Clinical trials: Spinal Fusion
Spine, Pain
Effect of Magnesium on Neuromonitoring
Intraoperative neurophysiologic monitoring (IONM) is commonly used during complex spinal surgery to monitor the integrity of neural structures and improve the perioperative safety profile.
- Conditions
- Spine, Pain, Spine Surgery, Spine Surgery With Neuromonitoring
- Trial name
- MgNm (NCT06975072)
- Testing
- Magnesium sulfate administration
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, San Francisco
Spinal Fusion
Remifentanil Propofol Infusion in Pediatric Spinal Surgery
Total intravenous anesthesia(TIVA) is a commonly used anesthetic technique. Although TIVA can be accomplished with a variety of drug combinations, infusions of Propofol and Remifentanil are often used with dosage adjusted…
- Trial name
- NCT00761072
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Children's Hospital of Philadelphia
Degenerative Changes, Stenosis
Accell Evo3™ Demineralized Bone Matrix in Instrumented Lumbar Spine Fusion
The objective of this study is to prospectively evaluate the performance of Integra Accell Evo3 Demineralized Bone Matrix as an adjunct for instrumented posterolateral spine fusion, as compared to local autograft.
- Conditions
- Degenerative Changes, Stenosis, Spondylosis
- Trial name
- NCT02018445
- Testing
- Posterolateral Fusion
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- SeaSpine, Inc.
Spine Surgery
3rd-year Post-surgical Evaluation of Adjacent Segment Disc Degeneration Onset in Lumbar Spine (Spinal Fusion vs. Lumbar Arthroplasty With Disc Replacement)
The main objective of the study is to compare the onset of adjacent segment disk degeneration in two groups of patients (one "spinal fusion group" and one "lumbar arthroplasty with disc replacement" group) with each patient…
- Trial name
- ARTHRO-DEGE (NCT05561322)
- Testing
- Consultation involving pain evaluation, questionnaires and the Lasègue Manoeuver, Magnetic Resonance Imaging of the lumbar spine
- Where
- France
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Lumbar Spinal Stenosis, Lumbar Spondylolisthesis
Cognitive Behavioral Therapy (CBT) After Lumbar Spinal Fusion in Patients With High Pain Catastrophizing
Catastrophizing has emerged as the strongest independent predictor for persistent postsurgical pain. Although behavioral interventions, including Cognitive Behavioral Therapy (CBT), have been shown to reduce the impact of…
- Conditions
- Lumbar Spinal Stenosis, Lumbar Spondylolisthesis, Lumbar Instability, Spinal Disease
- Trial name
- TRIBECA (NCT03969602)
- Testing
- Cognitive-behavioral Therapy, Biomedical and surgery-specific education
- Where
- Switzerland
- Volunteers
- 126 people
- Sponsor
- Neurocenter of Southern Switzerland
Adolescent Idiopathic Scoliosis (AIS)
Effectiveness of Virtual Reality- Based Rehabilitation Program in Individuals With Adolescent Idiopathic Scoliosis After Posterior Fusion Surgery
The aim of this clinical study is to investigate the effect of virtual reality based rehabilitation program on kinesiophobia, respiratory muscle strength, spinal mobility, physical activity, spinopelvic parameters and quality of…
- Trial name
- NCT06753383
- Testing
- To the Virtual Reality Based Exercise, Routine physiotherapy and rehabilitation program
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Elif Yagmur Ozger
Ossification of the Posterior Longitudinal Ligament
A Prospective Study Comparing the Efficacy of Laminoplasty and Laminectomy With Fusion for Ossification of the Posterior Longitudinal Ligament With High Occupation Rate in Cervical Spine
The efficacy of laminoplasty and laminectomy with fusion for ossification of the posterior longitudinal ligament with high occupation rate in the cervical spine is not clear in the literature report so far.
- Trial name
- NCT05019001
- Testing
- Laminoplasty, Laminectomy With Fusion
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University Third Hospital
Spine Fusion, Spine Disease
Erector Spinae Plane Block for Cervical Spine Surgery
The study aims to assess the interfacial plane blocks' effect on pain level, course of postoperative rehabilitation, and anti-inflammatory analgesic effect.
- Conditions
- Spine Fusion, Spine Disease, Spinal Disease
- Trial name
- NCT06393530
- Testing
- 0.9%sodium chloride, 0.2% ropivacaine
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Poznan University of Medical Sciences
Degenerative Disc Disease Lumbar, Spondylolisthesis, Grade 1
PMCF Study Fortilink-TS Ti
This study is setup to be able to gather information on the safety and performance of the Fortilink-TS Ti cage of Paradigm Spine GmbH, up to one-year after the surgery.
- Trial name
- NCT07834736
- Testing
- Posterior lumbar interbody fusion surgery
- Where
- 2 sites in Spain
- Volunteers
- 50 people
- Sponsor
- BAAT Medical Products B.V.
Degenerative Spondylolisthesis or Retrolisthesis, Spinal Stenosis
A Clinical Study of the Dynesys(R) Spinal System
This non-inferiority study will compare the clinical outcomes of subjects implanted with the Dynesys Spinal System versus the clinical outcomes of subjects implanted with an instrumented posterior lateral spinal fusion.
- Conditions
- Degenerative Spondylolisthesis or Retrolisthesis, Spinal Stenosis, Stenosing Lesion.
