Clinical trials: Spinal Cord Injury (SCI)
Spinal Cord Injuries
Dual Stimulation for Spinal Cord Injury
The goal of this Spinal Cord Injury (SCI) Open-Label Clinical Trial is to test the safety and feasibility of the intervention. The study aims to answer whether implementing this intervention on inpatients at a specialized…
- Trial name
- DS-SCI (NCT07467850)
- Testing
- tsDCS+pDCS, Low-level laser therapy
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Spaulding Rehabilitation Hospital
Spinal Cord Injury, Constipation
Utility of an Animated Bowel Biofeedback Training Routine to Improve Bowel Function in Individuals With SCI
An injury to the spinal cord results in a number of secondary medical problems, including the inability to voluntarily control the bowels.
- Conditions
- Spinal Cord Injury, Constipation, Fecal Incontinence, Neurogenic Bowel
- Trial name
- NCT02406859
- Testing
- Bowel Biofeedback, Anorectal Manometry
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injuries
Spinal Neurorehabilitation for Veterans With SCI
Chronic spinal cord injury (SCI) is a debilitating disorder in Veterans and the broader U.S. population that does not have a cure.
- Trial name
- NCT07222046
- Testing
- Neurophysiological and anatomical testing, Transcutaneous Spinal Stimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injuries (SCI)
The Predictive Value of Lower Extremity Hypertonia on Neurogenic Detrusor Overactivity After Spinal Cord Injury
The goal of this observational study is to evaluate whether increased lower extremity muscle tone can serve as an independent predictor of neurogenic detrusor overactivity (NDO) in adult patients (aged 18-80 years) with upper…
- Trial name
- NCT07695662
- Volunteers
- 300 people
- Sponsor
- Shengjing Hospital
Spinal Cord Injuries
FES Therapy:Restoring Voluntary Grasping Function in Chronic SCI
The main objective of this study is to determine the effectiveness of a new treatment regime that uses electrical stimulation for the improvement of hand function in persons with spinal cord injuries (SCI).
- Trial name
- NCT01208688
- Testing
- FES Therapy, Conventional Occupational Therapy
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Toronto Rehabilitation Institute
Spinal Cord Injury, Pressure Ulcers
Skin Blood Flow Response to Insulin Iontophoresis in Pressure Ulcers of SCI
Pressure ulcers (PU) are skin breakdowns that often form after blood flow in the skin is reduced from prolonged and repeated exposure to externally applied forces.
- Trial name
- NCT02585765
- Testing
- Pioglitazone
- Where
- United States
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Spinal Cord Injuries
Long-term PAS in Rehabilitation After SCI
The investigators have recently shown in two pilot incomplete SCI patients that long-term paired associative stimulation is capable of restoring voluntary control over some paralyzed muscles and enhancing motor output in the weak…
- Trial name
- NCT03045744
- Testing
- long-term paired associative stimulation
- Where
- Finland
- Volunteers
- 5 people
- Sponsor
- Helsinki University Central Hospital
SCI - Spinal Cord Injury
Robot Assisted Gait Training in Persons With a Spinal Cord Injury
Over the past decade, RAGT has emerged as a promising method for improving ambulation after spinal cord injury (SCI). Early reports of this therapy were very promising, yet a recent study suggested that even though RAGT may…
- Trial name
- NCT05401734
- Testing
- Observation and follow up measurement
- Where
- Belgium
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Thomas More Kempen
Spinal Cord Injuries, Paraplegia, Spinal
Transspinal Stimulation Plus Locomotor Training for SCI
Locomotor training is often used with the aim to improve corticospinal function and walking ability in individuals with Spinal Cord Injury.
- Conditions
- Spinal Cord Injuries, Paraplegia, Spinal, Tetraplegia/Tetraparesis, Paraplegia, Spastic
- Trial name
- NCT04807764
- Testing
- Standing transspinal stimulation followed by robotic gait training, Lying transspinal stimulation followed by robotic gait training
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- City University of New York
Spinal Cord Injuries
Epidural Stimulation and Resistance Training After SCI
Spinal cord injury (SCI) is a devastating health problem for tens of thousands of military personnel, Veterans and civilians annually. Many persons with SCI must use a wheelchair for their entire life.
