Clinical trials: Spinal Disorders/Injuries
Spinal Cord Injuries
Vibration for Muscle Spasms After Spinal Cord Injury
This study uses closed-loop control of tendon vibration to implement clinically meaningful management of muscle spasms after spinal cord injury (SCI), and to understand the mechanisms responsible for spasm generation change in…
- Trial name
- NCT03598504
- Testing
- Wearable EMG/Vibration device
- Where
- United States
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injuries
Mindfulness, Exercise and Nutrition To Optimize Resilience for Individuals With a Spinal Cord Injury.
The purpose of this study is to examine the effects of onsite and telehealth programs for individuals with spinal cord injury. The primary aim of this study is to compare the effectiveness of a blended 5-day onsite health…
- Trial name
- MENTOR (NCT03207737)
- Testing
- MENTOR + Telehealth, Telehealth Only
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Alabama at Birmingham
Spinal Cord Injuries
Spinal Cord and Artificial Intelligence
The aim of this study was to analyze using an artificial intelligence engine (IA) the influence of the pathophysiological environment (set parametric monitoring data, imaging, biology etc.) of acute spinal cord trauma on spinal…
- Trial name
- SKY (NCT02833428)
- Testing
- Biomedical equipment (Eclipse Nim, Medtronic®)
- Where
- France
- Volunteers
- 1 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Spinal Cord Injury, Paraplegia
Exoskeletal-assisted Walking to Improve Mobility, Bowel Function and Cardio-Metabolic Profiles in Persons With SCI
The primary objective of this study is to achieve successful walking skills using exoskeletal walking devices over the course of 36 sessions in 3 months at specific velocities and distances in people with chronic SCI who are…
- Conditions
- Spinal Cord Injury, Paraplegia, Tetraplegia
- Trial name
- EAWSCI (NCT02314221)
- Testing
- Exoskeletal-assisted walking (ReWalk, Ekso)
- Where
- 3 sites in United States
- Volunteers
- 73 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Obstructive Sleep Apnea, Hypercapnia
Home-Based Diagnosis and Management of Sleep-Related Breathing Disorders in Spinal Cord Injury
Patients with spinal cord injury (SCI) usually breathe without any mechanical assistance, but significant breathing problems occur often during sleep, either because the upper airway closes (obstructive sleep apnea; OSA), or…
- Conditions
- Obstructive Sleep Apnea, Hypercapnia, Spinal Cord Injury
- Trial name
- NCT01882257
- Testing
- BiPAP, BiPAP/AVAPS (Phillips Respironics)
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- University of Michigan
Cervical Spinal Cord Injury, Tetraplegia
Nerve Transfer to Improve Function in High Level Tetraplegia
The goal of this observational study is to determine if nerve transfer surgeries improve upper extremity function and quality of life in patients with a high level cervical spinal cord injury.
- Trial name
- NCT06288763
- Where
- 10 sites in United States, Canada
- Volunteers
- 30 people
- Sponsor
- Washington University School of Medicine
Pain Management
Combined Peripheral (BreEStim) and Central Electrical Stimulation (tDCS) for Neuropathic Pain Management - Spinal Cord Injury
This study looks at the effect of combined breathing-controlled electrical stimulation (BreEStim) and transcranial direct current stimulation (tDCS) on neuropathic pain after spinal cord injury, amputation, or brain injury.
- Trial name
- NCT03302793
- Testing
- BreEStim, tDCS
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- The University of Texas Health Science Center, Houston
Spinal Cord Injuries, Stroke
Restorative Neuromodulation for Lower Extremity Functions
The overall objective of the proposed study is to restore lower-extremity functions of paraplegic individuals. Paralysis following Stroke or spinal cord injury (SCI) result harsh sufferings including lifelong dependence on…
- Conditions
- Spinal Cord Injuries, Stroke, Paralysis
- Trial name
- NCT04171375
- Testing
- trans-spinal Electrical Stimulation (tsES)
- Where
- Hong Kong
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Spinal Cord Injury (SCI)
Trunk Balance and Functional Independence in Individuals With SCI
This study investigates the relationship between trunk balance, position sense, wheelchair skills, and functional independence in individuals with thoracic spinal cord injury.
- Trial name
- SCI (NCT06612112)
- Testing
- No Interventions
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Afyonkarahisar Health Sciences University
Spinal Cord Injuries
Exercise for People with Spinal Cord Injury
The purpose of the study is to examine the impact of a transitional exercise intervention implemented in the community for people with SCI on psychological well-being, social factors, and physiological health.