- Trial name
- NCT00759057
- Testing
- Posterior Pedicle Screw System
- Where
- 26 sites in United States
- Volunteers
- 399 people
- Sponsor
- Zimmer Biomet
Posterior Lumbar Spinal Fusion Surgery
Protective Effect of Tranexamic Acid on Shedding of the Endothelial Glycocalyx in Patients Undergoing Spinal Fusion Surgery
The aim of this study was to determine whether the administration of tranexamic acid in patients undergoing lumbar spinal fusion surgery can inhibit damage in endothelial glycocalyx layer.
- Trial name
- NCT03697681
- Testing
- Tranexamic acid, 0.9% NaCl (normal saline)
- Where
- South Korea
- Volunteers
- 128 people
- Sponsor
- Yonsei University
Degenerative Disc Disease
Post-Market Surveillance Study of the TM Ardis Interbody Fusion System
This study is a post-market clinical follow-up study to fulfill the post-market surveillance obligations according to Medical Device Directive and MEDDEV 2.12-2_Rev2_January 2012.
- Trial name
- NCT02429908
- Testing
- TM-Ardis Interbody
- Where
- 10 sites in Belgium, Canada and 4 more
- Volunteers
- 80 people
- Sponsor
- Zimmer Biomet
Degenerative Conditions of the Lumbar Spine, Lumbar Spinal Stenosis
Post-Market Clinical Study of Functional Motion Outcomes in Subjects Treated With the Minuteman Device
This is a prospective, multi-center open-label single arm post-market study where the purpose is to evaluate the effectiveness and safety of the market approved Spinal Simplicity Minuteman G5 MIS Fusion Plate and bone graft…
- Conditions
- Degenerative Conditions of the Lumbar Spine, Lumbar Spinal Stenosis, Spondylolisthesis
- Trial name
- STABILITY (NCT06355791)
- Testing
- Minuteman G5 Device
- Where
- 6 sites in United States
- Volunteers
- 150 people
- Sponsor
- Spinal Simplicity LLC
Paralytic Scoliosis, Pelvic Obliquity
Posterior Minimally Invasive Surgery for Treating Paralytic Scoliosis With Pelvic Obliquity in Children Following Spinal Cord Injury
This randomized controlled trial compares posterior minimally invasive correction surgery with conventional posterior spinal fusion for children with paralytic scoliosis and severe pelvic obliquity following spinal cord injury.
- Conditions
- Paralytic Scoliosis, Pelvic Obliquity, Spinal Cord Injury, Neuromuscular Scoliosis
- Trial name
- NCT07594574
- Testing
- Posterior Minimally Invasive Correction Surgery, Conventional Posterior Spinal Fusion
- Where
- China
- Volunteers
- 39 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Postoperative Bracing for Spinal Deformity
Utility of Postoperative Bracing
The study is being done to assess if the use of bracing helps improve quality of life of patients that are undergoing a spinal fusion for deformity.
- Trial name
- NCT03947541
- Testing
- Thoracolumbosacral (TLSO) brace, No Bracing
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Duke University
Degenerative Instability, Spondylolisthesis
PMCF Study on the Safety and Performance of PROSPACE 3D / PROSPACE 3D OBLIQUE / TSPACE 3D
Prospective, pure data collection of all PROSPACE 3D, PROSPACE 3D Oblique, TSPACE 3D patients in selected centers (not interventional, multicenter
- Conditions
- Degenerative Instability, Spondylolisthesis, Post-discectomy Syndrome, Post-traumatic Instabilities
- Trial name
- PROTONTO (NCT04542577)
- Where
- 2 sites in Germany
- Volunteers
- 208 people
- Sponsor
- Aesculap AG
Non-idiopathic Scoliosis
Non-Idiopathic Scoliosis Treated With Tranexamic Acid
Investigation of tranexamic acid (TXA) for reducing perioperative blood loss and transfusion requirement in pediatric patients with secondary scoliosis undergoing posterior spinal fusion.
- Trial name
- NCT01089140
- Testing
- Tranexamic acid 10mg/kg/hr, Tranexamic acid 100 mg/kg/h infusion, Saline solution
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- The Hospital for Sick Children
Scoliosis Idiopathic, Scoliosis;Congenital
Hypertonic Saline in Posterior Spinal Fusion
This is a prospective, randomized study in patients greater than or equal to 10 years of age scheduled for an posterior spinal fusion that requires invasive monitoring of arterial blood pressure.
- Trial name
- NCT06822374
- Testing
- Normosol-R, buffered 2% hypertonic saline
- Where
- United States
- Sponsor
- Joseph D. Tobias
Spinal Fusion
Endothelial Damage in Major Spine Surgery, Measured by Circulating Syndecan-1: an Observational Study.(GlycOrtho)
The goal of this observational study is to learn about endothelial damage in major spine surgery, expressed as rise in circulating Syndecan-1.
- Trial name
- GlycOrtho (NCT06119542)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Istituto Ortopedico Rizzoli
Spinal Stenosis, Spondylolisthesis
Retrospective, Multicenter Clinical Evaluation of Health Economic Drivers and Complications for Two Lumbar Fusion Procedures
The purpose of this retrospective data review is to evaluate the health economic drivers and complications of two surgical procedures: transsacral lumbar interbody fusion and transforaminal lumbar interbody fusion when used in…
- Conditions
- Spinal Stenosis, Spondylolisthesis, Degenerative Disc Disease (DDD)
- Trial name
- NCT02171169
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- Baxano Surgical, Inc.