- Trial name
- REST-SCI (NCT04782947)
- Testing
- Exoskeletal assisted walking, Epidural Stimulation, Resistance Training
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- United States Department of Defense
Spinal Cord Injuries
Pressure Ulcer Prevention Study in SCI
The purpose of this study is to conduct a randomized controlled trial of a lifestyle redesign intervention's ability to (1)reduce the incidence of medically serious pressure ulcers and associated surgeries in adults with spinal…
- Trial name
- PUPS (NCT01999816)
- Testing
- Lifestyle Redesign
- Where
- 2 sites in United States
- Volunteers
- 170 people
- Sponsor
- University of Southern California
Spinal Cord Injury (SCI)
Safety Study of Human Spinal Cord-derived Neural Stem Cell Transplantation for the Treatment of Chronic SCI
This is a safety study of human spinal cord-derived neural stem cell (HSSC) transplantation for the treatment of chronic spinal cord injury.
- Trial name
- SCI (NCT01772810)
- Testing
- Human spinal cord stem cells.
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Neuralstem Inc.
Spinal Cord Injury, Sleep Disordered Breathing
Role of Enhancing Serotonin Receptors Activity for Sleep Apnea Treatment in Patients With SCI
The purpose of this study is to look at the effect of exciting using drugs to target a specific pathway in the body, that relies on a natural chemical the body produces called 'serotonin', in patients with spinal cord injury…
- Trial name
- REST-SCI (NCT02458469)
- Testing
- Buspirone, Trazodone
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Spinal Cord Injuries
NeuroSuitUp: Neurorehabilitation Through Synergistic Man-machine Interfaces
NeuroSuitUp is a multidisciplinary neurophysiological \& neural rehabilitation engineering project, developed by the Lab of Medical Physics \& Digital Innovation, School of Medicine, Faculty of Health Science Aristotle University…
- Trial name
- NeuroSuitUp (NCT05465486)
- Testing
- Brain-Computer Interface control of robotic arms with augmented reality, Serious game with augmented reality
- Where
- Greece
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Spinal Cord Injuries
Individual Patient Expanded Access IND of Hope Biosciences Autologous Adipose-derived Mesenchymal Stem Cells for Spinal Cord Injury
HBSCI02: This protocol is part of an FDA Individual Patient Non-emergency Expanded Access Request submitted on behalf of a 38-year-old father and husband who on August 4, 2017 at about 4:30pm, slipped off a boat head-first while…
- Trial name
- NCT04064957
- Testing
- HB-adMSCs
- Where
- United States
- Sponsor
- Hope Biosciences Research Foundation
Spinal Cord Injuries
Training Therapists in Motivational Interviewing
The purpose of this study is to test the efficacy of a Motivational Interviewing intervention on therapy participation as performed by physical and occupational therapists in an inpatient setting with patients with spinal cord…
- Trial name
- NCT03322202
- Testing
- Motivational Interviewing
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injuries
SCI Step Together: Improving Physical Activity Participation Among Individuals With SCI Who Ambulate
The project aims to test the feasibility of a new digital (mHealth) physical activity support program, delivered through an innovative mHealth platform (Curatio) for individuals living with spinal cord injury (SCI) who walk.
- Trial name
- NCT05063617
- Testing
- SCI Step Together
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- University of British Columbia
Spinal Cord Injury
Autologous Stem Cells for Spinal Cord Injury (SCI) in Children
The purpose of this research study is: 1. To see if Bone Marrow Cell harvest and transplantation are safe in children with Spinal Cord Injury, and 2.
- Trial name
- NCT01328860
- Testing
- bone marrow progenitor cells (BMPC) autologous transplantation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Aryn Knight
Spinal Cord Injury, Paraplegia
The Safety of ahSC in Chronic SCI With Rehabilitation
The purpose of this study is to assess the safety of autologous human Schwann cell (ahSC) transplantation in participants with chronic SCI.
- Conditions
- Spinal Cord Injury, Paraplegia, Quadriplegia, Tetraplegia
- Trial name
- NCT02354625
- Testing
- Autologous human Schwann cells
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- W. Dalton Dietrich
Spinal Cord Injury
Safety and Efficacy of Routine Colonoscopy Preparations
Periodic screening for colon cancer has become the standard of care in individuals over the age of 50. In this context, it is generally accepted that colonoscopy is the most sensitive modality for the detection of colon cancer…
- Trial name
- NCT00856440
- Testing
- Fleets Oral Sodium Phosphate Solution (OSPS), Colyte, Dual (OSPS & Colyte)
- Where
- United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs