Clinical trials: Spinal Cord Stimulation
Diabetic Neuropathies
tSCS and AR on Pain and Balance in Diabetic Peripheral Neuropathy
tSCS and AR-based training have individually shown benefits in neuromotor rehabilitation; no study to date has evaluated their combined effects on pain, balance, lower-limb strength, retention, and vibration sense in diabetic…
- Trial name
- NCT07619794
- Testing
- transcutaneous spinal cord stimulation, Augmented Reality
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Endometriosis, Pelvic Pain
tDCS Versus tsDCS for Endometriosis-related Chronic Pelvic Pain Treatment
The purpose of the study is to compare the analgesic effect of 2 mA anodal direct current stimulation on the right primary motor cortex (M1) (tDCS) with a similar stimulation on the spine (D10) (tsDCS) in healthy volunteers (HV)…
- Conditions
- Endometriosis, Pelvic Pain, Transcranial Direct Current Stimulation, Spinal Cord Stimulation
- Trial name
- DCSErCPP (NCT02958423)
- Testing
- Transcranial DCS Healthy Volunteers, Transspinal DCS Healthy Volunteers, Transcranial DCS CPP patients
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Jean Schoenen
Parkinson Disease
Exploring the Effects of Spinal Cord Stimulation in Parkinson's Disease.
Parkinson Disease (PD) patients experience a variety of motor issues such as walking difficulties, loss of balance, and freezing while walking, which impacts their quality of life.
- Trial name
- SCS for FOG (NCT03526991)
- Testing
- Spinal Cord Stimulator (SCS)
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Nora Vanegas
Healthy Control, Spinal Cord Injury
Paired Stimulation Plasticity for Motor Recovery in Humans With and Without Spinal Cord Injury
This study will investigate how aging and spinal cord injury (SCI) affect the transmission and plasticity of the corticospinal and reticulospinal tracts, which are important pathways for motor control.
- Trial name
- NCT07814313
- Testing
- CST PAS, RST PAS
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Chronic Pain
A Prospective Trial for the Effectiveness of the Use of Spinal Cord Stimulation (SCS) in Failed Knee Surgery
A study for patients who have chronic postoperative pain who had knee replacement surgery. If qualified, a 14 day trial and an implantation of spinal cord stimulator for control of pain will be administered.
- Trial name
- NCT01912924
- Testing
- Spinal cord stimulator (Boston Scientific)
- Where
- United States
- Sponsor
- Coastal Orthopedics & Sports Medicine
Spinal Cord Injury, Stroke
Control of Unsupported Paraplegic Standing
The study will investigate the feasibility of using functional electrical stimulation (FES) of the calf muscles of paraplegic subjects to assist in posture stabilisation during standing.
- Trial name
- NCT00204113
- Testing
- Multi-purpose rehabilitation frame, Surface Functional Electrical Stimulation
- Where
- 2 sites in United Kingdom
- Volunteers
- 10 people
- Sponsor
- University of Glasgow
Failed Back Surgery Syndrome
Improvement of Gait by Spinal Stimulation in Patients With Postoperative Chronic Lumbosciatalgia: Pilot Study (GaitStim)
The purpose of this study is to explore the changes in objective walking parameters induced by medullary stimulation in patients with Fail Back Surgery Syndrome, after chronic stimulation, in comparison with preoperative…
- Trial name
- GAITSTIM (NCT05857696)
- Testing
- walking quantified analysis
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Pain, Neuropathic, Failed Back Surgery Syndrome
Coordinated Reset Spinal Cord Stimulation
The goal of this study is to evaluate whether a new spinal cord stimulation paradigm, called Coordinate Reset (CR) Stimulation, can provide equivalent or better pain relief with reduced energy requirements.
- Trial name
- NCT04997278
- Testing
- Coordinated Reset spinal cord stimulation
- Where
- United States
- Sponsor
- Stanford University
Refractory Chronic Migraine
A Feasibility Clinical Trial to Evaluate High Frequency Spinal Cord Stimulation for the Treatment of Patients With Chronic Migraine
The purpose of this study is to assess short- and long-term safety, tolerability and efficacy of cervical High Frequency Spinal Cord Stimulation (HF-SCS) in patients suffering from chronic migraine refractory to conventional…
- Trial name
- rCM HF-SCS (NCT01653340)
- Testing
- Senza™, High Frequency Spinal Cord Stimulator for Refractory Chronic Migraine
- Where
- Italy
- Volunteers
- 18 people
- Sponsor
- University of Roma La Sapienza
Failed Back Surgery Syndrome
Efficacy Study of the Octapolar Lead in Patients With Failed Back Surgery Syndrome (FBSS) With Chronic Pain
Spinal cord stimulation (SCS) has been used for over 40 years to treat neuropathic pain. Various clinical studies have shown a beneficial effect of SCS on pain in patients with Failed Back Surgery Syndrome (FBSS).