- Trial name
- NCT04007445
- Testing
- Formally Directed Group (Exercise Group), Self-Directed Group (Control Group)
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Washington University School of Medicine
Spinal Cord Injuries, Anxiety
Biofeedback Treatment of Anxiety Associated With Chronic Spinal Cord Injury
The purpose of this research is to test the feasibility of an intervention using biofeedback to treat stress and anxiety among individuals with tetraplegia.
- Conditions
- Spinal Cord Injuries, Anxiety, Stress, Tetraplegia
- Trial name
- NCT03975075
- Testing
- Psychophysiological monitoring, Biofeedback training
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Craig Hospital
Neurogenic Bladder, Incomplete Spinal Cord Injury
Effects Of App-Supported Transitional Care On Neurogenic Bladder In Spinal Cord Injury Patients
This is a single-blind randomized controlled trial for patients with neurogenic bladder after incomplete spinal cord injury. Participants are randomly divided into two groups.
- Trial name
- NCT07641101
- Testing
- Mobile Application Based Transitional Care, routine standardized inpatient bladder nursing
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Xiamen University
Spinal Deformity, Spinal Degenerative Disorder
The Ailliance Post-Market Clinical Study
The purpose of this clinical study is to collect performance and safety data for post-market Medtronic devices indicated for cranial and/or spinal indication(s). Subjects are enrolled and followed postoperatively to 24 months.
- Conditions
- Spinal Deformity, Spinal Degenerative Disorder, Spinal Fusion Failure, Spinal Trauma
- Trial name
- NCT05856370
- Testing
- Follow-up schedule: pre-operative baseline up to 24-months post-procedure
- Where
- 29 sites in United States, France and 4 more
- Volunteers
- 1,000 people
- Sponsor
- Medtronic Spinal and Biologics
Spinal Cord Injuries
Needs of Persons with Spinal Cord Injury (SCI)
Persons with spinal cord injury (PwSCI) are at a greater risk for major health conditions and poorer health outcomes than persons without spinal cord injury (SCI).
- Trial name
- NCT04422769
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Washington University School of Medicine
Axial Spondyloarthritis, Rheumatoid Arthritis
Enthesis Differences in Rheumatoid Arthritis and Axial Spondyloarthropathy
The aim of this study is to investigate the sonographic differences in entheses in patients with Rheumatoid arthritis and Axial Spondyloarthropathy.
- Conditions
- Axial Spondyloarthritis, Rheumatoid Arthritis, Enthesitis, Enthesopathy
- Trial name
- NCT05942976
- Testing
- ULTRASOUND
- Where
- Turkey (Türkiye)
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Istanbul Training and Research Hospital
Spinal Cord Injuries, Rehabilitation
Effects of Walking Training on Different Surfaces on Walking Ability in Ambulatory Patients With Spinal Cord Injury
The study compares effects of 4-week walking training program on a walking track with difference surface [WTDS] and a firm ground on functional ability of ambulatory individuals with incomplete spinal cord injury [iSCI], using…
- Trial name
- NCT03622710
- Testing
- Rehabilitation therapy
- Where
- Thailand
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Spinal Cord Injuries, Stroke
Transcutaneous Spinal Cord Stimulation for Upper Extremity Function
Transcutaneous electrical stimulation (tcES) of the spinal cord has shown great promise in restoring upper extremity function after spinal cord injury (SCI).
- Trial name
- NCT06596369
- Testing
- Transcutaneous spinal cord stimulation, Upper extremity rehabilitation
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- University of Alberta
Spinal Cord Injury
Mobility and Therapeutic Benefits Resulting From Exoskeleton Use in a Home and Community Setting (SC140121 Study 3)
The proposed study is a pilot study intended to inform the hypothesis that regular walking in an exoskeleton within the home and community might offer health benefit, neurological recovery, and/or mobility benefit to the user.
- Trial name
- NCT04149769
- Testing
- Indego Exoskeleton
- Where
- 3 sites in United States
- Sponsor
- Vanderbilt University
Osteoporosis, Vertebral Fracture
Percutaneous Vertebroplasty: Prophylactic Treatment of Adjacent Vertebra
Percutaneous vertebroplasty is a treatment for painful osteoporotic compression fractures. Multiple reports have shown as high as 20 % refracturerates in vertebrae adjacent to those that have been treated with percutaneous…
- Trial name
- NCT00635297
- Testing
- Percutaneous vertebroplasty
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Ullevaal University Hospital
Central Cord Syndrome
The Natural History of Traumatic Spinal Cord Injury Using fMRI, MRS and DTI
Traumatic spinal cord injury is a common injury to the spine and can lead to a clinical syndrome called central cord syndrome (CCS).
- Trial name
- NCT00790361
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's