for Painful Bone Lesions
The aim of this research study is to assess the effectiveness of combined ablation and cementoplasty in the treatment of spinal, pelvic, and extraspinal lesions causing pain resistant to conventional treatment at our centre.
- Conditions
- Bone Lesion, Bone Metastases, Spine Metastases
- Trial name
- NCT04635137
- Testing
- Ablation and Cementoplasty
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- University of Calgary
Vertebral Metastasis
Prospective Observational Study on Vertebral Metastasis
Perspective observational cohort study in which the data relating to patients affected by one or more vertebral metastases or by vertebral localization of hemolifoproliferative malact and surgical treatment candidates will be…
- Trial name
- CVODMetsVert (NCT05985434)
- Testing
- Surgical treatment
- Where
- Italy
- Volunteers
- 191 people
- Sponsor
- Istituto Ortopedico Rizzoli
Secondary Osteoporosis, Spinal Cord Injury
The Efficacy of Denosumab in Incomplete Patients Spinal Cord Injury
The purpose of this study is to determine the usefulness of a drug, denosumab, to prevent the loss of bone in participants legs due to SCI.
- Trial name
- NCT03029442
- Testing
- Denosumab (Prolia)
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Bone Metastases in Subjects With Advanced Cancer
Research on the Optimization of Treatment for Spinal Metastases With Radioactive Particle Implantation Using TPS and Mechanical Dual Simulation
This prospective, open-label randomized trial evaluates a dual-simulation planning strategy that combines standard brachytherapy TPS with patient-specific biomechanical modeling for radioactive seed implantation in bone…
- Trial name
- NCT07171996
- Testing
- Dual-Simulation TPS + Biomechanical Planning, Conventional TPS Planning
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Li Min
Paraplegia, Upper Limb Pain
Adjusting Wheelchair Set-Up to Minimize Shoulder Joint Forces During Propulsion
Individuals who use a manual wheelchair depend upon their upper limbs to provide a means of locomotion during completion of their activities of daily living.
- Trial name
- NCT00785278
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Spine Metastasis, Early Goal Directed Therapy
Efficacy of Angiographic Embolization vs Non-embolization of Moderate/Poor Vascularized Vertebral Metastases on Intraoperative Bleeding During Surgery Decompression and Vertebral Stabilization.
Although angiographic embolization has been introduced for preoperative management of spine metastases in 1975 and is suggested today by many authors in the management of such pathologies, it needs to be confirmed by RCT.
- Conditions
- Spine Metastasis, Early Goal Directed Therapy, Embolization, Therapeutic, Blood Loss
- Trial name
- Embart (NCT03853434)
- Testing
- Embolization
- Where
- Italy
- Volunteers
- 4 people
- Sponsor
- Istituto Ortopedico Rizzoli
Degenerative Disc Disease
Comparison of IDD Therapy and Non-surgical Treatment for Low Back Pain Caused by Degenerative Disc Disease
This study is looking at a new machine called the Accu-Spina which administers internal disc decompression by following a computer program.
- Trial name
- NCT00165893
- Testing
- Accu-Spina Device/IDD therapy, Physical Therapy
- Volunteers
- 50 people
- Sponsor
- Emory University
Thoracic Cancer, Spine Cancer
Studying a New Piece of Equipment That Can Help Plan Radiation Therapy of the Spine
Participants will receive an MRI with a custom-built MRI coil for each participant. The purpose is to find out whether this custom-built MRI coil can help doctors see the different parts of the spine as well as or better than…
- Conditions
- Thoracic Cancer, Spine Cancer, Thoracic Diseases, Spine Disease
- Trial name
- NCT04227717
- Testing
- MRI with custom MRI spine coil
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Intervertebral Disc Displacement, Intervertebral Disc Degeneration
Safety and Efficacy With NOVOCART® Disc Plus (ADCT) for the Treatment of Degenerative Disc Disease in Lumbar Spine
NOVOCART® Disc plus is being investigated to explore its clinical applicability, safety and efficacy in the repair of a herniated disc with an indication for an elective sequestrectomy, and of the adjacent degenerated disc, if…
- Trial name
- NDisc (NCT01640457)
- Testing
- NOVOCART® Disc plus, NOVOCART® Disc basic
- Where
- 10 sites in Austria, Germany
- Volunteers
- 120 people
- Sponsor
- Tetec AG
Hepatocellular Carcinoma, Spine Metastasis
Diffusion-Weighted Magnetic Resonance Imaging
Recently, diffusion-weighted (DW) MR imaging has widened its application on various oncologic applications. Especially, it is expected the DW MRI could provide valuable information about early response evaluation after treatment…
- Trial name
- NCT02242786
- Testing
- External beam radiation therapy
- Where
- South Korea
- Volunteers
- 17 people
- Sponsor
- Samsung Medical Center
Spine Metastasis
A Study to Quantify Tumour Perfusion for Spine Metastasis Treated With Stereotactic Body Radiotherapy (SBRT)
Pre-clinical evidence suggests that radiotherapy reduces tumour-associated vasculature. The investigators will conduct a single-arm prospective study to quantify the reduction in tumour vasculature post-radiotherapy
- Trial name
- NCT03072979
- Testing
- Stereotactic body radiotherapy
- Where
- Singapore
- Volunteers
- 18 people
- Sponsor
- National University Hospital, Singapore
Spinal Metastasis
RELIEVE: Research on Effectiveness of Surgery and Radiotherapy on Relieving Spine Tumor Pain in Patients with Vertebral Metastases
This is a prospective, multicenter, observational study focusing on assessing and managing pain in patients with metastatic spinal tumors.
- Trial name
- RELIEVE (NCT06746103)
- Testing
- Surgery
- Volunteers
- 250 people
- Sponsor
- AO Foundation, AO Spine
Metastasis Spinal Tumor
Tranexamic Acid Use for Bleeding Prevention in the Surgical Treatment of Metastatic Spinal Tumor in Lung Cancer Patients
Massive blood loss occurs in metastatic spinal tumor resection and may cause severe complications. The objective of this study is to investigate whether the use of tranexamic acid will reduce perioperative and postoperative…
- Trial name
- NCT06023212
- Testing
- Tranexamic Acid, stroke-physiological saline solution (SPSS)
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Post-Lumbar Puncture Headache
Epidural Blood Patch on the Resolution of Postdural Puncture Headache (PDPH)
The purpose of this study is to address the question, "What is the volume of blood for injection at epidural blood patch that most effectively relieves post-dural puncture headache?"
- Trial name
- NCT00373074
- Testing
- Epidural Blood Patch
- Where
- United States
- Sponsor
- The University of Texas Health Science Center, Houston
Spinal Anesthetics Causing Adverse Effects in Therapeutic Use
Multimodal Approach to the Intrathecal Catheter for Obstetric Accidental Dural Puncture
Accidental dural puncture is an uncommon complication of epidural analgesia and can cause postdural puncture headache.
- Trial name
- NCT05910086
- Testing
- collection of data from the medical record
- Where
- France
- Volunteers
- 39 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne