Clinical trials: Soft Tissues
Soft Tissue Atrophy
Using of Collagen Matrix for Maxillary Tuberosity Donor Area Preservation
An interventional prospective randomised clinical trial (RCT) in parallel groups is planned. The sample size was 30 patients who will be randomly divided into two groups based on the surgical procedure.
- Trial name
- NCT06039839
- Testing
- Closure of the donor area after CTG harvesting without the use of collagen matrix, Closure of the donor area after CTG harvesting with collagen matrix
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Gastrointestinal Stromal Tumors
Nilotinib Roll-over Protocol for Patients in Novartis-sponsored Nilotinib Study and Benefiting From Nilotinib Treatment
The purpose of this study is to collect and assess long-term safety of nilotinib in patients who are on nilotinib treatment in a Novartis-sponsored, Oncology Clinical Development \& Medical Affairs study and are benefiting from…
- Trial name
- NCT01863745
- Testing
- nilotinib
- Where
- 11 sites in Japan
- Volunteers
- 15 people
- Sponsor
- Novartis Pharmaceuticals
Urticaria Pigmentosa
Natural History of Urticaria Pigmentosa in Children
The purpose of this study is to determine how long the skin lesions usually last and what kind of symptoms and signs children with urticaria pigmentosa may develop over the years.
- Trial name
- UP (NCT00467792)
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Medical College of Wisconsin
Sarcoma,Soft Tissue
A Study to Compare Adjuvant Concurrent Chemoradiation (CCRT) to Adjuvant Radiation Therapy (RT) in Grade 2 and 3 Extremity Soft Tissue Sarcomas
The aim of the study is to retrospectively evaluate the outcome of adjuvant concurrent chemoradiation delivered to patients with high grade non-metastatic soft tissue sarcomas of the extremities at the investigators institution…
- Trial name
- NCT02994264
- Testing
- adjuvant concurrent chemoradiation
- Volunteers
- 80 people
- Sponsor
- Institut de Cancérologie de Lorraine
Flexibility, Hamstring Tightness
Instrument Assisted Soft Tissue Mobilization vs Therapeutic Cupping on Hamstring Tightness Among Football Players
The study is randomized and single-blinded. Ethical approval is taken from ethical committee of Riphah International University, Lahore.
- Conditions
- Flexibility, Hamstring Tightness, Instrument Assisted Soft Tissue Mobilization, Range of Motion
- Trial name
- NCT06197971
- Testing
- Instrument Assisted Soft Tissue Mobilization, Therapeutic Cupping Technique
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Leiomyoma
Hemostatic Effect of Intrauterine Instillation of Oxytocin in Hysteroscopic Myomectomy
There is no previous study on the hemostatic effect of intrauterine instillation of oxytocin in hysteroscopic myomectomy. All previous studies focused on intravenous administration of oxytocin.
- Trial name
- oxytocin (NCT04996498)
- Testing
- Oxytocin, sterile bacteriostatic water ampule
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Soft Tissue Sarcoma
Study Evaluating the Safety and Efficacy of MEDI5752 in Combination With Stereotactic Radiotherapy in Patients With Metastatic Sarcoma
This is a phase I, multicenter, open-label study starting with a dose exploration phase and followed by an expansion phase to evaluate the safety profile and the preliminary activity of the bispecific antibody anti PD-1/CTLA-4…
- Trial name
- MEDISARC-SBRT (NCT05821231)
- Testing
- SBRT + MEDI5752
- Where
- 5 sites in France
- Volunteers
- 14 people
- Sponsor
- Institut Claudius Regaud
Calcaneus Fracture
External Fixation Versus Splinting of Acute Calcaneus Fractures
Aim: Determine if external fixation decreases soft tissue complications compared to splinting. Determine if external fixation decreases time to definitive surgical stabilization and improves final fixation compared to splinting.
- Trial name
- NCT04063657
- Testing
- External fixator, Splinting
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of California, Davis
Soft Tissue Sarcoma Adult, High Grade Sarcoma
Efficacy and Safety of Anlotinib in Adjuvant Therapy for High-grade Soft Tissue Sarcoma
To evaluate the efficacy and safety of Anlotinib Hydrochloride Capsule combined with Best Supportive Therapy in the adjuvant treatment of patients with high-grade soft tissue sarcoma after operation, as compared with placebo…
- Trial name
- NCT03951571
- Testing
- Anlotinib Hydrochloride
- Where
- 5 sites in China
- Volunteers
- 88 people
- Sponsor
- Fudan University
Myxoid Liposarcoma, Round Cell Liposarcoma
Recombinant Interferon Gamma in Treating Patients With Soft Tissue Sarcoma
This pilot clinical trial studies the effect of recombinant interferon gamma on tissue in treating patients with soft tissue sarcoma. Interferon gamma may interfere with the growth of tumor cells.
