Clinical trials: Spinal Metastases
Post-lumbar Puncture Headache, Backache
What Needle Diameter Should Physician Use When They Perform Lumbar Puncture ? A Randomized Controlled Trial
This study is intended to help guide the choice of needle diameter when performing a lumbar puncture. Smaller spinal needles have been shown to decrease rate of adverse events such as post-lumbar puncture headache and hearing…
- Trial name
- NCT01481922
- Testing
- whitacre 24 gauge, whitacre 22 gauge
- Where
- Canada
- Volunteers
- 62 people
- Sponsor
- McGill University
Spinal Cord Metastasis, Spinal Cord Tumor Malignant Intramedullary
Microsurgical Resection of Intramedullary Spinal Cord Metastases
The aim of the study is to establish a multi-center, retrospective database for patients with intramedullary spinal cord metastases (ISCM) and analyse the functional outcome in surgically treated ISCM patients.
- Conditions
- Spinal Cord Metastasis, Spinal Cord Tumor Malignant Intramedullary, Functional Outcome, Radiotherapy; Complications
- Trial name
- NCT06042946
- Testing
- Microsurgical resection of ISCM
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Cantonal Hospital of St. Gallen
Hypotension After Neuraxial Anesthesia, Cesarean Section
Comparing Spinal, Epidural, and Dural Puncture Epidural Anesthesia for Cesarean Delivery: Hemodynamics and Block Quality
The goal of this clinical trial is to compare three regional anesthesia techniques (spinal, epidural, and dural puncture epidural anesthesia) in healthy pregnant women undergoing planned (elective) cesarean delivery.
- Conditions
- Hypotension After Neuraxial Anesthesia, Cesarean Section, Anesthesia, Obstetrical, Post-Dural Puncture Headache
- Trial name
- NCT07883733
- Testing
- Spinal Anesthesia, Epidural Anesthesia, Dural Puncture Epidural Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Cesarean Section, Postoperative Nausea and Vomiting (PONV)
Restrictive vs Liberal Intraoperative Fluid Strategy and Postoperative Outcomes After Elective Cesarean Section
Spinal anesthesia for elective cesarean section is frequently associated with hemodynamic instability and postoperative complications such as postoperative nausea and vomiting (PONV) and delayed gastrointestinal recovery.
- Conditions
- Cesarean Section, Postoperative Nausea and Vomiting (PONV), Postdural Puncture Headache (PDPH), Postoperative Ileus
- Trial name
- NCT07440667
- Testing
- Restrictive intraoperative crystalloid fluid strategy (≤3 mL/kg/h), Liberal intraoperative crystalloid fluid strategy (>3 mL/kg/h)
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Nigde Omer Halisdemir University
Spinal Metastasis
Combining Intraoperative Radiotherapy With Kyphoplasty for Treatment of Spinal Metastases
The primary objective is to evaluate the tolerability (side effects) of the intraoperative radio therapy (IORT) (e.g., wound healing, infections, bone necrosis, nerve, spinal cord damage, and pathological fracture), and the…
- Trial name
- KYPHO-IORT (NCT02480036)
- Testing
- IORT with Kyphoplasty, Intrabeam®
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Loyola University
Brain and Central Nervous System Tumors, Metastatic Cancer
Tamoxifen, Carboplatin, and Topotecan in Treating Patients With CNS Metastases or Recurrent Brain or Spinal Cord Tumors
RATIONALE: Drugs used in chemotherapy, such as carboplatin and topotecan, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Brain and Central Nervous System Tumors, Metastatic Cancer, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00541138
- Testing
- carboplatin, tamoxifen citrate, topotecan hydrochloride
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- City of Hope Medical Center
Postdural Puncture Headache, Cerebrospinal Fluid Leak
Sphenopalatine Ganglion Nerve Block for Postdural Puncture Headache in Obstetrics
The SNOB study is a prospective, randomized, double-blind, placebo-controlled, cross-over pragmatic trial that has been designed in accordance with the CONSORT guidelines.
- Conditions
- Postdural Puncture Headache, Cerebrospinal Fluid Leak, Spinal; Puncture, Complications, Headache
- Trial name
- SNoB (NCT03181464)
- Testing
- Lidocaine 4%
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Hadassah Medical Organization
Breast Cancer, Prostate Cancer
Stereotactic Body Radiation Therapy for Spinal Metastases in Favorite Tumors
Stereotactic Body Radiation Therapy(SBRT) for spinal metastases has been proved a good results in pain relieve and local control, However,the longterm of efficacy and safety of this regimen is unclear.The purpose of the study is…
- Conditions
- Breast Cancer, Prostate Cancer, Non Small Cell Lung Cancer
- Trial name
- NCT03392233
- Testing
- Stereotactic Body Radiation Therapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- RenJi Hospital
Hypotension After Spinal Anesthesia, Post-Dural Puncture Headache
Effects of Preoperative Coffee Consumption in Cesarean Sections Under Spinal Anesthesia
The prospective study is planned in a university hospital. Spinal anesthesia is widely used for cesarean section currently for its safety, low cost, reliability, easiness to administer, immediate effect, and well-operating…
- Trial name
- NCT05262933
- Testing
- coffee, Water
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Sleep Apnea, Spinal Cord Injuries
Untreated Sleep Apnea as an Aggravating Factor for Other Secondary Medical Conditions After Spinal Cord Injury
This cross-sectional prospective study will assess the potential association of more severe sleep apnea after spinal cord injury with more intense neuropathic pain, more severe spasticity, and more significant cardiovascular…
- Conditions
- Sleep Apnea, Spinal Cord Injuries, Spasticity, Muscle, Neuropathic Pain
- Trial name
- NCT05687097
- Testing
- Home-based sleep screening test or hospital-unattended sleep screening test, Cardiovascular beat-to-beat monitoring, ECG monitoring
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University Health Network, Toronto
Lumbar Central Spinal Stenosis, Restless Legs Syndrome
Epidural Steroid Injection for Restless Legs Symptoms in Lumbar Stenosis
Lumbar central spinal stenosis (LCSS) is a common degenerative spinal disorder characterized by narrowing of the spinal canal, resulting in chronic low back pain, leg pain, and neurogenic claudication.
