Clinical trials: Spinal Injuries
Acute Spinal Cord Injury (SCI)
Expanded Access to Elezanumab
This is an expanded access program (EAP) for eligible participants. This program is designed to provide access to Elezanumab prior to approval by the local regulatory agency. Availability will depend on territory eligibility.
- Trial name
- NCT04278235
- Testing
- Elezanumab
- Sponsor
- AbbVie
Spinal Cord Injuries (SCI), Neurogenic Lower Urinary Tract Dysfunction
Radio-frequency (RF) Bladder Monitor
The goal of this pilot feasibility study is to evaluate a wearable microwave (MW)-based bladder monitoring system in adult volunteers and those with spinal cord injury (SCI) who use self-catheterization for bladder management.
- Conditions
- Spinal Cord Injuries (SCI), Neurogenic Lower Urinary Tract Dysfunction, Neurogenic Bladder (NB)
- Trial name
- NCT07639541
- Testing
- Wearable microwave Bladder Monitoring System
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Spinal Cord Injury
Customized Employment for Veterans With Spinal Cord Injury
The reason for conducting this study is to learn about the best ways to help Veterans with spinal cord injury (SCI) gain meaningful employment.
- Trial name
- ACCESS-Vets (NCT04832802)
- Testing
- ACCESS, IPS
- Where
- 2 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Spinal Cord Injuries
Musculoskeletal Plasticity After Spinal Cord Injury
Patients with spinal cord injury (SCI) experience metabolic syndrome, diabetes, obesity, pressure ulcers, and cardiovascular disease at far greater rates than the general population.
- Trial name
- NCT02622295
- Testing
- Single-session electrically induced exercise, Electrically-induced exercise training
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Richard K Shields
Cervical Spinal Cord Injury
Abdominal Functional Electrical Stimulation Training and Its Effect on Mechanical Insufflation-Exsufflation
Compromised respiratory function as a result of tetraplegia is a leading cause of rehospitalisation for the tetraplegic patient group.
- Trial name
- NCT01800409
- Testing
- AFES
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- NHS Greater Glasgow and Clyde
Spinal Cord Injuries, Cardiometabolic Diseases
High Intensity Interval Exercise SCI
This study will determine if the implementation of a home-based telehealth high intensity interval exercise-training (HIIT)program can significantly improve cardiometabolic health and physical function in a cohort of individuals…
- Trial name
- NCT04940598
- Testing
- high intensity interval exercise, No-exercise control group
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Alabama at Birmingham
Spinal Cord Injuries, Photobiology
Clinical Study of Treatment of Acute Spinal Cord Injury by Near Infrared Light Irradiation
The purpose of this study was to observe the therapeutic effect of near-infrared light irradiation on the treatment of acute spinal cord injury in humans, and whether it can promote the recovery of neurological function.
- Conditions
- Spinal Cord Injuries, Photobiology, Neurological Rehabilitation, Near Infrared Light Irradiation
- Trial name
- NCT03643419
- Testing
- Laminectomy, Spinal nerve laser therapeutic apparatus（Composed of 808-band fully automatic control laser device and implantable 360° scattering medical fiber）
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xijing Hospital
Spinal Cord Injuries, Constipation
Neostigmine and Glycopyrrolate by Iontophoresis
To determine a lower effective dose of neostigmine to induce bowel evacuation by transcutaneous administration by iontophoresis.
- Conditions
- Spinal Cord Injuries, Constipation, Fecal Incontinence, Neurogenic Bowel
- Trial name
- NCT06351995
- Testing
- Combination of Neostigmine and Glycopyrrolate, I-Box by Dynatronics
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Spinal Cord Injury
Effect of Immersion Level on Respiratory Function of Spinal Cord Injury Patients During Balneotherapy
Balneotherapy is a physiotherapy technique which allows patients to work out in a weightless environment and which is often used in patients with spinal cord injury.
- Trial name
- BALNEORESPI (NCT01831414)
- Testing
- Water immersion at cervical level, Water immersion at xyphoid level
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
Tetraplegia, Spinal Cord Injury
Abdominal Functional Electrical Stimulation in Tetraplegia
People with high spinal lesions are at risk of respiratory complications because they have partial or complete paralysis of breathing muscles.
- Trial name
- NCT00202631
- Testing
- Surface Functional Electrical Stimulation
- Where
- United Kingdom
- Volunteers
- 4 people
- Sponsor
- South Glasgow University Hospitals NHS Trust
Chronic Pain
Targin® for Chronic Pain Management in Patients With Spinal Cord Injury
The study will be investigating the effectiveness of oxycodone-naloxone (brand name Targin®) at treating chronic pain in individuals with spinal cord injury.
