Clinical trials: Solid Tumor Malignancies
Solid Tumors, Advanced Solid Tumors
A Two Part Study of RO6870810. Dose-Escalation Study in Participants With Advanced Solid Tumors and Expansion Study in Participants With Selected Malignancies
This is a Phase 1, non-randomized, dose-escalating, open label, multi-center study to be conducted in two parts (Part A and Part B).
- Trial name
- NCT01987362
- Testing
- RO6870810
- Where
- 4 sites in United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Neoplasm Malignant
Evaluation of SAR408701 in Japanese Patients With Advanced Malignant Solid Tumors
Primary Objective: To evaluate tolerability and safety of SAR408701 when administered as a single agent according to the investigational medicinal product (IMP) related dose limiting toxicities (DLTs) to determine the recommended…
- Trial name
- NCT03324113
- Testing
- SAR408701, dexamethasone, naphazoline
- Where
- 3 sites in Japan
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Sanofi
Locally Advanced or Metastatic Solid Tumor Harboring an NTRK Gene Fusion
Food Effect Study on the Pharmacokinetics of VC004 Capsules in Healthy Adult Subjects
This study will adopt a randomized, open-label, two-period, 2-way crossover design to evaluate pharmacokinetics of a single oral dose of VC004 capsules under fasting and fed conditions in healthy subjects.
- Trial name
- NCT05528120
- Testing
- VC004 Capsules
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Jiangsu vcare pharmaceutical technology co., LTD
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia
Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
This study collects blood and tissue samples from patients with cancer and without cancer to evaluate tests for early cancer detection.
- Conditions
- Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Ann Arbor Stage I Lymphoma, Ann Arbor Stage II Lymphoma
- Trial name
- NCT05334069
- Testing
- Questionnaire Administration, Biospecimen Collection
- Where
- 751 sites in United States
- Volunteers
- 2,900 people, healthy volunteers welcome
- Sponsor
- Alliance for Clinical Trials in Oncology
Cancer, Brain Tumor
Medical Treatment Decision Making Using Adaptive Conjoint Analysis
In the setting of progressive or recurrent cancer, adolescent and young adult (AYA) patients, parents, and healthcare providers (HCP) are faced with multiple therapeutic options.
- Conditions
- Cancer, Brain Tumor, Solid Tumor, Leukemia
- Trial name
- NCT02608307
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- St. Jude Children's Research Hospital
Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
On the BRINK: PhotoBiomodulation (PBM) for Mucositis in Patients Undergoing Allogeneic Hematopoietic Stem Cell TRansplant (HSCT) - Implementing the Evidence & Discovering New Knowledge
This study evaluates mucositis and other oral symptoms in patients undergoing photobiomodulation in patients undergoing hematopoietic stem cell transplantation.
- Trial name
- NCT06625619
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Refractory Solid Tumors, Lymphomas
A Double-Blind Study in Healthy Volunteers to Assess the Effect of E7080 on the QTc Interval
This is a double-blind (vis-a-vis lenvatinib), randomized, placebo-controlled, three-treatment, three-way crossover study in healthy subjects. There are two phases in this study: Pre-Randomization and Randomization.
- Trial name
- NCT01525394
- Testing
- Lenvatinib, Moxifloxacin 400 mg
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
Unspecified Adult Solid Tumor
Holographic Mm-Wave Imaging in Patients Undergoing Radiation Therapy
This trial studies the quality of holographic mm-wave imaging in patients undergoing radiation therapy. Holographic mm-wave imaging is a common type of imaging used in airport body scanners that may be helpful in improving the…
- Trial name
- NCT03789773
- Testing
- Millimeter-Wave Holographic Imaging
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Southern California
Unspecified Adult Solid Tumor, Protocol Specific
Nutrition Education for Low-Income Healthy Participants Who Eat an Unhealthy Diet
RATIONALE: Decreasing the amount of fat in the diet and increasing fruit and vegetable intake may help prevent some types of cancer.
- Trial name
- NCT00301691
- Testing
- behavioral dietary intervention, educational intervention, preventative dietary intervention
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Brown University
Hematopoietic and Lymphoid System Neoplasm, Malignant Solid Neoplasm
Analysis of Whole Body Magnetic Resonance Imaging and Liquid Biopsy for Early Detection of Cancer in Patients With a Strong Family History of Cancer
This study evaluates patient acceptability of whole body magnetic resonance imaging (WBM) and liquid biopsies (LB) in detecting early stage cancer in patients with a strong family history of cancer.