- Trial name
- NCT01096147
- Testing
- Spinal cord stimulation with eight polar electrode
- Where
- 8 sites in Belgium, Norway and 1 more
- Volunteers
- 80 people
- Sponsor
- Rik Buschman, PhD
Multiple Sclerosis, Mobility Limitation
Innovative Approaches to Enhance Balance and Neuroplasticity in Multiple Sclerosis
This study will evaluate the effects of combining balance training with electrical stimulation techniques in individuals with Multiple Sclerosis (MS).
- Conditions
- Multiple Sclerosis, Mobility Limitation, Balance; Distorted, Gait
- Trial name
- NCT07174973
- Testing
- Balance training with FES, Balance training wiith combined neuromodulation (TSCS+FES), Balance training only
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- University Health Network, Toronto
Multiple Sclerosis
Pilot Study of tSCS for Improving Upper Limb Function in People With Multiple Sclerosis
The goal of this clinical trial is to evaluate whether non-invasive spinal cord neuromodulation with the SCONE™ device can improve upper limb function in people with multiple sclerosis.
- Trial name
- tSCS-MS (NCT07152145)
- Testing
- Active stimulation tSCS, Occupational/Upper Limb Rehabilitation Therapy
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Parc de Salut Mar
Brain Injury, Cerebral Palsy
Combination Therapy of Cord Blood and G-CSF for Patients With Brain Injury or Neurodegenerative Disorders
This open label trial is conducted to investigate the efficacy and safety of the combination therapy of allogeneic umbilical cord blood (UCB) and granulocyte-colony stimulating factor (G-CSF) for patients with brain injury or…
- Conditions
- Brain Injury, Cerebral Palsy, Amyotrophic Lateral Sclerosis, Parkinson's Disease
- Trial name
- NCT02236065
- Testing
- Umbilical cord blood therapy, Filgrastim
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- MinYoung Kim, M.D.
Parkinson Disease, Atypical Parkinsonism
Spinal Cord Stimulation for Gait in Parkinson Disease
Balance and gait impairment increases the risk of falls and contributes to a reduced quality of life and shorter survival in Parkinson disease (PD) and atypical Parkinsonism patients.
- Trial name
- NCT03079310
- Testing
- Spinal cord stimulation
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Western University, Canada
Spinal Cord Injuries, Stroke
Transcutaneous Spinal Cord Stimulation for Upper Extremity Function
Transcutaneous electrical stimulation (tcES) of the spinal cord has shown great promise in restoring upper extremity function after spinal cord injury (SCI).
- Trial name
- NCT06596369
- Testing
- Transcutaneous spinal cord stimulation, Upper extremity rehabilitation
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- University of Alberta
Spinal Cord Injuries
Technology Development for Physical Rehabilitation of Patients With Upper Extremity Motor Deficits (RePlay)
Injuries and disease processes that produce upper extremity deficits are devastating to patients and their families. One potential avenue to treat these neurological disorders is through the enhancement of neural plasticity…
- Trial name
- RePlay (NCT03621969)
- Testing
- Physical exam and medical history, Assessments, Patient Instruction and use of Device (RePlay)
- Where
- 2 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Dallas
Spinal Cord Injuries
Spinal Stimulation + FES-Assisted Cough Training in SCI
The overall objective of this proposal is to determine if transcutaneous spinal cord stimulation (tSCS) delivered concurrently with functional electrical stimulation (FES)-assisted cough training (FES-Cough) is an effective…
- Trial name
- NCT07683780
- Testing
- tSCS combined with FES-Cough
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Milap Sandhu
Spinal Cord Injuries
Locomotor and Bladder Function in Individuals With Acute Spinal Cord Injury
The loss of movement and walking ability significantly affects quality of life after spinal cord injury. In addition, bladder dysfunction consistently ranks as one of the top disorders affecting quality of life after spinal cord…
- Trial name
- MC-PP-3 (NCT04879862)
- Testing
- Epidural stimulation + Stand Training, Epidural stimulation + Step Training, Epidural stimulation + Bladder Capacity Training
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Claudia Angeli
Spinal Cord Injuries, Spinal Cord Diseases
Spinal Cord Transcutaneous Stimulation Effect on Blood Pressure in Acute Spinal Cord Injury (SCI)
The goal of this clinical trial is to evaluate the effect of transcutaneous spinal cord stimulation on blood pressure in individuals with an acute spinal cord injury (within 30 days of injury).
- Conditions
- Spinal Cord Injuries, Spinal Cord Diseases, Trauma, Nervous System, Nervous System Diseases
- Trial name
- SCI (NCT05731986)
- Testing
- Orthostatic challenge, Biostim-5 transcutaneous spinal stimulation - Mapping, Biostim-5 transcutaneous spinal stimulation - "Optimal" testing
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Kessler Foundation
Spinal Cord Injuries
FES and Upper Limb Loading Exercises Outcome Comparison on Hand Function in Spinal Cord Injury Patients
This study is conducted to assess the effectiveness of functional electrical stimulation Vs limb loading exercises on hand grip strength,dexterity and function in patients with subacute cervical spinal cord injury.
- Trial name
- OCONHAND (NCT05863988)
- Testing
- Functional Electrical Stimulation, Upper Limb Loading Exercises
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Riphah International University