- Trial name
- NCT07637643
- Testing
- Lumbar Interlaminar Epidural Steroid Injection
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Saglik Bilimleri Universitesi
Vertebral Metastasis
Multicentre Medical-economic Study Evaluating the Efficacy of Adding ZOlédronique Acid to STERéotaxique Radiotherapy in the Treatment of Vertebral Metastases
Hypo-fractured radiotherapy in stereotactic conditions (RSHF) of bone metastases allows high doses to be delivered to the affected bone segment while sparing adjacent healthy tissues as well as possible.
- Trial name
- ZOSTER (NCT03951493)
- Testing
- Zoledronic Acid 4Mg Solution for Injection + Hypo-fractured radiotherapy in stereotactic conditions, Hypo-fractured radiotherapy in stereotactic conditions
- Where
- 7 sites in France
- Volunteers
- 225 people
- Sponsor
- Institut Cancerologie de l'Ouest
Chronic Pain
Targin® for Chronic Pain Management in Patients With Spinal Cord Injury
The study will be investigating the effectiveness of oxycodone-naloxone (brand name Targin®) at treating chronic pain in individuals with spinal cord injury.
- Trial name
- NCT03179475
- Testing
- Oxycodone Naloxone Combination
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of British Columbia
Surgery, Brain Tumor
Neurosurgical Transitional Care Programme
Readmissions increasingly serve as a metric of hospital performance, inviting quality improvement initiatives in both medicine and surgery.
- Conditions
- Surgery, Brain Tumor, Brain Tumor, Recurrent, Brain Pathology
- Trial name
- TCP (NCT03593330)
- Testing
- Transitional Care Programme
- Where
- United Kingdom
- Volunteers
- 242 people
- Sponsor
- Barts & The London NHS Trust
Venous Thromboembolism (VTE), Deep Vein Thrombosis (DVT)
Extended Prophylactic Anticoagulation Following Spinal Surgery for Metastatic Disease
People who have surgery on their spine to treat cancer that has spread (metastatic disease) have a high chance of developing dangerous blood clots in the legs or lungs.
- Conditions
- Venous Thromboembolism (VTE), Deep Vein Thrombosis (DVT), Pulmonary Embolism (PE), Spine Metastasis
- Trial name
- NCT07713875
- Testing
- Apixaban
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- James Bayley
Vertebral Bony Metastases
Intensity-modulated Radiotherapy With Integrated-boost in Patients With Spinal Bone Metastases
The primary goal of the study is to determine the local control-rate after radiotherapy (RT) with and without simultaneous integrated boost (SIB) concepts in patients with bone metastases of the spine.
- Trial name
- IRON-2 (NCT02832765)
- Testing
- A, B, C
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Heidelberg University
Spinal Metastases
Evaluation of Spinal Metastatic Tumour for Aggressive Spinal Sugery by Dual Energy CT
Metastatic vertebral disease is a major hazard for oncological patients because the performance and life quality will substantially deteriorate if presence of neoplastic compression.
- Trial name
- NCT03631095
- Where
- Taiwan
- Volunteers
- 61 people
- Sponsor
- National Taiwan University Hospital
Chest Wall Tumor, Breast Cancer
Pharmacologic Therapies to Mitigate Radiation- Associated Heart Disease
Radiation therapy is an essential treatment for tumors in the chest area, including breast, lung, esophageal, mediastinal cancers, and spine metastases.
- Conditions
- Chest Wall Tumor, Breast Cancer, Lung Cancer, Esophageal Cancer
- Trial name
- NCT07685938
- Testing
- Atorvastatin and Lisinopril
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Ankylosing Spondylitis, Axial Spondyloarthritis
Terbinafine Treatment of Axial Spondyloarthropathy
This is a pilot study to determine if further research is warranted to assess if anti-fungal therapy is an effective adjunctive treatment for axial spondyloarthropathy
- Conditions
- Ankylosing Spondylitis, Axial Spondyloarthritis, Psoriatic Spondylitis, Spondylitis Secondary to Inflammatory Bowel Disease
- Trial name
- FUN (NCT05119712)
- Testing
- Terbinafine Tablets, Laboratory Testing
- Where
- United States
- Sponsor
- Oregon Health and Science University
Spinal Cord Injury (=3 Years), Sublesional Bone Loss Secondary to SCI
Romosozumab to Improve Bone Mineral Density and Architecture in Chronic SCI
Treatment for sublesional bone loss (osteoporosis) in persons with chronic, motor-complete spinal cord injury (SCI) has been limited and unsuccessful to date.
- Trial name
- Chronic Romo (NCT04232657)
- Testing
- Romosozumab, Denosumab
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- VA Office of Research and Development