- Trial name
- NCT03179475
- Testing
- Oxycodone Naloxone Combination
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of British Columbia
Kyphosis, Spinal Fractures
Intra-operative Assessment of the Intellirod LOADPRO Spinal Rod Strain Sensor for Use During Kyphotic Corrective Surgery
The LOADPRO Study is an intra-operative, non-significant risk (NSR) case series feasibility assessment of the Intellirod LOADPRO™ System measuring spinal rod strain in long spinal kyphotic corrective constructs.
- Trial name
- LOADPRO (NCT02768675)
- Testing
- LOADPRO
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Intellirod Spine
Acute Spinal Cord Injury
Functional Neural Regeneration Collagen Scaffold Transplantation in Acute Spinal Cord Injury Patients
The study is designed to assess the safety and efficacy of functional neural regeneration collagen scaffold transplanted into acute spinal cord injury patients.
- Trial name
- NCT02510365
- Testing
- Functional collagen scaffold
- Where
- 5 sites in China
- Volunteers
- 20 people
- Sponsor
- Chinese Academy of Sciences
Ankylosing Spondylitis
Clinical Trial of Osteoporosis in Ankylosing Spondylitis
This is an observational study aiming to study the prevalence and risk factors for osteoporosis and vertebral fractures in patients with ankylosing spondylitis attending three Rheumatology clinics in Western Sweden.
- Trial name
- NCT00858819
- Where
- Sweden
- Volunteers
- 250 people
- Sponsor
- Göteborg University
Spinal Cord Injuries
Effects of Ambulation Training Utilizing an Exoskeleton Robot on Subjects With Spinal Cord Injury
The present study aims to investigate the effects of ReWalk exoskeleton robot training on various physiological and psychological parameters among subjects with spinal cord injury, including body composition and bone mineral…
- Trial name
- NCT03340792
- Testing
- Ambulation training utilizing an exoskeleton robot
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- China Medical University Hospital
Vertebral Artery Dissection, Cerebrovascular Accident
Changes in Cerebral Blood Flow With Spinal Manipulative Therapy vs. Voluntary Motion
The investigators are performing a study to determine whether changes in blood flow occur in the neck and back of the brain following a series of head positions and a manipulation of the upper neck.
- Conditions
- Vertebral Artery Dissection, Cerebrovascular Accident, Cerebrovascular Stroke
- Trial name
- NCT01205490
- Testing
- head positions and spinal manipulation
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Canadian Memorial Chiropractic College
Detrusor Muscle Hyperactivity
Neurogenic Detrusor Overactivity Following Spinal Cord Injury or Multiple Sclerosis
The purpose of this study is to determine the efficacy and safety of a single dose of 750 U of Dysport compared to placebo for the improvement in the daily incontinence episode frequency for each administration mode in subjects…
- Trial name
- NCT01357980
- Testing
- Botulinum toxin type A
- Where
- 17 sites in Czechia, France and 3 more
- Volunteers
- 47 people
- Sponsor
- Ipsen
Spinal Cord Injuries
Telehealth Virtual Reality Exergaming for Spinal Cord Injury
This pilot feasibility study aims to test whether youth and adults with spinal cord injury can use a group virtual reality gaming intervention to exercise.
- Trial name
- NCT05318079
- Testing
- Virtual Reality Gaming
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Sarcopenic Obesity, Spinal Cord Injuries
Sarcopenic Obesity in Neurodisabilities
To describe the frequency and thresholds for sarcopenic obesity in neurodisabled persons and the fat and lean mass distribution based on various neurodisabilities
- Conditions
- Sarcopenic Obesity, Spinal Cord Injuries, Stroke, Multiple Sclerosis
- Trial name
- SarcObeNDS (NCT03863379)
- Testing
- whole body DXA
- Where
- Greece
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Dionyssiotis, Yannis, M.D.
FESD, Rehabilitation
Cost-Effectiveness Analysis of a Rehabilitation Protocol With FES Cycling in Persons With Complete SCI
20 patients were recruited by two hospitals (AOUP and AOUC) in Italy from January 2015 to January 2018. The participants have been addressed to two different groups: the ones recruited by the AOUP were submitted to an…
- Conditions
- FESD, Rehabilitation, Spinal Cord Injuries, Complete Spinal Cord Injury
- Trial name
- NCT04592679
- Testing
- FES-C, Standard Treatment
- Volunteers
- 20 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana