Clinical trials: Spinal Cord Injury, Acute
Spinal Cord Injuries (SCI)
Spasticity in SCI Following Acute Intermittent Hypoxia
This study aims to observe the effects of administration of a breathing intervention (Acute Intermittent Hypoxia (AIH)) on spasticity (tightness) in individuals with incomplete Spinal Cord Injury.
- Trial name
- NCT07583498
- Testing
- Acute Intermittent Hypoxia (AIH)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Zev Rymer
Spinal Cord Injuries
Timing and Dosage of Acute Intermittent Hypoxia in Persons With SCI
This study will utilize short duration and mild levels of reduced oxygen (hypoxia) to induce spinal plasticity while evaluating the appropriate timing schedule for this intervention, as well as, the effects of superimposing…
- Trial name
- NCT03774043
- Testing
- Acute Intermittent Hypoxia
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Shirley Ryan AbilityLab
Fecal Incontinence
Acute Genital Nerve Stimulation for Neurogenic Bowel Dysfunction in Individuals Living With Spinal Cord Injury
Bowel issues occur in nearly all people after spinal cord injury (SCI) and one major complication is fecal incontinence (accidents).
- Trial name
- NCT05626816
- Testing
- Genital Nerve Stimulation, Clinical exam, Collection of SCI common data elements
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- MetroHealth Medical Center
Acute Spinal Cord Injury
Autologous Bone Marrow Cell Transplantation in Persons With Acute Spinal Cord Injury- An Indian Pilot Study.
Pilot study on 7 subjects in each group (total 21 subjects) to establish the safety and feasibility of autologous bone marrow cell transplantation in case of acute complete spinal cord injury by each of the following techniques…
- Trial name
- NCT02260713
- Testing
- autologous bone marrow cell
- Where
- India
- Volunteers
- 21 people
- Sponsor
- Indian Spinal Injuries Centre
Spinal Cord Injury
Study to Assess the Efficacy and Safety of MT-3921 in Subjects With Acute Traumatic Cervical Spinal Cord Injury
The purpose of this study is to compare the efficacy and safety of intravenous (IV) infusions of MT-3921 to placebo in subjects with acute traumatic cervical spinal cord injury.
- Trial name
- NCT04683848
- Testing
- MT-3921
- Where
- 23 sites in United States, Canada and 1 more
- Volunteers
- 72 people
- Sponsor
- Tanabe Pharma America, Inc.
Spinal Cord Injury
Autologous Bone Marrow-derived Mononuclear Cells for Acute Spinal Cord Injury
The purpose of this study is to evaluate the safety and effectiveness of intrathecal transplantation of autologous bone marrow-derived mononuclear cells for the treatment of traumatic acute spinal cord injury.
- Trial name
- NCT04528550
- Testing
- Autologous bone marrow-derived mononuclear cells
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Shanghai Changzheng Hospital
Spinal Cord Injury
Safety of Riluzole in Patients With Acute Spinal Cord Injury
The purpose of the study is to find out if the use of the drug Riluzole is both safe and improves outcome in patients with acute traumatic spinal cord injury (SCI).
- Trial name
- NCT00876889
- Testing
- Riluzole
- Where
- 8 sites in United States, Canada
- Volunteers
- 36 people
- Sponsor
- The Methodist Hospital Research Institute
Traumatic Thoracic Acute Spinal Cord Injury
The INSPIRE Study: Probable Benefit of the Neuro-Spinal Scaffold for Treatment of AIS A Thoracic Acute Spinal Cord Injury
This is an HDE probable benefit, open-label, non- randomized, single-arm, multicenter study to evaluate the safety and probable benefit of the poly(lactic-co-glycolic acid)-b-poly(L-lysine) Scaffold ("Scaffold") in subjects with…
- Trial name
- NCT02138110
- Testing
- Neuro-Spinal Scaffold
- Where
- 8 sites in United States
- Volunteers
- 20 people
- Sponsor
- InVivo Therapeutics
Spinal Cord Injuries
Acute Effects of Continuous Verses Interval Aerobic Training in Spinal Cord Injury Patient
To determine the Acute effects of continuous verses interval aerobic training on autonomic dysreflexia in Spinal Cord injury Patient. To Determine the Acute effects of these training on, Exercise Self efficacy and pain.
- Trial name
- NCT05061160
- Testing
- Interval Aerobic Exercise training Group, Continuous Aerobic Exercise training Group
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- Riphah International University
Spinal Cord Injury
Cerebrospinal Fluid Drainage (CSFD) in Acute Spinal Cord Injury
The purpose of this Phase IIB randomized controlled trial is to evaluate the safety and efficacy of CSFD and to provide a preliminary clinical efficacy evaluation of the combination of CSFD and elevation of mean arterial pressure…
- Trial name
- NCT02495545
- Testing
- CSFD and elevation of MAP, Maintenance of MAP
- Where
- 3 sites in United States
- Volunteers
- 15 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Spinal Cord Injuries, Neurogenic Bowel
Use of Point-of-care Neuro-sacral Electrophysiology Following Spinal Cord Injury
Assessing the sacral nerves is an integral aspect of the evaluation after a spinal cord injury. Being located at the lower end of the spinal cord, the sacral nerves reflect how signals travel through the injured spinal cord.