- Conditions
- Myxoid Liposarcoma, Round Cell Liposarcoma, Synovial Sarcoma
- Trial name
- NCT01957709
- Testing
- Laboratory Biomarker Analysis, Recombinant Interferon Gamma
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Fred Hutchinson Cancer Center
Ovarian Carcinoma, Fallopian Tube Carcinoma
NM32-2668 in Adult Patients With Selected Advanced Solid Tumors
This is a first-in-human, open-label, multi-center, Phase 1, dose-escalation study with expansion cohorts to evaluate NM32-2668 for safety and immunogenicity, to determine the maximal tolerated dose and recommended Phase 2 dose…
- Conditions
- Ovarian Carcinoma, Fallopian Tube Carcinoma, Peritoneal Carcinoma, Endometrial Cancer
- Trial name
- NCT06299163
- Testing
- NM32-2668
- Where
- 11 sites in United States
- Volunteers
- 11 people
- Sponsor
- Numab Therapeutics AG
Triangular Fibrocartilage Complex Injuries
Exploration of Wrist Soft Tissue Injuries Associated With Wrist Fractures
The purpose of this study is to describe and stage lesions of the triangular fibrocartilage complex (TFCC) in association with distal radius fractures.
- Trial name
- NCT01145716
- Testing
- Arthroscopy, surgery
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Linkoeping University
Oral Cancer
Lateral Arm Free Flap for Reconstruction of the Oral Cavity and Head and Neck Soft Tissue Defects.
The excision of oral cancers causes extensive impairment of the oral cavity soft tissue. Complete excision of the tumors is vital, and the reconstruction of the resected area influences not only the postoperative recovery period…
- Trial name
- NCT05296811
- Testing
- Lateral Arm Free Flap
- Where
- Egypt
- Volunteers
- 15 people
- Sponsor
- hassan harby mohamed
Multiple Osteochondroma
Descriptive Analysis of Surgeries in Patients With Multiple Osteochondromas
Multiple Osteochondromas (MO), also known as Multiple Cartilaginous Exostoses, is an autosomal dominant skeletal disorder with an incidence of approximately 1 in 50,000 in Western populations.
- Trial name
- CHIROS (NCT07556874)
- Testing
- Surgery for osteochondromas
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Istituto Ortopedico Rizzoli
Lymphangioleiomyomatosis
Safety and Durability of Sirolimus for Treatment of LAM
The MIDAS study aims to follow male and female LAM patients who are currently taking, have previously failed or been intolerant of, or may (at some time in the future) take mTOR inhibitors (sirolimus or everolimus) as part of…
- Trial name
- MIDAS (NCT02432560)
- Testing
- Sirolimus, Everolimus
- Where
- 20 sites in United States
- Volunteers
- 600 people
- Sponsor
- University of Cincinnati
Advanced Malignant Mesothelioma, Epithelial Mesothelioma
Erlotinib in Treating Patients With Malignant Mesothelioma of the Lung
Erlotinib may interfere with the growth of tumor cells and slow the growth of the tumor. This phase II trial is studying how well erlotinib works in treating patients with malignant mesothelioma of the lung
- Conditions
- Advanced Malignant Mesothelioma, Epithelial Mesothelioma, Recurrent Malignant Mesothelioma, Sarcomatous Mesothelioma
- Trial name
- NCT00039182
- Testing
- erlotinib hydrochloride, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- National Cancer Institute (NCI)
Sarcoma, Ewing, Sarcoma
SM-88 Maintenance Therapy for Advanced Ewing's Sarcoma and as Salvage Therapy for Sarcoma
The primary objective is to evaluate the efficacy of SM-88, a combination metabolic cancer treatment, in two study cohorts: Clinically advanced Ewing's Sarcoma patients who have not progressed at the conclusion of systemic…
- Trial name
- HopES (NCT03778996)
- Testing
- Combination metyrosine-derivative, low-dose methoxsalen, phenytoin and sirolimus (MPS)
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Sarcoma Oncology Research Center, LLC
Finger Injuries, Soft Tissue Injuries
Repair of Multiple Finger Defects Using the Dorsal Homodigital Island Flaps
Multiple finger defects are common in hand trauma and result in functional disability. These injuries are often complex and severe, and thus reconstructive alternatives are limited.
- Trial name
- NCT01767727
- Testing
- Soft tissue coverage
- Where
- China
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- The Second Hospital of Tangshan
Soft Tissue Wound Healing
Effect of Hyaluronic Acid on Oral Mucosal Wound Healing - Focus on Pain and Re-epithelisation
Establishment of a sufficiently wide and thick keratinized gingival/mucosal tissue cuff around teeth/implants is considered of importance for long-term stability.
- Trial name
- NCT05099718
- Testing
- palatal soft tissue harvesting, Hyaluronic acid
- Where
- Sweden
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Malmö University
Gingival Recession
A New Therapeutic Approach for Root Coverage
Different surgical techniques have been proposed for root coverage, showing varying results especially in areas of deep recessions.
- Trial name
- NCT01143610
- Testing
- Newly forming bone technique for root coverage, Subepithelial connective tissue graft for root coverage.
- Where
- Brazil
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo