Clinical trials: Sore Throat
Obstructive Tonsillar Hypertrophy, Tonsillitis
Randomized Controlled Study of Plasmaknife Tonsillectomy Versus Monopolar Tonsillectomy
Study objective is to provide prospective randomized controlled data on pediatric pain levels found in PlasmaKnife tonsillectomy and monopolar tonsillectomy.
- Trial name
- jPK (NCT00466544)
- Testing
- Plasmaknife, Monopolar
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Children's Hospital of Michigan
Recurrent Tonsillitis, Chronic Tonsillitis
Recovery From Tonsil Surgery.
The goal of this study is to optimize the duration of sick leave and the usage of opioids following partial tonsillar surgery in adults by comparing the recovery after extracapsular tonsillectomy (ECTE) with recovery after…
- Trial name
- FINITE-2 (NCT07598201)
- Testing
- extracapsular tonsillectomy, intracapsular tonsillectomy
- Volunteers
- 90 people
- Sponsor
- Turku University Hospital
Intubation, Intratracheal, Postoperative Complications
Endobronchial Intubation of Double-lumen Tube: Conventional Method vs Fiberoptic Bronchoscope Guide Method
Double lumen tube (DLT) needs to be intubated to isolate ventilations of left and right lungs for thoracic surgery. Post-operative sore throat and hoarseness are more frequent with DLT intubation than with single one.
- Conditions
- Intubation, Intratracheal, Postoperative Complications, Sore Throat, Hoarseness
- Trial name
- NCT03368599
- Testing
- Bronchoscope guided advancement, Conventional advancement
- Where
- South Korea
- Volunteers
- 136 people
- Sponsor
- Seoul National University Bundang Hospital
Postoperative Sore Throat, Nasal Obstruction
Pharyngeal Mucosal Conditioning to Prevent Postoperative Sore Throat in Septoplasty Patients With Severe Nasal Obstruction
Postoperative sore throat (POST) affects 21-65% of patients after endotracheal intubation and is among the most common complaints after general anesthesia.
- Conditions
- Postoperative Sore Throat, Nasal Obstruction, Septoplasty
- Trial name
- POST-MUCOSAL R (NCT07870252)
- Testing
- Nebulized 0.9% Normal Saline, Water-Soluble Lubricant Gel on Endotracheal Tube
- Where
- Saudi Arabia
- Volunteers
- 105 people
- Sponsor
- Mansoura University
Sinusitis, Otitis
Complicated Infections in Otorhinolaryngology
This observational study aims to learn more about complicated infections treated by otorhinolaryngologists. The main questions to answer are: What is the management of complicated sinonasal infections in Ljubljana, Slovenia, What…
- Conditions
- Sinusitis, Otitis, Laryngitis, Lymphadenitis
- Trial name
- ENT_infect (NCT06023550)
- Testing
- Treatment with surgery and/or conservative measures
- Where
- Slovenia
- Volunteers
- 2,550 people
- Sponsor
- University Medical Centre Ljubljana
Tonsillectomy, Tonsillitis
EXPAREL® for Pain After Tonsillectomy
The purpose of this study is to determine whether liposomal bupivacaine (long acting injectable anesthetic) provides greater post operative pain relief compared to the standard post operative pain regiment for tonsillectomy…
- Conditions
- Tonsillectomy, Tonsillitis, Post-operative Pain
- Trial name
- NCT02444533
- Testing
- Liposomal Bupivacaine
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Streptococcus Group A
Mol Epi GrAS in Nicaragua
The purpose of this study is to determine the epidemiology of throat isolates of group A streptococci among 3-15 year-old children with pharyngitis (sore throat) living in Leon, Nicaragua.
- Trial name
- NCT00170521
- Where
- Nicaragua
- Volunteers
- 13,000 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Tonsillitis
A Multicenter, Randomized, Double-Blind, Double-Dummy Study Of Azithromycin SR Versus Amoxicillin For The Treatment Of Strep Throat In Children
The objective was to determine if a single 60 mg/kg dose of azithromycin SR was as safe and effective as a 10-day regimen of amoxicillin (45 mg/kg/day, given in divided doses every 12 hours) when used to treat children with strep…
- Trial name
- NCT00643149
- Testing
- amoxicillin, azithromycin SR
- Where
- 46 sites in United States, Canada and 3 more
- Volunteers
- 693 people
- Sponsor
- Pfizer
Anti-Infective Agents
Special Drug Use Investigation - Assessment of Efficacy and Safety in Treating Secondary Infection of Chronic Respiratory Disease
The objective of this study is to assess the efficacy and safety of Avelox Tablet 400 mg (hereinafter as "Avelox") in treating secondary infection of chronic respiratory disease.It is a local prospective and observational study…
- Trial name
- NCT01690533
- Testing
- Avelox (Moxifloxacin, BAY12-8039)
- Where
- Japan
- Volunteers
- 497 people
- Sponsor
- Bayer
Tonsillitis, Pharyngitis
TELI TAD - Telithromycin in Tonsillitis in Adolescents and Adults
This is a multinational, randomized (1:1), double blind, comparator-controlled, 2 parallel treatment group study in subjects equal to or over 13 years of age, with Streptococcus pyogenes tonsillitis/pharyngitis (T/P).
- Trial name
- NCT00315549
- Testing
- Telithromycin, Penicillin
- Where
- 4 sites in United States, Argentina and 2 more
- Volunteers
- 233 people
- Sponsor
- Sanofi
Peritonsillar Abscess
Peritonsillar Abscess: Aspiration Versus Tonsillectomy a Chaud
Peritonsillar abscess (PTA) has a relatively high incidence of 41 per 100,000/year in Denmark. In spite of that, there is no regional or national consensus on treatment of PTA.
- Trial name
- NCT03326661
- Testing
- Aspiration, Tonsillectomy a chaud, Penicillin V + metronidazol (Penicillin allergy: Clindamycin alone)
- Where
- Denmark
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Sore Throat
The Effect of Cold Vapor Application on Postoperative Sore Throat
To determine the effect of cold vapor given in the post-extubation period on sore throat.
- Trial name
- NCT05317520
- Testing
- Cold vapor
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Burdur Mehmet Akif Ersoy University
Enlargement of Tonsil or Adenoid
Bioclinical Profile of Adenotonsillar Hypertrophy in the Pediatric Population
Adenotonsillar hypertrophy is the principal cause of obstructive sleep apnea of childhood, yet little is known with regard to its pathophysiologic and molecular mechanisms.
- Trial name
- NCT03541434
- Testing
- Complete Blood Count, Tympanometry, Tonsillectomy and/or adenoidectomy
- Where
- 2 sites in Greece
- Volunteers
- 134 people
- Sponsor
- University of Patras
Laparoscopic Surgery, Tracheal Intubation Morbidity
Effect of Cuff Pressure of Endotracheal Tube on POST
The main objective of this study is to evaluate the association between the duration of intraoperative cuff overpressure and the development of postoperative sore throat.
- Conditions
- Laparoscopic Surgery, Tracheal Intubation Morbidity, Sore-throat
- Trial name
- NCT05542823
- Where
- 2 sites in South Korea
- Volunteers
- 337 people
- Sponsor
- Seoul National University Hospital
Streptococcal Pharyngitis
GRoup A StrePtococcus
The purpose of the research is to help understand why some children become carriers of strep and whether children who are carriers need to be treated with antibiotics.
- Trial name
- GRASP (NCT01558804)
- Testing
- Identifying group A strep carriers
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Wisconsin, Madison
Influenza
Phase 3 Efficacy and Safety Study of Favipiravir for Treatment of Uncomplicated Influenza in Adults - T705US316
The purpose of this study is to determine if favipiravir is effective in reducing the time to resolution of influenza symptoms.
- Trial name
- NCT02026349
- Testing
- favipiravir
- Where
- 225 sites in United States, Australia and 12 more
- Volunteers
- 860 people
- Sponsor
- MDVI, LLC
Intubation Complication
Effect of Benzydamine Hydrochloride to Postoperative Sore Throat in Pediatric Patients
This study is designed to examine the effect of benzydamine hydrochloride to postoperative sore throat in pediatric patients. We will spray benzydmaine hydrochloride or normal saline at oral cavity and the tip of endotracheal…
- Trial name
- NCT03074968
- Testing
- Benzydamine Hydrochloride, Normal saline
- Where
- South Korea
- Volunteers
- 142 people
- Sponsor
- Seoul National University Hospital
Postoperative Sore Throat, Cough, Hoarseness, Thyroid and Parathyroid Surgery
Sore Throat After Open Neck Elective Surgery
This randomized clinical trial aims to evaluate the effectiveness of two medications-hydrocortisone ointment and lidocaine solution-applied to the endotracheal tube in reducing postoperative throat pain, hoarseness, and cough…
- Trial name
- STONES (NCT07124650)
- Testing
- Hydrocortisone Acetate 1% Ointment, Lidocaine hydrochloride 0,05% with chlorhexidine
- Where
- Russia
- Volunteers
- 764 people
- Sponsor
- Saint Petersburg State University, Russia
Tonsillitis
Multicenter, Open, Randomized Comparative Trial To Compare The Efficacy Of Azithromycin Versus Amoxicillin In Children With Strep Throat
The primary objective was to compare the bacteriological efficacy at Day 10 of azithromycin pediatric suspension (20 mg/kg/day once daily for 3 consecutive days) versus amoxicillin pediatric suspension (50 mg/kg/day in 2 doses…
- Trial name
- NCT00643539
- Testing
- Zithromax, Clamoxyl
- Where
- 45 sites in France
- Volunteers
- 360 people
- Sponsor
- Pfizer
Tonsillitis
Improving the Diagnosis of Tonsillitis in Emergency Rooms
A point-of-care laboratory (POC) was set at North Hospital, Marseille, France for the diagnosis in less than two hours of tonsillitis caused by known pathogens, close to the reception of Emergency service.
- Trial name
- NCT02858687
- Testing
- Nasopharyngeal swab
- Where
- France
- Volunteers
- 312 people
- Sponsor
- Assistance Publique Hopitaux De Marseille