- Trial name
- NCT05868486
- Testing
- Biospecimen Collection, Genetic Testing for Cancer Risk, Liquid Biopsy
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Graft Versus Host Disease, Hematopoietic and Lymphatic System Neoplasm
Evaluating the Effects of Propionate and Butyrate Supplementation on the Intestinal Health of Healthy Volunteers
This clinical trial evaluates how propionate and butyrate supplementation alters intestinal health in healthy volunteers and whether it would be feasible to administer these supplements to patients undergoing allogeneic…
- Conditions
- Graft Versus Host Disease, Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
- Trial name
- NCT07611370
- Testing
- Biospecimen Collection, Microencapsulated Sodium Butyrate, Microencapsulated Sodium Propionate
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Hematopoietic and Lymphoid System Neoplasm, Malignant Solid Neoplasm
Evaluation of a Couple-Based Physical Activity Intervention
This clinical trial tests how well a couple-based physical activity (PA) intervention, Mates in Motion, works in patients undergoing hematopoietic cell transplantation (HCT) or chimeric antigen receptor T-cell therapy (CART) and…
- Trial name
- NCT06073951
- Testing
- Best Practice, Exercise Counseling, Exercise Intervention
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Solid Tumor, Healthy
Ex Vivo Expansion (ACT-X)
The purpose of this study is to understand how the body's immune cells respond to a new type of vaccine (neoantigen vaccine) designed to help the immune system recognize and fight cancer.
- Conditions
- Solid Tumor, Healthy, Malignant Solid Neoplasm
- Trial name
- NCT07137312
- Testing
- Blood Draw, Apheresis
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Advanced Solid Tumor
γδ T-PD-1 Ab Cells in the Treatment of Advanced Solid Tumors
This study intends to combine the advantages of γδ T cells and PD-1 monoclonal antibody to conduct an exploratory clinical study on the safety and efficacy of PD-1 antibody armored γδ T cells (γδ T-PD-1 Ab cells) in the treatment…
- Trial name
- NCT06404281
- Testing
- γδ T-PD-1 Ab cells
- Where
- China
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Changzhou No.2 People's Hospital
Solid Tumor, Solid Tumor, Adult
DESCANSO, a Mental Health Intervention for Depression, Insomnia, and Fatigue Symptoms in Latino People With Cancer
The purpose of this study is to improve ways of providing mental health support to Spanish-speaking Latino participants who have cancer and experience depression, insomnia, and fatigue.
- Trial name
- NCT07225088
- Testing
- DESCANSO/Depresión/Depressed Mood, Cansancio/Fatigue, and Sueño/Sleep; Rest in English
- Where
- 8 sites in United States, Puerto Rico
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Ponce Medical School Foundation, Inc.
Breast Cancer, Unspecified Adult Solid Tumor, Protocol Specific
Effects of Fetal, Infant, and Early Childhood Exposures on Adult Cancer Risk in Women
RATIONALE: Gathering information about pregnancy, infancy, and early childhood exposures may help doctors identify cancer risk factors, and may help the study of cancer.
- Trial name
- NCT00559039
- Testing
- questionnaire administration, evaluation of cancer risk factors
- Where
- United States
- Volunteers
- 128,700 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Hematopoietic and Lymphoid System Neoplasm, Malignant Solid Neoplasm
Financial Health Educational Program for Increasing Financial Literacy Among Underserved Communities in Western New York
This clinical trial evaluates a financial health educational program to educate and increase knowledge for financial health and well-being, and to ensure access to financial knowledge and resources among underserved community…
- Trial name
- NCT05997589
- Testing
- Behavioral Intervention, Educational Intervention, Questionnaire Administration
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute
Prostate Cancer
Cultured Circulating Tumor Cells in Prostate and Other Cancers
The purpose of this study is to evaluate the number of circulating tumor cells (CTC) before and after treatment using an experimental method for detecting CTC, compared to commercial CTC assay results, in patients with prostate…
- Trial name
- NCT02123862
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Oscar Goodman, Jr.
Advanced Solid Tumor
A Food Effect Study of SPH5030 Tablets.
The purpose of this study is to evaluate the food effect of SPH5030 tablets in healthy Chinese adult subjects.
- Trial name
- NCT06372223
- Testing
- SPH5030
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Shanghai Pharmaceuticals Holding Co., Ltd
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Measuring the Impact of MANNA s Medically Tailored Meal Program in Patients With a Non-terminal Cancer Diagnosis
This study identifies patient-important outcome measures and develops a survey that assesses the impact of nutritional interventions among cancer patients.
- Trial name
- NCT05118802
- Testing
- Interview, Survey Administration
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University