- Conditions
- Spinal Cord Injuries, Neurogenic Bowel, Neurogenic Bladder Dysfunction
- Trial name
- NCT06333886
- Testing
- Sacral electromyography
- Where
- Canada
- Volunteers
- 450 people
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Acute Spinal Cord Injury
Transplantation of Autologous Adipose Derived Stem Cells (ADSCs) in Spinal Cord Injury Treatment
This study is designed to assess the safety and effect of autologous adipose derived stem cell (ADSCs) transplantation in acute spinal cord injury patients. 1.
- Trial name
- NCT02034669
- Testing
- Laminectomy, Intradural space, Intrathecal
- Where
- Vietnam
- Volunteers
- 48 people
- Sponsor
- Tri Phuoc Biotechnology., JSC
Spinal Cord Injury, Acute, Neurogenic Bladder
Sacral Nerve Stimulation in Improving Bladder Function After Acute Traumatic Spinal Cord Injury
The purpose of this study is to see what effects sacral neuromodulation has on bladder function and quality of life in patients with acute spinal cord injury.
- Conditions
- Spinal Cord Injury, Acute, Neurogenic Bladder, Incontinence, Urinary Tract Infections
- Trial name
- NCT03083366
- Testing
- PrimeAdvanced Surescan 97702 Neurostimulator - Medtronic (Minneapolis, MN)
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- University of Utah
Spinal Cord Injuries, Acute Spinal Cord Injury
Stem Cells in Spinal Cord Injury
This is a multicenter, randomized, double-blind, placebo-controlled and delayed-start phase II/III clinical study.
- Conditions
- Spinal Cord Injuries, Acute Spinal Cord Injury, Paraplegia, Spinal, Paraplegia; Traumatic
- Trial name
- SCI2 (NCT03935724)
- Testing
- Neuro-Cells
- Where
- 2 sites in Denmark, Spain
- Volunteers
- 16 people
- Sponsor
- Neuroplast
Spinal Cord Injury, Acute
Cord Blood Cells in Patients With Acute SCI
This is a prospective, single-blinded, single-center, randomized, comparative, interventional clinical study of systemic mononuclear multiple allogenic cord blood cells administration safety and efficiency in patients having…
- Trial name
- SUBSCI II (NCT05693181)
- Testing
- Multiple systemic (i.v.) administration of allogenic non-related group- and rhesus-compatible mononuclear cord blood cells, Control vehicle (sterile saline)
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- Sklifosovsky Institute of Emergency Care
Incomplete Spinal Cord Injury
The Effect of Acute Intermittent Hypoxia on Motor Learning
The goal of this study is to examine the effect of repetitive acute intermittent hypoxia on motor learning abilities in able-bodied individuals for subsequent study in individuals with incomplete spinal cord injury.
- Trial name
- NCT05341466
- Testing
- Acute Intermittent Hypoxia
- Where
- 2 sites in United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Spinal Cord Injuries
Pairing Intermittent Hypoxia and Transcutaneous Electrical Spinal Cord Stimulation to Promote Arm Use After Cervical SCI
The purpose of this study is to test the efficacy of mild breathing bouts of low oxygen (intermittent hypoxia) combined with transcutaneous electrical spinal cord stimulation on restoring hand function in persons with chronic…
- Trial name
- NCT04854057
- Testing
- AIH - Intermittent Hypoxia - hypoxia air mixture, TESS - Transcutaneous Electrical Spinal Cord Stimulation + Functional Task Practice
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Spaulding Rehabilitation Hospital
Spinal Cord Injury
Acute Effect of Ventilatory Support During Exercise in Spinal Cord Injury
The investigators have an existing exercise program (N>70) with a unique population of individuals with spinal cord injury (SCI) who have been enrolled in Functional Electrical Stimulation - Rowing Training (FES-RT) for at least…
- Trial name
- NIV-Ex-CS (NCT03267212)
- Testing
- Non-invasive ventilation(NIV), Functional Electrical Stimulation Row Training (FESRT)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Spaulding Rehabilitation Hospital
Spinal Cord Injury
Treatment for Acute Spinal Cord Injury
This clinical trial aims to treat a damaged spinal cord by injecting your own bone marrow stromal cells (autologous bone marrow stromal cells) into cerebrospinal fluid through the lumbar puncture, and assess the safety and…
- Trial name
- NCT00695149
- Testing
- Transplantation of bone marrow stromal cell
- Where
- Japan
- Volunteers
- 5 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Spinal Cord Injuries, Neurogenic Bladder
Detrusor Activity Recovery in Acute Traumatic Spinal Cord Injuries
Determining the most appropriate time to evaluate detrusor activity in urodynamic studies for both traumatic and non-traumatic spinal cord injuries
- Conditions
- Spinal Cord Injuries, Neurogenic Bladder, Spinal Shock
- Trial name
- NCT05207826
- Testing
- Cystometrogram
- Sponsor
- Pusan National University Yangsan Hospital